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The Application of Clinical Genetics Volume 11, 2018 - Issue
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Original Research

IRS-1 genetic polymorphism (r.2963G>A) in type 2 diabetes mellitus patients associated with insulin resistance

Anas A Yousef1 Department of Clinical and Chemical Pathology, Benha Faculty of Medicine, Benha University, Benha, Egypt, [email protected]
,
Eman G Behiry1 Department of Clinical and Chemical Pathology, Benha Faculty of Medicine, Benha University, Benha, Egypt, [email protected]Correspondence[email protected]
,
Wafaa M Abd Allah1 Department of Clinical and Chemical Pathology, Benha Faculty of Medicine, Benha University, Benha, Egypt, [email protected]
,
Ahmed M Hussien2 Department of Internal Medicine, Benha Faculty of Medicine, Benha University, Benha, Egypt
,
Abdelmoneam A Abdelmoneam2 Department of Internal Medicine, Benha Faculty of Medicine, Benha University, Benha, Egypt
,
Mahmoud H Imam2 Department of Internal Medicine, Benha Faculty of Medicine, Benha University, Benha, Egypt
&
Doaa M Hikal1 Department of Clinical and Chemical Pathology, Benha Faculty of Medicine, Benha University, Benha, Egypt, [email protected]
 show all
Pages 99-106 | Published online: 28 Sep 2018

References

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  • McgettrickAJFeenerEPKahnCRHuman insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylationJ Biol Chem200528086441644615590636
  • El MkademSALautierCMacariFRole of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndromeDiabetes20015092164216811522686
  • VilluendasGBotella-CarreteroJIRoldánBSanchoJEscobar-MorrealeHFSan MillánJLPolymorphisms in the insulin receptor substrate-1 (IRS-1) gene and the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controlsHum Reprod200520113184319116037106
  • RungJCauchiSAlbrechtsenAGenetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemiaNat Genet200941101110111519734900
  • ShuXOLongJCaiQIdentification of new genetic risk variants for type 2 diabetesPLoS Genet201069e100112720862305

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