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Research and Reports in Urology Volume 13, 2021 - Issue
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Original Research

The Role of Ga-68-PSMA PET/CT in the Initial Staging of Prostate Cancer – A Single Center 4 Year Experience

João P Lima1 Urology and Renal Transplantation Department, Coimbra University Hospital Center, Coimbra, PortugalCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-6955-2485
ORCID Icon,
João Carvalho1 Urology and Renal Transplantation Department, Coimbra University Hospital Center, Coimbra, Portugal
,
Vasco Quaresma1 Urology and Renal Transplantation Department, Coimbra University Hospital Center, Coimbra, Portugal
,
Edgar Tavares-da-Silva1 Urology and Renal Transplantation Department, Coimbra University Hospital Center, Coimbra, PortugalORCID Iconhttps://orcid.org/0000-0002-8612-0147
ORCID Icon,
Rodolfo Silva2 Nuclear Medicine Department, Coimbra University Hospital Centre, Coimbra, Portugal
,
Paulo Azinhais2 Nuclear Medicine Department, Coimbra University Hospital Centre, Coimbra, Portugal
,
Gracinda Costa2 Nuclear Medicine Department, Coimbra University Hospital Centre, Coimbra, Portugal
&
Arnaldo Figueiredo1 Urology and Renal Transplantation Department, Coimbra University Hospital Center, Coimbra, Portugal
 show all
Pages 479-485 | Published online: 07 Jul 2021

References

  • Hövels AM, Heesakkers RAM, Adang EM, et al. The diagnostic accuracy of CT and MRI in the staging of pelvic lymph nodes in patients with prostate cancer: a meta-analysis. Clin Radiol. 2008;63(4):387–395. doi:10.1016/j.crad.2007.05.022
  • Shen G, Deng H, Hu S, Jia Z. Comparison of choline-PET/CT, MRI, SPECT, and bone scintigraphy in the diagnosis of bone metastases in patients with prostate cancer: a meta-analysis. Skeletal Radiol. 2014;43(11):1503–1513. doi:10.1007/s00256-014-1903-9
  • Haran C, McBean R, Parsons R, Wong D. Five-year trends of bone scan and prostate-specific membrane antigen positron emission tomography utilization in prostate cancer: a retrospective review in a private centre. J Med Imaging Radiat Oncol. 2019;63(4):495–499. doi:10.1111/1754-9485.12885
  • Esen T, Kılıç M, Seymen H, et al. Can Ga-68 PSMA PET/CT replace conventional imaging modalities for primary lymph node and bone staging of prostate cancer? Eur Urol Focus. 2020;6:218–220. doi:10.1016/j.euf.2019.05.005
  • Mottet N, Bellmunt J, Briers E, et al. WT members of the E– e– e –SIOG PCGP. EAU – ESTRO – ESUR – SIOG guidelines on prostate cancer. 2020.
  • Hofman MS, Lawrentschuk N, Francis RJ, et al. Prostate-specific membrane antigen PET-CT in patients with high-risk prostate cancer before curative-intent surgery or radiotherapy (proPSMA): a prospective, randomised, multi-centre study. Lancet. 2020;6736(20):1–9. doi:10.1016/s0140-6736(20)30314-7
  • Roach PJ, Francis R, Emmett L, et al. The impact of (68) Ga-PSMAPET/CT on management intent in prostate cancer: results of an Australian prospective multicenter study. J Nucl Med. 2018;59(1):82–88. doi:10.2967/jnumed.117.197160
  • Yaxley JW, Raveenthiran S, Nouhaud FX, et al. Outcomes of primary lymph node staging of intermediate and high risk prostate cancer with (68) Ga-PSMAPositron emission tomography/computerized tomography compared to histological correlation of pelvic lymph node pathology. J Urol. 2019;201(4):815–820. doi:10.1097/JU.0000000000000053
  • Kulkarni SC, Sundaram PS, Padma S. In primary lymph nodal staging of patients with high-risk and intermediate-risk prostate cancer, how critical is the role of Gallium-68 prostate-specific membrane antigen positron emission tomography-computed tomography? Nucl Med Commun. 2020;41(2):139–146. doi:10.1097/MNM.0000000000001110
  • Petersen LJ, Zacho HD. PSMA PET for primary lymph node staging of intermediate and high-risk prostate cancer: an expedited systematic review. Cancer Imaging. 2020;20(1):1–8. doi:10.1186/s40644-020-0290-9
  • Herlemann A, Wenter V, Kretschmer A, et al. 68Ga-PSMA positron emission tomography/computed tomography provides accurate staging of lymph node regions prior to lymph node dissection in patients with prostate cancer. Eur Urol. 2016;70(4):553–557. doi:10.1016/j.eururo.2015.12.051
  • Demirci E, Kabasakal L, Şahin OE, et al. Can SUVmax values of Ga-68-PSMA PET/CT scan predict the clinically significant prostate cancer? Nucl Med Commun. 2019;40(1):86–91. doi:10.1097/MNM.0000000000000942
  • Uslu-Beşli L, Bakır B, Asa S, et al. Correlation of SUVmax and apparent diffusion coefficient values detected by Ga-68 PSMA PET/MRI in primary prostate lesions and their significance in lymph node metastasis: preliminary results of an on-going study. Mol Imaging Radionucl Ther. 2019;28(3):104–111. doi:10.4274/mirt.galenos.2019.63825

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