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Review

Stem cell technology in breast cancer: current status and potential applications

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Pages 17-29 | Published online: 26 Apr 2016

References

  • LapidotTSirardCVormoorJA cell initiating human acute myeloid leukaemia after transplantation into SCID miceNature199436764646456487509044
  • Al-HajjMWichaMSBenito-HernandezAMorrisonSJClarkeMFProspective identification of tumorigenic breast cancer cellsProc Natl Acad Sci U S A200310073983398812629218
  • SinghSKHawkinsCClarkeIDIdentification of human brain tumour initiating cellsNature2004432701539640115549107
  • YangZFNgaiPHoDWIdentification of local and circulating cancer stem cells in human liver cancerHepatology200847391992818275073
  • DalerbaPDyllaSJParkIKPhenotypic characterization of human colorectal cancer stem cellsProc Natl Acad Sci U S A200710424101581016317548814
  • SchattonTMurphyGFFrankNYIdentification of cells initiating human melanomasNature2008451717634534918202660
  • QuintanaEShackletonMSabelMSFullenDRJohnsonTMMorrisonSJEfficient tumour formation by single human melanoma cellsNature2008456722259359819052619
  • McDermottSPWichaMSTargeting breast cancer stem cellsMol Oncol20104540441920599450
  • LiYLaterraJCancer stem cells: distinct entities or dynamically regulated phenotypes?Cancer Res201272357658022298594
  • TomasettiCVogelsteinBCancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisionsScience20153476217788125554788
  • ChafferCLBrueckmannIScheelCNormal and neoplastic nonstem cells can spontaneously convert to a stem-like stateProc Natl Acad Sci U S A2011108197950795521498687
  • EirewPStinglJRaoufAA method for quantifying normal human mammary epithelial stem cells with in vivo regenerative abilityNat Med200814121384138919029987
  • GinestierCHurMHCharafe-JauffretEALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcomeCell Stem Cell20071555556718371393
  • KarstenUGoletzSWhat makes cancer stem cell markers different?Springerplus20132130123888272
  • ProiaTAKellerPJGuptaPBGenetic predisposition directs breast cancer phenotype by dictating progenitor cell fateCell Stem Cell20118214916321295272
  • LimEVaillantFWuDAberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriersNat Med200915890791319648928
  • MolyneuxGGeyerFCMagnayFABRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cellsCell Stem Cell20107340341720804975
  • CastanoZFillmoreCMKimCFMcAllisterSSThe bed and the bugs: interactions between the tumor microenvironment and cancer stem cellsSemin Cancer Biol2012225–646247022548722
  • ReyaTMorrisonSJClarkeMFWeissmanILStem cells, cancer, and cancer stem cellsNature2001414685910511111689955
  • ShackletonMQuintanaEFearonERMorrisonSJHeterogeneity in cancer: cancer stem cells versus clonal evolutionCell2009138582282919737509
  • TangDGUnderstanding cancer stem cell heterogeneity and plasticityCell Res201222345747222357481
  • DickJELooking ahead in cancer stem cell researchNat Biotechnol2009271444619131997
  • NowellPCThe clonal evolution of tumor cell populationsScience197619442602328959840
  • CampbellLLPolyakKBreast tumor heterogeneity: cancer stem cells or clonal evolution?Cell Cycle20076192332233817786053
  • GreavesMMaleyCCClonal evolution in cancerNature2012481738130631322258609
  • VermeulenLde Sousa e MeloFRichelDJMedemaJPThe developing cancer stem-cell model: clinical challenges and opportunitiesLancet Oncol2012132e83e8922300863
  • ManiSAGuoWLiaoMJThe epithelial-mesenchymal transition generates cells with properties of stem cellsCell2008133470471518485877
  • ScheelCEatonENLiSHParacrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breastCell2011145692694021663795
  • OwensTWNaylorMJBreast cancer stem cellsFront Physiol2013422523986719
  • BorovskiTDe SousaEMFVermeulenLMedemaJPCancer stem cell niche: the place to beCancer Res201171363463921266356
  • MeadsMBGatenbyRADaltonWSEnvironment-mediated drug resistance: a major contributor to minimal residual diseaseNat Rev Cancer20099966567419693095
  • DeNardoDGBrennanDJRexhepajELeukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapyCancer Discov201111546722039576
  • SampieriKFoddeRCancer stem cells and metastasisSemin Cancer Biol201222318719322774232
  • TheodoropoulosPAPolioudakiHAgelakiSCirculating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancerCancer Lett201028819910619619935
  • BaccelliISchneeweissARiethdorfSIdentification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assayNat Biotechnol201331653954423609047
  • GiordanoAGaoHAnfossiSEpithelial-mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancerMol Cancer Ther201211112526253422973057
  • AktasBTewesMFehmTHauchSKimmigRKasimir-BauerSStem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patientsBreast Cancer Res2009114R4619589136
  • RaimondiCGradiloneANasoGEpithelial-mesenchymal transition and stemness features in circulating tumor cells from breast cancer patientsBreast Cancer Res Treat2011130244945521298334
  • MegoMGaoHLeeBNPrognostic value of EMT-circulating tumor cells in metastatic breast cancer patients undergoing high-dose chemotherapy with autologous hematopoietic stem cell transplantationJ Cancer2012336938023074378
  • BalicMLinHYoungLMost early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotypeClin Cancer Res200612195615562117020963
  • LiuHGChenCYangHPanYFZhangXHCancer stem cell subsets and their relationshipsJ Transl Med201195021542915
  • ChiotakiRPolioudakiHTheodoropoulosPACancer stem cells in solid and liquid tissues of breast cancer patients: characterization and therapeutic perspectivesCurr Cancer Drug Targets201515325626925669721
  • FernandezSVBinghamCFittipaldiPTP53 mutations detected in circulating tumor cells present in the blood of metastatic triple negative breast cancer patientsBreast Cancer Res201416544525307991
  • FehmTBeckerSDuerr-StoerzerSDetermination of HER2 status using both serum HER2 levels and circulating tumor cells in patients with recurrent breast cancer whose primary tumor was HER2 negative or of unknown HER2 statusBreast Cancer Res200795R7417963511
  • LiXLewisMTHuangJIntrinsic resistance of tumorigenic breast cancer cells to chemotherapyJ Natl Cancer Inst2008100967267918445819
  • ChenKHuangYHChenJLUnderstanding and targeting cancer stem cells: therapeutic implications and challengesActa Pharmacol Sin201334673274023685952
  • AbdullahLNChowEKMechanisms of chemoresistance in cancer stem cellsClin Transl Med201321323369605
  • MadjdZMehrjerdiAZSharifiAMMolanaeiSShahzadiSZAsadi-LariMCD44+ cancer cells express higher levels of the anti-apoptotic protein Bcl-2 in breast tumoursCancer Immun20099419385591
  • KleffelSSchattonTTumor dormancy and cancer stem cells: Two sides of the same coin?Adv Exp Med Biol201373414517923143979
  • ShachafCMKopelmanAMArvanitisCMYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancerNature200443170121112111715475948
  • SchoberMFuchsETumor-initiating stem cells of squamous cell carcinomas and their control by TGF-beta and integrin/focal adhesion kinase (FAK) signalingProc Natl Acad Sci U S A201110826105441054921670270
  • TobarNVillarVSantibanezJFROS-NFkappaB mediates TGF-beta1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasionMol Cell Biochem20103401–219520220204677
  • ThieryJPSleemanJPComplex networks orchestrate epithelial-mesenchymal transitionsNat Rev Mol Cell Biol20067213114216493418
  • NietoMAEpithelial plasticity: a common theme in embryonic and cancer cellsScience20133426159123485024202173
  • SinghRMoYYRole of microRNAs in breast cancerCancer Biol Ther201314320121223291983
  • JovanovicJRonnebergJATostJKristensenVThe epigenetics of breast cancerMol Oncol20104324225420627830
  • ThieryJPAcloqueHHuangRYNietoMAEpithelial-mesenchymal transitions in development and diseaseCell2009139587189019945376
  • YangJWeinbergRAEpithelial-mesenchymal transition: at the crossroads of development and tumor metastasisDev Cell200814681882918539112
  • AnsieauSEMT in breast cancer stem cell generationCancer Lett20133381636822634497
  • DrasinDJRobinTPFordHLBreast cancer epithelial-to-mesenchymal transition: examining the functional consequences of plasticityBreast Cancer Res201113622622078097
  • DaveBMittalVTanNMChangJCEpithelial-mesenchymal transition, cancer stem cells and treatment resistanceBreast Cancer Res201214120222264257
  • MorelAPLievreMThomasCHinkalGAnsieauSPuisieuxAGeneration of breast cancer stem cells through epithelial-mesenchymal transitionPloS One200838e288818682804
  • VoonDCWangHKooJKRunx3 protects gastric epithelial cells against epithelial-mesenchymal transition-induced cellular plasticity and tumorigenicityStem Cells201230102088209922899304
  • SarrioDRodriguez-PinillaSMHardissonDCanoAMoreno-BuenoGPalaciosJEpithelial-mesenchymal transition in breast cancer relates to the basal-like phenotypeCancer Res200868498999718281472
  • ManiSAYangJBrooksMMesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancersProc Natl Acad Sci U S A200710424100691007417537911
  • MizunoHSpikeBTWahlGMLevineAJInactivation of p53 in breast cancers correlates with stem cell transcriptional signaturesProc Natl Acad Sci U S A201010752227452275021149740
  • LiuJLiaoSDiop-FrimpongBTGF-beta blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stromaProc Natl Acad Sci U S A201210941166181662322996328
  • PeceSTosoniDConfalonieriSBiological and molecular heterogeneity of breast cancers correlates with their cancer stem cell contentCell20101401627320074520
  • McCubreyJADavisNMAbramsSLTargeting breast cancer initiating cells: advances in breast cancer research and therapyAdv Biol Regul2014568110724913694
  • VieiraAFRicardoSAblettMPP-cadherin is coexpressed with CD44 and CD49f and mediates stem cell properties in basal-like breast cancerStem Cells201230585486422389315
  • RibeiroASParedesJP-Cadherin linking breast cancer stem cells and invasion: A promising marker to identify an “intermediate/metastable” EMT stateFront Oncol2014437125601904
  • PolioudakiHAgelakiSChiotakiRVariable expression levels of keratin and vimentin reveal differential EMT status of circulating tumor cells and correlation with clinical characteristics and outcome of patients with metastatic breast cancerBMC Cancer20151539925962645
  • PapadakiMAKallergiGZafeiriouZCo-expression of putative stemness and epithelial-to-mesenchymal transition markers on single circulating tumour cells from patients with early and metastatic breast cancerBMC Cancer20141465125182808
  • BockCRackBHuoberJAndergassenUJeschkeUDoisneau-SixouSDistinct expression of cytokeratin, N-cadherin and CD133 in circulating tumor cells of metastatic breast cancer patientsFuture Oncol201410101751176525303055
  • BarriereGRiouallonARenaudieJTartaryMRigaudMMesenchymal and stemness circulating tumor cells in early breast cancer diagnosisBMC Cancer20121211422443102
  • KrawczykNMeier-StiegenFBanysMNeubauerHRuckhaeberleEFehmTExpression of stem cell and epithelial-mesenchymal transition markers in circulating tumor cells of breast cancer patientsBio Med Res Int20142014415721
  • LecciaFDel VecchioLMariottiEABCG2, a novel antigen to sort luminal progenitors of BRCA1-breast cancer cellsMol Cancer20141321325216750
  • Fernandez-ZapicoMEGLI1 finds a new role in cancer stem cell biologyEMBO Mol Med20135448348523505092
  • LianidouESMarkouACirculating tumor cells in breast cancer: detection systems, molecular characterization, and future challengesClin Chem20115791242125521784769
  • BrockGCastellanos-RizaldosEHuLCottichiaCSkogJLiquid biopsy for cancer screening, patient stratification and monitoringTransl Cancer Res201543280290
  • Paterlini-BrechotPBenaliNLCirculating tumor cells (CTC) detection: clinical impact and future directionsCancer Lett2007253218020417314005
  • NagaiahGAbrahamJCirculating tumor cells in the management of breast cancerClin Breast Cancer201010320921620497919
  • Alunni-FabbroniMSandriMTCirculating tumour cells in clinical practice: Methods of detection and possible characterizationMethods201050428929720116432
  • HongBZuYDetecting circulating tumor cells: current challenges and new trendsTheranostics20133637739423781285
  • RiethdorfSFritscheHMullerVDetection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch systemClin Cancer Res200713392092817289886
  • StottSLHsuCHTsukrovDIIsolation of circulating tumor cells using a microvortex-generating herringbone-chipProc Natl Acad Sci U S A201010743183921839720930119
  • FehmTHoffmannOAktasBDetection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cellsBreast Cancer Res2009114R5919664291
  • DanilaDCPantelKFleisherMScherHICirculating tumors cells as biomarkers: progress toward biomarker qualificationCancer J201117643845022157288
  • ReubenJMLeeBNGaoHPrimary breast cancer patients with high risk clinicopathologic features have high percentages of bone marrow epithelial cells with ALDH activity and CD44(+)CD24lo cancer stem cell phenotypeEur J Cancer201147101527153621334874
  • Nora DicksonMTsinbergPTangZBischoffFZWilsonTLeonardEFEfficient capture of circulating tumor cells with a novel immunocytochemical microfluidic deviceBiomicrofluidics20115334119341191522662044
  • Saucedo-ZeniNMewesSNiestrojRA novel method for the in vivo isolation of circulating tumor cells from peripheral blood of cancer patients using a functionalized and structured medical wireInt J Oncol20124141241125022825490
  • BalicMDandachiNLinHDatarRHCancer metastasis: advances in the detection and characterization of disseminated tumour cells facilitate clinical translationNatl Med J India200518525025516433139
  • SatelliABrownleeZMitraAMengQHLiSCirculating tumor cell enumeration with a combination of epithelial cell adhesion moleculeand cell-surface vimentin-based methods for monitoring breast cancer therapeutic responseClin Chem201561125926625336717
  • Alix-PanabieresCEPISPOT assay: detection of viable DTCs/CTCs in solid tumor patientsRecent Results Cancer Res2012195697622527495
  • OzkumurEShahAMCicilianoJCInertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cellsSci Transl Med20135179179ra147
  • KarabacakNMSpuhlerPSFachinFMicrofluidic, marker-free isolation of circulating tumor cells from blood samplesNat Protoc20149369471024577360
  • VonaGSabileALouhaMIsolation by size of epithelial tumor cells: a new method for the immunomorphological and molecular characterization of circulating tumor cellsAm J Pathol20001561576310623654
  • FaraceFMassardCVimondNA direct comparison of CellSearch and ISET for circulating tumour-cell detection in patients with metastatic carcinomasBr J Cancer2011105684785321829190
  • HardtOWildSOerleckeIHighly sensitive profiling of CD44+/CD24− breast cancer stem cells by combining global mRNA amplification and next generation sequencing: evidence for a hyperactive PI3K pathwayCancer Lett2012325216517422771536
  • PhucPVKhuongTTTDongLVTruongKDTranGPhanNKIsolation and characterization of breast cancer stem cells from malignant tumours in Vietnamese womenJCAB2010412163169
  • LiuSCongYWangDBreast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterpartsStem Cell Reports201421789124511467
  • Leth-LarsenRTerpMGChristensenAGFunctional heterogeneity within the CD44 high human breast cancer stem cell-like compartment reveals a gene signature predictive of distant metastasisMol Med2012181109112122692575
  • MeyerMJFlemingJMLinAFHussnainSAGinsburgEVonderhaarBKCD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancerCancer Res201070114624463320484027
  • ZhangLRidgwayLDWetzelMDThe identification and characterization of breast cancer CTCs competent for brain metastasisSci Transl Med20135180180ra148
  • D’AmicoLPataneSGrangeCPrimary breast cancer stem-like cells metastasise to bone, switch phenotype and acquire a bone tropism signatureBr J Cancer2013108122525253623801032
  • WillinghamSBVolkmerJPGentlesAJThe CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumorsProc Natl Acad Sci U S A2012109176662666722451913
  • MajetiRChaoMPAlizadehAACD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cellsCell2009138228629919632179
  • ChaoMPAlizadehAATangCTherapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemiaCancer Res20117141374138421177380
  • TrusolinoLBertottiAComoglioPMMET signalling: principles and functions in development, organ regeneration and cancerNat Rev Mol Cell Biol2010111283484821102609
  • CreightonCJLiXLandisMResidual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating featuresProc Natl Acad Sci U S A200910633138201382519666588
  • GenerPGouveiaLPSabatGRFluorescent CSC models evidence that targeted nanomedicines improve treatment sensitivity of breast and colon cancer stem cellsNanomedicine20151181883189226238079
  • SchottAFLandisMDDontuGPreclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumorsClin Cancer Res20131961512152423340294
  • LambROzsvariBLisantiCLAntibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious diseaseOncotarget2015674569458425625193
  • LambRFiorilloMChadwickADoxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapyOncotarget2015616140051402526087309
  • ChangMYOhBRheeYHLeeSHDoxycycline supplementation allows for the culture of human ESCs/iPSCs with media changes at 3-day intervalsStem Cell Res201515360861326513556
  • ChangMYRheeYHYiSHDoxycycline enhances survival and self-renewal of human pluripotent stem cellsStem Cell Reports20143235336425254347
  • GuptaPBOnderTTJiangGIdentification of selective inhibitors of cancer stem cells by high-throughput screeningCell2009138464565919682730
  • KimYJLiuYLiSCo-eradication of breast cancer cells and cancer stem cells by cross-linked multilamellar liposomes enhances tumor treatmentMol Pharm20151282811282226098197
  • YuMBardiaAAcetoNCancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibilityScience2014345619321622025013076
  • MominENVelaGZaidiHAQuinones-HinojosaAThe oncogenic potential of mesenchymal stem cells in the treatment of cancer: directions for future researchCurr Immunol Rev20106213714820490366
  • ShahKMesenchymal stem cells engineered for cancer therapyAdv Drug Deliv Rev201264873974821740940
  • QiaoLXuZZhaoTSuppression of tumorigenesis by human mesenchymal stem cells in a hepatoma modelCell Res200818450050718364678
  • OhtaNIshiguroSKawabataAHuman umbilical cord matrix mesenchymal stem cells suppress the growth of breast cancer by expression of tumor suppressor genesPloS One2015105e012375625942583
  • ChaoKCYangHTChenMWHuman umbilical cord mesenchymal stem cells suppress breast cancer tumourigenesis through direct cell-cell contact and internalizationJ Cell Mol Med20121681803181521973190
  • MaYHaoXZhangSZhangJThe in vitro and in vivo effects of human umbilical cord mesenchymal stem cells on the growth of breast cancer cellsBreast Cancer Res Treat2012133247348521947651
  • IllouzYGBreast cancer treatment by adipose-derived stem cells: an experimental studyJ Stem Cells20149421121725942336
  • BertoliniFPetitJYKoloninMGStem cells from adipose tissue and breast cancer: hype, risks and hopeBr J Cancer2015112341942325584493
  • RowanBGGimbleJMShengMHuman adipose tissue-derived stromal/stem cells promote migration and early metastasis of triple negative breast cancer xenograftsPloS One201492e8959524586900
  • OrecchioniSGregatoGMartin-PaduraIComplementary populations of human adipose CD34+ progenitor cells promote growth, angiogenesis, and metastasis of breast cancerCancer Res201373195880589123918796
  • KangNHHwangKAYiBRHuman amniotic fluid-derived stem cells expressing cytosine deaminase and thymidine kinase inhibits the growth of breast cancer cells in cellular and xenograft mouse modelsCancer Gene Ther201219641241922498724
  • KangNHYiBRLimSYHuman amniotic membrane-derived epithelial stem cells display anticancer activity in BALB/c female nude mice bearing disseminated breast cancer xenograftsInt J Oncol20124062022202822344679
  • Bagci-OnderTDuWFigueiredoJLMartinez-QuintanillaJShahKTargeting breast to brain metastatic tumours with death receptor ligand expressing therapeutic stem cellsBrain2015138Pt 61710172125910782
  • KanojiaDBalyasnikovaIVMorshedRANeural stem cells secreting anti-HER2 antibody improve survival in a preclinical model of HER2 overexpressing breast cancer brain metastasesStem Cells201533102985299426260958
  • SeolHJJinJSeongDHGenetically engineered human neural stem cells with rabbit carboxyl esterase can target brain metastasis from breast cancerCancer Lett2011311215215921868150
  • YiBRHwangKAAboodyKSJeungEBKimSUChoiKCSelective antitumor effect of neural stem cells expressing cytosine deaminase and interferon-beta against ductal breast cancer cells in cellular and xenograft modelsStem Cell Res2014121364824141111
  • HallBDembinskiJSasserAKStudenyMAndreeffMMariniFMesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehiclesInt J Hematol200786181617675260
  • KarnoubAEDashABVoAPMesenchymal stem cells within tumour stroma promote breast cancer metastasisNature2007449716255756317914389