Use of ICS/LABA (extra-fine and non-extra-fine) in elderly asthmatics

References

• VerbekenEKCauberghsMMertensIClementJLauwerynsJMVan de WoestijneKPThe senile lung. Comparison with normal and emphysematous lungs. 1. Structural aspectsChest199210137937991541148
   PubMed Web of Science ®Google Scholar
• AwDSilvaABPalmerDBImmunosenescence: emerging challenges for an ageing populationImmunology2007120443544617313487
   PubMed Web of Science ®Google Scholar
• FranceschiCBonafeMValensinSHuman immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological spaceVaccine200018161717172010689155
   PubMed Web of Science ®Google Scholar
• Global Initiative for Asthma (GINA) [homepage on the Internet]Global Strategy for Asthma Management and Prevention2015 Available from: http://www.ginasthma.org/Accessed June, 2016
   Google Scholar
• NairPAziz-Ur-RehmanARadfordKTherapeutic implications of ‘neutrophilic asthma’Curr Opin Pulm Med2015211333825415406
   PubMed Web of Science ®Google Scholar
• GibsonPGSimpsonJLSaltosNHeterogeneity of airway inflammation in persistent asthma: evidence of neutrophilic inflammation and increased sputum interleukin-8Chest200111951329133611348936
   PubMed Web of Science ®Google Scholar
• NyenhuisSMSchwantesEAEvansMDMathurSKAirway neutrophil inflammatory phenotype in older subjects with asthmaJ Allergy Clin Immunol201012551163116520381851
   PubMed Web of Science ®Google Scholar
• SinDDTuJVInhaled corticosteroid therapy reduces the risk of rehospitalization and all-cause mortality in elderly asthmaticsEur Respir J200117338038511405515
   PubMed Web of Science ®Google Scholar
• ThomasRAGreenRHBrightlingCEThe influence of age on induced sputum differential cell counts in normal subjectsChest200412661811181415596678
   PubMed Web of Science ®Google Scholar
• BramanSSGrowing old with asthma: what are the changes and challenges?Expert Rev Respir Med20104223924820406090
   PubMedGoogle Scholar
• YanezAChoSHSorianoJBAsthma in the elderly: what we know and what we have yet to knowWorld Allergy Organ J201471825152804
   PubMedGoogle Scholar
• OelkersWAdrenal insufficiencyN Engl J Med199633516120612128815944
   PubMed Web of Science ®Google Scholar
• MeibohmBHochhausGRohatagiSDependency of cortisol suppression on the administration time of inhaled corticosteroidsJ Clin Pharmacol19973787047109378842
   PubMed Web of Science ®Google Scholar
  ErratumJ Clin Pharmacol199737111000
   Google Scholar
• GarbeELeLorierJBoivinJFSuissaSInhaled and nasal glucocorticoids and the risks of ocular hypertension or open-angle glaucomaJAMA199727797227279042844
   PubMed Web of Science ®Google Scholar
• PritchardJNThe influence of lung deposition on clinical responseJ Aerosol Med200114suppl 1S19S2611424889
   PubMedGoogle Scholar
• LoebMPneumonia in older personsClin Infect Dis200337101335133914583867
   PubMed Web of Science ®Google Scholar
• MarrieTJCommunity-acquired pneumonia in the elderlyClin Infect Dis20003141066107811049791
   PubMed Web of Science ®Google Scholar
• AlmirallJBolibarISerra-PratMCommunity-Acquired Pneumonia in Catalan Countries (PACAP)Relationship between the use of inhaled steroids for chronic respiratory diseases and early outcomes in community-acquired pneumoniaPLoS One201389e7327124039899
   PubMed Web of Science ®Google Scholar
• KoivulaIStenMMakelaPHRisk factors for pneumonia in the elderlyAm J Med19949643133208166149
   PubMed Web of Science ®Google Scholar
• RiquelmeRTorresAEl-EbiaryMCommunity-acquired pneumonia in the elderly: a multivariate analysis of risk and prognostic factorsAm J Respir Crit Care Med19961545145014558912763
   PubMed Web of Science ®Google Scholar
• BansalVMangiMAJohnsonMMFesticEInhaled corticosteroids and incident pneumonia in patients with asthma: systematic review and meta-analysisActa Med Acad201544213515826702909
   PubMedGoogle Scholar
• McKeeverTHarrisonTWHubbardRShawDInhaled corticosteroids and the risk of pneumonia in people with asthma: a case-control studyChest201314461788179423990003
   PubMed Web of Science ®Google Scholar
• O’ByrnePMPedersenSCarlssonLGRisks of pneumonia in patients with asthma taking inhaled corticosteroidsAm J Respir Crit Care Med2011183558959520889908
   PubMed Web of Science ®Google Scholar
• AffrimeMBCussFPadhiDBioavailability and metabolism of mometasone furoate following administration by metered-dose and dry-powder inhalers in healthy human volunteersJ Clin Pharmacol200040111227123611075308
   PubMed Web of Science ®Google Scholar
• TorresABlasiFDartoisNAkovaMWhich individuals are at increased risk of pneumococcal disease and why? Impact of COPD, asthma, smoking, diabetes, and/or chronic heart disease on community-acquired pneumonia and invasive pneumococcal diseaseThorax2015701098498926219979
   PubMed Web of Science ®Google Scholar
• AnsaldiFTurelloVLaiPEffectiveness of a 23-valent polysaccharide vaccine in preventing pneumonia and non-invasive pneumococcal infection in elderly people: a large-scale retrospective cohort studyJ Int Med Res200533549050016222881
   PubMed Web of Science ®Google Scholar
• Ochoa-GondarOVila-CorcolesAAnsaXEffectiveness of pneumococcal vaccination in older adults with chronic respiratory diseases: results of the EVAN-65 studyVaccine200826161955196218343541
   PubMed Web of Science ®Google Scholar
• DerendorfHPharmacokinetic and pharmacodynamic properties of inhaled corticosteroids in relation to efficacy and safetyRespir Med199791suppl A22289474364
   PubMed Web of Science ®Google Scholar
• DerendorfHHochhausGMeibohmBMollmannHBarthJPharmacokinetics and pharmacodynamics of inhaled corticosteroidsJ Allergy Clin Immunol19981014 pt 2S440S4469563369
   PubMed Web of Science ®Google Scholar
• ColiceGLPharmacodynamic and pharmacokinetic considerations in choosing an inhaled corticosteroidTreat Respir Med20065424525316808544
   PubMedGoogle Scholar
• DerendorfHNaveRDrollmannACerasoliFWurstWRelevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthmaEur Respir J20062851042105017074919
   PubMed Web of Science ®Google Scholar
• BarnesNCThe properties of inhaled corticosteroids: similarities and differencesPrim Care Respir J200716314915417530144
   PubMedGoogle Scholar
• NicoliniGScichiloneNBizziAPapiAFabbriLMBeclomethasone/formoterol fixed combination for the management of asthma: patient considerationsTher Clin Risk Manag20084585586419209268
   PubMedGoogle Scholar
• Vanden BurgtJABusseWWMartinRJSzeflerSJDonnellDEfficacy and safety overview of a new inhaled corticosteroid, QVAR (hydrofluoroalkane-beclomethasone extrafine inhalation aerosol), in asthmaJ Allergy Clin Immunol200010661209122611112914
   PubMed Web of Science ®Google Scholar
• NaveRMeyerWFuhstRZechKFormation of fatty acid conjugates of ciclesonide active metabolite in the rat lung after 4-week inhalation of ciclesonidePulm Pharmacol Ther200518639039616179214
   PubMed Web of Science ®Google Scholar
• RohatagiSLuoYShenLProtein binding and its potential for eliciting minimal systemic side effects with a novel inhaled corticosteroid, ciclesonideAm J Ther200512320120915891262
   PubMedGoogle Scholar
• ValotisANeukamKElertOHoggerPHuman receptor kinetics, tissue binding affinity, and stability of mometasone furoateJ Pharm Sci20049351337135015067709
   PubMed Web of Science ®Google Scholar
• DietzelKEngelstatterRKellerACiclesonide: an on-site- activated steroidHanselTTBarnesPJNew Drugs for Asthma, Allergy and COPDBaselKarger20019193
   Google Scholar
• KellyHWComparative potency and clinical efficacy of inhaled corticosteroidsRespir Care Clin N Am19995453755310565880
   PubMedGoogle Scholar
• RichterKKanniessFBibergerCNaveRMagnussenHComparison of the oropharyngeal deposition of inhaled ciclesonide and fluticasone propionate in patients with asthmaJ Clin Pharmacol200545214615215647406
   PubMed Web of Science ®Google Scholar
• KalinerMAPharmacologic characteristics and adrenal suppression with newer inhaled corticosteroids: a comparison of ciclesonide and fluticasone propionateClin Ther200628331933116750447
   PubMed Web of Science ®Google Scholar
• HarrisonTWTattersfieldAEPlasma concentrations of fluticasone propionate and budesonide following inhalation from dry powder inhalers by healthy and asthmatic subjectsThorax200358325826012612308
   PubMed Web of Science ®Google Scholar
• RohatagiSAryaVZechKPopulation pharmacokinetics and pharmacodynamics of ciclesonideJ Clin Pharmacol200343436537812723457
   PubMed Web of Science ®Google Scholar
• DerendorfHHochhausGRohatagiSPharmacokinetics of triamcinolone acetonide after intravenous, oral, and inhaled administrationJ Clin Pharmacol19953533023057608322
   PubMed Web of Science ®Google Scholar
• RyrfeldtAAnderssonPEdsbackerSTonnessonMDaviesDPauwelsRPharmacokinetics and metabolism of budesonide, a selective glucocorticoidEur J Respir Dis Suppl198212286956958498
   PubMedGoogle Scholar
• Daley-YatesPTPriceACSissonJRPereiraADallowNBeclomethasone dipropionate: absolute bioavailability, pharmacokinetics and metabolism following intravenous, oral, intranasal and inhaled administration in manBr J Clin Pharmacol200151540040911421996
   PubMed Web of Science ®Google Scholar
• TunekASjodinKHallstromGReversible formation of fatty acid esters of budesonide, an antiasthma glucocorticoid, in human lung and liver microsomesDrug Metab Dispos19972511131113179351909
   PubMed Web of Science ®Google Scholar
• Miller-LarssonAJanssonPRunstromABrattsandRProlonged airway activity and improved selectivity of budesonide possibly due to esterificationAm J Respir Crit Care Med20001624 pt 11455146111029361
   PubMed Web of Science ®Google Scholar
• HubbardWCBlumAEBickelCAHellerNMSchleimerRPDetection and quantitation of fatty acid acyl conjugates of triamcinolone acetonide via gas chromatography-electron-capture negative-ion mass spectrometryAnal Biochem2003322224325014596834
   PubMed Web of Science ®Google Scholar
• BuhlRVinklerIMagyarPComparable efficacy of ciclesonide once daily versus fluticasone propionate twice daily in asthmaPulm Pharmacol Ther200619640441216310388
   PubMed Web of Science ®Google Scholar
• SzeflerSRohatagiSWilliamsJLloydMKunduSBanerjiDCiclesonide, a novel inhaled steroid, does not affect hypothalamic-pituitary-adrenal axis function in patients with moderate-to-severe persistent asthmaChest200512831104111416162694
   PubMed Web of Science ®Google Scholar
• ToogoodJHSide effects of inhaled corticosteroidsJ Allergy Clin Immunol199810257057139819285
   PubMed Web of Science ®Google Scholar
• PuolijokiHLiippoKHerralaJSalmiJTalaEInhaled beclomethasone decreases serum osteocalcin in postmenopausal asthmatic womenBone19921342852881389567
   PubMed Web of Science ®Google Scholar
• DaveluyARaignouxCMiremont-SalameGDrug interactions between inhaled corticosteroids and enzymatic inhibitorsEur J Clin Pharmacol200965774374519399485
   PubMed Web of Science ®Google Scholar
• BarnesPJBeta-adrenergic receptors and their regulationAm J Respir Crit Care Med199515238388607663795
   PubMed Web of Science ®Google Scholar
• RuffinREMcIntyreELLatimerKMWardHECrockettAJAlpersJHAssessment of beta-adrenoceptor antagonists in asthmatic patientsBr J Clin Pharmacol198213suppl 2325S335S6125185
   PubMed Web of Science ®Google Scholar
• CarstairsJRNimmoAJBarnesPJAutoradiographic visualization of beta-adrenoceptor subtypes in human lungAm Rev Respir Dis198513235415472864008
   PubMed Web of Science ®Google Scholar
• MakJCNishikawaMHaddadEBLocalisation and expression of beta-adrenoceptor subtype mRNAs in human lungEur J Pharmacol19963021–32152218791010
   PubMed Web of Science ®Google Scholar
• SpinaDRigbyPJPatersonJWGoldieRGAutoradiographic localization of beta-adrenoceptors in asthmatic human lungAm Rev Respir Dis19891405141014152554767
   PubMed Web of Science ®Google Scholar
• JohnsonMThe beta-adrenoceptorAm J Respir Crit Care Med19981585 pt 3S146S1539817738
   PubMed Web of Science ®Google Scholar
• CazzolaMImperatoreFSalzilloACardiac effects of formoterol and salmeterol in patients suffering from COPD with preexisting cardiac arrhythmias and hypoxemiaChest199811424114159726723
   PubMed Web of Science ®Google Scholar
• CazzolaMMateraMGDonnerCFInhaled beta2-adrenoceptor agonists: cardiovascular safety in patients with obstructive lung diseaseDrugs200565121595161016060696
   PubMed Web of Science ®Google Scholar
• TesfamariamBWaldronTSeymourAAQuantitation of tremor in response to beta-adrenergic receptor stimulation in primates: relationship with hypokalemiaJ Pharmacol Toxicol Methods199840420120510465154
   PubMed Web of Science ®Google Scholar
• ScheininMKouluMLaurikainenEAllonenHHypokalaemia and other non-bronchial effects of inhaled fenoterol and salbutamol: a placebo-controlled dose-response study in healthy volunteersBr J Clin Pharmacol19872456456532829953
   PubMed Web of Science ®Google Scholar
• Canepa-AnsonRDawsonJRKuanPDifferences between acute and long-term metabolic and endocrine effects of oral beta-adrenoceptor agonist therapy with pirbuterol for cardiac failureBr J Clin Pharmacol19872321731813828194
   PubMed Web of Science ®Google Scholar
• Du PlooyWJHayLKahlerCPSchuttePJBrandtHDThe dose-related hyper-and-hypokalaemic effects of salbutamol and its arrhythmogenic potentialBr J Pharmacol1994111173768012727
   PubMed Web of Science ®Google Scholar
• LipworthBJMcDevittDGStruthersADPrior treatment with diuretic augments the hypokalemic and electrocardiographic effects of inhaled albuterolAm J Med1989866 pt 16536572729315
   PubMed Web of Science ®Google Scholar
• NewnhamDMMcDevittDGLipworthBJThe effects of frusemide and triamterene on the hypokalaemic and electrocardiographic responses to inhaled terbutalineBr J Clin Pharmacol19913256306321954079
   PubMed Web of Science ®Google Scholar
• KnudsonRJConstantineHPAn effect of isoproterenol on ventilation-perfusion in asthmatic versus normal subjectsJ Appl Physiol19672234024066020222
   PubMed Web of Science ®Google Scholar
• ConnerMWReidLMMapping of beta-adrenergic receptors in rat lung: effect of isoproterenolExp Lung Res198462911016086301
   PubMed Web of Science ®Google Scholar
• WagnerPDDantzkerDRIacovoniVETomlinWCWestJBVentilation-perfusion inequality in asymptomatic asthmaAm Rev Respir Dis19781183511524707879
   PubMed Web of Science ®Google Scholar
• PhilipsonLHbeta-Agonists and metabolismJ Allergy Clin Immunol20021106 supplS313S31712464941
   PubMedGoogle Scholar
• MateraMGMartuscelliECazzolaMPharmacological modulation of beta-adrenoceptor function in patients with coexisting chronic obstructive pulmonary disease and chronic heart failurePulm Pharmacol Ther20102311819833222
   PubMed Web of Science ®Google Scholar
• ShortPMLipworthSIElderDHSchembriSLipworthBJEffect of beta blockers in treatment of chronic obstructive pulmonary disease: a retrospective cohort studyBMJ2011342d254921558357
   PubMed Web of Science ®Google Scholar
• HawkinsNMWangDPetrieMCCHARM Investigators and CommitteesBaseline characteristics and outcomes of patients with heart failure receiving bronchodilators in the CHARM programmeEur J Heart Fail201012655756520356870
   PubMed Web of Science ®Google Scholar
• BerminghamMO’CallaghanEDawkinsIAre beta2-agonists responsible for increased mortality in heart failure?Eur J Heart Fail201113888589121791542
   PubMed Web of Science ®Google Scholar
• ChanWLYangKPChaoTFThe association of asthma and atrial fibrillation – a nationwide population-based nested case-control studyInt J Cardiol2014176246446925127961
   PubMed Web of Science ®Google Scholar
• AuDHUdrisEMFanVSCurtisJRMcDonellMBFihnSDRisk of mortality and heart failure exacerbations associated with inhaled beta-adrenoceptor agonists among patients with known left ventricular systolic dysfunctionChest200312361964196912796175
   PubMed Web of Science ®Google Scholar
• FelkerGMO’ConnorCMRational use of inotropic therapy in heart failureCurr Cardiol Rep20013210811311177666
   PubMedGoogle Scholar
• CoughlinSSMetayerCMcCarthyEPRespiratory illness, beta-agonists, and risk of idiopathic dilated cardiomyopathy. The Washington, DC, Dilated Cardiomyopathy StudyAm J Epidemiol199514243954037625404
   PubMed Web of Science ®Google Scholar
• AuDHUdrisEMCurtisJRMcDonellMBFihnSDCHARM Investigators and CommitteesAssociation between chronic heart failure and inhaled beta-2-adrenoceptor agonistsAm Heart J2004148591592015523327
   PubMed Web of Science ®Google Scholar
• NgTMMungerMALombardiWLChronically inhaled salmeterol improves pulmonary function in heart failureJ Cardiovasc Pharmacol200240114014512072587
   PubMed Web of Science ®Google Scholar
• JenneJWCan oral beta2 agonists cause heart failure?Lancet19983529134108110829798578
   PubMed Web of Science ®Google Scholar
• AhrensRCSkeletal muscle tremor and the influence of adrenergic drugsJ Asthma199027111201968452
   PubMed Web of Science ®Google Scholar
• SmithSRKendallMJMetabolic responses to beta 2 stimulantsJ R Coll Physicians Lond19841831901946147409
   PubMedGoogle Scholar
• MillerWCRiceDLA comparison of oral terbutaline and fenoterol in asthmaAnn Allergy198044115187352688
   PubMedGoogle Scholar
• PrattHFAbuse of salbutamol inhalers in young peopleClin Allergy19821222032097074823
   PubMedGoogle Scholar
• CacciaSFongMHKinetics and distribution of the beta-adrenergic agonist salbutamol in rat brainJ Pharm Pharmacol19843632002026144759
   PubMed Web of Science ®Google Scholar
• CazzolaMProiettoAMateraMGIndacaterol for chronic obstructive pulmonary disease (COPD)Drugs Today (Barc)201046313915020467588
   PubMed Web of Science ®Google Scholar
• GuptaPO’MahonyMSPotential adverse effects of bronchodilators in the treatment of airways obstruction in older people: recommendations for prescribingDrugs Aging200825541544318447405
   PubMed Web of Science ®Google Scholar
• ScichiloneNVenturaMTBoniniMChoosing wisely: practical considerations on treatment efficacy and safety of asthma in the elderlyClin Mol Allergy2015131726101468
   PubMedGoogle Scholar
• VaquerizoMJCasanPCastilloJEffect of montelukast added to inhaled budesonide on control of mild to moderate asthmaThorax200358320421012612294
   PubMed Web of Science ®Google Scholar
• BozekAWarkocka-SzoltysekBFilipowska-GronskaAJarzabJMontelukast as an add-on therapy to inhaled corticosteroids in the treatment of severe asthma in elderly patientsJ Asthma201249553053422551116
   PubMed Web of Science ®Google Scholar
• BarnesNThomasMPriceDTateHThe national montelukast surveyJ Allergy Clin Immunol20051151475415637546
   PubMed Web of Science ®Google Scholar
• OhshimaNMatsuiHMatsuiYAddition of leukotriene receptor antagonists to inhaled corticosteroids improved QOL of patients with bronchial asthma surveyed in suburban Tokyo, JapanAllergol Int201160447348121681017
   PubMedGoogle Scholar
• YasuiHFujisawaTInuiNImpact of add-on pranlukast in stable asthma; the additive effect on peripheral airway inflammationRespir Med2012106450851422265857
   PubMed Web of Science ®Google Scholar
• BelliaVBattagliaSMateraMGCazzolaMThe use of bronchodilators in the treatment of airway obstruction in elderly patientsPulm Pharmacol Ther200619531131916260162
   PubMed Web of Science ®Google Scholar
• ConnollyMJCrowleyJJCharanNBNielsonCPVestalREImpaired bronchodilator response to albuterol in healthy elderly men and womenChest199510824014067634874
   PubMed Web of Science ®Google Scholar
• ScarpacePJBaresiLAIncreased beta-adrenergic receptors in the light-density membrane fraction in lungs from senescent ratsJ Gerontol1988436B163B1672846681
   PubMedGoogle Scholar
• ParkerALAging does not affect beta-agonist responsiveness after methacholine-induced bronchoconstrictionJ Am Geriatr Soc200452338839214962153
   PubMed Web of Science ®Google Scholar
• RodrigoGRodrigoCEffect of age on bronchodilator response in acute severe asthma treatmentChest1997112119239228351
   PubMed Web of Science ®Google Scholar
• U.S. Food and Drug Administration (FDA) [webpage on the Internet]DA Drug Safety Communication: Drug Labels Now Contain Updated Recommendations on the Appropriate Use of Long-Acting Inhaled Asthma Medications Called Long-Acting Beta-Agonists (LABAs)2010 Available from: http://www.fda.gov/Drugs/DrugSafety/Post-marketDrugSafetyInformationforPatientsandProviders/ucm213836.htmAccessed June 22, 2016
   Google Scholar
• RottenkolberMFischerRIbanezLPrescribing of long-acting beta-2-agonists/inhaled corticosteroids after the SMART trialBMC Pulm Med2015155525943421
   PubMed Web of Science ®Google Scholar
• PauwelsRASearsMRCampbellMRELIEF Study InvestigatorsFormoterol as relief medication in asthma: a worldwide safety and effectiveness trialEur Respir J200322578779414621086
   PubMed Web of Science ®Google Scholar
• SekiyaKNakataniEFukutomiYSevere or life-threatening asthma exacerbation: patient heterogeneity identified by cluster analysisClin Exp Allergy20164681043105527041475
   PubMed Web of Science ®Google Scholar
• BeehKMLaForceCGahlemannMWenzAToorawaRFlezarMRandomised, double-blind, placebo-controlled crossover study to investigate different dosing regimens of olodaterol delivered via respimat(R) in patients with moderate to severe persistent asthmaRespir Res2015168726177937
   PubMed Web of Science ®Google Scholar
• BattagliaSBasileMSpataforaMScichiloneNAre asthmatics enrolled in randomized trials representative of real-life outpatients?Respiration201589538338925791779
   PubMed Web of Science ®Google Scholar
• PriceDSmallIHaughneyJClinical and cost effectiveness of switching asthma patients from fluticasone-salmeterol to extra-fine particle beclometasone-formoterol: a retrospective matched observational study of real-world patientsPrim Care Respir J201322443944824186700
   PubMedGoogle Scholar
• BraidoFBaiardiniISumberesiMBlasiFCanonicaGWObstructive lung diseases and inhaler treatment: results from a national public pragmatic surveyRespir Res2013149424053694
   PubMed Web of Science ®Google Scholar
• ParkHWKimTWSongWJPrediction of asthma exacerbations in elderly adults: results of a 1-year prospective studyJ Am Geriatr Soc20136191631163224028367
   PubMed Web of Science ®Google Scholar