Neutrophil–lymphocyte ratio as an early new marker in AIV-H7N9-infected patients: a retrospective study

References

• Kile JC, Ren R, Liu L, et al. Update: increase in human infections with novel Asian lineage avian influenza A(H7N9) viruses during the fifth epidemic - China, October 1, 2016-August 7, 2017. MMWR Morb Mortal Wkly Rep. 2017;66(35):928–932. doi:10.15585/mmwr.mm6635a228880856
   PubMed Web of Science ®Google Scholar
• Huang F, Guo J, Zou Z, et al. Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients. Nat Commun. 2014;5:3595. doi:10.1038/ncomms597224800963
   PubMed Web of Science ®Google Scholar
• Chen Y, Li X, Tian L, et al. Dynamic behavior of lymphocyte subgroups correlates with clinical outcomes in human H7N9 infection. J Infect. 2014;69(4):358–365. doi:10.1016/j.jinf.2014.05.00624841136
   PubMed Web of Science ®Google Scholar
• Zahorec R. Ratio of neutrophil to lymphocyte counts–rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102(1):5–14.11723675
   PubMedGoogle Scholar
• Fan Z, EnQiang C, Yao DL, et al. Neutrophil-lymphocyte ratio predicts short term mortality in patients with hepatitis B virus-related acute-on-chronic liver failure treated with an artificial liver support system. PLoS One. 2017;12(4):e0175332. doi:10.1371/journal.pone.017533228426800
   PubMed Web of Science ®Google Scholar
• Hao X, Li D, Wu D, Zhang N. The relationship between hematological indices and autoimmune rheumatic diseases (ARDs), a meta-analysis. Sci Rep. 2017;7(1):10833. doi:10.1038/s41598-017-11398-428883472
   PubMed Web of Science ®Google Scholar
• Jeon TJ, Park JY. Clinical significance of the neutrophil-lymphocyte ratio as an early predictive marker for adverse outcomes in patients with acute pancreatitis. World J Gastroenterol. 2017;23(21):3883–3889. doi:10.3748/wjg.v23.i21.388328638228
   PubMed Web of Science ®Google Scholar
• Kumar P, Law S, Sriram KB. Evaluation of platelet lymphocyte ratio and 90-day mortality in patients with acute exacerbation of chronic obstructive pulmo7ary disease. J Thorac Dis. 2017;9(6):1509–1516. doi:10.21037/jtd.2017.05.7728740663
   PubMed Web of Science ®Google Scholar
• Li W, Ai X, Ni Y, Ye Z, The Association Between the Neutrophil-to-Lymphocyte Ratio and Mortality in Patients With Acute Respiratory Distress Syndrome: A Retrospective Cohort Study. Shock 2019;51(2):161–167.
   Google Scholar
• Liu X, He L, Han J, et al. Association of neutrophil-lymphocyte ratio and T lymphocytes with the pathogenesis and progression of HBV-associated primary liver cancer. PLoS One. 2017;12(2):e0170605. doi:10.1371/journal.pone.017060528231294
   PubMed Web of Science ®Google Scholar
• Suppiah A, Malde D, Arab T, et al. The prognostic value of the neutrophil-lymphocyte ratio (NLR) in acute pancreatitis: identification of an optimal NLR. J Gastrointest Surg. 2013;17(4):675–681. doi:10.1007/s11605-012-2121-123371356
   PubMed Web of Science ®Google Scholar
• Wang Y, Ju M, Chen C, et al. Neutrophil-to-lymphocyte ratio as a prognostic marker in acute respiratory distress syndrome patients: a retrospective study. J Thorac Dis. 2018;10(1):273–282. doi:10.21037/jtd.2017.12.13129600057
   PubMed Web of Science ®Google Scholar
• Yang W, Wang X, Zhang W, et al. Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio are 2 new inflammatory markers associated with pulmonary involvement and disease activity in patients with dermatomyositis. Clin Chim Acta. 2017;465:11–16. doi:10.1016/j.cca.2016.12.00727965019
   PubMed Web of Science ®Google Scholar
• Yao C, Liu X, Tang Z. Prognostic role of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio for hospital mortality in patients with AECOPD. Int J Chron Obstruct Pulmon Dis. 2017;12:2285–2290. doi:10.2147/COPD.S14176028814856
   PubMed Web of Science ®Google Scholar
• Salciccioli JD, Marshall DC, Pimentel MA, et al. The association between the neutrophil-to-lymphocyte ratio and mortality in critical illness: an observational cohort study. Crit Care. 2015;19:13. doi:10.1186/s13054-014-0731-625598149
   PubMed Web of Science ®Google Scholar
• Xiang F, Chen R, Cao X, et al. Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all-cause mortality in hemodialysis patients: a prospective cohort study. Hemodial Int Symp Home Hemodial. 2018;22(1):82–92. doi:10.1111/hdi.12549
   PubMed Web of Science ®Google Scholar
• Hufford MM, Richardson G, Zhou H, et al. Influenza-infected neutrophils within the infected lungs act as antigen presenting cells for anti-viral CD8(+) T cells. PLoS One. 2012;7(10):e46581. doi:10.1371/journal.pone.004658123056353
   PubMed Web of Science ®Google Scholar
• Shen Z, Chen Z, Li X, et al. Host immunological response and factors associated with clinical outcome in patients with the novel influenza A H7N9 infection. Clin Microbiol Infect. 2014;20(8):O493–500. doi:10.1111/1469-0691.1250524350809
   PubMed Web of Science ®Google Scholar
• Li Q, Zhou L, Zhou M, et al. Epidemiology of human infections with avian influenza A(H7N9) virus in China. N Engl J Med. 2014;370(6):520–532. doi:10.1056/NEJMoa130461723614499
   PubMed Web of Science ®Google Scholar
• Riche F, Gayat E, Barthelemy R, Le Dorze M, Mateo J, Payen D. Reversal of neutrophil-to-lymphocyte count ratio in early versus late death from septic shock. Critical Care. 2015;19:439. doi:10.1186/s13054-015-1144-x26671018
   PubMed Web of Science ®Google Scholar
• Hwang SY, Shin TG, Jo IJ, et al. Neutrophil-to-lymphocyte ratio as a prognostic marker in critically-ill septic patients. Am J Emerg Med. 2017;35(2):234–239. doi:10.1016/j.ajem.2016.10.05527806894
   PubMed Web of Science ®Google Scholar
• Cheng Q-L, Ding H, Sun Z, et al. Retrospective study of risk factors for mortality in human avian influenza A(H7N9) cases in Zhejiang Province, China, March 2013 to June 2014. Int J Infect Dis. 2015;39:95–101. doi:10.1016/j.ijid.2015.09.00826376223
   PubMed Web of Science ®Google Scholar
• Tate MD, Ioannidis LJ, Brooks AG, Croker B, Brown LE, Reading PC. The role of neutrophils during mild and severe influenza virus infections of mice. PLoS One. 2011;6(3):e17618. doi:10.1371/journal.pone.001761821423798
   PubMed Web of Science ®Google Scholar
• Tecchio C, Micheletti A, Cassatella MA. Neutrophil-derived cytokines: facts beyond expression. Front Immunol. 2014;5:508. doi:10.3389/fimmu.2014.0050825374568
   PubMed Web of Science ®Google Scholar
• Cassatella MA. Neutrophil-derived proteins: selling cytokines by the pound. Adv Immunol. 1999;73:369–509.10399011
   PubMed Web of Science ®Google Scholar
• Cheng OZ, Palaniyar N. NET balancing: a problem in inflammatory lung diseases. Front Immunol. 2013;4:1. doi:10.3389/fimmu.2013.0000123355837
   PubMed Web of Science ®Google Scholar
• Camp JV, Bagci U, Chu YK, et al. Lower respiratory tract infection of the ferret by 2009 H1N1 pandemic influenza a virus triggers biphasic, systemic, and local recruitment of neutrophils. J Virol. 2015;89(17):8733–8748. doi:10.1128/JVI.00817-1526063430
   PubMed Web of Science ®Google Scholar
• Abraham E. Neutrophils and acute lung injury. Crit Care Med. 2003;31(4 Suppl):S195–199. doi:10.1097/01.CCM.0000057843.47705.E812682440
   PubMed Web of Science ®Google Scholar
• Craig A, Mai J, Cai S, Jeyaseelan S. Neutrophil recruitment to the lungs during bacterial pneumonia. Infect Immun. 2009;77(2):568–575. doi:10.1128/IAI.00832-0819015252
   PubMed Web of Science ®Google Scholar
• Grommes J, Soehnlein O. Contribution of neutrophils to acute lung injury. Mol Med. 2011;17(3–4):293–307. doi:10.2119/molmed.2010.0013821046059
   PubMed Web of Science ®Google Scholar
• Narasaraju T, Harshini A. Neutrophils as possible therapeutic targets in severe influenza pneumonia. J Infect Pulm Dis 2016;2(2). doi:10.16966/2470-3176.115
   Google Scholar
• Kuiken T, Taubenberger JK. Pathology of human influenza revisited. Vaccine. 2008;26(Suppl 4):D59–66.19230162
   PubMed Web of Science ®Google Scholar
• Taubenberger JK, Morens DM. The pathology of influenza virus infections. Annu Rev Pathol. 2008;3:499–522. doi:10.1146/annurev.pathmechdis.3.121806.15431618039138
   PubMed Web of Science ®Google Scholar
• Perrone LA, Plowden JK, Garcia-Sastre A, Katz JM, Tumpey TM. H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice. PLoS Pathog. 2008;4(8):e1000115. doi:10.1371/journal.ppat.100011518670648
   PubMed Web of Science ®Google Scholar
• Long JP, Kotur MS, Stark GV, et al. Accumulation of CD11b(+)Gr-1(+) cells in the lung, blood and bone marrow of mice infected with highly pathogenic H5N1 and H1N1 influenza viruses. Arch Virol. 2013;158(6):1305–1322. doi:10.1007/s00705-012-1593-323397329
   PubMed Web of Science ®Google Scholar
• Camp JV, Chu YK, Chung DH, et al. Phenotypic differences in virulence and immune response in closely related clinical isolates of influenza A 2009 H1N1 pandemic viruses in mice. PLoS One. 2013;8(2):e56602. doi:10.1371/journal.pone.005660223441208
   PubMed Web of Science ®Google Scholar
• Rynda-Apple A, Robinson KM, Alcorn JF. Influenza and bacterial superinfection: illuminating the immunologic mechanisms of disease. Infect Immun. 2015;83(10):3764–3770. doi:10.1128/IAI.00298-1526216421
   PubMed Web of Science ®Google Scholar
• Yu L, Wang Z, Chen Y, et al. Clinical, virological, and histopathological manifestations of fatal human infections by avian influenza A(H7N9) virus. Clin Infect Dis. 2013;57(10):1449–1457. doi:10.1093/cid/cit54123943822
   PubMed Web of Science ®Google Scholar
• To KF, Chan PK, Chan KF, et al. Pathology of fatal human infection associated with avian influenza A H5N1 virus. J Med Virol 2001;63(3):242–246.
   Google Scholar
• Liu S, Pang L, Ruan S, Zhang X. Global dynamics of avian influenza epidemic models with psychological effect. Comput Math Methods Med. 2015;2015:913726. doi:10.1155/2015/91372625861378
   PubMed Web of Science ®Google Scholar
• Tumpey TM, Lu X, Morken T, Zaki SR, Katz JM. Depletion of lymphocytes and diminished cytokine production in mice infected with a highly virulent influenza A (H5N1) virus isolated from humans. J Virol. 2000;74(13):6105–6116. doi:10.1128/jvi.74.13.6105-6116.200010846094
   PubMed Web of Science ®Google Scholar
• To KF, Chan PK, Chan KF, et al. Pathology of fatal human infection associated with avian influenza A H5N1 virus. J Med Virol. 2001;63(3):242–246.11170064
   PubMed Web of Science ®Google Scholar
• Banoei MM, Vogel HJ, Weljie AM, et al. Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia. Critical Care. 2017;21(1):97. doi:10.1186/s13054-017-1686-128424077
   PubMed Web of Science ®Google Scholar
• Akashi K, Hayashi S, Gondo H, et al. Involvement of interferon-gamma and macrophage colony-stimulating factor in pathogenesis of haemophagocytic lymphohistiocytosis in adults. Br J Haematol. 1994;87(2):243–250.7947264
   PubMed Web of Science ®Google Scholar
• Alkhouri N, Morris-Stiff G, Campbell C, et al. Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease. Liver Int. 2012;32(2):297–302. doi:10.1111/j.1478-3231.2011.02639.x22097893
   PubMed Web of Science ®Google Scholar
• Ichikawa A, Kuba K, Morita M, et al. CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med. 2013;187(1):65–77. doi:10.1164/rccm.201203-0508OC23144331
   PubMed Web of Science ®Google Scholar
• Morita M, Kuba K, Ichikawa A, et al. The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell. 2013;153(1):112–125. doi:10.1016/j.cell.2013.02.02723477864
   PubMed Web of Science ®Google Scholar
• Guo J, Huang F, Liu J, et al. The serum profile of hypercytokinemia factors identified in H7N9-infected patients can predict fatal outcomes. Sci Rep. 2015;5:10942. doi:10.1038/srep1094226028236
   PubMed Web of Science ®Google Scholar
• Zhu L, Liu L, Zhang Y, et al. High level of neutrophil extracellular traps correlates with poor prognosis of severe influenza a infection. J Infect Dis. 2018;217(3):428–437. doi:10.1093/infdis/jix47529325098
   PubMed Web of Science ®Google Scholar
• Zheng S, Tang L, Gao H, et al. Benefit of early initiation of neuraminidase inhibitor treatment to hospitalized patients with avian influenza A(H7N9) virus. Clin Infect Dis. 2018;66(7):1054–1060. doi:10.1093/cid/cix93029077848
   PubMed Web of Science ®Google Scholar
• Ma W, Huang H, Chen J, et al. Predictors for fatal human infections with avian H7N9 influenza, evidence from four epidemic waves in Jiangsu Province, Eastern China, 2013–2016. Influenza Other Resp Virus. 2017;11(5):418–424. doi:10.1111/irv.12461
   PubMed Web of Science ®Google Scholar
• Yang Y, Guo F, Zhao W, et al. Novel avian-origin influenza A (H7N9) in critically ill patients in China*. Crit Care Med. 2015;43(2):339–345. doi:10.1097/CCM.000000000000069525365721
   PubMed Web of Science ®Google Scholar
• Gao R, Wang L, Bai T, Zhang Y, Bo H, Shu Y. C-reactive protein mediating immunopathological lesions: a potential treatment option for severe influenza a diseases. EBioMedicine. 2017;22:133–142. doi:10.1016/j.ebiom.2017.07.01028734805
   PubMed Web of Science ®Google Scholar
• Hanshaoworakul W, Simmerman JM, Narueponjirakul U, et al. Severe human influenza infections in Thailand: oseltamivir treatment and risk factors for fatal outcome. PLoS One. 2009;4(6):e6051. doi:10.1371/journal.pone.000605119557130
   PubMed Web of Science ®Google Scholar
• Thiele JR, Zeller J, Bannasch H, Stark GB, Peter K, Eisenhardt SU. Targeting C-reactive protein in inflammatory disease by preventing conformational changes. Mediators Inflamm. 2015;2015:372432. doi:10.1155/2015/12538026089599
   PubMed Web of Science ®Google Scholar
• Cheng QL, Ding H, Sun Z, et al. Retrospective study of risk factors for mortality in human avian influenza A(H7N9) cases in Zhejiang Province, China, March 2013 to June 2014. Int J Infect Dis. 2015;39:95–101. doi:10.1016/j.ijid.2015.09.00826376223
   PubMed Web of Science ®Google Scholar
• Wu W, Shi D, Fang D, et al. A new perspective on C-reactive protein in H7N9 infections. Int J Infect Dis. 2016;44:31–36. doi:10.1016/j.ijid.2016.01.00926809124
   PubMed Web of Science ®Google Scholar