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Review

Multimorbidity in chronic disease: impact on health care resources and costs

Pages 143-156 | Published online: 05 Jul 2016

References

  • LehnertTHeiderDLeichtHReview: health care utilization and costs of elderly persons with multiple chronic conditionsMed Care Res Rev201168438742021813576
  • BarlowJWrightCSheasbyJTurnerAHainsworthJSelf-management approaches for people with chronic conditions: a reviewPatient Educ Couns200248217718712401421
  • BoydCMDarerJBoultCFriedLPBoultLWuAWClinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performanceJAMA2005294671672416091574
  • WeingartenSRHenningJMBadamgaravEInterventions used in disease management programmes for patients with chronic illness which ones work? Meta-analysis of published reportsBMJ2002325737092512399340
  • McPhailSMSchippersMMarshallALWaiteMKuipersPPerceived barriers and facilitators to increasing physical activity among people with musculoskeletal disorders: a qualitative investigation to inform intervention developmentClin Interv Aging201492113212225584023
  • OnderGPalmerKNavickasRTime to face the challenge of multimorbidity. A European perspective from the joint action on chronic diseases and promoting healthy ageing across the life cycle (JA-CHRODIS)Eur J Intern Med201526315715925797840
  • WolffJLStarfieldBAndersonGPrevalence, expenditures, and complications of multiple chronic conditions in the elderlyArch Intern Med2002162202269227612418941
  • BrownRSPeikesDPetersonGSchoreJRazafindrakotoCMSix features of Medicare coordinated care demonstration programs that cut hospital admissions of high-risk patientsHealth Aff201231611561166
  • WittenbergRThe challenge of measuring multi-morbidity and its costsIsr J Health Policy Res20154125949796
  • McPhailSMSchippersMMarshallALAge, physical inactivity, obesity, health conditions, and health-related quality of life among patients receiving conservative management for musculoskeletal disordersClin Interv Aging201491069108025031532
  • LefèvreTd’IvernoisJFDe AndradeVCrozetCLombrailPGagnayreRWhat do we mean by multimorbidity? An analysis of the literature on multimorbidity measures, associated factors, and impact on health services organizationRev Epidemiol Sante Publique201462530531425444838
  • DamerySFlanaganSCombesGThe effectiveness of interventions to achieve co-ordinated multidisciplinary care and reduce hospital use for people with chronic diseases: study protocol for a systematic review of reviewsSyst Rev201546425951820
  • HuntleyALJohnsonRPurdySValderasJMSalisburyCMeasures of multimorbidity and morbidity burden for use in primary care and community settings: a systematic review and guideAnn Fam Med201210213414122412005
  • SmithSMSoubhiHFortinMHudonCO’DowdTManaging patients with multimorbidity: systematic review of interventions in primary care and community settingsBMJ2012345e520522945950
  • YurkovichMAvina-ZubietaJAThomasJGorenchteinMLacailleDA systematic review identifies valid comorbidity indices derived from administrative health dataJ Clin Epidemiol201568131425441702
  • CharlsonMCharlsonREBriggsWHollenbergJCan disease management target patients most likely to generate high costs? The impact of comorbidityJ Gen Intern Med200722446446917372794
  • CharlsonMECharlsonREPetersonJCMarinopoulosSSBriggsWMHollenbergJPThe Charlson comorbidity index is adapted to predict costs of chronic disease in primary care patientsJ Clin Epidemiol200861121234124018619805
  • PerkinsAJKroenkeKUnützerJCommon comorbidity scales were similar in their ability to predict health care costs and mortalityJ Clin Epidemiol200457101040104815528055
  • ZulmanDMCheeCPWagnerTHMultimorbidity and healthcare utilisation among high-cost patients in the US Veterans Affairs Health Care SystemBMJ Open201554e007771
  • CharlsonMEPompeiPAlesKLMacKenzieCRA new method of classifying prognostic comorbidity in longitudinal studies: development and validationJ Chronic Dis19874053733833558716
  • SundararajanVHendersonTPerryCMuggivanAQuanHGhaliWANew ICD-10 version of the Charlson comorbidity index predicted in-hospital mortalityJ Clin Epidemiol200457121288129415617955
  • ClarkDOKorffMVSaundersKBaluchWMSimonGEA chronic disease score with empirically derived weightsMed Care19953387837957637401
  • ValderasJMStarfieldBSibbaldBSalisburyCRolandMDefining comorbidity: implications for understanding health and health servicesAnn Fam Med20097435736319597174
  • Calderón-LarrañagaAAbad-DíezJMGimeno-FeliuLAGlobal health care use by patients with type-2 diabetes: does the type of comorbidity matter?Eur J Intern Med201526320321025765442
  • Bernabeu-WittelMAlonso-CoelloPRico-BlázquezMRotaeche del CampoRSánchez GómezSCasariego ValesEDevelopment of clinical practice guidelines for patients with comorbidity and multiple diseasesRev Clín Esp2014214632833524856043
  • FortinMStewartMPoitrasMEAlmirallJMaddocksHA systematic review of prevalence studies on multimorbidity: toward a more uniform methodologyAnn Fam Med201210214215122412006
  • MoussaviSChatterjiSVerdesETandonAPatelVUstunBDepression, chronic diseases, and decrements in health: results from the World Health SurveysLancet2007370959085185817826170
  • El-AtemNAWojcikKHorsfallLPatterns of service utilisation within Australian hepatology clinics: high prevalence of advanced liver diseaseIntern Med J201646442042626762655
  • BarnettKMercerSWNorburyMWattGWykeSGuthrieBEpidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional studyLancet20123809836374322579043
  • DixonAKhachatryanAGilmourSDoes general practice reduce health inequalities? Analysis of quality and outcomes framework dataEur J Public Health201222191321148179
  • MuellerCSchurCO’ConnellJPrescription drug spending: the impact of age and chronic disease statusAm J Public Health19978710162616299357343
  • SloanePDOudenhovenMDBroylesIMcNabneyMChallenges to cost-effective care of older adults with multiple chronic conditions: perspectives of Program of All-Inclusive Care for the Elderly medical directorsJ Am Geriatr Soc201462356456524628628
  • BodenheimerTChenEBennettHDConfronting the growing burden of chronic disease: can the U.S. health care workforce do the job?Health Aff20092816474
  • HeidenreichPATrogdonJGKhavjouOAForecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart AssociationCirculation2011123893394421262990
  • WangYCMcPhersonKMarshTGortmakerSLBrownMHealth and economic burden of the projected obesity trends in the USA and the UKLancet2011378979381582521872750
  • FoxMHReichardADisability, health, and multiple chronic conditions among people eligible for both Medicare and Medicaid, 2005–2010Prev Chronic Dis201310E15724050527
  • LawsonKDMercerSWWykeSDouble trouble: the impact of multimorbidity and deprivation on preference-weighted health related quality of life a cross sectional analysis of the Scottish Health SurveyInt J Equity Health2013126723962150
  • LimSSVosTFlaxmanADA comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010Lancet201238098592224226023245609
  • McPhailSSchippersMAn evolving perspective on physical activity counselling by medical professionalsBMC Fam Pract20121313122524484
  • DixonAKhachatryanAWallaceAPeckhamSBoyceTGillamSThe quality and outcomes framework (QOF): does it reduce health inequalitiesFinal reportLondon, UKNIHR2010
  • TinettiMEFriedTRBoydCMDesigning health care for the most common chronic condition – multimorbidityJAMA2012307232493249422797447
  • SalisburyCMultimorbidity: redesigning health care for people who use itLancet201238098367922579042
  • RizzoJAChenJGunnarssonCLNaimALoflandJHAdjusting for comorbidities in cost of illness studiesJ Med Econ2015181122825253504
  • BohenskyMAAdemiZdeSteigerRQuantifying the excess cost and resource utilisation for patients with complications associated with elective knee arthroscopy: a retrospective cohort studyKnee201421249149624331732
  • CrystalSJohnsonRWHarmanJSambamoorthiUKumarROut-of-pocket health care costs among older AmericansJ Gerontol B Psychol Sci Soc Sci2000551S51S6210728130
  • KarveSCandrilliSKappelmanMDTolleson-RinehartSTennisPAndrewsEHealthcare utilization and comorbidity burden among children and young adults in the United States with systemic lupus erythematosus or inflammatory bowel diseaseJ Pediatr20121614662670.e66222578787
  • LeeDWMeyerJWClouseJImplications of controlling for comorbid conditions in cost-of-illness estimates: a case study of osteoarthritis from a managed care system perspectiveValue Health20014432933411705300
  • American Diabetes AssociationEconomic costs of diabetes in the U.S. in 2007Diabetes Care200831359661518308683
  • HungerMThorandBSchunkMMultimorbidity and health-related quality of life in the older population: results from the German KORA-age studyHealth Qual Life Outcomes20119111021223594
  • MarventanoSAyalaAGonzalezNRodríguez–BlázquezCGarcia-GutierrezSForjazMJMultimorbidity and functional status in community-dwelling older adultsEur J Intern Med201425761061624997486
  • TyackZFrakesKABarnettACornwellPKuysSMcPhailSPredictors of health-related quality of life in people with a complex chronic disease including multimorbidity: a longitudinal cohort studyQual Life Res2016 Epub452016
  • AndrewsGHendersonSHallWPrevalence, comorbidity, disability and service utilisation overview of the Australian National Mental Health SurveyBr J Psychiatry2001178214515311157427
  • HopmanPHeinsMJRijkenMSchellevisFGHealth care utilization of patients with multiple chronic diseases in The Netherlands: Differences and underlying factorsEur J Intern Med201526319019625704328
  • FahlmanCLynnJDobermanDGabelJFinchMPrescription drug spending for Medicare+ Choice beneficiaries in the last year of lifeJ Palliat Med20069488489316910803
  • MoxeyEDO’ConnorJPNovielliKDTeutschSNashDBPrescription drug use in the elderly: a descriptive analysisHealth Care Financ Rev200224412714114628405
  • Ramage-MorinPLMedication use among senior CanadiansHealth Rep2009201374419388367
  • RogowskiJLillardLAKingtonRThe financial burden of prescription drug use among elderly personsGerontologist19973744754829279036
  • LandisSEGaynesBNMorrisseyJPVinsonNEllisARDominoMEGeneralist care managers for the treatment of depressed medicaid patients in North Carolina: a pilot studyBMC Fam Pract20078717338822
  • StarfieldBLemkeKWBernhardtTFoldesSSForrestCBWeinerJPComorbidity: implications for the importance of primary care in “case” managementAnn Fam Med20031181415043174
  • ChanDKChongRBasilikasJMathieMHungWTSurvey of major chronic illnesses and hospital admissions via the emergency department in a randomized older population in Randwick, AustraliaEmerg Med2002144387392
  • ChuLWPeiCKRisk factors for early emergency hospital readmission in elderly medical patientsGerontology199945422022610394080
  • CondeliusAEdbergAKJakobssonUHallbergIRHospital admissions among people 65+ related to multimorbidity, municipal and outpatient careArch Gerontol Geriatr2008461415517403548
  • RapoportJJacobsPBellNRKlarenbachSRefining the measurement of the economic burden of chronic diseases in CanadaChronic Dis Can2004251132115298484
  • SchneiderKMO’DonnellBEDeanDPrevalence of multiple chronic conditions in the United States’ Medicare populationHealth Qual Life Outcomes20097828219737412
  • XakellisGCAre patients who use a generalist physician healthier than those who seek specialty care directly?Fam Med2005371071972616273451
  • PaezKAZhaoLHwangWRising out-of-pocket spending for chronic conditions: a ten-year trendHealth Aff20092811525
  • GravesNCourtneyMEdwardsHChangAParkerAFinlaysonKCost-effectiveness of an intervention to reduce emergency re-admissions to hospital among older patientsPLoS One2009410e745519829702
  • HwangWWellerWIreysHAndersonGOut-of-pocket medical spending for care of chronic conditionsHealth Aff2001206267278
  • SchoenCOsbornRSquiresDDotyMMPiersonRApplebaumSHow health insurance design affects access to care and costs, by income, in eleven countriesHealth Aff2010291223232334
  • SchoenbergNEKimHEdwardsWFlemingSTBurden of common multiple-morbidity constellations on out-of-pocket medical expenditures among older adultsGerontologist200747442343717766664
  • O’TooleJHamblyRCoxAMO’SheaBDarkerCMethadone-maintained patients in primary care have higher rates of chronic disease and multimorbidity, and use health services more intensively than matched controlsEur J Gen Pract201420427528024798090
  • Hordijk-TrionMLenzenMWijnsWPatients enrolled in coronary intervention trials are not representative of patients in clinical practice: results from the Euro Heart Survey on Coronary RevascularizationEur Heart J200627667167816423872
  • ZimmermanMMattiaJIPosternakMAAre subjects in pharmacological treatment trials of depression representative of patients in routine clinical practice?Am J Psychiatry2002159346947311870014
  • MasoudiFAHavranekEPWolfePMost hospitalized older persons do not meet the enrollment criteria for clinical trials in heart failureAm Heart J2003146225025712891192
  • CherubiniASignoreSDOuslanderJSemlaTMichelJPFighting against age discrimination in clinical trialsJ Am Geriatr Soc20105891791179620863340
  • DrummondMFDaviesLEconomic analysis alongside clinical trials. Revisiting the methodological issuesInt J Technol Assess Health Care1991745615731778701
  • O’brienBEconomic evaluation of pharmaceuticals. Frankenstein’s monster or vampire of trials?Med Care19963412 SupplDS99DS1088969318
  • RamseySWillkeRBriggsAGood research practices for cost-effectiveness analysis alongside clinical trials: the ISPOR RCT-CEA task force reportValue health20058552153316176491
  • CoventryPLovellKDickensCIntegrated primary care for patients with mental and physical multimorbidity: cluster randomised controlled trial of collaborative care for patients with depression comorbid with diabetes or cardiovascular diseaseBMJ2015350
  • JägerCFreundTSteinhäuserJJoosSWensingMSzecsenyiJA tailored implementation intervention to implement recommendations addressing polypharmacy in multimorbid patients: study protocol of a cluster randomized controlled trialTrials201314142024308282
  • BozorgmehrKSzecsenyiJOseDPractice network-based care management for patients with type 2 diabetes and multiple comorbidities (GEDIMAplus): study protocol for a randomized controlled trialTrials20141524324952740
  • HsiehHMGuSMShinSJKaoHYLinYCChiuHCCost-effectiveness of a diabetes pay-for-performance program in diabetes patients with multiple chronic conditionsPLoS One2015107e013316326173086
  • RitzwollerDPGlasgowRESukhanovaAYEconomic analyses of the Be Fit Be Well program: a weight loss program for community health centersJ Gen Intern Med201328121581158823733374
  • VilaAVillegasECruanyesJCost-effectiveness of a Barcelona home care program for individuals with multimorbidityJ Am Geriatr Soc20156351017102425940863
  • DrummondMFMcGuireAEconomic Evaluation in Health Care: Merging Theory with PracticeNew York, NYOxford University Press2001
  • WeinsteinMCO’BrienBHornbergerJPrinciples of good practice for decision analytic modeling in health-care evaluation: report of the ISPOR task force on good research practices – modeling studiesValue Health20036191712535234
  • KatonWJLinEHBVon KorffMCollaborative care for patients with depression and chronic illnessesN Engl J Med2010363272611262021190455
  • KatonWRussoJLinEHCost-effectiveness of a multicondition collaborative care intervention: a randomized controlled trialArch GenPsychiatry2012695506514
  • SchmittdielJVijanSFiremanBLafataJEOestreicherNSelbyJVPredicted quality-adjusted life years as a composite measure of the clinical value of diabetes risk factor controlMed Care200745431532117496715
  • LindströmJPeltonenMErikssonJImproved lifestyle and decreased diabetes risk over 13 years: long-term follow-up of the randomised Finnish Diabetes Prevention Study (DPS)Diabetologia201356228429323093136
  • LiGZhangPWangJThe long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up studyLancet200837196261783178918502303
  • DPPR GroupLong-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes StudyLancet Diabetes Endocrinol201531186687526377054
  • TostesonAJönssonBGrimaDO’BrienBBlackDAdachiJChallenges for model-based economic evaluations of postmenopausal osteoporosis interventionsOsteopor Int20011210849857
  • SprangersMASchwartzCEIntegrating response shift into health-related quality of life research: a theoretical modelSoc Sci Med199948111507151510400253
  • McPhailSHainesTThe response shift phenomenon in clinical trialsJ Clin Res Best Pract20106218
  • GrootWAdaptation and scale of reference bias in self-assessments of quality of lifeJ Health Econ200019340342010977197
  • MenzelPDolanPRichardsonJOlsenJAThe role of adaptation to disability and disease in health state valuation: a preliminary normative analysisSoc Sci Med200255122149215812409128
  • PostPNStiggelboutAMWakkerPPThe utility of health states after stroke: a systematic review of the literatureStroke20013261425142911387509
  • McPhailSComansTHainesTEvidence of disagreement between patient-perceived change and conventional longitudinal evaluation of change in health-related quality of life among older adultsClin Rehabil201024111036104420702509
  • HowardGSDaileyPRResponse-shift bias: a source of contamination of self-report measuresJ Appl Psychol1979642144
  • DaltroyLHLarsonMGEatonHMPhillipsCBLiangMHDiscrepancies between self-reported and observed physical function in the elderly: the influence of response shift and other factorsSoc Sci Med199948111549156110400256
  • McPhailSHainesTResponse shift, recall bias and their effect on measuring change in health-related quality of life amongst older hospital patientsHealth Qual Life Outcomes201086520618978
  • SchwartzCESprangersMAMethodological approaches for assessing response shift in longitudinal health-related quality-of-life researchSoc Sci Med199948111531154810400255
  • OortFJUsing structural equation modeling to detect response shifts and true changeQual Life Res200514358759816022054
  • AhmedSMayoNEWood-DauphineeSHanleyJACohenSRThe structural equation modeling technique did not show a response shift, contrary to the results of the then test and the individualized approachesJ Clin Epidemiol200558111125113316223655
  • SnyderCAaronsonNChoucairAImplementing patient-reported outcomes assessment in clinical practice: a review of the options and considerationsQual Life Res20122181305131422048932
  • HickeyABarkerMMcGeeHO’BoyleCMeasuring health-related quality of life in older patient populationsPharmacoeconomics2005231097199316235972
  • LogsdonRGGibbonsLEMcCurrySMTeriLAssessing quality of life in older adults with cognitive impairmentPsychosom Med200264351051912021425
  • McPhailSBellerEHainesTReference bias: presentation of extreme health states prior to EQ-VAS improves health-related quality of life scores. A randomised cross-over trialHealth Qual Life Outcomes20108114621126374
  • SneeuwKCSprangersMAAaronsonNKThe role of health care providers and significant others in evaluating the quality of life of patients with chronic diseaseJ Clin Epidemiol200255111130114312507678
  • McPhailSBellerEHainesTTwo perspectives of proxy reporting of health-related quality of life using the Euroqol-5D, an investigation of agreementMed Care200846111140114818953224
  • PickardASKnightSJProxy evaluation of health-related quality of life: a conceptual framework for understanding multiple proxy perspectivesMed Care200543549315838415
  • YachDHawkesCGouldCLHofmanKJThe global burden of chronic diseases: overcoming impediments to prevention and controlJAMA2004291212616262215173153
  • PanagiotiMRichardsonGMurrayEReducing Care Utilisation through Self-management Interventions (RECURSIVE): A Systematic Review and Meta-analysisSouthampton, UKQueen’s Printer and Controller of HMSO2014
  • RussellLBPreventing chronic disease: an important investment, but don’t count on cost savingsHealth Aff20092814245
  • ThompsonKMTebbensRJDRetrospective cost-effectiveness analyses for polio vaccination in the United StatesRisk Anal20062661423144017184390
  • JohannessonMAt what coronary risk level is it cost-effective to initiate cholesterol lowering drug treatment in primary prevention?Eur Heart J2001221191992511428815
  • RafteryJPYaoGLMurchiePCampbellNCRitchieLDCost effectiveness of nurse led secondary prevention clinics for coronary heart disease in primary care: follow up of a randomised controlled trialBMJ2005330749370715716289
  • HankeyGJWarlowCPTreatment and secondary prevention of stroke: evidence, costs, and effects on individuals and populationsLancet199935491881457146310543686
  • GaspozJMCoxsonPGGoldmanPACost effectiveness of aspirin, clopidogrel, or both for secondary prevention of coronary heart diseaseN Engl J Med2002346231800180612050341
  • FaganKZhaoEYHorsfallLBurden of decompensated cirrhosis and ascites on hospital services in a tertiary care facility: time for change?Intern Med J201444986587224893971
  • PriceEBakerRKrauseJKeenCOrganisation of services for people with cardiovascular disorders in primary care: transfer to primary care or to specialist-generalist multidisciplinary teams?BMC Fam Pract20141515825245456
  • SanmuganathanPGhahramaniPJacksonPWallisERamsayLAspirin for primary prevention of coronary heart disease: safety and absolute benefit related to coronary risk derived from meta-analysis of randomised trialsHeart200185326527111179262
  • NakamuraHArakawaKItakuraHPrimary prevention of cardiovascular disease with pravastatin in Japan (MEGA Study): a prospective randomised controlled trialLancet200636895421155116317011942
  • RemboldCMNumber needed to screen: development of a statistic for disease screeningBMJ199831771543073129685274
  • CaroJKlittichWMcGuireAThe West of Scotland coronary prevention study: economic benefit analysis of primary prevention with pravastatinBMJ19973157122157715829437275
  • RidkerPMRifaiNClearfieldMMeasurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary eventsN Engl J Med2001344261959196511430324
  • McPhailSMSchippersMMaherCAMarshallALPatient preferences for receiving remote-communication support for lifestyle physical activity behaviour change: the perspective of patients with musculoskeletal disorders from three hospital servicesBioMed Res Int2015201539035226491667
  • DranoveDPricing by non-profit institutions. The case of hospital cost-shiftingJ Health Econ198871475710302654
  • WuVYHospital cost shifting revisited: new evidence from the balanced budget act of 1997Int J Health Care Finance Econ2010101618319672707
  • FuchsVRCost shifting does not reduce the cost of health careJAMA20093029999100019724049
  • FraktABHow much do hospitals cost shift? A review of the evidenceMilbank Q20118919013021418314
  • MurrayRSetting hospital rates to control costs and boost quality: the Maryland experienceHealth Aff200928513951405
  • DuckettSThe Australian Health Care SystemNew York, NYOxford University Press2004
  • SchoenCOsbornRSquiresDDotyMPiersonRApplebaumSNew 2011 survey of patients with complex care needs in eleven countries finds that care is often poorly coordinatedHealth Aff2011301224372448
  • WennbergJEFisherESStukelTASkinnerJSSharpSMBronnerKKUse of hospitals, physician visits, and hospice care during last six months of life among cohorts loyal to highly respected hospitals in the United StatesBMJ2004328744060715016692
  • ChanRWebsterJEnd-of-life care pathways for improving outcomes in caring for the dyingCochrane Database Syst Rev20101CD00800620091660
  • HoganCLunneyJGabelJLynnJMedicare beneficiaries’ costs of care in the last year of lifeHealth Aff2001204188195
  • FrostDWCookDJHeylandDKFowlerRAPatient and healthcare professional factors influencing end-of-life decision-making during critical illness: a systematic reviewCrit Care Med20113951174118921336127
  • CandrilliSDMeyersJLBoyeKBaeJPHealth care resource utilization and costs during episodes of care for type 2 diabetes mellitus-related comorbiditiesJ Diabetes Complicat201529452953325660136
  • TonelliMWiebeNGuthrieBComorbidity as a driver of adverse outcomes in people with chronic kidney diseaseKidney Int201588485986626221754
  • MayCREtonDTBoehmerKRethinking the patient: using Burden of Treatment Theory to understand the changing dynamics of illnessBMC Health Serv Res201414111124382312
  • ShippeeNDShahNDMayCRMairFSMontoriVMCumulative complexity: a functional, patient-centered model of patient complexity can improve research and practiceJ Clin Epidemiol201265101041105122910536
  • GlasgowREChambersDDeveloping robust, sustainable, implementation systems using rigorous, rapid and relevant scienceClin Transl Sci201251485522376257
  • ParchmanMScoglioCSchummPUnderstanding the implementation of evidence-based care: a structural network approachImplement Sci2011611421349194