Clinical utility of ingenol mebutate in the management of actinic keratosis: perspectives from clinical practice

References

• FilosaAFilosaGActinic keratosis and squamous cell carcinoma: clinical and pathological featuresG Ital Dermatol Venereol2015150437938426099352
   PubMed Web of Science ®Google Scholar
• LaiVCranwellWSinclairREpidemiology of skin cancer in the mature patientClin Dermatol2018362167176 Epub 2017 Oct 1329566921
   PubMed Web of Science ®Google Scholar
• PereraEGnaneswaranNStainesCWinAKSinclairRIncidence and prevalence of non-melanoma skin cancer in Australia: A systematic reviewAustralas J Dermatol2015564258267 Epub 2015 Feb 2525716064
   PubMed Web of Science ®Google Scholar
• FargnoliMCAltomareGBenatiEPrevalence and risk factors of actinic keratosis in patients attending Italian dermatology clinicsEur J Dermatol201727659960829311040
   PubMed Web of Science ®Google Scholar
• GreenACEpidemiology of actinic keratosesCurr Probl Dermatol2015461725561199
   PubMedGoogle Scholar
• ArenbergerPArenbergerovaMNew and current preventive treatment options in actinic keratosisJ Eur Acad Dermatol Venereol201731Suppl 5131728805940
   PubMed Web of Science ®Google Scholar
• Warszawik-HendzelOOlszewskaMMajMRakowskaACzuwaraJRudnickaLNon-invasive diagnostic techniques in the diagnosis of squamous cell carcinomaJ Dermatol Case Rep201594899726848316
   PubMedGoogle Scholar
• Fernandez FiguerasMTFrom actinic keratosis to squamous cell carcinoma: pathophysiology revisitedJ Eur Acad Dermatol Venereol201731Suppl 257
   PubMed Web of Science ®Google Scholar
• JetterNChandanNWangSTsoukasMField Cancerization Therapies for Management of Actinic Keratosis: A Narrative ReviewAm J Clin Dermatol201819454355729582369
   PubMed Web of Science ®Google Scholar
• ConfortiCBeninantiEDianzaniCAre actinic keratoses really squamous cell cancer? How do we know if they would become malignant?Clin Dermatol201836343043229908585
   PubMed Web of Science ®Google Scholar
• JorizzoJLCarneyPSKoWYTreatment options in the management of actinic keratosisCutis200474Suppl6917
   Google Scholar
• JerryKLTanDThomasRPoulinYMaddinFTanJEfficacy of Imiquimod as an Adjunct to Cryotherapy for Actinic KeratosesJ Cutan Med Surg200711619520118042331
   PubMed Web of Science ®Google Scholar
• RatushnyVGoberMDHickRRidkyTWSeykoraJTFrom keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinomaJ Clin Invest2012122246447222293185
   PubMed Web of Science ®Google Scholar
• SiegelJAKorgavkarKWeinstockMACurrent perspective on actinic keratosis: a reviewBr J Dermatol2017177235035827500794
   PubMed Web of Science ®Google Scholar
• WernerRNSammainAErdmannRThe natural history of actinic keratosis: a systematic reviewBr J Dermatol201316950251823647091
   PubMed Web of Science ®Google Scholar
• KoCJCjKActinic keratosis: facts and controversiesClin Dermatol201028324925320541675
   PubMed Web of Science ®Google Scholar
• ChettyPChoiFMitchellTPrimary care review of actinic keratosis and its therapeutic options: a global perspectiveDermatol Ther2015511935
   PubMed Web of Science ®Google Scholar
• AliFRWlodekCLearJTThe role of ingenol mebutate in the treatment of actinic keratosesDermatol Ther2012218
   Google Scholar
• AdityaSGuptaSIngenol mebutate: A novel topical drug for actinic keratosisIndian Dermatol Online J20134324624923984250
   PubMedGoogle Scholar
• GreenACBeardmoreGLHome treatment of skin cancer and solar keratosesAustralas J Dermatol19882931271303272119
   PubMedGoogle Scholar
• BobyrICampanatiAConsalesVGiuliodoriKScaliseAOffidaniAEfficacyOAEfficacy, safety and tolerability of field treatment of actinic keratosis with ingenol mebutate 0.015% gel: a single center case seriesSpringerplus2016562727330893
   PubMedGoogle Scholar
• GuptaAKPaquetMIngenol Mebutate: A Promising Treatment for Actinic Kératoses and Non melanoma Skin CancersJ Cutan Med Surg201317317317923673300
   PubMed Web of Science ®Google Scholar
• AlchinDRIngenol mebutate: a succinct review of a succinct therapyDermatol Ther201442157164
   Google Scholar
• MartinGSwansonNClinical findings using ingenol mebutate gel to treat actinic keratosesJ Am Acad Dermatol2013681 Suppl 1S39S4823228305
   PubMed Web of Science ®Google Scholar
• LiLShuklaSLeeAThe skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multi-drug transporter (ABCB1) and targets tumor vasculatureCancer Res201070114509451920460505
   PubMed Web of Science ®Google Scholar
• RosenRHGuptaAKTyringSKDual mechanism of action of ingenol mebutate gel for topical treatment of actinic keratoses: rapid lesion necrosis followed by lesion-specific immune responseJ Am Acad Dermatol201266348649322055282
   PubMed Web of Science ®Google Scholar
• FidlerBGoldbergTIngenol mebutate gel (Picato): a novel agent for the treatment of actinic keratosesP T2014391404624672213
   PubMedGoogle Scholar
• FallenRSGooderhamMIngenol mebutate: an introductionSkin Therapy Lett20121713
   Google Scholar
• Ortega del OlmoRSalido-VallejoRIngenol mebutate for the treatment of actinic keratosis: effectiveness and safety in 246 patients treated in real-life clinical practiceJ Dermatolog Treat2018294129384038
   PubMed Web of Science ®Google Scholar
• KeatingGMIngenol mebutate gel 0.015% and 0.05%: in actinic keratosisDrugs201272182397240523231025
   PubMed Web of Science ®Google Scholar
• Jim OnSCKnudsenKMSkovTRelationship between severity of the local skin reactions and the rate of local skin reaction resolution in patients treated with ingenol mebutate gelClin Cosmet Investig Dermatol20169211216
   PubMed Web of Science ®Google Scholar
• AndersonLSchmiederGJWerschlerWPRandomized, double-blind, double-dummy, vehicle-controlled study of ingenol mebutate gel 0.025% and 0.05% for actinic keratosisJ Am Acad Dermatol200960693494319467365
   PubMed Web of Science ®Google Scholar
• LebwohlMSwansonNAndersonLLMelgaardAXuZBermanBIngenol mebutate gel for actinic keratosisN Engl J Med2012366111010101922417254
   PubMed Web of Science ®Google Scholar
• AugustinMTuJHKnudsenKMErntoftSLarssonTHankeCWIngenol mebutate gel for actinic keratosis: The link between quality life, treatment satisfication, and clinical outcomesJ Am Acad Dermatol201572581682125770879
   PubMed Web of Science ®Google Scholar
• Jubert-EsteveEdel Pozo-HernandoLJIzquierdo-HerceNBauzá-AlonsoAMartín-SantiagoAJones-CaballeroMQuality of life and side effects in patients with actinic keratosis treated with ingenol mebutate: a pilot studyActas Dermosifiliogr2015106864465026130156
   PubMedGoogle Scholar
• RicciFTamboneSNeriLReal-life efficacy and safety of ingenol mebutate for the treatment of actinic keratosis of the face and scalp: A single arm retrospective studyJ Dermatolog Treat201627652553027043050
   PubMed Web of Science ®Google Scholar
• BenhadjiKASerovaMGhoulAAntiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cellsBr J Cancer200899111808181519034280
   PubMed Web of Science ®Google Scholar
• MayatiALe VeeMMoreauAProtein kinase C-dependent regulation of human hepatic drug transporter expressionBiochem Pharmacol201598470371726462574
   PubMed Web of Science ®Google Scholar
• StahihutMBertelsenMHoyer-HansenMIngenol mebutate: induced cell death patterns in normal and cancer epithelial cellsJ Drugs Dermatol2010111011811192
   Web of Science ®Google Scholar
• VegterSTolleyKA network meta-analysis of the relative efficacy of treatments for actinic keratosis of the face or scalp in EuropePLoS One201496e9682924892649
   PubMed Web of Science ®Google Scholar
• AugustinMJhTKnudsenKMIngenol mebutate gel for actinic keratosis: The link between quality of life, treatment satisfaction, and clinical outcomesJ Am Acad Dermatol201572581682125770879
   PubMed Web of Science ®Google Scholar
• PellacaniGPerisKGuillenCA randomized trial comparing simultaneous vs. sequential field treatment of actinic keratosis with ingenol mebutate on two separate areas of the head and bodyJ Eur Acad Dermatol Venereol201529112192219826300464
   PubMed Web of Science ®Google Scholar
• NisticòSTorchiaVGliozziMBottoniUdel DucaEMuscoliCPharmacoeconomy of drugs used in the treatment of actinic keratosesInt J Immunopathol Pharmacol201629479680427207444
   PubMed Web of Science ®Google Scholar
• AndersonLJarrattMSchmiederGShumackSKatsamasWPToler-ability and pharmacokinetics of ingenol mebutate 0.05% gel applied to treatment areas up to 100 cm2 on the forearm(s) of patients with actinc keratosisClinical Aesthetic Dermatology20147121929
   Google Scholar
• BermanBSafety and tolerability of ingenol mebutate in the treatment of actinic keratosisExpert Opin Drug Saf201514121969197826524598
   PubMed Web of Science ®Google Scholar
• KostovicKGulinSJMokosZBCeovicRTopical Ingenol Mebutate: A New Treatment Modality for Multiple Actinic Keratoses and Field CancerizationAnticancer Agents Med Chem2017171018
   Web of Science ®Google Scholar
• DirschkaTGuptaGMicaliGReal-world approach to actinic keratosis management: practical treatment algorithm for office-based dermatologyJ Dermatolog Treat201728543144227796187
   PubMed Web of Science ®Google Scholar
• DrénoBAmiciJMBasset-SeguinNManagement of actinic keratosis: a practical report and treatment algorithm from AKTeam™ expert cliniciansJ Eur Acad Dermatol Venereol20142891141114924612407
   PubMed Web of Science ®Google Scholar
• NorrlidHNorlinJMHolmstrupHPatient-reported outcomes in topical field treatment of actinic keratosis in Swedish and Danish patientsJ Dermatolog Treat2018291687328658998
   PubMed Web of Science ®Google Scholar
• SkrozaNProiettiIBernardiniNFactors influencing response to ingenol mebutate therapy for actinic keratosis of face and scalpWorld J Clin Oncol20178540541129067277
   PubMed Web of Science ®Google Scholar
• GrandiVDelfinoCPimpinelliNIngenol mebutate in the treatment of ‘Hydroxyurea-induced Squamous Dysplasia’: a single centre experienceJ Eur Acad Dermatol Venereol20163071129113227072602
   PubMed Web of Science ®Google Scholar
• Sanchez-PalaciosCGuitartJHydroxyurea-associated squamous dysplasiaJ Am Acad Dermatol200451229330015280852
   PubMed Web of Science ®Google Scholar
• AthanasakisKBoubouchairopoulouNTarantilisFTsiantouVKontodimasSKyriopoulosJCost-effectiveness of Ingenol Mebutate Gel for the Treatment of Actinic Keratosis in GreeceClin Ther2017395993100228449867
   PubMed Web of Science ®Google Scholar