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Review

Updated Evaluation of Dupilumab in the Treatment of Asthma: Patient Selection and Reported Outcomes

Pages 181-187 | Published online: 04 Mar 2020

References

  • Hermosa JL, Sanchez CB, Rubio MC, Minguez MM, Walther JL. Factors associated with the control of severe asthma. J Asthma. 2010;47(2):124–130. doi:10.3109/02770900903518835
  • Peters MC, Kerr S, Dunican EM, et al. Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids. J Allergy Clin Immunol. 2019;143(1):104. doi:10.1016/j.jaci.2017.12.1009
  • Robinson D, Humbert M, Buhl R. Revisiting type 2-high and type 2-low airway inflammation in asthma: current knowledge and therapeutic implications. Clin Exp Allergy. 2017;47(2):161–175. doi:10.1111/cea.12880
  • Dupixent [package insert]. Tarrytown, NY: Regeneron Pharmaceuticals; 2019.
  • Castro M, Corren J, Pavord ID, et al. Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma. N Engl J Med. 2018;378(26):2486–2496. doi:10.1056/NEJMoa1804092
  • Rabe KF, Nair P, Brusselle G, et al. Efficacy and safety of dupilumab in glucocorticoid-dependent severe asthma. N Engl J Med. 2018;378(26):2475–2485. doi:10.1056/NEJMoa1804093
  • Corren J, Castro M, O’Riordan T, et al. Dupilumab efficacy in patients with uncontrolled moderate-to-severe allergic asthma. J Allergy Clin Immunol. 2020;8(2):516–526. doi:10.1016/j.jaip.2019.08.050
  • Corren J, Castro M, Ford LB, et al. Dupilumab improves asthma outcomes irrespective of frequency of previous asthma exacerbation history. Ann Allergy Asthma Immunol. 2019;123(2):222–224. doi:10.1016/j.anai.2019.04.028
  • Simpson EL, Bieber T, Guttman-Yassky E, et al. Two phase 3 trials of dupilumab versus placebo in atopic dermatitis. N Engl J Med. 2016;375(24):2335–2348. doi:10.1056/NEJMoa1610020
  • Blauvelt A, de Bruin-weller M, Gooderham M, et al. Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year randomized, double-blinded, placebo-controlled, phase 3 trial. Lancet. 2017;389(10086):2287–2303. doi:10.1016/S0140-6736(17)31191-1
  • Bachert C, Mannent L, Naclerio RM, et al. Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis. JAMA. 2016;315(5):469–479. doi:10.1001/jama.2015.19330
  • Bachert C, Hellings PW, Mullol J, et al. Dupilumab improves patient-reported outcomes in patients with chronic rhinosinusitis with nasal polyps and comorbid asthma. J Allergy Clin Immunol. 2019;7(7):2447–2449. doi:10.1016/j.jaip.2019.03.023
  • Bachert C, Jan JK, Desrosiers M, et al. Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicenter, randomized, double-blind, placebo-controlled, parallel-group phase 3 trials. Lancet. 2019;394(10209):1638–1650. doi:10.1016/S0140-6736(19)31881-1
  • Han JK, Bachert C, Desrosiers M, et al. Efficacy and safety of dupilumab in patients with chronic rhinosinusitis with nasal polyps: results from the randomized phase 3 Sinus-24 study [abstract]. J Allergy Clin Immunol. 2019;143(2):AB422. doi:10.1016/j.jaci.2018.12.948
  • Bachert C, Desrosiers M, Mullol J, et al. A randomized phase 3 study, Sinus-52, evaluating the efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps [abstract]. J Allergy Clin Immunol. 2019;143(2):AB433. doi:10.1016/j.jaci.2018.12.980
  • Maspero JF, Katelaris CH, Busse WW, et al. Dupilumab efficacy in uncontrolled moderate-to-severe asthma with self-reported chronic rhinosinusitis. J Allergy Clin Immunol. 2020;8(2):527–539. doi:10.1016/j.jaip.2019.07.016
  • Weinstein SF, Katial R, Jayawardena S, et al. Efficacy and safety of dupilumab in perennial allergic rhinitis and comorbid asthma. J Allergy Clin Immunol. 2018;142(1):171–177. doi:10.1016/j.jaci.2017.11.051
  • Menzella F, Montari G, Patricelli G, et al. A case of chronic eosinophilic pneumonia in a patient treated with dupilumab. Ther Clin Risk Manag. 2019;15:869–875. doi:10.2147/TCRM.S207402