Multidirectional percutaneous drilling and autologous bone marrow injection for the treatment of femoral diaphyseal nonunions: a prospective interventional study

References

• Neumann MV, Sudkamp NP, Strohm PC. Management of femoral shaft fractures. Acta Chir Orthop Traumatol Cech. 2015;82(1):22–32.25748658
   PubMed Web of Science ®Google Scholar
• Bostman O, Varjonen L, Vainionpaa S, Majola A, Rokkanen P. Incidence of local complications after intramedullary nailing and after plate fixation of femoral shaft fractures. J Trauma. 1989;29(5):639–645. doi:10.1097/00005373-198905000-000192724381
   PubMedGoogle Scholar
• Wolinsky PR, McCarty E, Shyr Y, Johnson K. Reamed intramedullary nailing of the femur: 551 cases. J Trauma. 1999;46(3):392–399. doi:10.1097/00005373-199903000-0000710088839
   PubMed Web of Science ®Google Scholar
• Winquist RA, Hansen ST Jr., Clawson DK. Closed intramedullary nailing of femoral fractures. A report of five hundred and twenty cases. J Bone Joint Surg Am. 2001;83–A(12):1912. doi:10.2106/00004623-200112000-00021
   Web of Science ®Google Scholar
• Niu Y, Bai Y, Xu S, et al. Treatment of lower extremity long bone nonunion with expandable intramedullary nailing and autologous bone grafting. Arch Orthop Trauma Surg. 2011;131(7):885–891. doi:10.1007/s00402-010-1226-921165632
   PubMed Web of Science ®Google Scholar
• Nauth A, Lane J, Watson JT, Giannoudis P. Bone graft substitution and augmentation. J Orthop Trauma. 2015;29(Suppl 12):S34–S38. doi:10.1097/BOT.000000000000046426584264
   PubMed Web of Science ®Google Scholar
• Kumar G, Narayan B. Morbidity at bone graft donor sites In: Banaszkiewicz PA, Kader DF, editors. Classic Papers in Orthopaedics. London: Springer; 2014:503–505.
   Google Scholar
• Calori GM, Colombo M, Mazza EL, Mazzola S, Malagoli E, Mineo GV. Incidence of donor site morbidity following harvesting from iliac crest or RIA graft. Injury. 2014;45(Suppl 6):S116–S120. doi:10.1016/j.injury.2014.10.03425457330
   PubMed Web of Science ®Google Scholar
• Robertson PA, Wray AC. Natural history of posterior iliac crest bone graft donation for spinal surgery: a prospective analysis of morbidity. Spine (Phila Pa 1976). 2001;26(13):1473–1476. doi:10.1097/00007632-200107010-0001811458153
   PubMed Web of Science ®Google Scholar
• Goulet JA, Senunas LE, DeSilva GL, Greenfield ML. Autogenous iliac crest bone graft. Complications and functional assessment. Clin Orthop Relat Res. 1997;339:76–81. doi:10.1097/00003086-199706000-00011
   PubMed Web of Science ®Google Scholar
• Galois L, Bensoussan D, Diligent J, et al. Autologous bone marrow graft and treatment of delayed and non-unions of long bones: technical aspects. Biomed Mater Eng. 2009;19(4–5):277–281. doi:10.3233/BME-2009-059220042794
   PubMed Web of Science ®Google Scholar
• Goel A, Sangwan SS, Siwach RC, Ali AM. Percutaneous bone marrow grafting for the treatment of tibial non-union. Injury. 2005;36(1):203–206. doi:10.1016/j.injury.2004.01.00915589942
   PubMed Web of Science ®Google Scholar
• Singh AK, Shetty S, Saraswathy JJ, Sinha A. Percutaneous autologous bone marrow injections for delayed or non-union of bones. J Orthop Surg (Hong Kong). 2013;21(1):60–64. doi:10.1177/23094990130210011623629990
   PubMedGoogle Scholar
• Healey JH, Zimmerman PA, McDonnell JM, Lane JM. Percutaneous bone marrow grafting of delayed union and nonunion in cancer patients. Clin Orthop Relat Res. 1990;256:280–285.
   PubMed Web of Science ®Google Scholar
• Braly HL, O’Connor DP, Brinker MR. Percutaneous autologous bone marrow injection in the treatment of distal meta-diaphyseal tibial nonunions and delayed unions. J Orthop Trauma. 2013;27(9):527–533. doi:10.1097/BOT.0b013e31828bf07723443050
   PubMed Web of Science ®Google Scholar
• Sugaya H, Mishima H, Aoto K, et al. Percutaneous autologous concentrated bone marrow grafting in the treatment for nonunion. Eur J Orthop Surg Traumatol. 2014;24(5):671–678. doi:10.1007/s00590-013-1369-924275891
   PubMedGoogle Scholar
• Iwakura T, Miwa M, Sakai Y, et al. Human hypertrophic nonunion tissue contains mesenchymal progenitor cells with multilineage capacity in vitro. J Orthop Res. 2009;27(2):208–215. doi:10.1002/jor.2073918752274
   PubMed Web of Science ®Google Scholar
• Guimaraes JA, Duarte ME, Fernandes MB, et al. The effect of autologous concentrated bone-marrow grafting on the healing of femoral shaft non-unions after locked intramedullary nailing. Injury. 2014;45(Suppl 5):S7–S13. doi:10.1016/S0020-1383(14)70013-0
   PubMed Web of Science ®Google Scholar
• Hernigou P, Poignard A, Manicom O, Mathieu G, Rouard H. The use of percutaneous autologous bone marrow transplantation in nonunion and avascular necrosis of bone. J Bone Joint Surg Br. 2005;87(7):896–902. doi:10.1302/0301-620X.87B7.1628915972899
   PubMedGoogle Scholar
• Kassem MS. Percutaneous autogenous bone marrow injection for delayed union or non union of fractures after internal fixation. Acta Orthop Belg. 2013;79(6):711–717.24563979
   PubMed Web of Science ®Google Scholar
• Hernigou P, Mathieu G, Poignard A, Manicom O, Beaujean F, Rouard H. Percutaneous autologous bone-marrow grafting for nonunions. Surgical technique. J Bone Joint Surg Am. 2006;88(Suppl 1 Pt 2):322–327. doi:10.2106/JBJS.F.0020316951103
   PubMedGoogle Scholar
• Whelan DB, Bhandari M, Stephen D, et al. Development of the radiographic union score for tibial fractures for the assessment of tibial fracture healing after intramedullary fixation. J Trauma. 2010;68(3):629–632. doi:10.1097/TA.0b013e3181a7c16d19996801
   PubMedGoogle Scholar
• Megas P. Classification of non-union. injury. 2005;10:8.
   Google Scholar
• Portal-Nunez S, Lozano D, Esbrit P. Role of angiogenesis on bone formation. Histol Histopathol. 2012;27(5):559–566. doi:10.14670/HH-27.55922419020
   PubMed Web of Science ®Google Scholar
• Berner A, Reichert JC, Muller MB, et al. Treatment of long bone defects and non-unions: from research to clinical practice. Cell Tissue Res. 2012;347(3):501–519. doi:10.1007/s00441-011-1184-821574059
   PubMed Web of Science ®Google Scholar
• Dickson K, Katzman S, Delgado E, Contreras D. Delayed unions and nonunions of open tibial fractures. Correlation with arteriography results. Clin Orthop Relat Res. 1994;302:189–193.
   Google Scholar
• Hernigou P, Poignard A, Beaujean F, Rouard H. Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. J Bone Joint Surg Am. 2005;87(7):1430–1437. doi:10.2106/JBJS.D.0221515995108
   PubMed Web of Science ®Google Scholar
• Scaglione M, Fabbri L, Dell’Omo D, Gambini F, Guido G. Long bone nonunions treated with autologous concentrated bone marrow-derived cells combined with dried bone allograft. Musculoskelet Surg. 2014;98(2):101–106. doi:10.1007/s12306-013-0271-223700322
   PubMedGoogle Scholar
• Garg NK, Gaur S, Sharma S. Percutaneous autogenous bone marrow grafting in 20 cases of ununited fracture. Acta Orthop Scand. 1993;64(6):671–672.8291415
   PubMed Web of Science ®Google Scholar
• Leonardi E, Devescovi V, Perut F, Ciapetti G, Giunti A. Isolation, characterisation and osteogenic potential of human bone marrow stromal cells derived from the medullary cavity of the femur. Chir Organi Mov. 2008;92(2):97–103. doi:10.1007/s12306-008-0057-018791684
   PubMedGoogle Scholar
• Paley D, Young MC, Wiley AM, Fornasier VL, Jackson RW. Percutaneous bone marrow grafting of fractures and bony defects. An experimental study in rabbits. Clin Orthop Relat Res. 1986;208:300–312.
   PubMed Web of Science ®Google Scholar
• Phedy P, Dilogo IH, Jusuf AA, Kholinne E, Efendi Z. Iliac crest and femoral bone marrow as the source of plastic-adherent cells. Med J Indonesia. 2011. doi:10.13181/mji.v20i2.436
   Google Scholar
• Tiedeman JJ, Connolly JF, Strates BS, Lippiello L. Treatment of nonunion by percutaneous injection of bone marrow and demineralized bone matrix. An experimental study in dogs. Clin Orthop Relat Res. 1991;268:294–302.
   Google Scholar
• Muschler GF, Boehm C, Easley K. Aspiration to obtain osteoblast progenitor cells from human bone marrow: the influence of aspiration volume. J Bone Joint Surg Am. 1997;79(11):1699–1709. doi:10.2106/00004623-199711000-000129384430
   PubMed Web of Science ®Google Scholar
• Centeno CJ, Schultz JR, Cheever M, Freeman M, Robinson B, Faulkner SJ. A case series of percutaneous treatment of non-union fractures with autologous, culture expanded, bone marrow derived, mesenchymal stem cells and platelet lysate. J Bioeng Biomed Sci. 2011;01(S2). doi:10.4172/2155-9538.S2-007
   Google Scholar
• Hernigou P. Growth factors released from bone marrow are promising tools in orthopedic surgery. Rev Rhum Engl Ed. 1998;65(2):79–84.9540115
   PubMedGoogle Scholar