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Review

Stem cell technology for bone regeneration: current status and potential applications

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Pages 39-48 | Published online: 10 Feb 2015

References

  • KnightMNHankensonKDMesenchymal stem cells in bone regenerationAdv Wound Care (New Rochelle)20132630631624527352
  • DengSHuangRWangJMiscellaneous animal models accelerate the application of mesenchymal stem cells for cartilage regenerationCurr Stem Cell Res Ther20149322323324524791
  • BillströmGHBlomAWLarssonSBeswickADApplication of scaffolds for bone regeneration strategies: current trends and future directionsInjury201344Suppl 1S28S3323351866
  • YarlagaddaPKChandrasekharanMShyanJYRecent advances and current developments in tissue scaffoldingBiomed Mater Eng200515315917715911997
  • TevlinRMcArdleAAtashrooDBiomaterials for Craniofacial Bone EngineeringJ Dent Res2014
  • OswaldJBoxbergerSJørgensenBMesenchymal stem cells can be differentiated into endothelial cells in vitroStem Cells200422337738415153614
  • BiancoPRobeyPGSimmonsPJMesenchymal stem cells: revisiting history, concepts, and assaysCell Stem Cell20082431331918397751
  • DominiciMLe BlancKMuellerIMinimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statementCytotherapy20068431531716923606
  • MosnaFSensebéLKramperaMHuman bone marrow and adipose tissue mesenchymal stem cells: a user’s guideStem Cells Dev201019101449147020486777
  • WagnerWFeldmannREJrSeckingerAThe heterogeneity of human mesenchymal stem cell preparations – evidence from simultaneous analysis of proteomes and transcriptomesExp Hematol200634453654816569600
  • RussellKCPhinneyDGLaceyMRBarrilleauxBLMeyertholenKEO’ConnorKCIn vitro high-capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitmentStem Cells201028478879820127798
  • De SchauwerCMeyerEVan de WalleGRVan SoomAMarkers of stemness in equine mesenchymal stem cells: a plea for uniformityTheriogenology20117581431144321196039
  • da Silva MeirellesLCaplanAINardiNBIn search of the in vivo identity of mesenchymal stem cellsStem Cells20082692287229918566331
  • PojdaZMachajEKurzykAMesenchymal stem cellsPostepy Biochemi2013592187197 Polish
  • YoungHESteeleTABrayRAHuman reserve pluripotent mesenchymal stem cells are present in the connective tissues of skeletal muscle and dermis derived from fetal, adult, and geriatric donorsAnat Rec20012641516211505371
  • NakaharaHGoldbergVMCaplanAICulture-expanded human periosteal-derived cells exhibit osteochondral potential in vivoJ Orthop Res1991944654762045973
  • DiefenderferDLBrightonCTMicrovascular pericytes express aggrecan message which is regulated by BMP-2Biochem Biophys Res Commun2000269117217810694496
  • De BariCDell’AccioFLuytenFPHuman periosteum-derived cells maintain phenotypic stability and chondrogenic potential throughout expansion regardless of donor ageArthritis Rheum2001441859511212180
  • SpitzerTLRojasAZelenkoZPerivascular human endometrial mesenchymal stem cells express pathways relevant to self-renewal, lineage specification, and functional phenotypeBiol Reprod20128625822075475
  • CaplanAIAll MSCs are pericytes?Cell Stem Cell20083322923018786406
  • FriedensteinAJOsteogenic stem cells in bone marrowHeerscheJNMKanisJABone and Mineral ResearchAmsterdamElsevier1990243272
  • BennettJHJoynerCJTriffittJTOwenMEAdipocytic cells cultured from marrow have osteogenic potentialJ Cell Sci199199Pt 11311391757497
  • BeresfordJNBennettJHDevlinCLeboyPSOwenMEEvidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell culturesJ Cell Sci1992102Pt 23413511400636
  • KomoriTYagiHNomuraSTargeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblastsCell19978957557649182763
  • GalottoMCampanileGRobinoGCanceddaFDBiancoPCanceddaRHypertrophic chondrocytes undergo further differentiation to osteoblast-like cells and participate in the initial bone formation in developing chick embryoJ Bone Miner Res199498123912497976506
  • GentiliCBiancoPNeriMCell proliferation, extracellular matrix mineralization, and ovotransferrin transient expression during in vitro differentiation of chick hypertrophic chondrocytes into osteoblast-like cellsJ Cell Biol199312237037128393014
  • ZhaoJYangCSuCReconstruction of orbital defects by implantation of antigen-free bovine cancellous bone scaffold combined with bone marrow mesenchymal stem cells in ratsGraefes Arch Clin Exp Ophthalmol201325151325133323519882
  • MinamideAYoshidaMKawakamiMThe use of cultured bone marrow cells in type I collagen gel and porous hydroxyapatite for posterolateral lumbar spine fusionSpine (Phila Pa 1976)200530101134113815897826
  • FernandesMBGuimarãesJACasadoPLThe effect of bone allografts combined with bone marrow stromal cells on the healing of segmental bone defects in a sheep modelBMC Vet Res2014103624495743
  • VélezRHernández-FernándezACaminalMTreatment of femoral head osteonecrosis with advanced cell therapy in sheepArch Orthop Trauma Surg2012132111611161822821379
  • ChenWLiuJManuchehrabadiNWeirMDZhuZXuHHUmbilical cord and bone marrow mesenchymal stem cell seeding on macroporous calcium phosphate for bone regeneration in rat cranial defectsBiomaterials201334389917992524054499
  • RoseTPengHShenHCThe role of cell type in bone healing mediated by ex vivo gene therapyLangenbecks Arch Surg2003388534735514534793
  • YueyiCXiaoguangHJingyingWCalvarial defect healing by recruitment of autogenous osteogenic stem cells using locally applied simvastatinBiomaterials201334379373938024016857
  • ShamsulBSTanKKChenHCAminuddinBSRuszymahBHPosterolateral spinal fusion with ostegenesis induced BMSC seeded TCP/HA in a sheep modelTissue Cell201446215215824630213
  • ArinzehTLPeterSJArchambaultMPAllogeneic mesenchymal stem cells regenerate bone in a critical-sized canine segmental defectJ Bone Joint Surg Am200385-A101927193514563800
  • GanYDaiKZhangPTangTZhuZLuJThe clinical use of enriched bone marrow stem cells combined with porous beta-tricalcium phosphate in posterior spinal fusionBiomaterials200829293973398218639333
  • LiuXLiaoXLuoEChenWBaoCXuHHMesenchymal stem cells systemically injected into femoral marrow of dogs home to mandibular defects to enhance new bone formationTissue Eng Part A2014203–488389224125551
  • BonabMMAlimoghaddamKTalebianFGhaffariSHGhavamzadehANikbinBAging of mesenchymal stem cell in vitroBMC Cell Biol200671416529651
  • IzadpanahRTryggCPatelBBiologic properties of mesenchy-mal stem cells derived from bone marrow and adipose tissueJ Cell Biochem20069951285129716795045
  • IzadpanahRKaushalDKriedtCLong-term in vitro expansion alters the biology of adult mesenchymal stem cellsCancer Res200868114229423818519682
  • WagnerWHornPCastoldiMReplicative senescence of mesenchymal stem cells: a continuous and organized processPLoS One200835e221318493317
  • ShoshaniOZiporiDMammalian cell dedifferentiation as a possible outcome of stressStem Cell Rev20117348849321279479
  • BianchiGBanfiAMastrogiacomoMEx vivo enrichment of mesenchymal cell progenitors by fibroblast growth factor 2Exp Cell Res200328719810512799186
  • SotiropoulouPAPerezSASalagianniMBaxevanisCNPapamichailMCharacterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cellsStem Cells200624246247116109759
  • PhinneyDGFunctional heterogeneity of mesenchymal stem cells: implications for cell therapyJ Cell Biochem201211392806281222511358
  • RussellKCLaceyMRGilliamJKTuckerHAPhinneyDGO’ConnorKCClonal analysis of the proliferation potential of human bone marrow mesenchymal stem cells as a function of potencyBiotechnol Bioeng2011108112716272621538337
  • KuçiZSeiberthJLatifi-PupovciHClonal analysis of multipotent stromal cells derived from CD271+ bone marrow mononuclear cells: functional heterogeneity and different mechanisms of allosuppressionHaematologica201398101609161623975178
  • LeeCCChristensenJEYoderMCTarantalAFClonal analysis and hierarchy of human bone marrow mesenchymal stem and progenitor cellsExp Hematol2010381465419900502
  • ZukPAZhuMMizunoHMultilineage cells from human adipose tissue: implications for cell-based therapiesTissue Eng20017221122811304456
  • RehmanJTraktuevDLiJSecretion of angiogenic and antiapoptotic factors by human adipose stromal cellsCirculation2004109101292129814993122
  • TraktuevDOMerfeld-ClaussSLiJA population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networksCirc Res20081021778517967785
  • JamesAWZaraJNZhangXPerivascular stem cells: a prospectively purified mesenchymal stem cell population for bone tissue engineeringStem Cells Transl Med20121651051923197855
  • HamidAAIdrusRBSaimABSathappanSChuaKHCharacterization of human adipose-derived stem cells and expression of chondrogenic genes during induction of cartilage differentiationClinics (Sao Paulo)20126729910622358233
  • CaplanAICorreaDThe MSC: an injury drugstoreCell Stem Cell201191111521726829
  • SchäfflerABüchlerCConcise review: adipose tissue-derived stromal cells – basic and clinical implications for novel cell-based therapiesStem Cells200725481882717420225
  • GuilakFLottKEAwadHAClonal analysis of the differentiation potential of human adipose-derived adult stem cellsJ Cell Physiol2006206122923716021633
  • CowanCMShiYYAalamiOOAdipose-derived adult stromal cells heal critical-size mouse calvarial defectsNat Biotechnol200422556056715077117
  • LeviBJamesAWNelsonERHuman adipose derived stromal cells heal critical size mouse calvarial defectsPLoS One201056e1117720567510
  • AbudusaimiAAihemaitijiangYWangYHCuiLMaimaitimingSAbulikemuMAdipose-derived stem cells enhance bone regeneration in vascular necrosis of the femoral head in the rabbitJ Int Med Res20113951852186022117986
  • PetersonBZhangJIglesiasRHealing of critically sized femoral defects, using genetically modified mesenchymal stem cells from human adipose tissueTissue Eng2005111–212012915738667
  • SunayOCanGCakirZAutologous rabbit adipose tissue-derived mesenchymal stromal cells for the treatment of bone injuries with distraction osteogenesisCytotherapy201315669070223522867
  • HsuWKWangJCLiuNQStem cells from human fat as cellular delivery vehicles in an athymic rat posterolateral spine fusion modelJ Bone Joint Surg Am20089051043105218451397
  • CuiLLiuBLiuGRepair of cranial bone defects with adipose derived stem cells and coral scaffold in a canine modelBiomaterials200728365477548617888508
  • RequichaJFViegasCAAlbuquerqueCMAzevedoJMReisRLGomesMEEffect of anatomical origin and cell passage number on the stemness and osteogenic differentiation potential of canine adipose-derived stem cellsStem Cell Rev2012841211122222773405
  • BellottiCStancoDRagazziniSAnalysis of the karyotype of expanded human adipose-derived stem cells for bone reconstruction of the maxillo-facial regionInt J Immunopathol Pharmacol201326Suppl 13924046944
  • GuercioADi BellaSCasellaSDi MarcoPRussoCPiccioneGCanine mesenchymal stem cells (MSCs): characterization in relation to donor age and adipose tissue-harvesting siteCell Biol Int201337878979823505013
  • De MiguelMPFuentes-JuliánSBlázquez-MartínezAImmunosuppressive properties of mesenchymal stem cells: advances and applicationsCurr Mol Med201212557459122515979
  • LeeSHJinSYSongJSSeoKKChoKHParacrine effects of adipose-derived stem cells on keratinocytes and dermal fibroblastsAnn Dermatol201224213614322577262
  • MoonKMParkYHLeeJSThe effect of secretory factors of adipose-derived stem cells on human keratinocytesInt J Mol Sci20121311239125722312315
  • NakaoNNakayamaTYahataTAdipose Tissue-Derived Mesenchymal Stem Cells Facilitate Hematopoiesis in Vitro and in VivoAm J Pathol2010177254755420558580
  • GimbleJMGraysonWGuilakFLopezMJVunjak-NovakovicGAdipose tissue as a stem cell source for musculoskeletal regenerationFront Biosci (Schol Ed)20113698121196358
  • Ostrand-RosenbergSMyeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunityCancer Immunol Immunother201059101593160020414655
  • Carrade HoltDDWoodJAGranickJLWalkerNJClarkKCBorjessonDLEquine mesenchymal stem cells inhibit T cell proliferation through different mechanisms depending on tissue sourceStem Cells Dev201423111258126524438346
  • KimJHLeeYTHongJMHwangYISuppression of in vitro murine T cell proliferation by human adipose tissue-derived mesenchymal stem cells is dependent mainly on cyclooxygenase-2 expressionAnat Cell Biol201346426227124386599
  • MohammadzadehAPourfathollahAAShahrokhiSHashemiSMMoradiSLSoleimaniMImmunomodulatory effects of adipose-derived mesenchymal stem cells on the gene expression of major transcription factors of T cell subsetsInt Immunopharmacol201420231632124704622
  • DjouadFPlencePBonyCImmunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animalsBlood2003102103837384412881305
  • CuiffoBGKarnoubAEMesenchymal stem cells in tumor development: emerging roles and conceptsCell Adh Migr20126322023022863739
  • KarnoubAEDashABVoAPMesenchymal stem cells within tumour stroma promote breast cancer metastasisNature2007449716255756317914389
  • KarnoubAEWeinbergRAChemokine networks and breast cancer metastasisBreast Dis200626758517473367
  • MuehlbergFLSongYHKrohnATissue-resident stem cells promote breast cancer growth and metastasisCarcinogenesis200930458959719181699
  • CrisanMYapSCasteillaLA perivascular origin for mesenchymal stem cells in multiple human organsCell Stem Cell20083330131318786417
  • CorselliMChenCWSunBYapSRubinJPPéaultBThe tunica adventitia of human arteries and veins as a source of mesenchymal stem cellsStem Cells Dev20122181299130821861688
  • LinGGarciaMNingHDefining stem and progenitor cells within adipose tissueStem Cells Dev20081761053106318597617
  • SiowRCMallawaarachchiCMWeissbergPLMigration of adventitial myofibroblasts following vascular balloon injury: insights from in vivo gene transfer to rat carotid arteriesCardiovasc Res200359121222112829192
  • CorselliMChenCWCrisanMLazzariLPéaultBPerivascular ancestors of adult multipotent stem cellsArterioscler Thromb Vasc Biol20103061104110920453168
  • ZhaoHFengJSeidelKSecretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisorCell Stem Cell201414216017324506883
  • CorselliMCrisanMMurrayIRIdentification of perivascular mesenchymal stromal/stem cells by flow cytometryCytometry A201383871472023818229
  • AskarinamAJamesAWZaraJNHuman perivascular stem cells show enhanced osteogenesis and vasculogenesis with Nel-like molecule I proteinTissue Eng Part A20131911–121386139723406369
  • AsatrianGCCJamesAWLiangPHuman Perivascular Mesenchymal Stem cells Promote Lumbar Spinal Fusion Via Induction of Osteogenesis and VasculogenesisSeattle, WAInternational Association for Dental Research2013
  • ChungCG KJVelascoOAsatrianGPerivascular Stem Cells with NELL-1 Protein Induce Robust Spinal FusionCharlotte, NCAmerican Association of Dental Research2014
  • JamesAWZaraJNCorselliMUse of human perivascular stem cells for bone regenerationJ Vis Exp201263e295222664543
  • JamesAWZaraJNCorselliMAn abundant perivascular source of stem cells for bone tissue engineeringStem Cells Transl Med20121967368423197874
  • TellesPDMachadoMASakaiVTNörJEPulp tissue from primary teeth: new source of stem cellsJ Appl Oral Sci201119318919421625731
  • ShiSGronthosSPerivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulpJ Bone Miner Res200318469670412674330
  • MoshaveriniaAChenCXuXBone regeneration potential of stem cells derived from periodontal ligament or gingival tissue sources encapsulated in RGD-modified alginate scaffoldTissue Eng Part A2014203–461162124070211
  • MenicaninDMrozikKMWadaNPeriodontal-ligament-derived stem cells exhibit the capacity for long-term survival, self-renewal, and regeneration of multiple tissue types in vivoStem Cells Dev20142391001101124351050
  • ZhengYLiuYZhangCMStem cells from deciduous tooth repair mandibular defect in swineJ Dent Res200988324925419329459
  • KimSHKimKHSeoBMAlveolar bone regeneration by transplantation of periodontal ligament stem cells and bone marrow stem cells in a canine peri-implant defect model: a pilot studyJ Periodontol200980111815182319905951
  • d’AquinoRDe RosaALanzaVHuman mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexesEur Cell Mater200918758319908196
  • GiulianiAManescuALangerMThree years after transplants in human mandibles, histological and in-line holotomography revealed that stem cells regenerated a compact rather than a spongy bone: biological and clinical implicationsStem Cells Transl Med20132431632423502599
  • AnnibaliSCicconettiACristalliMPA comparative morphometric analysis of biodegradable scaffolds as carriers for dental pulp and periosteal stem cells in a model of bone regenerationJ Craniofac Surg201324386687123714898
  • MoradGKheiriLKhojastehADental pulp stem cells for in vivo bone regeneration: a systematic review of literatureArch Oral Biol201358121818182724095289
  • ZhangWWalboomersXFvan OschGJvan den DolderJJansenJAHard tissue formation in a porous HA/TCP ceramic scaffold loaded with stromal cells derived from dental pulp and bone marrowTissue Eng Part A200814228529418333781
  • YangXHanGPangXFanMChitosan/collagen scaffold containing bone morphogenetic protein-7 DNA supports dental pulp stem cell differentiation in vitro and in vivoJ Biomed Mater Res A2012
  • ZhangWWalboomersXFvan KuppeveltTHDaamenWFBianZJansenJAThe performance of human dental pulp stem cells on different three-dimensional scaffold materialsBiomaterials200627335658566816916542
  • YuJHeHTangCDifferentiation potential of STRO-1+ dental pulp stem cells changes during cell passagingBMC Cell Biol2010113220459680
  • KarpJMFerreiraLSKhademhosseiniAKwonAHYehJLangerRSCultivation of human embryonic stem cells without the embryoid body step enhances osteogenesis in vitroStem Cells200624483584316253980
  • TongWBrownSEKrebsbachPHHuman embryonic stem cells undergo osteogenic differentiation in human bone marrow stromal cell microenvironmentsJ Stem Cells20072313914720671800
  • HuJSmithLAFengKLiuXSunHMaPXResponse of human embryonic stem cell-derived mesenchymal stem cells to osteogenic factors and architectures of materials during in vitro osteogenesisTissue Eng Part A201016113507351420594153
  • HallBKMiyakeTDivide, accumulate, differentiate: cell condensation in skeletal development revisitedInt J Dev Biol19953968818938901191
  • MacDonaldMEHallBKAltered timing of the extracellular-matrix-mediated epithelial-mesenchymal interaction that initiates mandibular skeletogenesis in three inbred strains of mice: development, heterochrony, and evolutionary change in morphologyJ Exp Zool2001291325827311598914
  • AszódiABatemanJFGustafssonEBoot-HandfordRFässlerRMammalian skeletogenesis and extracellular matrix: what can we learn from knockout mice?Cell Struct Funct2000252738410885577
  • MaPXBiomimetic materials for tissue engineeringAdv Drug Deliv Rev200860218419818045729
  • GrinnemoKHKumagai-BraeschMMånsson-BrobergAHuman embryonic stem cells are immunogenic in allogeneic and xenogeneic settingsReprod Biomed Online200613571272417169186
  • AldahmashAAtteyaMElsafadiMTeratoma formation in immunocompetent mice after syngeneic and allogeneic implantation of germline capable mouse embryonic stem cellsAsian Pac J Cancer Prev201314105705571124289566
  • WorringerKARandTAHayashiYThe let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genesCell Stem Cell2014141405224239284
  • WaliaBSatijaNTripathiRPGangenahalliGUInduced pluripotent stem cells: fundamentals and applications of the reprogramming process and its ramifications on regenerative medicineStem Cell Rev20128110011521671061
  • TakahashiKYamanakaSInduction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factorsCell2006126466367616904174
  • YuJVodyanikMASmuga-OttoKInduced pluripotent stem cell lines derived from human somatic cellsScience200731858581917192018029452
  • OhradanovaAGradinKBarathovaMHypoxia upregulates expression of human endosialin gene via hypoxia-inducible factor 2Br J Cancer20089981348135618813310
  • KaoCLTaiLKChiouSHResveratrol promotes osteogenic differentiation and protects against dexamethasone damage in murine induced pluripotent stem cellsStem Cells and Dev2010192247258
  • UtoSNishizawaSTakasawaYBone and cartilage repair by transplantation of induced pluripotent stem cells in murine joint defect modelBiomed Res201334628128824389404
  • JinGZKimTHKimJHBone tissue engineering of induced pluripotent stem cells cultured with macrochanneled polymer scaffoldJ Biomed Mater Res A201310151283129123065721
  • LeviBHyunJSMontoroIn vivo directed differentiation of pluripotent stem cells for skeletal regenerationProc Natl Acad Sci USA201210950203792038423169671
  • KumazakiTKurataSMatsuoTMitsuiYTakahashiTEstablishment of human induced pluripotent stem cell lines from normal fibroblast TIG-1Hum Cell20112429610321562774
  • BrambrinkTForemanRWelsteadGGSequential expression of pluripotency markers during direct reprogramming of mouse somatic cellsCell Stem Cell20082215115918371436
  • StadtfeldMMaheraliNBreaultDTHochedlingerKDefining molecular cornerstones during fibroblast to iPS cell reprogramming in mouseCell Stem Cell20082323024018371448
  • RomagnoliCBrandiMLAdipose mesenchymal stem cells in the field of bone tissue engineeringWorld J Stem Cells20146214415224772241
  • FangDNguyenTKLeishearKA tumorigenic subpopulation with stem cell properties in melanomasCancer Res200565209328933716230395