106
Views
4
CrossRef citations to date
0
Altmetric
Original Research

The Human Genetic Variants CYP2J2 rs2280275 and EPHX2 rs751141 and Risk of Diabetic Nephropathy in Egyptian Type 2 Diabetic Patients

ORCID Icon, , , &
Pages 165-178 | Published online: 19 Nov 2020

References

  • Wei L, Xiao Y, Li L, et al. The susceptibility genes in diabetic nephropathy. Kidney Dis. 2018;4(4):226–237. doi:10.1159/000492633
  • Hill CJ, Cardwell CR, Patterson CC, et al. Chronic kidney disease and diabetes in the national health service: a cross-sectional survey of the U.K. national diabetes audit. Diabet Med. 2014;31(4):448–454. doi:10.1111/dme.12312
  • Gurley SB, Ghosh S, Johnson SA, et al. Inflammation and immunity pathways regulate genetic susceptibility to diabetic nephropathy. Diabetes. 2018;67(10):2096–2106. doi:10.2337/db17-1323
  • Shao J, Wang H, Yuan G, et al. Involvement of the arachidonic acid cytochrome P450 epoxygenase pathway in the proliferation and invasion of human multiple myeloma cells. Peer J. 2016;4:e1925. doi:10.7717/peerj.1925
  • Chen G, Xu R, Wang Y, et al. Genetic disruption of soluble epoxide hydrolase is protective against streptozotocin-induced diabetic nephropathy. Am J Physiol Endocrinol Metab. 2012;303(5):E563–E575. doi:10.1152/ajpendo.00591.2011
  • Gervasini G, García-Cerrada M, Coto E, et al. A 3ʹ-UTR polymorphism in soluble epoxide hydrolase gene is associated with acute rejection in renal transplant recipients. PLoS One. 2015;10(7):e0133563. doi:10.1371/journal.pone.0133563
  • Enayetallah AE, French RA, Thibodeau MS, et al. Distribution of soluble epoxide hydrolase and of cytochrome P450 2C8, 2C9, and 2J2 in human tissues. J Histochem Cytochem. 2004;52(4):447–454. doi:10.1177/002215540405200403
  • Hye Khan MA, Hwang SH, Sharma A, et al. A dual COX-2/sEH inhibitor improves the metabolic profile and reduces kidney injury in Zucker diabetic fatty rat. Prostaglandins Other Lipid Mediat. 2016;125:40–47. doi:10.1016/j.prostaglandins.2016.07.003
  • Nelson DR. The cytochrome p450 homepage. Hum Genomics. 2009;4(1):59–65. doi:10.1186/1479-7364-4-1-59
  • Aliwarga T, Evangelista EA, Sotoodehnia N, et al. Regulation of CYP2J2 and EET levels in cardiac disease and diabetes. Int J Mol Sci. 2018;19(7):1916. doi:10.3390/ijms19071916
  • King LM, Ma J, Srettabunjong S, et al. Cloning of CYP2J2 gene and identification of functional polymorphisms. Mol Pharmacol. 2002;61(4):840–852. doi:10.1124/mol.61.4.840
  • Spiecker M, Darius H, Hankeln T, et al. Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2. Circulation. 2004;110(15):2132–2136. doi:10.1161/01.CIR.0000143832.91812.60
  • Zhu Q, Fu Z, Ma Y, et al. A novel polymorphism of the CYP2J2 gene is associated with coronary artery disease in Uygur population in China. Clin Biochem. 2013;46(12):1047–1054. doi:10.1016/j.clinbiochem.2013.05.003
  • Polonikov AV, Ponomarenko IV, Bykanova MA, et al. A comprehensive study revealed SNP-SNP interactions and a sex-dependent relationship between polymorphisms of the CYP2J2 gene and hypertension risk. Hypertens Res. 2019;42(2):257–272. doi:10.1038/s41440-018-0142-1
  • Abdu E, Bruun DA, Yang D, et al. Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures. J Neurochem. 2011;117(4):632–642. doi:10.1111/j.1471-4159.2010.07139.x
  • Elmarakby AA, Faulkner J, Al-Shabrawey M, et al. Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes. Am J Physiol RegulIntegr Comp Physiol. 2011;301(5):R1307–R1317. doi:10.1152/ajpregu.00759.2010
  • Liu JY. Inhibition of Soluble Epoxide Hydrolase for Renal Health. Front Pharmacol. 2019;9:1551. doi:10.3389/fphar.2018.01551
  • Larsson C, White I, Johansson C, et al. Localization of the human soluble epoxide hydrolase gene (EPHX2) to chromosomal region 8p21-p12. Hum Genet. 1995;95(3):356–358. doi:10.1007/bf00225209
  • Przybyla-Zawislak BD, Srivastava PK, Vazquez-Matias J, et al. Polymorphisms in human soluble epoxide hydrolase. Mol Pharmacol. 2003;64(2):482–490. doi:10.1124/mol.64.2.482
  • Yi X, Lin J, Li J, et al. Epoxyeicosatrienoic acids are mediated by EPHX2 variants and may be a predictor of early neurological deterioration in acute minor ischemic stroke. J Atheroscler Thromb. 2017;24(12):1258–1266. doi:10.5551/jat.41145
  • Lee SH, Lee J, Cha R, et al. Genetic variations in soluble epoxide hydrolase and graft function in kidney transplantation. Transplant Proc. 2008;40(5):1353–1356. doi:10.1016/j.transproceed.2008.03.137
  • Lee JP, Yang SH, Kim DK, et al. In vivo activity of epoxide hydrolase according to sequence variation affects the progression of human IgA nephropathy. Am J Physiol Renal Physiol. 2011;300(6):F1283–F1290. doi:10.1152/ajprenal.00733.2010
  • Ma L, Yan M, Kong X, et al. Association of EPHX2 R287Q polymorphism with diabetic nephropathy in chinese type 2 diabetic patients. J Diabetes Res. 2018:ID 2786470. doi:10.1155/2018/2786470.
  • American Diabetes Association.Classification and diagnosis of diabetes. Sec. 2.In Standards of Medical Care in Diabetes-2015. Diabetes Care. 2015:38(Supplement. 1):S8–S16.
  • Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report [published correction appears in JAMA. 2003 Jul 9; 290(2):197]. JAMA. 2003;289(19):2560–2572. doi:10.1001/jama.289.19.2560
  • Trinder P. determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. J Ann Clin Biochem. 1969;6:24–25. doi:10.1177/000456326900600108
  • Gonen B, Rubenstein A. Determination of glycohemoglobin. Diabetologia. 1978;15:1–5. doi:10.1007/BF01219319
  • Siedel J, Hagele E, Ziegenhorn J, et al. Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency. Clin Chem. 1983;29:1075–1080. doi:10.1093/clinchem/29.6.1075
  • Friedwald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-denisty lipoprotein in plasma, without use of the preparative ultra-centrifuge. Clin Chem. 1972;18(6):499–502. doi:10.1093/clinchem/18.6.499
  • Levey AS, Coresh J, Greene T, et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate [published correction appears in ann intern med. 2008 Oct 7;149(7):519]. Ann Intern Med. 2006;145(4):247–254. doi:10.7326/0003-4819-145-4-200608150-00004
  • Imig JD. Epoxyeicosatrienoic acids, hypertension, and kidney injury. Hypertension. 2015;65(3):476–482. doi:10.1161/HYPERTENSIONAHA.114.03585
  • Capdevila JH, Pidkovka N, Mei S, et al. The Cyp2c44 epoxygenase regulates epithelial sodium channel activity and the blood pressureresponses to increased dietary salt. J Biol Chem. 2014;289(7):4377–4386. doi:10.1074/jbc.M113.508416
  • Gschwendtner A, Ripke S, Freilinger T, et al. Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with an increased risk of ischemic stroke in white Europeans. Stroke. 2008;39(5):1593–1596. doi:10.1161/STROKEAHA.107.502179
  • Luo P, Zhou Y, Chang HH, et al. Glomerular 20-HETE, EETs, and TGF-beta1 in diabetic nephropathy. Am J Physiol Renal Physiol. 2009;296(3):F556–F563. doi:10.1152/ajprenal.90613.2008
  • Srivastava PK, Sharma VK, Kalonia DS, et al. Polymorphisms in human soluble epoxide hydrolase: effects on enzyme activity, enzyme stability, and quaternary structure. Arch BiochemBiophys. 2004;427(2):164–169. doi:10.1016/j.abb.2004.05.003
  • Zhang L, Ding H, Yan J, et al. Genetic variation in cytochrome P450 2J2 and soluble epoxide hydrolase and risk of ischemic stroke in a Chinese population. Pharmacogenet Genomics. 2008;18(1):45–51. doi:10.1097/FPC.0b013e3282f313e8
  • Donnelly MK, Conley YP, Crago EA, et al. Genetic markers in the EET metabolic pathway are associated with outcomes in patients with aneurysmal subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2015;35(2):267–276. doi:10.1038/jcbfm.2014.195
  • Katary MM, Pye C, Elmarakby AA. Meloxicam fails to augment the reno-protective effects of soluble epoxide hydrolase inhibition in streptozotocin-induced diabetic rats via increased 20-HETE levels. Prostaglandins Other Lipid Mediat. 2017;132:3–11. doi:10.1016/j.prostaglandins.2016.08.004
  • Askari A, Thomson SJ, Edin ML, et al. Roles of the epoxygenase CYP2J2 in the endothelium. Prostaglandins Other Lipid Mediat. 2013;107:56–63. doi:10.1016/j.prostaglandins.2013.02.003