Unclassified renal cell carcinoma: diagnostic difficulties and treatment modalities

References

• ThoenesWStörkelSRumpeltHJHistopathology and classification of renal cell tumors (adenomas, oncocytomas and carcinomas). The basic cytological and histopathological elements and their use for diagnosticsPathol Res Pract198618121251433737468
   PubMed Web of Science ®Google Scholar
• KovacsGAkhtarMBeckwithBJThe Heidelberg classification of renal cell tumoursJ Pathol199718321311339390023
   PubMed Web of Science ®Google Scholar
• StörkelSEbleJNAdlakhaKClassification of renal cell carcinoma: Workgroup No. 1. Union Internationale Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC)Cancer19978059879899307203
   PubMed Web of Science ®Google Scholar
• EbleJNSGEpsteinJISesterhennIAPathology and Genetics of Tumors of the Urinary System and Male Genital OrgansLyonIARC Press2004
   Google Scholar
• SrigleyJRDelahuntBEbleJNISUP Renal Tumor PanelThe International Society of Urological Pathology (ISUP) Vancouver Classification of Renal NeoplasiaAm J Surg Pathol201337101469148924025519
   PubMed Web of Science ®Google Scholar
• MochHCubillaALHumphreyPAReuterVEUlbrightTMThe 2016 WHO classification of tumours of the urinary system and male genital organs-part a: renal, penile, and testicular tumoursEur Urol20167019310526935559
   PubMed Web of Science ®Google Scholar
• NguyenDPVertosickEACorradiRBHistological subtype of renal cell carcinoma significantly affects survival in the era of partial nephrectomyUrol Oncol2016346259.e1e8
   Web of Science ®Google Scholar
• AminMBAminMBTamboliPPrognostic impact of histologic subtyping of adult renal epithelial neoplasms: an experience of 405 casesAm J Surg Pathol200226328129111859199
   PubMed Web of Science ®Google Scholar
• LiYReuterVEMatosoANettoGJEpsteinJIArganiPRe-evaluation of 33 “unclassified”eosinophilic renal cell carcinomas in young patientsHistopathology201872458860028898443
   PubMed Web of Science ®Google Scholar
• PerrinoCMGrignonDJWilliamsonSRIdreesMTEbleJNChengLMorphological spectrum of renal cell carcinoma, unclassified: an analysis of 136 casesHistopathology201872230531928833389
   PubMed Web of Science ®Google Scholar
• National Comprehensive Cancer NetworkNCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines)-Kidney Cancer2018 Available from: https://www.nccn.org/Accessed November 13, 2018
   Google Scholar
• KryvenkoONRoqueroLGuptaNSLeeMWEpsteinJILow-grade clear cell renal cell carcinoma mimicking hemangioma of the kidney: a series of 4 casesArch Pathol Lab Med2013137225125423368867
   PubMed Web of Science ®Google Scholar
• ReuterVEArganiPZhouMDelahuntBMembers of the ISUP Immunohistochemistry in Diagnostic Urologic Pathology GroupBest practices recommendations in the application of immunohistochemistry in the kidney tumors: report from the International Society of Urologic Pathology consensus conferenceAm J Surg Pathol2014388e35e4925025368
   PubMed Web of Science ®Google Scholar
• RohanSMXiaoYLiangYClear-cell papillary renal cell carcinoma: molecular and immunohistochemical analysis with emphasis on the von Hippel-Lindau gene and hypoxia-inducible factor pathway-related proteinsMod Pathol20112491207122021602815
   PubMed Web of Science ®Google Scholar
• LeroyXCamparoPGnemmiVClear cell papillary renal cell carcinoma is an indolent and low-grade neoplasm with overexpression of cyclin-D1Histopathology20146471032103624382138
   PubMed Web of Science ®Google Scholar
• MantillaJGAnticTTretiakovaMGATA3 as a valuable marker to distinguish clear cell papillary renal cell carcinomas from morphologic mimicsHum Pathol20176615215828705707
   PubMed Web of Science ®Google Scholar
• HakimiAATickooSKJacobsenATCEB1-mutated renal cell carcinoma: a distinct genomic and morphological subtypeMod Pathol201528684585325676555
   PubMed Web of Science ®Google Scholar
• DemlKFSchildhausHUCompératEClear cell papillary renal cell carcinoma and renal angiomyoadenomatous tumor: two variants of a morphologic, immunohistochemical, and genetic distinct entity of renal cell carcinomaAm J Surg Pathol201539788990125970683
   PubMed Web of Science ®Google Scholar
• Cancer Genome Atlas Research NetworkLinehanWMSpellmanPTRickettsCJComprehensive Molecular Characterization of Papillary Renal-Cell CarcinomaN Engl J Med2016374213514526536169
   PubMed Web of Science ®Google Scholar
• ArganiPOlgacSTickooSKXp11 translocation renal cell carcinoma in adults: expanded clinical, pathologic, and genetic spectrumAm J Surg Pathol20073181149116017667536
   PubMed Web of Science ®Google Scholar
• MagersMJUdagerAMMehraRMiT family translocation-associated renal cell carcinoma: a contemporary update with emphasis on morphologic, immunophenotypic, and molecular mimicsArch Pathol Lab Med2015139101224123326414466
   PubMed Web of Science ®Google Scholar
• RaoQWilliamsonSRZhangSTFE3 break-apart FISH has a higher sensitivity for Xp11.2 translocation-associated renal cell carcinoma compared with TFE3 or cathepsin K immunohistochemical staining alone: expanding the morphologic spectrumAm J Surg Pathol201337680481523598965
   PubMed Web of Science ®Google Scholar
• ArganiPYonescuRMorsbergerLMolecular confirmation of t(6;11)(p21;q12) renal cell carcinoma in archival paraffin-embedded material using a break-apart TFEB FISH assay expands its clinicopathologic spectrumAm J Surg Pathol201236101516152622892601
   PubMed Web of Science ®Google Scholar
• AminMBCrottyTBTickooSKFarrowGMRenal oncocytoma: a reappraisal of morphologic features with clinicopathologic findings in 80 casesAm J Surg Pathol19972111128990136
   PubMed Web of Science ®Google Scholar
• WilliamsonSRGaddeRTrpkovKDiagnostic criteria for oncocytic renal neoplasms: a survey of urologic pathologistsHum Pathol20176314915628315424
   PubMed Web of Science ®Google Scholar
• WilliamsonSREbleJNAminMBSuccinate dehydrogenase-deficient renal cell carcinoma: detailed characterization of 11 tumors defining a unique subtype of renal cell carcinomaMod Pathol2015281809425034258
   PubMed Web of Science ®Google Scholar
• GillAJHesOPapathomasTSuccinate dehydrogenase (SDH)-deficient renal carcinoma: a morphologically distinct entity: a clinicopathologic series of 36 tumors from 27 patientsAm J Surg Pathol201438121588160225025441
   PubMed Web of Science ®Google Scholar
• MiettinenMSarlomo-RikalaMMcCuePMapping of succinate dehydrogenase losses in 2258 epithelial neoplasmsAppl Immunohistochem Mol Morphol2014221313623531856
   PubMedGoogle Scholar
• GuoJTretiakovaMSTroxellMLTuberous sclerosis-associated renal cell carcinoma: a clinicopathologic study of 57 separate carcinomas in 18 patientsAm J Surg Pathol201438111457146725093518
   PubMed Web of Science ®Google Scholar
• TrpkovKAbou-OufHHesOEosinophilic Solid and Cystic Renal Cell Carcinoma (ESC RCC): Further Morphologic and Molecular Characterization of ESC RCC as a Distinct EntityAm J Surg Pathol201741101299130828786877
   PubMed Web of Science ®Google Scholar
• BardellaCEl-BahrawyMFrizzellNAberrant succination of proteins in fumaratehydratase-deficient mice and HLRCC patients is a robust biomarker of mutation statusJ Pathol2011225141121630274
   PubMed Web of Science ®Google Scholar
• OheCSmithSCSirohiDReappraisal of morphologic differences between renal medullary carcinoma, collecting duct carcinoma, and fumaratehydratase-deficient renal cell carcinomaAm J Surg Pathol201842327929229309300
   PubMed Web of Science ®Google Scholar
• GuptaRBillisAShahRBCarcinoma of the collecting ducts of Bellini and renal medullary carcinoma: clinicopathologic analysis of 52 cases of rare aggressive subtypes of renal cell carcinoma with a focus on their interrelationshipAm J Surg Pathol20123691265127822895263
   PubMed Web of Science ®Google Scholar
• SinghJAOheCSmithSCHigh grade infiltrative adenocarcinomas of renal cell origin: New insights into classification, morphology, and molecular pathogenesisPathol Int201868526527729665139
   PubMed Web of Science ®Google Scholar
• CarvalhoJCThomasDGMcHughJBShahRBKunjuLPp63, CK7, PAX8 and INI-1: an optimal immunohistochemical panel to distinguish poorly differentiated urothelial cell carcinoma from high-grade tumours of the renal collecting systemHistopathology201260459760822260386
   PubMed Web of Science ®Google Scholar
• AminMBTrpkovKLopez-BeltranAGrignonDMembers of the ISUP Immunohistochemistry in Diagnostic Urologic Pathology GroupBest practices recommendations in the application of immunohistochemistry in the bladder lesions: report from the International Society of Urologic Pathology consensus conferenceAm J Surg Pathol2014388e203425029121
   PubMed Web of Science ®Google Scholar
• SirohiDSmithSCOheCRenal cell carcinoma, unclassified with medullary phenotype: poorly differentiated adenocarcinomas overlapping with renal medullary carcinomaHum Pathol20176713414528716439
   PubMed Web of Science ®Google Scholar
• ShuchBSaidJLa RochelleJCCytoreductive nephrectomy for kidney cancer with sarcomatoid histology--is up-front resection indicated and, if not, is it avoidable?J Urol200918252164217119758641
   PubMed Web of Science ®Google Scholar
• HuZYPangLJQiYUnclassified renal cell carcinoma: a clinicopathological, comparative genomic hybridization, and whole-genome exon sequencing studyInt J Clin Exp Pathol2014773865387525120763
   PubMed Web of Science ®Google Scholar
• Cancer Genome Atlas Research NetworkComprehensive molecular characterization of clear cell renal cell carcinoma.Nature20134997456434923792563
   PubMed Web of Science ®Google Scholar
• ChenYBXuJSkanderupAJMolecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsetsNat Commun201671313127713405
   PubMed Web of Science ®Google Scholar
• PierorazioPMJohnsonMHPatelHDManagement of renal masses and localized renal cancerRockville (MD)AHRQ Comparative Effectiveness Reviews No. 1672016 Available from: https://www.ncbi.nlm.nih.gov/books/NBK350333/Accessed November 11, 2018
   Google Scholar
• GeorgiadesCSHongKBizzellCGeschwindJFRodriguezRSafety and efficacy of CT-guided percutaneous cryoablation for renal cell carcinomaJ Vasc Interv Radiol20081991302131018725093
   PubMed Web of Science ®Google Scholar
• KunkleDAUzzoRGCryoablation or radiofrequency ablation of the small renal mass: a meta-analysisCancer2008113102671268018816624
   PubMed Web of Science ®Google Scholar
• LaneBRAbouassalyRGaoTActive treatment of localized renal tumors may not impact overall survival in patients aged 75 years or olderCancer2010116133119312620564627
   PubMed Web of Science ®Google Scholar
• RiniBIPlimackERTakagiTA Phase II Study of Pazopanib in Patients with Localized Renal Cell Carcinoma to Optimize Preservation of Renal ParenchymaJ Urol2015194229730325813447
   PubMed Web of Science ®Google Scholar
• KaramJADevineCEUrbauerDLPhase 2 trial of neoadjuvan-taxitinib in patients with locally advanced nonmetastatic clear cell renal cell carcinomaEur Urol201466587488024560330
   PubMed Web of Science ®Google Scholar
• PowlesTSarwarNStockdaleASafety and efficacy of pazopanib therapy prior to planned nephrectomy in metastatic clear cell renal cancerJAMA Oncol20162101303130927254750
   PubMed Web of Science ®Google Scholar
• MotzerRJRussoPCytoreductive nephrectomy-patient selection is keyN Engl J Med2018379548148229860908
   PubMedGoogle Scholar
• ArmstrongAJHalabiSEisenTEverolimus versus sunitinib for patients with metastatic non-clear cell renal cell carcinoma (ASPEN): a multicentre, open-label, randomised phase 2 trialLancet Oncol201617337838826794930
   PubMed Web of Science ®Google Scholar
• TannirNMJonaschEAlbigesLEverolimus Versus Sunitinib Prospective Evaluation in Metastatic Non-Clear Cell Renal Cell Carcinoma (ESPN): A Randomized Multicenter Phase 2 TrialEur Urol201669586687426626617
   PubMed Web of Science ®Google Scholar
• MotzerRJBarriosCHKimTMPhase II randomized trial comparing sequential first-line everolimus and second-line sunitinib versus first-line sunitinib and second-line everolimus in patients with metastatic renal cell carcinomaJ Clin Oncol201432252765277225049330
   PubMed Web of Science ®Google Scholar
• CiccareseCIacovelliRBrunelliMAddressing the best treatment for non-clear cell renal cell carcinoma: A meta-analysis of randomised clinical trials comparing VEGFR-TKis versus mTORi-targeted therapiesEur J Cancer20178323724628756136
   PubMed Web of Science ®Google Scholar
• ButiSBersanelliMMainesFFirst-Line PAzopanib in NOn-clear-cell RenalcArcinoMA: The Italian Retrospective Multicenter PANORAMA StudyClin Genitourin Cancer2017154e609e61428108284
   PubMed Web of Science ®Google Scholar
• DutcherJPde SouzaPMcDermottDEffect of temsirolimus versus interferon-alpha on outcome of patients with advanced renal cell carcinoma of different tumor histologiesMed Oncol200926220220919229667
   PubMed Web of Science ®Google Scholar
• XuJXMaherVEZhangLFDA Approval summary: nivolumab in advanced renal cell carcinoma after anti-angiogenic therapy and exploratory predictive biomarker analysisOncologist201722331131728232599
   PubMed Web of Science ®Google Scholar
• MotzerRJEscudierBMcDermottDFCheckMate 025 InvestigatorsNivolumab versus Everolimus in Advanced Renal-Cell CarcinomaN Engl J Med2015373191803181326406148
   PubMed Web of Science ®Google Scholar
• EscudierBSharmaPMcDermottDFCheckMate 025 investigatorsCheckMate 025 Randomized Phase 3 Study: outcomes by key baseline factors and prior therapy for nivolumab versus everolimus in advanced renal cell carcinomaEur Urol201772696297128262413
   PubMed Web of Science ®Google Scholar
• AchkarTArjunanAWangHHigh-dose interleukin 2 in patients with metastatic renal cell carcinoma with sarcomatoid featuresPLoS One20171212e019008429261796
   PubMed Web of Science ®Google Scholar
• NoguchiGTsutsumiSYasuiMSignificant response to nivolumab for metastatic chromophobe renal cell carcinoma with sarcomatoid differentiation: a case reportBMC Urol20181812629669553
   PubMed Web of Science ®Google Scholar
• RouvinovKOsyntsovLShaco-LevyRBaramNAriadSMermershtainWRapid response to nivolumab in a patient with sarcomatoid transformation of chromophobe renal cell carcinomaClin Genitourin Cancer2017156e1127e113028673798
   PubMed Web of Science ®Google Scholar
• MizutaniKHorieKNagaiSResponse to nivolumab in metastatic collecting duct carcinoma expressing PD-L1: A case reportMol Clin Oncol20177698899029285361
   PubMed Web of Science ®Google Scholar
• ShuchBHahnAWAgarwalNCurrent Treatment Landscape of Advanced Papillary Renal CancerJ Clin Oncol201735262981298328737973
   PubMed Web of Science ®Google Scholar
• ChoueiriTKPlimackEArkenauHTBiomarker-based Phase II trial of savolitinib in patients with advanced papillary renal cell cancerJ Clin Oncol201735262993300128644771
   PubMed Web of Science ®Google Scholar