Cardiac function and hypertension in patients with obstructive sleep apnea

References

• Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360(9349):1903–1913.
   PubMed Web of Science ®Google Scholar
• Dzau VJ, Antman EM, Black HR, et al. The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part I: Pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease). Circulation. 2006;114(25):2850–2870.
   Web of Science ®Google Scholar
• Kapur V, Strohl KP, Redline S, Iber C, O’Connor G, Nieto J. Underdiagnosis of sleep apnea syndrome in US communities. Sleep Breath. 2002;6(2):49–54.
   PubMedGoogle Scholar
• Young T, Evans L, Finn L, Palta M. Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle-aged men and women. Sleep. 1997;20(9):705–706.
   PubMed Web of Science ®Google Scholar
• Tufik S, Santos-Silva R, Taddei JA, Bittencourt LR. Obstructive sleep apnea syndrome in the Sao Paulo Epidemiologic Sleep Study. Sleep Med. 2010;11(5):441–446.
   PubMed Web of Science ®Google Scholar
• Wolk R, Shamsuzzaman AS, Somers VK. Obesity, sleep apnea, and hypertension. Hypertension. 2003;42(6):1067–1074.
   PubMed Web of Science ®Google Scholar
• Somers VK, White DP, Amin R, et al. Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing. In collaboration with the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health). Circulation. 2008;118(10):1080–1111.
   PubMed Web of Science ®Google Scholar
• Drager LF, Genta PR, Pedrosa RP, et al. Characteristics and predictors of obstructive sleep apnea in patients with systemic hypertension. Am J Cardiol. 2010;105(8):1135–1139.
   Web of Science ®Google Scholar
• Cintra FD, Tufik S, Paola A, et al. Cardiovascular profile in patients with obstructive sleep apnea. Arq Bras Cardiol. 2011;96(4):293–299.
   Web of Science ®Google Scholar
• Hla KM, Young TB, Bidwell T, Palta M, Skatrud JB, Dempsey J. Sleep apnea and hypertension. A population-based study. Ann Intern Med. 1994;120(5):382–388.
   PubMed Web of Science ®Google Scholar
• Young T, Peppard P, Palta M, et al. Population-based study of sleep-disordered breathing as a risk factor for hypertension. Arch Intern Med. 1997;157(15):1746–1752.
   PubMedGoogle Scholar
• Nieto FJ, Young TB, Lind BK, et al. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA. 2000;283(14):1829–1836.
   PubMed Web of Science ®Google Scholar
• Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med. 2000;342(19):1378–1384.
   PubMed Web of Science ®Google Scholar
• Punjabi NM, Caffo BS, Goodwin JL, et al. Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Med. 2009;6(8):e1000132.
   PubMed Web of Science ®Google Scholar
• Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med. 2002;165(9):1217–1239.
   PubMed Web of Science ®Google Scholar
• Myers KA, Mrkobrada M, Simel DL. Does this patient have obstructive sleep apnea?: The Rational Clinical Examination systematic review. JAMA. 2013;310(7):731–741.
   PubMed Web of Science ®Google Scholar
• Fletcher EC, DeBehnke RD, Lovoi MS, Gorin AB. Undiagnosed sleep apnea in patients with essential hypertension. Ann Intern Med. 1985;103(2):190–195.
   PubMed Web of Science ®Google Scholar
• Lavie P, Ben-Yosef R, Rubin AE. Prevalence of sleep apnea syndrome among patients with essential hypertension. Am Heart J. 1984;108(2):373–376.
   Web of Science ®Google Scholar
• Worsnop CJ, Naughton MT, Barter CE, Morgan TO, Anderson AI, Pierce RJ. The prevalence of obstructive sleep apnea in hypertensives. Am J Respir Crit Care Med. 1998;157(1):111–115.
   Web of Science ®Google Scholar
• Gonzaga CC, Gaddam KK, Ahmed MI, et al. Severity of obstructive sleep apnea is related to aldosterone status in subjects with resistant hypertension. J Clin Sleep Med. 2010;6(4):363–368.
   PubMed Web of Science ®Google Scholar
• Logan AG, Perlikowski SM, Mente A, et al. High prevalence of unrecognized sleep apnoea in drug-resistant hypertension. J Hypertens. 2001;19(12):2271–2277.
   PubMed Web of Science ®Google Scholar
• Lloberes P, Lozano L, Sampol G, et al. Obstructive sleep apnoea and 24-h blood pressure in patients with resistant hypertension. J Sleep Res. 2010;19(4):597–602.
   Web of Science ®Google Scholar
• Pedrosa RP, Drager LF, Gonzaga CC, et al. Obstructive sleep apnea: the most common secondary cause of hypertension associated with resistant hypertension. Hypertension. 2011;58(5):811–817.
   PubMed Web of Science ®Google Scholar
• Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991;14(6):540–545.
   PubMed Web of Science ®Google Scholar
• Netzer NC, Stoohs RA, Netzer CM, Clark K, Strohl KP. Using the Berlin Questionnaire to identify patients at risk for the sleep apnea syndrome. Ann Intern Med. 1999;131(7):485–491.
   PubMed Web of Science ®Google Scholar
• Ryan CF, Love LL, Peat D, Fleetham JA, Lowe AA. Mandibular advancement oral appliance therapy for obstructive sleep apnoea: effect on awake calibre of the velopharynx. Thorax. 1999;54(11):972–977.
   PubMed Web of Science ®Google Scholar
• Hoffstein V. Review of oral appliances for treatment of sleep-disordered breathing. Sleep Breath. 2007;11(1):1–22.
   PubMed Web of Science ®Google Scholar
• Sutherland K, Vanderveken OM, Tsuda H, et al. Oral appliance treatment for obstructive sleep apnea: an update. J Clin Sleep Med. 2014;10(2):215–227.
   PubMed Web of Science ®Google Scholar
• Epstein LJ, Kristo D, Strollo PJ Jr, et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med. 2009;5(3):263–276.
   PubMed Web of Science ®Google Scholar
• Elshaug AG, Moss JR, Southcott AM, Hiller JE. Redefining success in airway surgery for obstructive sleep apnea: a meta analysis and synthesis of the evidence. Sleep. 2007;30(4):461–467.
   Web of Science ®Google Scholar
• Verrier RLM, MA. Sleep-related cardiac risk. In: Kryger MH, Roth T, Dement WC, editors. Principles and Practice of Sleep Medicine. 5th ed. St Louis, MO, USA: Elsevier Saunders; 2011.
   Google Scholar
• Narkiewicz K, van de Borne PJ, Pesek CA, Dyken ME, Montano N, Somers VK. Selective potentiation of peripheral chemoreflex sensitivity in obstructive sleep apnea. Circulation. 1999;99(9):1183–1189.
   PubMed Web of Science ®Google Scholar
• Narkiewicz K, van de Borne PJ, Cooley RL, Dyken ME, Somers VK. Sympathetic activity in obese subjects with and without obstructive sleep apnea. Circulation. 1998;98(8):772–776.
   PubMed Web of Science ®Google Scholar
• Fletcher EC, Bao G, Li R. Renin activity and blood pressure in response to chronic episodic hypoxia. Hypertension. 1999;34(2):309–314.
   Web of Science ®Google Scholar
• Kato M, Roberts-Thomson P, Phillips BG, et al. Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. Circulation. 2000;102(21):2607–2610.
   PubMed Web of Science ®Google Scholar
• Gjorup PH, Sadauskiene L, Wessels J, Nyvad O, Strunge B, Pedersen EB. Abnormally increased endothelin-1 in plasma during the night in obstructive sleep apnea: relation to blood pressure and severity of disease. Am J Hypertens. 2007;20(1):44–52.
   PubMed Web of Science ®Google Scholar
• Ip MS, Lam B, Chan LY, et al. Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure. Am J Respir Crit Care Med. 2000;162(6):2166–2171.
   Web of Science ®Google Scholar
• Somers VK, Javaheri S. Cardiovascular effects of sleep-related breathing disorders. In: Kryger MH, Roth T, Dement WC, editors. Principles and Practice of Sleep Medicine. 5th ed. St Louis, MO, USA: Elsevier Saunders; 2011:1370–1380.
   Google Scholar
• Mombouli JV, Vanhoutte PM. Endothelial dysfunction: from physiology to therapy. J Mol Cell Cardiol. 1999;31(1):61–74.
   PubMed Web of Science ®Google Scholar
• Biegelsen ES, Loscalzo J. Endothelial function and atherosclerosis. Coron Artery Dis. 1999;10(4):241–256.
   PubMed Web of Science ®Google Scholar
• Somers VK, Mark AL, Zavala DC, Abboud FM. Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans. J Appl Physiol (1985). 1989;67(5):2101–2106.
   PubMed Web of Science ®Google Scholar
• Somers VK, Mark AL, Zavala DC, Abboud FM. Influence of ventilation and hypocapnia on sympathetic nerve responses to hypoxia in normal humans. J Appl Physiol (1985). 1989;67(5):2095–2100.
   PubMed Web of Science ®Google Scholar
• Somers VK, Dyken ME, Mark AL, Abboud FM. Sympathetic-nerve activity during sleep in normal subjects. N Engl J Med. 1993;328(5):303–307.
   PubMed Web of Science ®Google Scholar
• Horner RL, Brooks D, Kozar LF, Tse S, Phillipson EA. Immediate effects of arousal from sleep on cardiac autonomic outflow in the absence of breathing in dogs. J Appl Physiol (1985). 1995;79(1):151–162.
   Web of Science ®Google Scholar
• Weiss JW, Remsburg S, Garpestad E, Ringler J, Sparrow D, Parker JA. Hemodynamic consequences of obstructive sleep apnea. Sleep. 1996;19(5):388–397.
   Web of Science ®Google Scholar
• Sociedade Brasileira de Cardiologia; Sociedade Brasileira de Hipertensão; Sociedade Brasileira de Nefrologia. [VI Brazilian Guidelines on Hypertension]. Arq Bras Cardiol. 2010;95(Suppl 1):1–51. Portuguese.
   Google Scholar
• Kearney PM, Whelton M, Reynolds K, Whelton PK, He J. Worldwide prevalence of hypertension: a systematic review. J Hypertens. 2004;22(1):11–19.
   PubMed Web of Science ®Google Scholar
• McAlister FA, Wilkins K, Joffres M, et al. Changes in the rates of awareness, treatment and control of hypertension in Canada over the past two decades. CMAJ. 2011;183(9):1007–1013.
   Web of Science ®Google Scholar
• Egan BM, Zhao Y, Axon RN. US trends in prevalence, awareness, treatment, and control of hypertension, 1988–2008. JAMA. 2010;303(20):2043–2050.
   PubMed Web of Science ®Google Scholar
• Cipullo JP, Martin JF, Ciorlia LA, et al. [Hypertension prevalence and risk factors in a Brazilian urban population]. Arq Bras Cardiol. 2010;94(4):519–526. Portuguese.
   Web of Science ®Google Scholar
• Calhoun DA, Jones D, Textor S, et al. Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Circulation. 2008;117(25):e510–e526.
   PubMed Web of Science ®Google Scholar
• de la Sierra A, Segura J, Banegas JR, et al. Clinical features of 8295 patients with resistant hypertension classified on the basis of ambulatory blood pressure monitoring. Hypertension. 2011;57(5):898–902.
   PubMed Web of Science ®Google Scholar
• Daugherty SL, Powers JD, Magid DJ, et al. Incidence and prognosis of resistant hypertension in hypertensive patients. Circulation. 2012; 125(13):1635–1642.
   PubMed Web of Science ®Google Scholar
• Egan BM, Zhao Y, Axon RN, Brzezinski WA, Ferdinand KC. Uncontrolled and apparent treatment resistant hypertension in the United States, 1988 to 2008. Circulation. 2011;124(9):1046–1058.
   PubMed Web of Science ®Google Scholar
• O’Brien E, Parati G, Stergiou G, et al. European Society of Hypertension position paper on ambulatory blood pressure monitoring. J Hypertens. 2013;31(9):1731–1768.
   PubMed Web of Science ®Google Scholar
• Davies CW, Crosby JH, Mullins RL, Barbour C, Davies RJ, Stradling JR. Case-control study of 24 hour ambulatory blood pressure in patients with obstructive sleep apnoea and normal matched control subjects. Thorax. 2000;55(9):736–740.
   Web of Science ®Google Scholar
• Baguet JP, Barone-Rochette G, Pepin JL. Hypertension and obstructive sleep apnoea syndrome: current perspectives. J Hum Hypertens. 2009;23(7):431–443.
   Web of Science ®Google Scholar
• Marrone O, Romano S, Insalaco G, Bonsignore MR, Salvaggio A, Bonsignore G. Influence of sampling interval on the evaluation of nocturnal blood pressure in subjects with and without obstructive sleep apnoea. Eur Respir J. 2000;16(4):653–658.
   Web of Science ®Google Scholar
• Sasaki N, Ozono R, Yamauchi R, et al. Age-related differences in the mechanism of nondipping among patients with obstructive sleep apnea syndrome. Clin Exp Hypertens. 2012;34(4):270–277.
   PubMed Web of Science ®Google Scholar
• Gaddam K, Pimenta E, Thomas SJ, et al. Spironolactone reduces severity of obstructive sleep apnoea in patients with resistant hypertension: a preliminary report. J Hum Hypertens. 2010;24(8):532–537.
   PubMed Web of Science ®Google Scholar
• Friedman O, Bradley TD, Chan CT, Parkes R, Logan AG. Relationship between overnight rostral fluid shift and obstructive sleep apnea in drug-resistant hypertension. Hypertension. 2010;56(6):1077–1082.
   PubMed Web of Science ®Google Scholar
• Mirrakhimov AE. Supine fluid redistribution: should we consider this as an important risk factor for obstructive sleep apnea? Sleep Breath. 2013;17(2):511–523.
   Web of Science ®Google Scholar
• Fischer MK, Martinez D, Cassol CM, Rahmeier L, Vieira LR. Immediate and overnight recumbence-dependent changes of neck circumference: relationship with OSA severity in obese and nonobese subjects. Sleep Med. 2012;13(6):650–655.
   Web of Science ®Google Scholar
• Redolfi S, Arnulf I, Pottier M, et al. Attenuation of obstructive sleep apnea by compression stockings in subjects with venous insufficiency. Am J Respir Crit Care Med. 2011;184(9):1062–1066.
   Web of Science ®Google Scholar
• Ueno LM, Drager LF, Rodrigues AC, et al. Effects of exercise training in patients with chronic heart failure and sleep apnea. Sleep. 2009;32(5):637–647.
   PubMed Web of Science ®Google Scholar
• Awad KM, Malhotra A, Barnet JH, Quan SF, Peppard PE. Exercise is associated with a reduced incidence of sleep-disordered breathing. Am J Med. 2012;125(5):485–490.
   PubMed Web of Science ®Google Scholar
• Calhoun DA, Nishizaka MK, Zaman MA, Harding SM. Aldosterone excretion among subjects with resistant hypertension and symptoms of sleep apnea. Chest. 2004;125(1):112–117.
   PubMed Web of Science ®Google Scholar
• Pratt-Ubunama MN, Nishizaka MK, Boedefeld RL, Cofield SS, Harding SM, Calhoun DA. Plasma aldosterone is related to severity of obstructive sleep apnea in subjects with resistant hypertension. Chest. 2007;131(2):453–459.
   PubMed Web of Science ®Google Scholar
• Møller DS, Lind P, Strunge B, Pedersen EB. Abnormal vasoactive hormones and 24-hour blood pressure in obstructive sleep apnea. Am J Hypertens. 2003;16(4):274–280.
   Web of Science ®Google Scholar
• Guillot M, Sforza E, Achour-Crawford E, et al. Association between severe obstructive sleep apnea and incident arterial hypertension in the older people population. Sleep Med. 2013;14(9):838–842.
   PubMed Web of Science ®Google Scholar
• Asha’ari ZA, Hasmoni MH, Ab Rahman J, Yusof RA, Ahmad RA. The association between sleep apnea and young adults with hypertension. Laryngoscope. 2012;122(10):2337–2342.
   Web of Science ®Google Scholar
• Marin JM, Agusti A, Villar I, et al. Association between treated and untreated obstructive sleep apnea and risk of hypertension. JAMA. 2012;307(20):2169–2176.
   PubMed Web of Science ®Google Scholar
• Symplicity HTN-2 Investigators, Esler MD, Krum H, et al. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2010;376(9756):1903–1909.
   PubMed Web of Science ®Google Scholar
• Witkowski A, Prejbisz A, Florczak E, et al. Effects of renal sympathetic denervation on blood pressure, sleep apnea course, and glycemic control in patients with resistant hypertension and sleep apnea. Hypertension. 2011;58(4):559–565.
   PubMed Web of Science ®Google Scholar
• Bhatt DL, Kandzari DE, O’Neill WW, et al. A controlled trial of renal denervation for resistant hypertension. N Engl J Med. 2014;370(15):1393–1401.
   PubMed Web of Science ®Google Scholar
• Levy P, Ryan S, Oldenburg O, Parati G. Sleep apnoea and the heart. Eur Respir Rev. 2013;22(129):333–352.
   Google Scholar
• Gami AS, Hodge DO, Herges RM, et al. Obstructive sleep apnea, obesity, and the risk of incident atrial fibrillation. J Am Coll Cardiol. 2007;49(5):565–571.
   PubMed Web of Science ®Google Scholar
• Mehra R, Benjamin EJ, Shahar E, et al. Association of nocturnal arrhythmias with sleep-disordered breathing: The Sleep Heart Health Study. Am J Respir Crit Care Med. 2006;173(8):910–916.
   PubMed Web of Science ®Google Scholar
• Shepard JW, Garrison MW, Grither DA, Dolan GF. Relationship of ventricular ectopy to oxyhemoglobin desaturation in patients with obstructive sleep apnea. Chest. 1985;88(3):335–340.
   Web of Science ®Google Scholar
• Gami AS, Howard DE, Olson EJ, Somers VK. Day-night pattern of sudden death in obstructive sleep apnea. N Engl J Med. 2005;352(12):1206–1214.
   PubMed Web of Science ®Google Scholar
• Monahan K, Storfer-Isser A, Mehra R, et al. Triggering of nocturnal arrhythmias by sleep-disordered breathing events. J Am Coll Cardiol. 2009;54(19):1797–1804.
   PubMed Web of Science ®Google Scholar
• Drager LF, Polotsky VY, Lorenzi-Filho G. Obstructive sleep apnea: an emerging risk factor for atherosclerosis. Chest. 2011;140(2):534–542.
   PubMed Web of Science ®Google Scholar
• Lui MM, Sau-Man M. OSA and atherosclerosis. J Thorac Dis. 2012;4(2):164–172.
   Web of Science ®Google Scholar
• Kylintireas I, Craig S, Nethononda R, et al. Atherosclerosis and arterial stiffness in obstructive sleep apnea – a cardiovascular magnetic resonance study. Atherosclerosis. 2012;222(2):483–489.
   Web of Science ®Google Scholar
• Seif F, Patel SR, Walia H, et al. Association between obstructive sleep apnea severity and endothelial dysfunction in an increased background of cardiovascular burden. J Sleep Res. 2013;22(4):443–451.
   Web of Science ®Google Scholar
• Lee CH, Khoo SM, Chan MY, et al. Severe obstructive sleep apnea and outcomes following myocardial infarction. J Clin Sleep Med. 2011;7(6):616–621.
   Web of Science ®Google Scholar
• Gottlieb DJ, Yenokyan G, Newman AB, et al. Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the Sleep Heart Health Study. Circulation. 2010;122(4):352–360.
   PubMed Web of Science ®Google Scholar
• Hetzenecker A, Buchner S, Greimel T, et al. Cardiac workload in patients with sleep-disordered breathing early after acute myocardial infarction. Chest. 2013;143(5):1294–1301.
   Web of Science ®Google Scholar
• Sert Kuniyoshi FH, Singh P, Gami AS, et al. Patients with obstructive sleep apnea exhibit impaired endothelial function after myocardial infarction. Chest. 2011;140(1):62–67.
   PubMed Web of Science ®Google Scholar
• Wang H, Parker JD, Newton GE, et al. Influence of obstructive sleep apnea on mortality in patients with heart failure. J Am Coll Cardiol. 2007;49(15):1625–1631.
   PubMed Web of Science ®Google Scholar
• Javaheri S, Parker TJ, Liming JD, et al. Sleep apnea in 81 ambulatory male patients with stable heart failure. Types and their prevalences, consequences, and presentations. Circulation. 1998;97(21):2154–2159.
   PubMed Web of Science ®Google Scholar
• Sin DD, Fitzgerald F, Parker JD, Newton G, Floras JS, Bradley TD. Risk factors for central and obstructive sleep apnea in 450 men and women with congestive heart failure. Am J Respir Crit Care Med. 1999;160(4):1101–1106.
   PubMed Web of Science ®Google Scholar
• Arias MA, García-Río F, Alonso-Fernández A, Mediano O, Martínez I, Villamor J. Obstructive sleep apnea syndrome affects left ventricular diastolic function: effects of nasal continuous positive airway pressure in men. Circulation. 2005;112(3):375–383.
   Web of Science ®Google Scholar
• Levy D, Larson MG, Vasan RS, Kannel WB, Ho KK. The progression from hypertension to congestive heart failure. JAMA. 1996;275(20):1557–1562.
   PubMed Web of Science ®Google Scholar
• Otto ME, Belohlavek M, Romero-Corral A, et al. Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea. Am J Cardiol. 2007;99(9):1298–1302.
   Web of Science ®Google Scholar
• Fung JW, Li TS, Choy DK, et al. Severe obstructive sleep apnea is associated with left ventricular diastolic dysfunction. Chest. 2002;121(2):422–429.
   PubMed Web of Science ®Google Scholar
• Kasai T, Bradley TD. Obstructive sleep apnea and heart failure: pathophysiologic and therapeutic implications. J Am Coll Cardiol. 2011;57(2):119–127.
   PubMed Web of Science ®Google Scholar
• Hedner J, Ejnell H, Caidahl K. Left ventricular hypertrophy independent of hypertension in patients with obstructive sleep apnoea. J Hypertens. 1990;8(10):941–946.
   Web of Science ®Google Scholar
• Kraiczi H, Peker Y, Caidahl K, Samuelsson A, Hedner J. Blood pressure, cardiac structure and severity of obstructive sleep apnea in a sleep clinic population. J Hypertens. 2001;19(11):2071–2078.
   Web of Science ®Google Scholar
• Noda A, Okada T, Yasuma F, Nakashima N, Yokota M. Cardiac hypertrophy in obstructive sleep apnea syndrome. Chest. 1995;107(6):1538–1544.
   Web of Science ®Google Scholar
• Floras JS. Clinical aspects of sympathetic activation and parasympathetic withdrawal in heart failure. J Am Coll Cardiol. 1993; 22(4 Suppl A):72A–84A.
   PubMed Web of Science ®Google Scholar
• Ryan CF. Sleep x 9: an approach to treatment of obstructive sleep apnoea/hypopnoea syndrome including upper airway surgery. Thorax. 2005;60(7):595–604.
   Web of Science ®Google Scholar
• Kuna ST, Reboussin DM, Borradaile KE, et al. Long-term effect of weight loss on obstructive sleep apnea severity in obese patients with type 2 diabetes. Sleep. 2013;36(5):641a–649a.
   PubMed Web of Science ®Google Scholar
• Waradekar NV, Sinoway LI, Zwillich CW, Leuenberger UA. Influence of treatment on muscle sympathetic nerve activity in sleep apnea. Am J Respir Crit Care Med. 1996;153(4 Pt 1):1333–1338.
   Web of Science ®Google Scholar
• Haentjens P, Van Meerhaeghe A, Moscariello A, et al. The impact of continuous positive airway pressure on blood pressure in patients with obstructive sleep apnea syndrome: evidence from a meta-analysis of placebo-controlled randomized trials. Arch Intern Med. 2007;167(8):757–764.
   PubMedGoogle Scholar
• Dudenbostel T, Calhoun DA. Resistant hypertension, obstructive sleep apnoea and aldosterone. J Hum Hypertens. 2012;26(5):281–287.
   PubMed Web of Science ®Google Scholar
• Barbe F, Duran-Cantolla J, Sanchez-de-la-Torre M, et al. Effect of continuous positive airway pressure on the incidence of hypertension and cardiovascular events in nonsleepy patients with obstructive sleep apnea: a randomized controlled trial. JAMA. 2012;307(20):2161–2168.
   PubMed Web of Science ®Google Scholar
• Rao M, Rajda G, Uppuluri S, Beck GR, Liu L, Bisognano JD. The role of continuous positive airway pressure in the treatment of hypertension in patients with obstructive sleep apnea-hypoapnea syndrome: a review of randomized trials. Rev Recent Clin Trials. 2010;5(1):35–42.
   Google Scholar