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Original Research

Predicting and managing sepsis in burn patients: current perspectives

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Pages 1107-1117 | Published online: 29 Aug 2017

References

  • American Burn AssociationNational Burn Repository 2016Chicago, IL2016 Available from: http://ameriburn.org/education/publications/
  • WilliamsFNHerndonDNHawkinsHKThe leading causes of death after burn injury in a single pediatric burn centerCrit Care2009136R18319919684
  • DasariHKumarASharmaBBurns septicemia: the leading cause of burn mortalityJ Punjab Acad Forensic Med Toxicol2008821016
  • SharmaBRHarishDSinghVPBangarSSepticemia as a cause of death in burns: an autopsy studyBurns200632554554916797127
  • D’AvignonLCHoganBKMurrayCKContribution of bacterial and viral infections to attributable mortality in patients with severe burns: an autopsy seriesBurns201036677377920074860
  • O’SullivanSTO’ConnorTPImmunosuppression following thermal injury: the pathogenesis of immunodysfunctionBr J Plast Surg19975086156239613404
  • SchwachaMGMacrophages and post-burn immune dysfunctionBurns200329111412543039
  • GirardotTRimmeleTVenetFMonneretGApoptosis-induced lymphopenia in sepsis and other severe injuriesApoptosis201722229530527812767
  • SingerMDeutschmanCSSeymourCWThe third international consensus definitions for sepsis and septic shock (sepsis-3)JAMA2016315880181026903338
  • GreenhalghDGSaffleJRHolmesJH4thAmerican Burn Association consensus conference to define sepsis and infection in burnsJ Burn Care Res200728677679017925660
  • HowellMDDavisAMManagement of sepsis and septic shockJAMA2017317884784828114603
  • FerrerRMartin-LoechesIPhillipsGEmpiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement programCrit Care Med20144281749175524717459
  • SterlingSAMillerWRPryorJPuskarichMAJonesAEThe impact of timing of antibiotics on outcomes in severe sepsis and septic shock: a systematic review and meta-analysisCrit Care Med20154391907191526121073
  • KumarARobertsDWoodKEDuration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shockCrit Care Med20063461589159616625125
  • BoneRCBalkRACerraFBDefinitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care MedicineChest19921016164416551303622
  • LevyMMFinkMPMarshallJC2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions ConferenceIntensive Care Med200329453053812664219
  • VincentJLMorenoRTakalaJThe SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care MedicineIntensive Care Med19962277077108844239
  • SeymourCWLiuVXIwashynaTJAssessment of clinical criteria for sepsis: For the third international consensus definitions for sepsis and septic shock (sepsis-3)JAMA2016315876277426903335
  • FreundYLemachattiNKrastinovaEPrognostic accuracy of sepsis-3 criteria for in-hospital mortality among patients with suspected infection presenting to the emergency departmentJAMA2017317330130828114554
  • HedegaardSSWisborgKHvasA-MDiagnostic utility of biomarkers for neonatal sepsis – a systematic reviewInfect Dis (London, England)2015473117124
  • DupuyA-MPhilippartFPeanYRole of biomarkers in the management of antibiotic therapy: an expert panel review: I – currently available biomarkers for clinical use in acute infectionsAnn Intensive Care2013312223837559
  • AssicotMGendrelDCarsinHRaymondJGuilbaudJBohuonCHigh serum procalcitonin concentrations in patients with sepsis and infectionLancet (London, England)19933418844515518
  • LongBKoyfmanAReady for prime time? Biomarkers in sepsisEmerg Med Clin North Am201735110912227908327
  • MeisnerMPathobiochemistry and clinical use of procalcitoninClin Chim Acta2002323172912135804
  • SchneiderHGLamQTProcalcitonin for the clinical laboratory: a reviewPathology20073938339017676478
  • JinMKhanAIProcalcitonin: uses in the clinical laboratory for the diagnosis of sepsisLab Med2010413173177
  • BeckerKLNylenESWhiteJCMullerBSniderRHJProcalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursorsJ Clin Endocrinol Metab20048941512152515070906
  • GendrelDAssicotMRaymondJProcalcitonin as a marker for the early diagnosis of neonatal infectionJ Pediatr199612845705738618197
  • SchlattmannPBrunkhorstFMProcalcitonin as a diagnostic marker for sepsisLancet Infect Dis201414318924571977
  • YangMGaoHChenJBacterial coinfection is associated with severity of avian influenza A (H7N9), and procalcitonin is a useful marker for early diagnosisDiagn Microbiol Infect Dis201684216516926639228
  • UgarteHSilvaEMercanDDe MendoncaAVincentJLProcalcitonin used as a marker of infection in the intensive care unitCrit Care Med199927349850410199528
  • BellKWattieMBythKProcalcitonin: a marker of bacteraemia in SIRSAnaesth Intensive Care200331662963614719423
  • SuprinECamusCGacouinAProcalcitonin: a valuable indicator of infection in a medical ICU?Intensive Care Med20002691232123811089747
  • BrunkhorstFMEberhardOKBrunkhorstRDiscrimination of infectious and noninfectious causes of early acute respiratory distress syndrome by procalcitoninCrit Care Med199927102172217610548201
  • SimonLGauvinFAmreDKSerum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysisClin Infect Dis20043920621715307030
  • UzzanBCohenRNicolasPCucheratMPerretG-YProcalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysisCrit Care Med20063471996200316715031
  • Clec’hCFerriereFKaroubiPDiagnostic and prognostic value of procalcitonin in patients with septic shockCrit Care Med20043251166116915190968
  • WackerCPrknoABrunkhorstFMSchlattmannPProcalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysisLancet Infect Dis201313542643523375419
  • von HeimburgDStieghorstWKhorram-SefatRPalluaNProcalcitonin – a sepsis parameter in severe burn injuriesBurns19982487457509915676
  • BrunkhorstFMWegscheiderKForyckiZFBrunkhorstRProcalcitonin for early diagnosis and differentiation of SIRS, sepsis, severe sepsis, and septic shockIntensive Care Med200026Suppl 2S148S15218470710
  • LavrentievaAKontakiotisTLazaridisLInflammatory markers in patients with severe burn injury: what is the best indicator of sepsis?Burns200733218919417215085
  • SachseCMachensHGFelmererGBergerAHenkelEProcalcitonin as a marker for the early diagnosis of severe infection after thermal injuryJ Burn Care Rehabil199920535436010501320
  • Abdel-HafezNMSaleh HassanYEl-MetwallyTHA study on biomarkers, cytokines, and growth factors in children with burn injuriesAnn Burns Fire Disasters20072028910021991076
  • BaratiMAlinejadFBaharMAComparison of WBC, ESR, CRP and PCT serum levels in septic and non-septic burn casesBurns200834677077418513877
  • GilleJOstermannHDraguASablotzkiAMR-proADM: a new biomarker for early diagnosis of sepsis in burned patientsJ Burn Care Res Epub3282017
  • SeoaneLPertegaSGaleirasRAstolaIBouzaTProcalcitonin in the burn unit and the diagnosis of infectionBurns201440222322924439927
  • ParatzJDLipmanJBootsRJMullerMJPatersonDLA new marker of sepsis post burn injury?Crit Care Med20144292029203624851744
  • NeelyANFowlerLAKaganRJWardenGDProcalcitonin in pediatric burn patients: an early indicator of sepsis?J Burn Care Rehabil2004251768014726743
  • BarguesLChancerelleYCatineauJJaultPCarsinHEvaluation of serum procalcitonin concentration in the ICU following severe burnBurns200733786086417532575
  • CabralLAfreixoVAlmeidaLPaivaJAThe use of procalcitonin (PCT) for diagnosis of sepsis in burn patients: a meta-analysisPLoS One20161112e016847528005932
  • SchuetzPBrielMChrist-CrainMProcalcitonin to guide initiation and duration of antibiotic treatment in acute respiratory infections: an individual patient data meta-analysisClin Infect Dis An Off Publ Infect Dis Soc Am2012555651662
  • SchuetzPBrielMMuellerBClinical outcomes associated with procalcitonin algorithms to guide antibiotic therapy in respiratory tract infectionsJAMA2013309771771823423417
  • PrknoAWackerCBrunkhorstFMSchlattmannPProcalcitonin-guided therapy in intensive care unit patients with severe sepsis and septic shock – a systematic review and meta-analysisCrit Care2013176R29124330744
  • ChuDCMehtaABWalkeyAJPractice patterns and outcomes associated with procalcitonin use in critically ill patients with sepsisClin Infect Dis201764111509151528329238
  • AndrioloBNAndrioloRBSalomaoRAtallahANEffectiveness and safety of procalcitonin evaluation for reducing mortality in adults with sepsis, severe sepsis or septic shockCochrane Database Syst Rev20171CD01095928099689
  • SurbatovicMVeljovicMJevdjicJPopovicNDjordjevicDRadakovicSImmunoinflammatory response in critically ill patients: severe sepsis and/or traumaMediators Inflamm2013201336279324371374
  • ParameswaranNPatialSTumor necrosis factor-alpha signaling in macrophagesCrit Rev Eukaryot Gene Expr20102028710321133840
  • YamadaYEndoSInadaKPlasma cytokine levels in patients with severe burn injury – with reference to the relationship between infection and prognosisBurns19962285875938982534
  • FinnertyCCHerndonDNChinkesDLJeschkeMGSerum cytokine differences in severely burned children with and without sepsisShock20072714917172973
  • DrostACBurlesonDGCioffiWGJMasonADJPruittBAJPlasma cytokines after thermal injury and their relationship to infectionAnn Surg1993218174788328832
  • ArslanEYavuzMDalayCThe relationship between tumor necrosis factor (TNF)-alpha and survival following granulocyte-colony stimulating factor (G-CSF) administration in burn sepsisBurns200026652152410869822
  • JawaRSAnilloSHuntoonKBaumannHKulaylatMAnalytic review: interleukin-6 in surgery, trauma, and critical care: part I: basic scienceJ Intensive Care Med201126131221262749
  • JawaRSAnilloSHuntoonKBaumannHKulaylatMInterleukin-6 in surgery, trauma, and critical care part II: clinical implicationsJ Intensive Care Med2011262738721464062
  • SchluterBKonigBBergmannUMullerFEKonigWInterleukin 6–a potential mediator of lethal sepsis after major thermal trauma: evidence for increased IL-6 production by peripheral blood mononuclear cellsJ Trauma19913112166316701749040
  • FinnertyCCHerndonDNPrzkoraRCytokine expression profile over time in severely burned pediatric patientsShock2006261131916783192
  • CarsinHAssicotMFegerFEvolution and significance of circulating procalcitonin levels compared with IL-6, TNF alpha and endotoxin levels early after thermal injuryBurns19972332182249232281
  • PalluaNvon HeimburgDPathogenic role of interleukin-6 in the development of sepsis. Part I: study in a standardized contact burn murine modelCrit Care Med20033151490149412771623
  • PalluaNLowJFAvon HeimburgDPathogenic role of interleukin-6 in the development of sepsis. Part II: significance of anti-interleukin-6 and anti-soluble interleukin-6 receptor-alpha antibodies in a standardized murine contact burn modelCrit Care Med20033151495150112771624
  • ZhangHWangH-YBassel-DubyRRole of interleukin-6 in cardiac inflammation and dysfunction after burn complicated by sepsisAm J Physiol Heart Circ Physiol20072925H2408H241617220181
  • MaLZhangHYinYRole of interleukin-6 to differentiate sepsis from non-infectious systemic inflammatory response syndromeCytokine20168812613527599258
  • BaggioliniMWalzAKunkelSLNeutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophilsJ Clin Invest1989844104510492677047
  • BaggioliniMClark-LewisIInterleukin-8, a chemotactic and inflammatory cytokineFEBS Lett19923071971011639201
  • VindenesHUlvestadEBjerknesRIncreased levels of circulating interleukin-8 in patients with large burns: relation to burn size and sepsisJ Trauma19953946356407473946
  • YehFLLinWLShenHDFangRHChanges in levels of serum IL-8 in burned patientsBurns1997237–85555599568323
  • KraftRHerndonDNFinnertyCCCoxRASongJJeschkeMGPredictive value of IL-8 for sepsis and severe infections after burn injury: a clinical studyShock201543322222725514427
  • AsadullahKSterryWVolkHDInterleukin-10 therapy–review of a new approachPharmacol Rev200355224126912773629
  • KumarSShuklaRRanjanPKumarAInterleukin-10: a compelling therapeutic target in patients with irritable bowel syndromeClin Ther201739363264328237672
  • MonneretGFinckM-EVenetFThe anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentrationImmunol Lett200495219319815388260
  • HotchkissRSMonneretGPayenDSepsis-induced immunosuppression: from cellular dysfunctions to immunotherapyNat Rev Immunol2013131286287424232462
  • CsontosCFoldiVPalinkasLTime course of pro- and anti-inflammatory cytokine levels in patients with burns – prognostic value of interleukin-10Burns201036448349420045261
  • PileriDAccardo PalomboAD’AmelioLConcentrations of cytokines Il-6 and Il-10 in plasma of burn patients: their relationship to sepsis and outcomeAnn Burns Fire Disasters200821418218521991134
  • YaegashiYSatoNSuzukiYEvaluation of a newly identified soluble CD14 subtype as a marker for sepsisJ Infect Chemother200511523423816258819
  • WuJHuLZhangGWuFHeTAccuracy of presepsin in sepsis diagnosis: a systematic review and meta-analysisPLoS One2015107e013305726192602
  • ShozushimaTTakahashiGMatsumotoNKojikaMEndoSOkamuraYUsefulness of presepsin (sCD14-ST) measurements as a marker for the diagnosis and severity of sepsis that satisfied diagnostic criteria of systemic inflammatory response syndromeJ Infect Chemother201117676476921560033
  • MussapMNotoAFravegaMFanosVSoluble CD14 subtype presepsin (sCD14-ST) and lipopolysaccharide binding protein (LBP) in neonatal sepsis: new clinical and analytical perspectives for two old biomarkersJ Matern Fetal Neonatal Med201124Suppl 21214
  • BehnesMBertschTLepiorzDDiagnostic and prognostic utility of soluble CD 14 subtype (presepsin) for severe sepsis and septic shock during the first week of intensive care treatmentCrit Care201418550725190134
  • Cakir MadenciOYakupogluSBenzonanaNYucelNAkbabaDOrcun KaptanagasiAEvaluation of soluble CD14 subtype (presepsin) in burn sepsisBurns201440466466924074718
  • ZhangJHuZ-DSongJShaoJDiagnostic value of presepsin for sepsis: a systematic review and meta-analysisMedicine (Baltimore)20159447e215826632748
  • LiuXRenHPengDSepsis biomarkers: an omics perspectiveFront Med201481586724481820
  • BarberRAragakiCRivera-ChavezFPurdueGHuntJHortonJTLR4 and TNF-α polymorphisms are associated with an increased risk for severe sepsis following burn injuryJ Med Genet2004411180881315520404
  • HuebingerRMRivera-ChavezFChangL-YIL-10 polymorphism associated with decreased risk for mortality after burn injuryJ Surg Res20101641e141e14520863526
  • XiaoWMindrinosMNSeokJA genomic storm in critically injured humansJ Exp Med2011208132581259022110166
  • BauerMGiamarellos-BourboulisEJKortgenAA transcriptomic biomarker to quantify systemic inflammation in sepsis – a prospective multicenter Phase II diagnostic studyEBioMedicine2016611412527211554
  • PorterCTompkinsRGFinnertyCCSidossisLSSumanOEHerndonDNThe metabolic stress response to burn trauma: current understanding and therapiesLancet20173881005214171426
  • JiangHPengJZhouZEstablishing (1)H nuclear magnetic resonance based metabonomics fingerprinting profile for spinal cord injury: a pilot studyChin Med J (Engl)2010123172315231921034541
  • PengJZengJCaiBEstablishment of quantitative severity evaluation model for spinal cord injury by metabolomic fingerprintingPLoS One201494e9373624727691
  • ZhangYCaiBJiangHUse of (1)H-nuclear magnetic resonance to screen a set of biomarkers for monitoring metabolic disturbances in severe burn patientsCrit Care2014184R15925059459
  • RhodesAEvansLEAlhazzaniWSurviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016Intensive Care Med201743330437728101605
  • ShirakuraYKuriyamaATiming of antibiotic administration in sepsis and septic shock: the impact that a meta-analysis does not depictCrit Care Med20164410e1004
  • WhiteCERenzEMAdvances in surgical care: management of severe burn injuryCrit Care Med2008367 SupplS318S32418594259
  • CarusoDMMatthewsMRMonitoring end points of burn resuscitationCrit Care Clin201632452553727600124
  • PruittBAJProtection from excessive resuscitation: “pushing the pendulum back”J Trauma200049356756811003341
  • LeDouxDAstizMECarpatiCMRackowECEffects of perfusion pressure on tissue perfusion in septic shockCrit Care Med20002882729273210966242
  • NorburyWHerndonDNTanksleyJJeschkeMGFinnertyCCInfection in burnsSurg Infect (Larchmt)201617225025526978531
  • BahemiaIAMuganzaAMooreRSahidFMenezesCNMicrobiology and antibiotic resistance in severe burns patients: a 5 year review in an adult burns unitBurns20154171536154226051799
  • Fekih HassenABen KhalifaSDaikiMEpidemiological and bacteriological profiles in children with burnsBurns20144051040104524331406
  • BariePSHydoLJShouJLaroneDHEachempatiSRInfluence of antibiotic therapy on mortality of critical surgical illness caused or complicated by infectionSurg Infect (Larchmt)200561415415865550
  • KumarAEllisPArabiYInitiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shockChest200913651237124819696123
  • IbrahimEHShermanGWardSFraserVJKollefMHThe influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU settingChest2000118114615510893372
  • PeykoVSmalleySCohenHProspective comparison of acute kidney injury during treatment with the combination of piperacillin–tazobactam and vancomycin versus the combination of cefepime or meropenem and vancomycinJ Pharm Pract201730220921326912532
  • GomesDMSmothermanCBirchAComparison of acute kidney injury during treatment with vancomycin in combination with piperacillin–tazobactam or cefepimePharmacotherapy201434766266924753221
  • De BusLDenysWCatteeuwJImpact of de-escalation of beta-lactam antibiotics on the emergence of antibiotic resistance in ICU patients: a retrospective observational studyIntensive Care Med20164261029103927025939
  • AlshukairiAAlserehiHEl-SaedAA de-escalation protocol for febrile neutropenia cases and its impact on carbapenem resistance: a retrospective, quasi-experimental single-center studyJ Infect Public Health20169444345126688375
  • Garnacho-MonteroJGutierrez-PizarrayaAEscoresca-OrtegaADe-escalation of empirical therapy is associated with lower mortality in patients with severe sepsis and septic shockIntensive Care Med2014401324024026297
  • GuoYGaoWYangHMaCSuiSDe-escalation of empiric antibiotics in patients with severe sepsis or septic shock: a meta-analysisHeart Lung201645545445927340006
  • SinghNPRaniMGuptaKSagarTKaurIRChanging trends in antimicrobial susceptibility pattern of bacterial isolates in a burn unitBurns20174351083108728153582
  • KeenEF3rdRobinsonBJHospenthalDRPrevalence of multidrug-resistant organisms recovered at a military burn centerBurns201036681982520080354
  • AdibhesamiHDouraghiMZeraatiHCarbapenem-resistant Acinetobacter baumannii (CRAB) recovered from burn patientsJ Pharm Pharm Sci201619333934827806248
  • De VosDPirnayJ-PBilocqFMolecular epidemiology and clinical impact of Acinetobacter calcoaceticus-baumannii complex in a Belgian burn wound centerPLoS One2016115e015623727223476
  • de Maio CarrillhoCMDGauderetoJJMartinsRCRColistin-resistant Enterobacteriaceae infections: clinical and molecular characterization and analysis of in vitro synergyDiagn Microbiol Infect Dis201787325325727939820
  • ViaggiBSbranaFMalacarnePTasciniCVentilator-associated pneumonia caused by colistin-resistant KPC-producing Klebsiella pneumoniae: a case report and literature reviewRespir Investig2015533124128
  • RattanRAllenCJSawyerRGPatients with complicated intra-abdominal infection presenting with sepsis do not require longer duration of antimicrobial therapyJ Am Coll Surg2016222444044626920994
  • ChastreJWolffMFagonJ-YComparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trialJAMA2003290192588259814625336
  • ChoudhuryGMandalPSinganayagamAAkramARChalmersJDHillATSeven-day antibiotic courses have similar efficacy to prolonged courses in severe community-acquired pneumonia – a propensity-adjusted analysisClin Microbiol Infect201117121852185821919994
  • StruckMFGilleJFungal infections in burns: a comprehensive reviewAnn Burns Fire Disasters201326314715324563641
  • BallardJEdelmanLSaffleJPositive fungal cultures in burn patients: a multicenter reviewJ Burn Care Res200829121322118182925
  • RussellJAWalleyKRSingerJVasopressin versus norepinephrine infusion in patients with septic shockN Engl J Med2008358987788718305265
  • LundyJBChungKKPamplinJCAinsworthCRJengJCFriedmanBCUpdate on severe burn management for the IntensivistJ Intensive Care Med201631849951026112758
  • WongC-HChangH-CPasupathySKhinL-WTanJ-LLowCONecrotizing fasciitis: clinical presentation, microbiology, and determinants of mortalityJ Bone Joint Surg Am200385-A81454146012925624
  • AzuhataTKinoshitaKKawanoDTime from admission to initiation of surgery for source control is a critical determinant of survival in patients with gastrointestinal perforation with associated septic shockCrit Care2014183R8724886954
  • GallagherJJBranskiLKWilliams-BouyerNVillarrealCHerndonDNChapter 12 – Treatment of infection in burns BT – total burn care4th edLondonW.B. Saunders2012137156.e2
  • PruittBAJThe diagnosis and treatment of infection in the burn patientBurns Incl Therm Inj198411279916525539
  • ColonNCSchlegelCChungDHChapter 37 – surgical management of complications of burn injury A2HerndonDavidNBT – Total burn care4th edLondonW.B. Saunders2012421431.e2
  • SolomkinJSMazuskiJEBradleyJSDiagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of AmericaSurg Infect (Larchmt)20101117910920163262