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Review

Current perspectives on neonatal hypoglycemia, its management, and cerebral injury risk

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Pages 17-30 | Published online: 02 Feb 2015

References

  • Hay WW Jr, Sparks JW. Placental, fetal, and neonatal carbohydrate metabolism. Clin Obstet Gynecol. 1985;28(3):473–485.
  • Diderholm B, Stridsberg M, Ewald U, Lindeberg-Nordén S, Gustafsson J. Increased lipolysis in non-obese pregnant women studied in the third trimester. BJOG. 2005;112:713–718.
  • Ward Platt M, Deshpande S. Metabolic adaptation at birth. Semin Fetal Neonatal Med. 2005;10(4):341–350.
  • Moe AJ. Placental amino acid transport. Am J Physiol. 1995;268(6 Pt 1):C1321–C1331.
  • Capková A, Jirásek JE. Glycogen reserves in organs of human fetuses in the first half of pregnancy. Biol Neonate. 1968;13:129–142.
  • Shelly HJ. Glycogen reserves and their changes at birth and in anoxia. Br Med Bull. 1961;17:137–143.
  • Adam PA, Räihä N, Rahiala EL, Kekomäki M. Oxidation of glucose and D- B-OH-butyrate by the early human fetal brain. Acta Paediatr Scand. 1975;64(1):17–24.
  • Hawdon J. . Glucose homeostasis in the healthy fetus and neonate. In: Rennie JM, editor. Metabolic and Endocrine Disorders. Textbook of Neonatology. London: Elsevier, Churchill Livingstone; 2005:851–852.
  • Obenshain SS, Adam PA, King KC, et al. Human fetal insulin response to sustained maternal hyperglycemia. N Engl J Med. 1970;283(11):566–570.
  • Sperling MA, Grajwer LA, Leake R, Fisher DA. Role of glucagon in perinatal glucose homeostasis. Metabolism. 1976;25(11 Suppl 1):1385–1386.
  • Sperling MA, Ganguli S, Leslie N, Landt K. Fetal-perinatal catecholamine secretion: role in perinatal glucose homeostasis. Am J Physiol. 1984;247:E69–E74.
  • Soothill PW, Nicolaides KH, Campbell S. Perinatal asphyxia, hyperlacticaemia, hypoglycaemia, and erythroblastosis in growth retarded fetuses. Br Med J (Clin Res Ed). 1987;294(6579):1051–1053.
  • Chobot A, Otto-Buczkowska E. Glucose homeostasis from foetus through childhood. Diabetologia Doświadczalna i Kliniczna. 2011; 11(1):29–38.
  • Van Assche FA, Aerts L. The fetal endocrine pancreas. Contrib Gynecol Obstet. 1979;5:44–57.
  • Piper K, Brickwood S, Turnpenny LW, et al. Beta cell differentiation during early human pancreas development. Journal of Endocrinology. 2004;181:11–23.
  • Bonwens L, Lu WG, De Krijgar R. Proliferation and differentiation in the human fetal endocrine pancreas. Diabetologia. 1997;40:398–404.
  • Robb P. The development of the islets of Langerhans in the human foetus. Q J Exp Physiol Cogn Med Sci. 1961;46:335–343.
  • Fowden AL. Pancreatic endocrine function and carbohydrate metabolism in the fetus. In: Abrecht E, Pepe GJ, editors. Research in Perinatal Medicine IV. Ithaca, NY: Perinatology Press; 1985:71–90.
  • Fowden AL. Endocrine regulation of fetal growth. Reprod Fertil Dev. 1995;7:351–363.
  • Weaver LT, Laker MF, Nelson R. Neonatal intestinal lactase activity. Arch Dis Child. 1986;61;896–899.
  • Boellner SW, Beard AG, Panos TC. Impairment of intestinal hydrolysis of lactose in newborn infants. Pediatrics. 1965;36(4):542–550.
  • Mayne A, Hughes CA, Sule D, Brown GA, McNeish AS. Development of intestinal disaccharidases in preterm infants. Lancet. 1983;2(8350):622–623.
  • Mericq V, Ong KK, Bazaes R, et al. Longitudinal changes in insulin sensitivity and secretion from birth to age three years in small- and appropriate-for-gestational-age children. Diabetologia. 2005;48:2609–2614.
  • Hägnevik K, Faxelius G, Irestedt L, Lagercrantz H, Lundell B, Persson B. Catecholamine surge and metabolic adaptation in the newborn after vaginal delivery and caesarean section. Acta Paediatr Scand. 1984;73(5):602–609.
  • Girard J. Gluconeogenesis in late fetal and early neonatal life. Biol Neonate. 1986;50:237–258.
  • Bier DM, Leake RD, Haymond MW, et al. Measurement of “true” glucose production rates in infancy and childhood with 6,6-dideuteroglucose. Diabetes. 1977;26:1016–1023.
  • Chandran S, Yap F, Hussain K. Genetic Disorders Leading to Hypoglycaemia. J Genet Syndr Gene Ther. 2013;4:192.
  • Medina JM, Fernandez E, Bolaros JP, Vicario C, Arizmendi L. Fuel supply to the brain during the early postnatal period. In: Cueza JM, Pasaud-Leone AM, Patel MS, editors. Endocrine development of the Fetus and Neonate. New York: Plenum Press; 1990:175–194.
  • Gustafsson J. Neonatal energy substrate production. Indian J Med Res. 2009;130:618–623.
  • Diderholm B, Ewald U, Ahlsson F, Gustafsson J. Energy substrate production in infants born small for gestational age. Acta Paediatr. 2007;96:29–34.
  • Marcus C, Ehrén H, Bolme P, Arner P. Regulation of lipolysis during the neonatal period. Importance of thyrotropin. J Clin Invest. 1988;82(5):1793–1797.
  • Marchini G, Persson B, Jonsson N, Marcus C. Influence of body temperature on thyrotropic hormone release and lipolysis in the newborn infant. Acta Paediatr. 1995;84(11):1284–1288.
  • Hawdon JM, Ward Platt MP, Aynsley-Green A. Patterns of metabolic adaptation for preterm and term infants in the first neonatal week. Arch Dis Child. 1992;67:357–365.
  • Aynsley-green A. . Metabolic and endocrine relationships in the human fetus and neonate: an overview the control of adaptation to postnatal nutrition. In: Linblad BA, editor. Perinatal Nutrition. New York: Academic press; 1988:162–191.
  • Lucas A, Aynsley Green A, Bloom SR. Gut hormones and the first meals. Clin Sci (Lond). 1981;60:349–353.
  • Heck LJ, Erenberg A. Serum glucose levels in term neonates during the first 48 hours of life. J Pediatr. 1987;110(1):119–122.
  • Srinivasan G, Pildes RS, Cattamanchi G, Voora S, Lilien LD. Plasma glucose values in normal neonates: a new look. J Pediatr. 1986; 109(1):114–117.
  • Cowett RM, Farrag HM. . Neonatal glucose homeostasis. In: Cowett RM, editor. Principles of Perinatal Neonatal Metabolism. 2nd ed. New York: Springer Verlag; 1998:683–722.
  • Sperling MA, DeLamater PV, Phelps D, Fiser RH, Oh W, Fisher DA. Spontaneous and amino acid-stimulated glucagon secretion in the immediate postnatal period. Relation to glucose and insulin. J Clin Invest. 1974;53(4):1159–1166.
  • Padbury JF, Roberman B, Oddie TH, Hobel CJ, Fisher DA. Fetal catecholamine release in response to labor and delivery. Obstet Gynecol. 1982;60(5):607–611.
  • Lang TF, Hussain K. Pediatric hypoglycemia. Adv Clin Chem. 2014;63:211–245.
  • Kalhan SC. Metabolism of glucose and methods of investigation in the fetus and the newborn. In: Polin RA, Fox WW, Abman SH, editors. Fetal and Neonatal Physiology. Philadelphia: Saunders/Elsevier; 2004:449–464.
  • Cowett RM, Farrag HM. Selected principles of perinatal-neonatal glucose metabolism. Semin Neonatol. 2004;9(1):37–47.
  • Cornblath M, Hawdon JM, Williams AF, et al. Controversies Regarding Definition of Neonatal Hypoglycemia: Suggested Operational Thresholds. Pediatrics. 2000;105(5):1141–1145.
  • Cornblath M, Reisner SH. Blood glucose in the neonate and its clinical significance. N Engl J Med. 1965;273:378–381.
  • Hussain K, Blankenstein O, De Lonlay P, Christesen HT. Hyperinsulinaemic hypoglycaemia: biochemical basis and the importance of maintaining normoglycaemia during management. Arch Dis Child. 2007;92(7):568–570.
  • Williams AF. Hypoglycaemia of the newborn: a review. Bull World Health Organ. 1997;75:261–290.
  • Aynsley-Green A, Hawdon JM. Hypoglycaemia in the neonate: current controversies. Acta Paediatr Jpn. 1997;39 Suppl 1:S12–S16.
  • Whipple AO, Frantz VK. Adenoma of Islet Cells with Hyperinsulinism: A Review. Ann Surg. 1935;101(6):1299–1335.
  • Cornblath M, Ichord R. Hypoglycaemia in the neonate. Semin Perinatol. 2000;24:136–149.
  • Tin W. Defining neonatal hypoglycaemia: a continuing debate. Semin Fetal Neonatal Med. 2014;19(1):27–32.
  • Pyrds O, Christensen NJ, Friis-Hansen B. Increased cerebral blood flow and plasma epinephrine in hypoglycaemic, preterm neonates. Pediatrics. 1990;85:172–176.
  • Koh TH, Aynsley-Green A, Tarbit M, Eyre JA. Neural dysfunction during hypoglycaemia. Arch Dis Child. 1988;63:1353–1358.
  • Greisen G, Pryds O. Neonatal hypoglycaemia. Lancet. 1989;1:1332–1333.
  • Pryds O, Greisen G, Friis-Hansen B. Compensatory increase of CBF in preterm infants during hypoglycaemia. Acta Paediatr Scand. 1988;77:632–637.
  • Lucas A, Morley R, Cole TJ. Adverse neurodevelopmental outcome of moderate neonatal hypoglycaemia. BMJ. 1988;297:1304–1308.
  • Tin W, Brunskill G, Kelly T, Fritz S. 15-year follow up of recurrent “hypoglycemia” in preterm infants. Pediatrics. 2012;130:e1497–e1503.
  • Arya VB, Senniappan S, Guemes M, Hussain K. Neonatal Hypoglycemia. Indian J Pediatr. 2014;81(1):58–65.
  • Collins JE, Leonard JV. Hyperinsulinism in asphyxiated and small-for-dates infants with hypoglycaemia. Lancet. 1984;2(8398):311–313.
  • Rosenkrantz TS, Philipps AF, Skrzypczak PS, Raye JR. Cerebral metabolism in the newborn lamb with polycythemia. Pediatr Res. 1988;23:329–333.
  • Nold JL, Georgieff MK. Infants of diabetic mothers. Pediatr Clin North Am. 2004;51(3):619–637.
  • Taylor R, Lee C, Kyne-grzebalski D, Marshall SM, Davison JM. Clinical outcomes of pregnancy in women with type 1 diabetes(1). Obstet Gynecol. 2002;99:537–541.
  • Kyne-Grzebalski D, Wood L, Marshall SM, Taylor R. Episodic hyperglycaemia in pregnant women with well-controlled Type 1 diabetes mellitus: a major potential factor underlying macrosomia. Diabet Med. 1999;16:702–706.
  • Bloom SR, Johnston DI. Failure of glucagon release in infants of diabetic mothers. Br Med J. 1972;4:453–454.
  • Kalhan SC, Savin SM, Adam PA. Atteunated glucose production rate in newborn infants of insulin dependent diabetic mothers. N Engl J Med. 1977;296:375–376.
  • Sunehag A, Ewald U, Larsson A, Gustafsson J. Attenuated hepatic glucose production but unimpaired lipolysis in newborn infants of mothers with diabetes. Pediatr Res. 1997;42:492–497.
  • Chong JH, Chandran S, Agarwal P, Rajadurai VS. Delayed presentation of prolonged hyperinsulinaemic hypoglycaemia in a preterm small-for-gestational age neonate. BMJ Case Rep. 2013;2013.
  • Arya VB, Flanagan SE, Kumaran A, et al. Clinical and molecular characterisation of hyperinsulinaemic hypoglycaemia in infants born small-for-gestational age. Arch Dis Child Fetal Neonatal Ed. 2013;98(4):F356–F358.
  • Senniappan S, Arya VB, Hussain K. The molecular mechanisms, diagnosis and management of congenital hyperinsulinism. Indian J Endocrinol Metab. 2013;17(1):19–30.
  • Chandran S, Yap F, Hussain K. Molecular mechanisms of protein induced hyperinsulinaemic hypoglycaemia. World J Diabetes. 2014 Oct 15;5(5):666–77.
  • Vanhaltren K, Malhotra A. Characteristics of infants at risk of hypoglycaemia secondary to being ‘infant of a diabetic mother’. J Pediatr Endocrinol Metab. 2013;26(9–10):861–865.
  • Aynsley-Green A, Hussain K, Hall J, et al. Practical management of hyperinsulinism in infancy. Arch Dis Child Fetal Neonatal Ed. 2000;82:F98–F107.
  • Hussain K. Investigations for neonatal hypoglycaemia. Clin Biochem. 2011;44:465–466.
  • Munns CF, Batch JA. Hyperinsulinism and Beckwith-Wiedemann syndrome. Arch Dis Child Fetal Neonatal Ed. 2001;84(1):F67–F69.
  • Deshpande S, Ward Platt M. The investigation and management of neonatal hypoglycaemia. Semin Fetal Neonatal Med. 2005;10:351–361.
  • Committee on Fetus and Newborn, Adamkin DH. Postnatal glucose homeostasis in late-preterm and term infants. Pediatrics. 2011;127(3):575–579.
  • Inoue S, Egi M, Kotani J, Morita K. Accuracy of blood-glucose measurements using glucose meters and arterial blood gas analyzers in critically ill adult patients: systematic review. Crit Care. 2013; 17(2):R48.
  • Harris DL, Battin MR, Weston PJ, Harding JE. Continuous glucose monitoring in newborn babies at risk of hypoglycemia. J Pediatr. 2010;157(2):198–202.
  • No authors listed. Screening guidelines for newborns at risk for low blood glucose. Paediatr Child Health. 2004;9(10):723–740.
  • de Rooy L, Hawdon J. Nutritional factors that affect the postnatal metabolic adaptation of full-term small- and large-for-gestational-age infants. Pediatrics. 2002;109:E42.
  • Cook P, Walker V. Investigation of the child with an acute metabolic disorder. J Clin Pathol. 2011;64:181–191.
  • Mola-Schenzle E, Staffler A, Klemme M, et al. Clinically stable very low birthweight infants are at risk for recurrent tissue glucose fluctuations even after fully established enteral nutrition. Arch Dis Child Fetal Neonatal Ed. Epub November 7, 2014.
  • Harris DL, Weston PJ, Signal M, Chase JG, Harding JE. Dextrose gel for neonatal hypoglycaemia (the Sugar Babies Study):a randomised, double-blind, placebo-controlled trial. Lancet. 2013;382(9910):2077–2083.
  • Peters CJ, Hindmarsh PC. Management of neonatal endocrinopathies – best practice guidelines. Early Hum Dev. 2007;83:553–561.
  • Senniappan S, Alexandrescu S, Tatevian N, et al. Sirolimus therapy in infants with severe hyperinsulinemic hypoglycemia. N Engl J Med. 2014;370(12):1131–1137.
  • Vannucci RC, Vannucci SJ. Hypoglycemic brain injury. Semin Neonatol. 2001;6:147–155.
  • Hawdon JM. Hypoglycemia and the neonatal brain. Eur J Pediatr. 1999;158 Suppl 1:S9–S12.
  • Rozance PJ, Hay WW. Hypoglycemia in newborn infants: Features associated with adverse outcome. Biol Neonate. 2006;90:74–86.
  • Cryer PE. Hypoglycemia-associated autonomic failure in diabetes. Am J Physiol Endocrinol Metab. 2001;281(6):E1115–E1121.
  • Zhou D, Qian J, Liu CX, Chang H, Sun RP. Repetitive and profound insulin-induced hypoglycemia results in brain damage in newborn rats: an approach to establish an animal model of brain injury induced by neonatal hypoglycemia. Eur J Pediatr. 2008;167(10):1169–1174.
  • Su J, Wang L. Research advances in neonatal hypoglycemic brain injury. Translational Pediatrics. 2012;1(2):108–115.
  • Wang L, Fan G, Ji X, Sun B, Guo Q. MRI findings of brain damage due to neonatal hypoglycemia. Zhonghua Fang She Xue Za Zhi. 2009,43:42–45.
  • Stenninger E, Flink R, Eriksson B, SahlÈn C. Long-term neurological dysfunction and neonatal hypoglycaemia after diabetic pregnancy. Arch Dis Child Fetal Neonatal Ed. 1998;79:F174–F179.
  • Duvanel CB, Fawer CL, Cotting J, Hohlfeld P, Matthieu JM. Long-term effects of neonatal hypoglycemia on brain growth and psychomotor development in small-for-gestational-age preterm infants. J Pediatr. 1999;134:492–498.
  • Filan PM, Inder TE, Cameron FJ, Kean MJ, Hunt RW. Neonatal hypoglycemia and occipital cerebral injury. J Pediatr. 2006;148:552–555.
  • Alkalay AL, Flores Sarnat L, Sarnat HB, Farber SJ, Simmons CF. Plasma glucose concentrations in profound neonatal hypoglycemia. Clin Pediatr (Phila). 2006;45:550–558.
  • Tam EW, Haeusslein LA, Bonifacio SL, et al. Hypoglycemia is associated with increased risk for brain injury and adverse neurodevelopmental outcome in neonates at risk for encephalopathy. J Pediatr. 2012;161:88–93.
  • Boluyt N, van Kempen A, Offringa M. Neurodevelopment after neonatal hypoglycemia: a systematic review and design of an optimal future study. Pediatrics. 2006;117(6):2231–2243.
  • Schrier AM, Brady Wilhelm P, Church RM, et al. Neonatal hypoglycemia in the rhesus monkey: Effect on development and behavior. Infant Behav Dev. 1990;13(2):189–207.
  • Yang Y, Chen HJ, Qian LH, et al. Effect of glucose levels on the cerebral synthesis of glucose transporter (GLUT) 3 in neonatal rats with hypoxic ischemia. Lin Chuang Er Ke Za Zhi. 2004;22:42–45.
  • Chen C, Chen HJ, Qian LH, et al. Influence of Different Blood Glucose Levels on Cerebral Pathology under Light Microscopy in Neonatal Rats with Hypoxic-Ischemia. Shi Yong Er Ke Lin Chuang Za Zhi. 2006;21:894–897.
  • Udani V, Munot P, Ursekar M, Gupta S. Neonatal hypoglycemic brain – injury a common cause of infantile onset remote symptomatic epilepsy. Indian Pediatr. 2009;46(2):127–132.
  • Kumaran A, Kar S, Kapoor RR, Hussain K. The clinical problem of hyperinsulinemic hypoglycemia and resultant infantile spasms. Pediatrics. 2010;126(5):e1231–e1236.
  • Burns CM, Rutherford MA, Boardman JP, Cowan FM. Patterns of cerebral injury and neurodevelopmental outcomes after symptomatic neonatal hypoglycemia. Pediatrics. 2008;122:65–74.
  • Kim SY, Goo HW, Lim KH, Kim ST, Kim KS. Neonatal hypoglycaemic encephalopathy: diffusion-weighted imaging and proton MR spectroscopy. Pediatr Radiol. 2006;36:144–148.
  • Yanagawa Y, Isoi N, Tokumaru AM, Sakamoto T, Okada Y. Diffusion-weighted MRI predicts prognosis in severe hypoglycemic encephalopathy. J Clin Neurosci. 2006;13:696–699.
  • Tam EW, Widjaja E, Blaser SI, Macgregor DL, Satodia P, Moore AM. Occipital lobe injury and cortical visual outcomes after neonatal hypoglycemia. Pediatrics. 2008;122(3):507–512.
  • McGowan JE, Chen L, Gao D, Trush M, Wei C. Increased mitochondrial reactive oxygen species production in newborn brain during hypoglycemia. Neurosci Lett. 2006;399:111–114.
  • Alfonso I, Rerecich A. Neonatal hypoglycemia and occipital cerebral injury. J Pediatr. 2007;151:e1–e2.
  • Mujsce DJ, Christensen MA, Vannucci RC. Regional cerebral blood flow and glucose utilization during hypoglycemia in newborn dogs. Am J Physiol. 1989;256:H1659–H1666.
  • Alkalay AL, Sarnat HB, Flores-Sarnat L, Flores-Sarnat L, Simmons CF. Neurologic aspects of neonatal hypoglycemia. Isr Med Assoc J. 2005;7:188–192.
  • Caraballo RH, Sakr D, Mozzi M, et al. Symptomatic occipital lobe epilepsy following neonatal hypoglycemia. Pediatr Neurol. 2004;31:24–29.
  • Barkovich AJ, Ali FA, Rowley HA, Bass N. Imaging patterns of neonatal hypoglycemia. AJNR Am J Neuroradiol. 1998;19:523–528.
  • Straussman S, Levitsky LL. Neonatal hypoglycemia. Curr Opin Endocrinol Diabetes Obes. 2010;17(1):20–24.