1,931
Views
7
CrossRef citations to date
0
Altmetric
Review

Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): Optimal Management

, , , ORCID Icon, , & ORCID Icon show all
Pages 663-672 | Published online: 24 Jul 2020

References

  • Schwartz WB, Bennett W, Curelop S, Bartter FC. A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. Am J Med. 1957;23(4):529–542. doi:10.1016/0002-9343(57)90224-3
  • Feldman BJ, Rosenthal SM, Vargas GA, et al. Nephrogenic syndrome of inappropriate antidiuresis. N Engl J Med. 2005;352(18):1884–1890. doi:10.1056/NEJMoa042743
  • Esposito P, Piotti G, Bianzina S, Malul Y, Dal Canton A. The syndrome of inappropriate antidiuresis: pathophysiology, clinical management and new therapeutic options. Nephron Clin Pract. 2011;119(1):62–73. doi:10.1159/000324653
  • Ball SG. Vasopressin and disorders of water balance: the physiology and pathophysiology of vasopressin. Ann Clin Biochem. 2007;44(5):417–431. doi:10.1258/000456307781646030
  • Tian Y, Sandberg K, Murase T, Baker EA, Speth RC, Verbalis JG. Vasopressin V2 receptor binding is down-regulated during renal escape from vasopressin-induced antidiuresis. Endocrinology. 2000;141(1):307–314. doi:10.1210/endo.141.1.7256
  • Verbalis JG. Whole-body volume regulation and escape from antidiuresis. Am J Med. 2006;119(7):21–29. doi:10.1016/j.amjmed.2006.05.004
  • Berardi R, Rinaldi S, Caramanti M, et al. Hyponatremia in cancer patients: time for a new approach. Crit Rev Oncol Hematol. 2016;102:15–25. doi:10.1016/j.critrevonc.2016.03.010
  • Hannon MJ, Thompson CJ. The syndrome of inappropriate antidiuretic hormone: prevalence, causes and consequences. Eur J Endocrinol. 2010;162(1):5–12. doi:10.1530/EJE-09-1063
  • Kanaji N, Watanabe N, Kita N, et al. Paraneoplastic syndromes associated with lung cancer. World J Clin Oncol. 2014;5(3):197–223. doi:10.5306/wjco.v5.i3.197
  • Cuesta M, Garrahy A, Thompson CJ. SIAD: practical recommendations for diagnosis and management. J Endocrinol Invest. 2016;39(9):991–1001. doi:10.1007/s40618-016-0463-3
  • Gray ST, Holbrook EH, Najm MH, Sadow PM, Curry WT, Lin DT. Syndrome of inappropriate antidiuretic hormone secretion in patients with olfactory neuroblastoma. Otolaryngol Head Neck Surg. 2012;147(1):147–151. doi:10.1177/0194599812438842
  • Sørensen JB, Andersen MK, Hansen HH. Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in malignant disease. J Intern Med. 1995;238(2):97–110. doi:10.1111/j.1365-2796.1995.tb00907.x
  • Robertson GL. Vincristine neurotoxicity and abnormal secretion of antidiuretic hormone. Arch Gen Intern Med. 1973;132(5):717–720. doi:10.1001/archinte.1973.03650110061013
  • Liamis G, Milionis H, Elisaf M. A review of drug-induced hyponatremia. Am J Kidney Dis. 2008;52(1):144–153. doi:10.1053/j.ajkd.2008.03.004
  • Berardi R, Santoni M, Rinaldi S, et al. Risk of hyponatraemia in cancer patients treated with targeted therapies: a systematic review and meta-analysis of clinical trials. PLoS One Epub. 2016;11(5).
  • Khaja M, Torchon F, Millerman K. A rare case of sorafenib-induced severe hyponatremia [case report]. SAGE Open Med Case Rep. 2019;7:2050313X19846048.
  • Jhaveri KD, Wanchoo R, Sakhiya V, Ross DW, Fishbane S. Adverse renal effects of novel molecular oncologic targeted therapies: a narrative review. Kidney Int Rep. 2016;2(1):108–123. doi:10.1016/j.ekir.2016.09.055
  • Spasovski G, Vanholder R, Allolio B, et al. Clinical practice guideline on diagnosis and treatment of hyponatraemia. Nephrol Dial Transplant. 2014;29(2):1–39.
  • Verbalis JG. Managing hyponatremia in patients with syndrome of inappropriate antidiuretic hormone secretion. J Hosp Med. 2010;5(3):18–26. doi:10.1002/jhm.783
  • Renneboog B, Sattar L, Decaux G. Attention and postural balance are much more affected in older than in younger adults with mild or moderate chronic hyponatremia. Eur J Intern Med. 2017;41:25–26. doi:10.1016/j.ejim.2017.02.008
  • Renneboog B, Musch W, Vandemergel X, Manto MU, Decaux G. Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits. Am J Med. 2006;119(1):71–78. doi:10.1016/j.amjmed.2005.09.026
  • Gankam KF, Andres C, Sattar L, et al. Mild hyponatremia and risk of fracture in the ambulatory elderly. Q J Med. 2008;101(7):583–588. doi:10.1093/qjmed/hcn061
  • Barsony J, Sugimura Y, Verbalis JG. Osteoclast response to low extracellular sodium and the mechanism of hyponatremia-induced bone loss. J Biol Chem. 2011;286(12):10864–10875. doi:10.1074/jbc.M110.155002
  • Berardi R, Morgese F, Rinaldi S, Torniai M. Electrolyte disorders in cancer patients: clinical implication and management. In: Blair MT, editor. New Developments in Oncology Research. Nova Science Publisher; 2019.
  • Liamis G, Rodenburg EM, Hofman A, Zietse R, Stricker BH, Hoorn EJ. Electrolyte disorders in community subjects: prevalence and risk factors. Am J Med. 2013;126(3):256–263. doi:10.1016/j.amjmed.2012.06.037
  • Wald R, Jaber BL, Price LL, Upadhyay A, Madias NE. Impact of hospital-associated hyponatremia on selected outcomes. Arch Intern Med. 2010;170(3):294–302. doi:10.1001/archinternmed.2009.513
  • Berardi R, Antonuzzo A, Blasi L, et al. Practical issues for the management of hyponatremia in oncology. Endocrine. 2018;61(1):158–164. doi:10.1007/s12020-018-1547-y
  • Oster JR, Singer I. Hyponatremia, hyposmolality, and hypotonicity: tables and fables. Arch Intern Med. 1999;159(4):333–336. doi:10.1001/archinte.159.4.333
  • Verbalis JG, Goldsmith SR, Greenberg A, et al. Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations. Am J Med. 2013;126(10):1–42. doi:10.1016/j.amjmed.2013.07.006
  • Castillo JJ, Vincent M, Justice E. Diagnosis and management of hyponatremia in cancer patients. Oncologist. 2012;17(6):756–765. doi:10.1634/theoncologist.2011-0400
  • Thaler SM, Teitelbaum I, Berl T. “Beer potomania” in non-beer drinkers: effect of low dietary solute intake. Am J Kidney Dis. 1998;31(6):1028–1031. doi:10.1053/ajkd.1998.v31.pm9631849
  • Grohè C, Berardi R, Burst V. Hyponatraemia-SIADH in lung cancer diagnostic and treatment algorithms. Crit Rev Oncol Hematol. 2015;96(1):1–8. doi:10.1016/j.critrevonc.2015.04.005
  • Tenny S, Thorell W. Cerebral Salt Wasting Syndrome. Treasure Island (FL): StatPearls Publishing; 2019.
  • Tudor RM, Thompson CJ. Posterior pituitary dysfunction following traumatic brain injury: review. Pituitary. 2019;22(3):296–304. doi:10.1007/s11102-018-0917-z
  • De Troyer A, Demanet JC. Correction of antidiuresis by demeclocycline. N Engl J Med. 1975;293(18):915–918. doi:10.1056/NEJM197510302931809
  • Cherrill DA, Stote RM, Birge JR, Singer I. Demeclocycline treatment in the syndrome of inappropriate antidiuretic hormone secretion. Ann Intern Med. 1975;83(5):654–656. doi:10.7326/0003-4819-83-5-654
  • Perks WH, Mohr P, Liversedge LA. Demeclocycline in inappropriate A.D.H. syndrome. Lancet. 1976;2(8000):1414. doi:10.1016/S0140-6736(76)91958-9
  • Onitilo AA, Kio E, Doi SA. Tumor-related hyponatremia. Clin Med Res. 2007;5(4):228–237. doi:10.3121/cmr.2007.762
  • Smith D, Moore K, Tormey W, Baylis PH, Thompson CJ. Downward resetting of the osmotic threshold for thirst in patients with SIADH. Am J Physiol Endocrinol Metab. 2004;287(5):E1019–E1023. doi:10.1152/ajpendo.00033.2004
  • Furst H, Hallows KR, Post J, et al. The urine/plasma electrolyte ratio: a predictive guide to water restriction. Am J Med Sci. 2000;319(4):240–244. doi:10.1097/00000441-200004000-00007
  • Runkle I, Villabona C, Navarro A, et al. Treatment of hyponatremia induced by the syndrome of Inappropriate antidiuretic hormone secretion: a multidisciplinary spanish algorithm. Nefrologia. 2014;34(4):439–450. doi:10.3265/Nefrologia.pre2014.Apr.12220
  • Santini D, Berardi R, Caramanti M, Peri A, Armento G, Barni S on behalf of the Italian Association of Medical Oncology (AIOM). Electrolytes disorder: recommendations for diagnosis and treatment in cancer patients. Position paper.
  • Verbalis JG, Adler S, Schrier RW, Berl T, Zhao Q, Czerwiec FS. SALT Investigators. Efficacy and safety of oral tolvaptan therapy in patients with the syndrome of inappropriate antidiuretic hormone secretion. Eur J Endocrinol. 2011;164(5):725–732. doi:10.1530/EJE-10-1078
  • Salahudeen AK, Ali N, George M, Lahoti A, Palla S. Tolvaptan in hospitalized cancer patients with hyponatremia: a double-blind, randomized, placebo-controlled clinical trial on efficacy and safety. Cancer. 2014;120(5):744–751. doi:10.1002/cncr.28468
  • Shoaf SE, Bricmont P, Mallikaarjun S. Effects of CYP3A4 inhibition and induction on the pharmacokinetics and pharmacodynamics of tolvaptan, a non-peptide AVP antagonist in healthy subjects. Br J Clin Pharmacol. 2012;73(4):579–587. doi:10.1111/j.1365-2125.2011.04114.x
  • Petereit C, Zaba O, Teber I, Lüders H, Grohé C. A rapid and efficient way to manage hyponatremia in patients with SIADH and small cell lung cancer: treatment with tolvaptan. BMC Pulm Med. 2013;13(1):55. doi:10.1186/1471-2466-13-55
  • Berardi R, Mastroianni C, Lo Russo G, et al. Syndrome of inappropriate anti-diuretic hormone secretion in cancer patients: results of the first multicenter Italian study. Ther Adv Med Oncol. 2019;11:1758835919877725.
  • Berardi R, Lo Russo G, Tiseo M, et al. ASSERT: A Prospective, Observational Study Measuring Sodium Improvement and Outcomes in Patients Treated for Moderate to Severe Hyponatremia Secondary to SIADH. Poster Presented At: European Society for Medical Oncology (ESMO) Congress. Barcelona: Spain; 2019 September 27.
  • Selmer C, Madsen JC, Torp-Pedersen C, Gislason GH, Faber J. Hyponatremia, all-cause mortality, and risk of cancer diagnoses in the primary care setting: a large population study. Eur J Intern Med. 2016;36:36–43. doi:10.1016/j.ejim.2016.07.028
  • Mohan S, Gu S, Parikh A, Radhakrishnan J. Prevalence of hyponatremia and association with mortality: results from NHANES. Am J Med. 2013;126(12):1127–1137. doi:10.1016/j.amjmed.2013.07.021
  • Kang SH, Kim HW, Lee SY, et al. Is the sodium level per se related to mortality in hospitalized patients with severe hyponatremia? Clin Nephrol. 2012;77(3):182–187. doi:10.5414/CN107177
  • Kinsella S, Moran S, Sullivan MO, Molloy MG, Eustace JA. Hyponatremia independent of osteoporosis is associated with fracture occurrence. Clin J Am Soc Nephrol. 2010;5(2):275–280. doi:10.2215/CJN.06120809
  • Hoorn EJ, Rivadeneira F, Van Meurs JB, et al. Mild hyponatremia as a risk factor for fractures: the rotterdam study. J Bone Miner Res. 2011;26(8):1822–1828. doi:10.1002/jbmr.380
  • Verbalis JG, Barsony J, Sugimura Y, et al. Hyponatremia-induced osteoporosis. J Bone Miner Res. 2010;25(3):554–563. doi:10.1359/jbmr.090827
  • Ayus JC, Negri AL, Kalantar-Zadeh K, Moritz ML. Is chronic hyponatremia a novel risk factor for hip fracture in the elderly? Nephrol Dial Transplant. 2012;27(10):3725–3731. doi:10.1093/ndt/gfs412
  • Berghmans T, Paesmans M, Body JJ. A prospective study on hyponatraemia in medical cancer patients: epidemiology, aetiology and differential diagnosis. Support Care Cancer. 2000;8(3):192–197. doi:10.1007/s005200050284
  • Petereit C, Zaba O, Teber I, Grohé C. Is hyponatraemia a prognostic marker of survival for lung cancer? Pneumologie. 2011;65(9):565–571. doi:10.1055/s-0030-1256668
  • Hansen O, Sørensen P, Hansen KH. The occurrence of hyponatremia in SCLC and the influence on prognosis: a retrospective study of 453 patients treated in a single institution in a 10-year period. Lung Cancer. 2010;68(1):111–114. doi:10.1016/j.lungcan.2009.05.015
  • Corona G, Giuliani C, Parenti G, et al. Moderate hyponatremia is associated with increased risk of mortality: evidence from a meta-analysis. PLoS One. 2013;8(12):e80451. doi:10.1371/journal.pone.0080451
  • Albain KS, Crowley JJ, LeBlanc M, Livingston RB. Survival determinants in extensive-stage non-small-cell lung cancer: the southwest oncology group experience. J Clin Oncol. 1991;9(9):1618–1626. doi:10.1200/JCO.1991.9.9.1618
  • Sengelov L, Kamby C, Geertsen P, Andersen LJ, Von der Maase H. Predictive factors of response to cisplatin-based chemotherapy and the relation of response to survival in patients with metastatic urothelial cancer. Cancer Chemother Pharmacol. 2000;46(5):357–364. doi:10.1007/s002800000176
  • Tai P, Yu E, Jones K, Sadikov E, Mahmood S, Tonita J. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) in patients with limited stage small cell lung cancer. Lung Cancer. 2006;53(2):211–215. doi:10.1016/j.lungcan.2006.05.009
  • Sengupta A, Banerjee SN, Biswas NM, et al. The incidence of hyponatraemia and its effect on the ECOG performance status among lung cancer patients. J Clin Diagn Res. 2013;7(8):1678–1682. doi:10.7860/JCDR/2013/5900.3225
  • Hermes A, Waschki B, Reck M. Hyponatremia as prognostic factor in small cell lung cancer, a retrospective single institution analysis. Respir Med. 2012;106(6):900–904. doi:10.1016/j.rmed.2012.02.010
  • Castillo JJ, Glezerman IG, Boklage SH, et al. The occurrence of hyponatremia and its importance as a prognostic factor in a cross-section of cancer patients. BMC Cancer. 2016;16(1):564. doi:10.1186/s12885-016-2610-9
  • Svaton M, Fiala O, Pesek M, et al. Predictive and prognostic significance of sodium levels in patients with NSCLC treated by erlotinib. Anticancer Res. 2014;34(12):7461–7465.
  • Berardi R, Santoni M, Newsom-Davis T, et al. Hyponatremia normalization as an independent prognostic factor in patients with advanced non-small cell lung cancer treated with first-line therapy. Oncotarget. 2017;8(14):23871–23879. doi:10.18632/oncotarget.13372
  • Kim HS, Yi SY, Jun HJ, et al. Clinical outcome of gastric cancer patients with bone marrow metastases. Oncology. 2007;73(3–4):192–197. doi:10.1159/000127386
  • Choi JS, Bae EH, Ma SK, Kweon SS, Kim SW. Prognostic impact of hyponatraemia in patients with colorectal cancer. Colorectal Dis. 2015;17(5):409–416. doi:10.1111/codi.12878
  • Berardi R, Caramanti M, Fiordoliva I, et al. Hyponatraemia is a predictor of clinical outcome for malignant pleural mesothelioma. Support Care Cancer. 2015;23(3):621–626. doi:10.1007/s00520-014-2398-6
  • Jeppesen AN, Jensen HK, Donskov F, Marcussen N, von der Maase H. Hyponatremia as a prognostic and predictive factor in metastatic renal cell carcinoma. Br J Cancer. 2010;102(5):867–872. doi:10.1038/sj.bjc.6605563
  • Vasudev NS, Brown JE, Brown SR, et al. Prognostic factors in renal cell carcinoma: association of preoperative sodium concentration with survival. Clin Cancer Res. 2008;14(6):1775–1781. doi:10.1158/1078-0432.CCR-07-1721
  • Tiseo M, Buti S, Boni, Mattioni R, Ardizzoni A. Prognostic role of hyponatremia in 564 small cell lung cancer patients treated with topotecan. Lung Cancer. 2014;86(1):91–95. doi:10.1016/j.lungcan.2014.07.022
  • Schutz FA, Xie W, Donskov F, et al. The impact of low serum sodium on treatment outcome of targeted therapy in metastatic renal cell carcinoma: results from the international metastatic renal cell cancer database consortium. Eur Urol. 2014;65(4):723–730. doi:10.1016/j.eururo.2013.10.013
  • Rinaldi S, Santoni M, Leoni G, et al. The prognostic and predictive role of hyponatremia in patients with advanced non-small cell lung cancer (NSCLC) with bone metastases. Support Care Cancer. 2019;27(4):1255–1261. doi:10.1007/s00520-018-4489-2
  • Peri A, Giuliani C. Management of euvolemic hyponatremia attributed to SIADH in the hospital setting. Minerva Endocrinol. 2014;39(1):33–41.
  • Berardi R, Caramanti M, Castagnani M, et al. Hyponatremia is a predictor of hospital length and cost of stay and outcome in cancer patients. Supp Care Cancer. 2015;23(10):3095–3101. doi:10.1007/s00520-015-2683-z
  • Nelson M, Palmer JL, Fu J, Williams JL, Yadav R, Guo Y. Hyponatraemia in cancer patients on an inpatient rehabilitation unit. Eur J Cancer Care. 2014;23(3):363–369. doi:10.1111/ecc.12140
  • Berardi R, Mastroianni C, Lo Russo G, et al. Syndrome of inappropriate anti-diuretic hormone secretion in cancer patients: results of the first multicenter Italian study. Ther Adv Med Oncol. 2019;11:1758835919877725. doi:10.1177/1758835919877725