Advanced search
Publication Cover
Risk Management and Healthcare Policy Volume 13, 2020 - Issue
Submit an article Journal homepage
103
Views
1
CrossRef citations to date
0
Altmetric
Original Research

Combined Detection of ACTN4 and SCC-Ag is a Promising Serological Biomarker for Cervical Intraepithelial Neoplasia 3 or Worse: A Case–Control Study

Bin Zhu1 Department of Clinical Laboratorial Examination, Fujian Medical University Union Hospital, Fuzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-7365-1371View further author information
ORCID Icon,
Binhua Dong2 Department of Gynecology, Laboratory of Gynecologic Oncology, Fujian Provincial Maternity and Children’s Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-5086-0696View further author information
ORCID Icon,
Simei Hong3 Department of Pathology, Fujian Provincial Cancer Hospital, Fuzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-4304-931XView further author information
ORCID Icon,
Meihua Wang1 Department of Clinical Laboratorial Examination, Fujian Medical University Union Hospital, Fuzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-3597-6631View further author information
ORCID Icon,
Weichao Dai4 Department of Gynecology, Fujian Medical University Union Hospital, Fuzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-6114-1104View further author information
ORCID Icon,
Qingzhu Zheng1 Department of Clinical Laboratorial Examination, Fujian Medical University Union Hospital, Fuzhou, People’s Republic of ChinaView further author information
,
Dan Wu5 Department of Pathology, Fujian Medical University Union Hospital, Fuzhou, People’s Republic of ChinaView further author information
&
Yingping Cao1 Department of Clinical Laboratorial Examination, Fujian Medical University Union Hospital, Fuzhou, People’s Republic of ChinaCorrespondence[email protected]
View further author information
 show all
Pages 2677-2687 | Published online: 20 Nov 2020

References

  • Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–386. doi:10.1002/ijc.2921025220842
  • de Sanjosé S, Diaz M, Castellsagué X, et al. Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis. 2007;7(7):453–459. doi:10.1016/S1473-3099(07)70158-517597569
  • Dickson EL, Vogel RI, Geller MA, Downs LS. Cervical cytology and multiple type HPV infection: a study of 8182 women ages 31–65. Gynecol Oncol. 2014;133(3):405–408. doi:10.1016/j.ygyno.2014.03.55224657488
  • Cohen PA, Jhingran A, Oaknin A, Denny L. Cervical cancer. Lancet. 2019;393(10167):169–182. doi:10.1016/S0140-6736(18)32470-X30638582
  • Schiffman M, Doorbar J, Wentzensen N, et al. Carcinogenic human papillomavirus infection. Nat Rev Dis Primers. 2016;2:16086.27905473
  • Arbyn M, Ronco G, Anttila A, et al. Evidence regarding human papillomavirus testing in secondary prevention of cervical cancer. Vaccine. 2012;30(Suppl 5):F88–99. doi:10.1016/j.vaccine.2012.06.09523199969
  • Valenti G, Vitale SG, Tropea A, Biondi A, Lagana AS. Tumor markers of uterine cervical cancer: a new scenario to guide surgical practice? Updates Surg. 2017;69(4):441–449. doi:10.1007/s13304-017-0491-328918603
  • Honda K. The biological role of actinin-4 (ACTN4) in malignant phenotypes of cancer. Cell Biosci. 2015;5(1):41. doi:10.1186/s13578-015-0031-026288717
  • Honda K, Yamada T, Hayashida Y, et al. Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer. Gastroenterology. 2005;128(1):51–62. doi:10.1053/j.gastro.2004.10.00415633123
  • Kikuchi S, Honda K, Tsuda H, et al. Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas. Clin Cancer Res. 2008;14(17):5348–5356. doi:10.1158/1078-0432.CCR-08-007518765526
  • Yamamoto S, Tsuda H, Honda K, et al. Actinin-4 expression in ovarian cancer: a novel prognostic indicator independent of clinical stage and histological type. Mod Pathol. 2007;20(12):1278–1285. doi:10.1038/modpathol.380096617873890
  • An HT, Yoo S, Ko J. Alpha-actinin-4 induces the epithelial-to-mesenchymal transition and tumorigenesis via regulation of snail expression and beta-catenin stabilization in cervical cancer. Oncogene. 2016;35(45):5893–5904. doi:10.1038/onc.2016.11727065319
  • Wang Q, Qin Q, Song R, et al. NHERF1 inhibits beta-catenin-mediated proliferation of cervical cancer cells through suppression of alpha-actinin-4 expression. Cell Death Dis. 2018;9(6):668. doi:10.1038/s41419-018-0711-x29867145
  • Jung J, Kim S, An HT, Ko J. α-actinin-4 regulates cancer stem cell properties and chemoresistance in cervical cancer. Carcinogenesis. 2020;41(7):940–949. doi:10.1093/carcin/bgz16831584624
  • Wang Q, Song R, Zhao C, et al. HPV16 E6 promotes cervical cancer cell migration and invasion by downregulation of NHERF1. Int J Cancer. 2019;144(7):1619–1632.30230542
  • Starodubtseva NL, Brzhozovskiy AG, Bugrova AE, et al. Label-free cervicovaginal fluid proteome profiling reflects the cervix neoplastic transformation. J Mass Spectrom. 2019;54(8):693–703. doi:10.1002/jms.437431116903
  • Van Raemdonck GA, Tjalma WA, Coen EP, Depuydt CE, Van Ostade XW. Identification of protein biomarkers for cervical cancer using human cervicovaginal fluid. PLoS One. 2014;9(9):e106488. doi:10.1371/journal.pone.010648825215525
  • Van Ostade X, Dom M, Tjalma W, Van Raemdonck G. Candidate biomarkers in the cervical vaginal fluid for the (self-)diagnosis of cervical precancer. Arch Gynecol Obstet. 2018;297(2):295–311. doi:10.1007/s00404-017-4587-229143101
  • Fang C, Li JJ, Deng T, Li BH, Geng PL, Zeng XT. Actinin-4 as a diagnostic biomarker in serum of breast cancer patients. Med Sci Monit. 2019;25:3298–3302. doi:10.12659/MSM.91240431054253
  • Liu Z, Shi H. Prognostic role of squamous cell carcinoma antigen in cervical cancer: a meta-analysis. Dis Markers. 2019;2019:6710352. doi:10.1155/2019/671035231275450
  • Guo Q, Zhu J, Wu Y, et al. Predictive value of preoperative serum squamous cell carcinoma antigen (SCC-Ag) level on tumor recurrence in cervical squamous cell carcinoma patients treated with radical surgery: a single-institution study. Eur J Surg Oncol. 2019;313(7068):1285–1290.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.