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Review

Barriers to achieving asthma control in adults: evidence for the role of tiotropium in current management strategies

Pages 423-435 | Published online: 14 Mar 2019

References

  • PriceDFletcherMvan der MolenTAsthma control and management in 8,000 European patients: the REcognise Asthma and Link to Symptoms and Experience (REALISE) surveyNPJ Prim Care Respir Med2014241400924921985
  • DemolyPPaggiaroPPlazaVPrevalence of asthma control among adults in France, Germany, Italy, Spain and the UKEur Respir Rev20091811210511220956130
  • ReddelHKSawyerSMEverettPWFloodPVPetersMJAsthma control in Australia: a cross-sectional web-based survey in a nationally representative populationMed J Aust2015202949249625971575
  • Global Initiative for AsthmaGINA report: global strategy for asthma management and prevention Available from: http://ginasthma.org/2018-gina-report-global-strategy-for-asthma-management-and-prevention/Accessed March 8, 2018
  • HamelmannESzeflerSJEfficacy and safety of tiotropium in children and adolescentsDrugs201878332733829368127
  • D’AmatoMVitaleCMolinoALanzaMD’AmatoGAnticholinergic drugs in asthma therapyCurr Opin Pulm Med201723110310827820743
  • CazzolaMOraJRoglianiPMateraMGRole of muscarinic antagonists in asthma therapyExpert Rev Respir Med201711323925328140686
  • FerrandoMBagnascoDBraidoFUmeclidinium for the treatment of uncontrolled asthmaExpert Opin Investig Drugs2017266761766
  • AlbertsonTEChenowethJAAdamsJYSutterMEMuscarinic antagonists in early stage clinical development for the treatment of asthmaExpert Opin Investig Drugs20172613549
  • BusseWWDahlRJenkinsCCruzAALong-acting muscarinic antagonists: a potential add-on therapy in the treatment of asthma?Eur Respir Rev201625139546426929422
  • HalpinDMKaplanAGRussellRKWhy choose tiotropium for my patient? A comprehensive review of actions and outcomes versus other bronchodilatorsRespir Med2017128284128610667
  • BarnesPJThe pharmacological properties of tiotropiumChest20001172 Suppl63S66S10673478
  • DisseBSpeckGARomingerKLWitekTJJrHammerRTiotropium (Spiriva): mechanistical considerations and clinical profile in obstructive lung diseaseLife Sci1999646–745746410069510
  • HaddadEBMakJCBarnesPJCharacterization of [3H]Ba 679 BR, a slowly dissociating muscarinic antagonist, in human lung: radioligand binding and autoradiographic mappingMol Pharmacol19944558999078190106
  • RadovanovicDSantusPBlasiFManteroMThe evidence on tiotro-pium bromide in asthma: from the rationale to the bedsideMultidiscip Respir Med2017121228484598
  • MeursHOenemaTAKistemakerLEGosensRA new perspective on muscarinic receptor antagonism in obstructive airways diseasesCurr Opin Pharmacol201313331632323643733
  • GibsonPGPowellHCoughlanJSelf-management education and regular practitioner review for adults with asthmaCochrane Database Syst Rev20021CD001117
  • ReddelHKJenkinsCRPartridgeMRSelf-management support and other alternatives to reduce the burden of asthma and chronic obstructive pulmonary diseaseInt J Tuberc Lung Dis201418121396140625517803
  • FosterJMSmithLUsherwoodTSawyerSMReddelHKGeneral practitioner-delivered adherence counseling in asthma: feasibility and usefulness of skills, training and support toolsJ Asthma201653331132026365203
  • CharriotJVachierIHalimiLFuture treatment for asthmaEur Respir Rev201625139779226929425
  • ZolnierekKBDimatteoMRPhysician communication and patient adherence to treatment: a meta-analysisMed Care200947882683419584762
  • WesterikJACarterVChrystynHCharacteristics of patients making serious inhaler errors with a dry powder inhaler and association with asthma-related events in a primary care settingJ Asthma201653332132926810934
  • JahediLDownieSRSainiBChanHKBosnic-AnticevichSInhaler technique in asthma: how does it relate to patients’ preferences and attitudes toward their inhalers?J Aerosol Med Pulm Drug Deliv2017301425227676193
  • CromptonGKBarnesPJBroedersMThe need to improve inhalation technique in Europe: a report from the Aerosol Drug Management Improvement TeamRespir Med200610091479149416495040
  • LavoriniFLevyMLCorriganCCromptonGADMIT Working GroupThe ADMIT series – issues in inhalation therapy. 6) Training tools for inhalation devicesPrim Care Respir J201019433534121049263
  • CraneMAJenkinsCRGoemanDPDouglassJAInhaler device technique can be improved in older adults through tailored education: findings from a randomised controlled trialNPJ Prim Care Respir Med2014241403425188403
  • ResnickDJGoldRLLee-WongMFeldmanBRRamakrishnanRDavisWJPhysicians’ metered dose inhaler technique after a single teaching sessionAnn Allergy Asthma Immunol19967621451488595532
  • BashetiIAThe effect of using simulation for training pharmacy students on correct device techniqueAm J Pharm Educ2014781017725657364
  • DalbyRNEicherJZierenbergBDevelopment of Respimat(®) Soft Mist™ Inhaler and its clinical utility in respiratory disordersMed Devices (Auckl)2011414515522915941
  • Moroni-ZentgrafPImpact of patient needs on design and usage of an inhalation device in respiratory medicineRespir Drug Deliv20131141
  • KerstjensHAEngelMDahlRTiotropium in asthma poorly controlled with standard combination therapyN Engl J Med2012367131198120722938706
  • KerstjensHACasaleTBBleeckerERTiotropium or salmeterol as add-on therapy to inhaled corticosteroids for patients with moderate symptomatic asthma: two replicate, double-blind, placebo-controlled, parallel-group, active-comparator, randomised trialsLancet Respir Med20153536737625682232
  • PaggiaroPHalpinDMBuhlRThe effect of tiotropium in symptomatic asthma despite low- to medium-dose inhaled corticosteroids: a randomized controlled trialJ Allergy Clin Immunol Pract20164110411326563670
  • OhtaKIchinoseMTohdaYLong-term once-daily tiotropium Respimat® is well tolerated and maintains efficacy over 52 weeks in patients with symptomatic asthma in Japan: a randomised, placebo-controlled studyPLoS One2015104e012410925894430
  • HamelmannEBatemanEDVogelbergCTiotropium add-on therapy in adolescents with moderate asthma: a 1-year randomized controlled trialJ Allergy Clin Immunol2016138244145026960245
  • VogelbergCEngelMLakiITiotropium add-on therapy improves lung function in children with symptomatic moderate asthmaJ Allergy Clin Immunol Pract Epub2018508
  • HamelmannEBernsteinJAVandewalkerMA randomised controlled trial of tiotropium in adolescents with severe symptomatic asthmaEur Respir J2017491160110027811070
  • SzeflerSJMurphyKHarperT3rdA Phase III randomized controlled trial of tiotropium add-on therapy in children with severe symptomatic asthmaJ Allergy Clin Immunol201714051277128728189771
  • BisgaardHVandewalkerMGrahamLMSafety of tiotropium in pre-school children with symptomatic persistent asthmaEur Respir J201648Suppl 60PA315
  • VogelbergCLakiISchmidtOSafety and tolerability of once-daily tiotropium Respimat® add-on therapy in children with moderate symptomatic asthmaEur Respir J201648Suppl 60PA4399
  • DahlREngelMDusserDSafety and tolerability of once-daily tiotropium Respimat(®) as add-on to at least inhaled corticosteroids in adult patients with symptomatic asthma: a pooled safety analysisRespir Med201611810211127578478
  • AndersonDEKewKMBoyterACLong-acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus the same dose of ICS alone for adults with asthmaCochrane Database Syst Rev2015248CD011397
  • KewKMDahriKLong-acting muscarinic antagonists (LAMA) added to combination long-acting beta2-agonists and inhaled corticosteroids (LABA/ICS) versus LABA/ICS for adults with asthmaCochrane Database Syst Rev2016211CD011721
  • RodrigoGJCastro-RodríguezJAWhat is the role of tiotropium in asthma?: a systematic review with meta-analysisChest2015147238839625322075
  • PetersSPKunselmanSJIcitovicNTiotropium bromide step-up therapy for adults with uncontrolled asthmaN Engl J Med2010363181715172620979471
  • AbadogluOBerkSTiotropium may improve asthma symptoms and lung function in asthmatic patients with irreversible airway obstruction: the real-life dataClin Respir J201610442142725335652
  • PriceDKaplanAJonesRLong-acting muscarinic antagonist use in adults with asthma: real-life prescribing and outcomes of add-on therapy with tiotropium bromideJ Asthma Allergy2015811325609985
  • PaggiaroPBacciEMontelukast in asthma: a review of its efficacy and place in therapyTher Adv Chronic Dis201121475823251741
  • Peters-GoldenMHendersonWRJrLeukotrienesN Engl J Med2007357181841185417978293
  • JoosSMikschASzecsenyiJMontelukast as add-on therapy to inhaled corticosteroids in the treatment of mild to moderate asthma: a systematic reviewThorax200863545346218443162
  • RobinsonDSCampbellDBarnesPJAddition of leukotriene antagonists to therapy in chronic persistent asthma: a randomised double-blind placebo-controlled trialLancet200135792732007201111438132
  • TonelliMZingoniMBacciEShort-term effect of the addition of leukotriene receptor antagonists to the current therapy in severe asthmaticsPulm Pharmacol Ther200316423724012850127
  • ChauhanBFDucharmeFMAddition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthmaCochrane Database Syst Rev2014241CD003137
  • MarcelloCCarloLAsthma phenotypes: the intriguing selective intervention with montelukastAsthma Res Pract201621127965779
  • PaggiaroPLGianniniDDi FrancoATestiRComparison of inhaled salmeterol and individually dose-titrated slow-release theophylline in patients with reversible airway obstruction. European Study GroupEur Respir J199698168916958866596
  • DahlRLarsenBBVengePEffect of long-term treatment with inhaled budesonide or theophylline on lung function, airway reactivity and asthma symptomsRespir Med200296643243812117043
  • BarnesPJTheophyllineAm J Respir Crit Care Med2013188890190623672674
  • UkenaDHarnestUSakalauskasRComparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthmaEur Respir J19971012275427609493656
  • LiJKangJWangCOmalizumab improves quality of life and asthma control in Chinese patients with moderate to severe asthma: a randomized Phase III studyAllergy Asthma Immunol Res20168431932827126725
  • BjermerLLemiereCMasperoJWeissSZangrilliJGerminaroMReslizumab for inadequately controlled asthma with elevated blood eosinophil levels: a randomized Phase 3 studyChest2016150478979827056586
  • OrtegaHGLiuMCPavordIDMepolizumab treatment in patients with severe eosinophilic asthmaN Engl J Med2014371131198120725199059
  • WenzelSCastroMCorrenJDupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal Phase 2b dose-ranging trialLancet201638810039314427130691
  • PavordIDKornSHowarthPMepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trialLancet2012380984265165922901886
  • RubinAZelmanovitzSCavalcantiMBronchial thermoplasty in a patient with difficult-to-control asthmaJ Bras Pneumol201642215515627167438
  • WahidiMMKraftMBronchial thermoplasty for severe asthmaAm J Respir Crit Care Med2012185770971422077066
  • CasaleTBBatemanEDVandewalkerMTiotropium Respimat add-on is efficacious in symptomatic asthma, independent of T2 phenotypeJ Allergy Clin Immunol Pract20186392393529174062
  • KerstjensHAMoroni-ZentgrafPTashkinDPTiotropium improves lung function, exacerbation rate, and asthma control, independent of baseline characteristics including age, degree of airway obstruction, and allergic statusRespir Med201611719820627492532
  • CasaleTBBatemanEDAalbersROnce-daily tiotropium Respimat add-on therapy improves lung function and asthma control in moderate symptomatic asthma, independent of baseline characteristicsEur Respir J201750PA647
  • BouletLPAsthma and obesityClin Exp Allergy201343182123278876
  • TaylorBManninoDBrownCCrockerDTwum-BaahNHolguinFBody mass index and asthma severity in the National Asthma SurveyThorax2008631142018156567
  • KhuranaSKerstjensHAPaggiaroPOnce-daily tiotropium Respimat® add-on to inhaled corticosteroid maintenance therapy reduces airflow obstruction in patients with symptomatic asthma, independent of body mass index scoreAm J Respir Crit Care Med2017195A6443
  • WechslerMECastroMLehmanEImpact of race on asthma treatment failures in the asthma clinical research networkAm J Respir Crit Care Med2011184111247125321885625
  • WechslerMEYawnBPFuhlbriggeALAnticholinergic vs long-acting β-agonist in combination with inhaled corticosteroids in black adults with asthma: the BELT randomized clinical trialJAMA2015314161720173026505596
  • OrtegaVEHawkinsGAMooreWCEffect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting β agonist treatment in a multiethnic asthma population: a genetic studyLancet Respir Med20142320421324621682
  • WechslerMEKunselmanSJChinchilliVMEffect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trialLancet200937497031754176419932356
  • PalmerCNLipworthBJLeeSIsmailTMacgregorDFMukhopadhyaySArginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterolThorax2006611194094416772309
  • BatemanEDKornmannOSchmidtPPivovarovaAEngelMFabbriLMTiotropium is noninferior to salmeterol in maintaining improved lung function in B16-Arg/Arg patients with asthmaJ Allergy Clin Immunol2011128231532221807250
  • GrahamLKerstjensHAVogelbergCSafety and tolerability of once-daily tiotropium Respimat® add-on therapy in African-American patients with symptomatic persistent asthma across a range of severitiesAm J Respir Crit Care Med2017195A6445
  • NunesCPereiraAMMorais-AlmeidaMAsthma costs and social impactAsthma Res Pract20173128078100
  • WillsonJBatemanEDPavordILloydAKrivasiTEsserDCost effectiveness of tiotropium in patients with asthma poorly controlled on inhaled glucocorticosteroids and long-acting β-agonistsAppl Health Econ Health Policy201412444745924974107
  • WillsonJBatemanEDPavordILloydAKrivasiTEsserDErratum to: Cost effectiveness of tiotropium in patients with asthma poorly controlled on inhaled glucocorticosteroids and long-acting β-agonistsAppl Health Econ Health Policy201614111912526816028
  • ZafariZSadatsafaviMFitzGeraldJMCanadian Respiratory Research NetworkCost-effectiveness of tiotropium versus omalizumab for uncontrolled allergic asthma in USCost Eff Resour Alloc2018161329422778