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Review

Uric Acid and Arterial Stiffness

, &
Pages 39-54 | Published online: 28 Jan 2020

References

  • Maiuolo J, Oppedisano F, Gratteri S, Muscoli C, Mollace V. Regulation of uric acid metabolism and excretion. Int J Cardiol. 2016;213:8–14. doi:10.1016/j.ijcard.2015.08.109
  • Feig DI, Kang D-H, Johnson RJ. Uric acid and cardiovascular risk. N Engl J Med. 2008;359(17):1811–1821. doi:10.1056/NEJMra0800885
  • Chaudhary K, Malhotra K, Sowers J, Aroor A. Uric acid key ingredient in the recipe for cardiorenal metabolic syndrome. Cardiorenal Med. 2013;3:208–220. doi:10.1159/000355405
  • Wang JG, Staessen JA. Raised concentrations of serum creatinine and uric acid and the risks of mortality and cardiovascular disease. Cardiovasc Rev Rep. 2002;23:393–399.
  • Wang JG, Staessen JA, Fagard RH, Birkenhager WH, Gong L, Liu L. Prognostic significance of serum creatinine and uric acid in older Chinese patients with isolated systolic hypertension. Hypertension. 2001;37:1069–1074. doi:10.1161/01.hyp.37.4.1069
  • Niskanen LK, Laaksonen DE, Nyyssonen K, et al. Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: a prospective cohort study. Arch Intern Med. 2004;164:1546–1551. doi:10.1001/archinte.164.14.1546
  • Verdecchia P, Schillaci G, Reboldi G, et al. Relation between serum uric acid and risk of cardiovascular disease in essential hypertension. The PIUMA study. Hypertension. 2000;36:1072–1078. doi:10.1161/01.hyp.36.6.1072
  • Vlachopoulos C, Azaouridis K, Stefanidis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol. 2010;55:1318–1327. doi:10.1093/eurheartj/ehq024
  • Cecelja M, Chowienczyk P. Dissociation of aortic pulse wave velocity with risk factors for cardiovascular disease other than hypertension: a systematic review. Hypertension. 2009;54:1328–1336. doi:10.1161/HYPERTENSIONAHA.109.137653
  • Laurent S, Cockroft J, Van Bortel L, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006;27:2588–2605. doi:10.1093/eurheartj/ehl254
  • Sun C-K. Cardio-ankle vascular index (CAVI) as an indicator of arterial stiffness. Integrated Blood Pressure Control. 2013;6:27–38. doi:10.2147/IBPC.S34423
  • El Ridi R, Tallima H. Physiological functions and pathogenic potential of uric acid: a review. J Adv Res. 2017;8:487–493. doi:10.1016/j.jare.2017.03.003
  • Backer BF. Towards the physiological function of uric acid. Review. Free Radic Biol Med. 1993;14(6):615–631. doi:10.1016/0891-5849(93)90143-i
  • Glantzounis GK, Tsimoyannis EC, Kappas AM, Galaris DA. Uric acid and oxidative stress. Curr Pharm Des. 2005;11(32):4145–4151. doi:10.2174/138161205774913255
  • Kurra V, Eraranta A, Jolma P, et al. Hyperuricemia, oxidative stress and carotid artery tone in experimental renal insufficiency. Am J Hypertens. 2009;22:964–970. doi:10.1038/ajh.2009.109
  • Waring WS, Convery A, Mishra V, Shenkin A, Webb DJ, Maxwell SR. Uric acid reduces exercise-induced oxidative stress in healthy adults. Clin Sci (Lond). 2003;105:425–430. doi:10.1042/CS20030149
  • Waring WS, Webb DJ, Maxwell SR. Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers. J Cardiovasc Pharmacol. 2001;38:365–371. doi:10.1097/00005344-200109000-00005
  • Waring WS, McNight JA, Webb DJ, Maxwell SR. Uric acid restores endothelial function in patients with type 1 diabetes and regular smoking. Diabetes. 2006;55:3127–3132. doi:10.2337/db06-0283
  • Sugihara S, Hisatome I, Kuwabara M, et al. Depletion of uric acid due to SCL22A12 (URAT1) loss-of-function mutation causes endothelial dysfunction in hypouricemia. Circ J. 2015;79(5):1125–1132. doi:10.1253/circj.CJ-14-1267
  • Patterson RA, Horsley ET, Leake DS. Prooxidant and antioxidant properties of human serum ultrafiltrates toward LDL: important role of uric acid. J Lipid Res. 2003;44:512–521. doi:10.1194/jlr.M200407-JLR200
  • Sánchez-Lozada LG, Soto V, Tapia E, et al. Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia. Am J Renal Physiol. 2008;295:F1134– F1141. doi:10.1152/ajprenal.00104.2008
  • Xie H, Sun J, Chen Y, Zong M, Li S, Wang Y. EGCG attenuates uric acid-induced inflammatory and oxidative stress responses by medicating the NOTCH pathway. Oxid Med Cell Longev. 2015;2015:214836. doi:10.1155/2015/214836
  • Choi Y-J, Yoon Y, Lee K-Y. Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis. FASEB J. 2014;28(7):3197–3204. doi:10.1096/fj.13-247148
  • Zharikov S, Krotova K, Hu H, et al. Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells. Am J Physiol Cell Physiol. 2008;295:C1183–C1190. doi:10.1152/ajpcell.00075.2008
  • Jin M, Yang F, Yang I, et al. Uric acid, hyperuricemia and vascular diseases. Front Biosci. 2012;17:656–669. doi:10.2741/3950
  • Suzuki T. Nitrosation of uric acid induced by nitric oxide under aerobic conditions. Nitric Oxide. 2007;16:266–273. doi:10.1016/j.niox.2006.10.008
  • Khosla UM, Zharikov S, Finch JL, et al. Hyperuricemia induces endothelial dysfunction. Kidney Int. 2005;67:1739–1742. doi:10.1111/j.1523-1755.2005.00273.x
  • Corry DB, Eslami P, Yamamoto K, Nyby MD, Makino H, Tuck ML. Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular rennin-angiotensin system. J Hypertens. 2008;26:269–275. doi:10.1097/HJH.0b013e3282f240bf
  • Drüppel V, Kusche-Vihrog K, Grossmann C, et al. Long-term application of the aldosterone antagonist spironolactone prevents stiff endothelial cell syndrome. FASEB J. 2013;27:3652–3659. doi:10.1096/fj.13-228312
  • Izzo JL Jr. Systolic hypertension, arterial stiffness, and vascular damage: role of the renin-angiotensin system. Blood Press Monit. 2000;5(Suppl 2):S7–S11. doi:10.1097/01.hco.0000126581.89648.10
  • Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis. N Engl J Med. 1994;331:1286–1292. doi:10.1056/NEJM199411103311907
  • Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol. 2005;25:932–943. doi:10.1161/01.ATV.0000160548.78317.29
  • Arai H, Hori S, Aramori I, Ohkubo H, Nakanishi S. Cloning and expression of a cDNA encoding an endothelin receptor. Nature. 1990;348:730–732. doi:10.1038/348730a0
  • Du Plooy CS, Martha Cornelia Mels C, Huisman HC, Kruger R. The association of endothelin-1 with markers of arterial stiffness in black South African women: the SABPA Study. J Amino Acids. 2015;2015:8. doi:10.1155/2015/481517
  • Kanellis J, Watanabe S, Li JH, et al. Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension. 2003;41:1287–1293. doi:10.1161/01.HYP.0000072820.07472.3B
  • Kang DH, Nakagawa T, Feng L, et al. A role for uric acid in the progression of renal disease. J Am Soc Nephrol. 2002;13:2888–2897. doi:10.1097/01.asn.0000034910.58454.fd
  • Rao GN, Corson MA, Berk BC. Uric acid stimulates vascular smooth muscle cell proliferation by increasing platelet-derived growth factor A-chain expression. J Biol Chem. 1991;266:8604–8608.
  • Liu T, Zhang L, Joo D, Sun S-C. NF-κB signaling in inflammation. Signal Transduct Target Ther. 2017;2:17023. doi:10.1038/sigtrans.2017.23
  • Kang DH, Park SK, Lee IK, Johnson RJ. Uric acid-induced C-reactive protein expression: implication on cell production of human vascular cells. J Am Soc Nephrol. 2005;16:3553–3562. doi:10.1681/ASN.2005050572
  • Netea MG, Kullberg BJ, Blok WL, Netea RT, van der Meer JW. The role of hyperuricemia in the increased cytokine production after lipopolysaccharide challenge in neutropenic mice. Blood. 1997;89:577–582. doi:10.1182/blood.V89.2.577
  • Park S, Lakatta EG. Role of inflammation in the pathogenesis of arterial stiffness. Yonsei Med J. 2012;53(2):258–261. doi:10.3349/ymj.2012.53.2.258
  • Ko J, Kang H-J, Kim D-A, et al. Uric acid induced the phenotype transition of vascular endothelial cells via induction of oxidative stress and glycocalyx shedding. FASEB J. 2019;25:fj201901148R. doi:10.1096/fj.201901148R
  • Yamanaka H, Osaka M, Takayama M, Munakata K, Nejima J, Katayama M. Age-adjusted level of circulating elastin as a cardiovascular risk factor in medical check-up individuals. J Cardiovasc Med (Hagerstown). 2014;15:364–370. doi:10.2459/JCM.0b013e328360940b
  • Kushiyama A, Nakatsu Y, Matsunaga Y, et al. Role of uric acid metabolism-related inflammation in the pathogenesis of metabolic syndrome components such as atherosclerosis and nonalcoholic steatohepatitis. Mediators Inlamm. 2016;2016. doi:10.1155/2016/8603164
  • Kuwabara M, Kanbay M, Hisatome I. Uric acid and hypertension because of arterial stiffness. Hypertension. 2018;72:582–584. doi:10.1161/HYPERTENSIONAHA.118.11496
  • Mishima M, Hamada T, Maharani N, et al. Effects of uric acid on the NO production of HUVECs and its restoration by urate lowering agents. Drug Res (STUTTG.). 2016;66:270–274. doi:10.1055/s-0035-1569405
  • Gicquel T, Robert S, Loyer P, et al. IL-1β production is dependent on the activation of purinergic receptors and NLRP3 pathway in human macrophages. FASEB J. 2015;29:4162–4173. doi:10.1096/fj.14-267393
  • Moriwaki Y, Yamamoto T, Suda M, et al. Purification and immunohistochemical tissue localization of human xanthine oxidase. Biochim Biophys Acta. 1993;1164(3):327–330. doi:10.1016/0167-4838(93)90266-t
  • Nomura J, Busso N, Yves A, et al. Xantine oxidase inhibition by fenbuxostat attenuates experimental atherosclerosis in mice. Sci Reports. 2014;4:4554. doi:10.1038/srep04554
  • Lastra G, Manrique C, Jia G, et al. Xanthine oxidase inhibition protects against Western diet-induced aortic stiffness and impaired vasorelaxation in female mice. Am J Physiol Regul Integr Comp Physiol. 2017;313:R67–R77. doi:10.1152/ajpregu.00483.2016
  • Aroor AR, Jiaa G, Habibia J, et al. Uric acid promotes vascular stiffness, maladaptive inflammatory responses and proteinuria in western diet fed mice. Metabolism. 2017;74:32–40. doi:10.1016/j.metabol.2017.06.006
  • Mehta T, Nuccio E, McFan K, Madero M, Sarnak MJ, Jala D. Association of uric acid with vascular stiffness in the Framingham study. Am J Hypertens. 2015;28(7):877–883. doi:10.1093/ajh/hpu253
  • Bae JS, Shin DH, Park PS, et al. The impact of serum uric acid level on arterial stiffness and carotid atherosclerosis: the Korean Multi-Rural Communities Cohort study. Atherosclerosis. 2013;231(1):145–151. doi:10.1016/j.atherosclerosis.2013.08.017
  • Liu H, Liu J, Zhao H, Zhou Y, Li L, Wang H, For the BEST Research Group. Relationship between serum uric acid and vascular function and structure markers and gender difference in a real-world population of China-From Beijing Vascular Disease Patients Evaluation Study (BEST) study. J Atheroscler Thromb. 2018;25:254–261. doi:10.5551/jat.39685.
  • Nagayama D, Yamaguchi T, Saiki A, et al. High serum uric acid is associated with increased cardio-ankle vascular index (CAVI) in healthy Japanese subjects: a cross-sectional study. Atherosclerosis. 2015;239(1):163–168. doi:10.1016/j.atherosclerosis.2015.01.011
  • Hwang J, Hwang JH, Chung SM, Kwon M-J, Ahn JK. Association between serum uric acid and arterial stiffness in a low-risk, middle-aged, large Korean population A cross-sectional study. Medicine. 2018;97:36. doi:10.1097/MD.0000000000012086
  • Choi HY, Kim S-H, Choi AR, et al. Hyperuricemia and risk of increased arterial stiffness in healthy women based on health screening Korean population. PLoS One. 2017;12(6):e0180406. doi:10.1371/journal.pone.0180406
  • Zheng X, Wei Q, Long J, et al. Gender-specific association of serum uric acid levels and cardio-ankle vascular index in Chinese adults. Lipids Health Dis. 2018;17:80. doi:10.1186/s12944-018-0712-x
  • Bian S, Guo H, Ye P, Luo L, Wu H, Xia W. Serum uric acid level and diverse impacts on regional arterial stiffness and wave reflection. Iranian J Publ Health. 2012;41(8):33–41.
  • Ishizaka N, Ishizaka Y, Toda E, Hashimoto H, Nagai R, Yamakado M. Higher serum uric acid is associated with increased arterial stiffness in Japanese individuals. Atherosclerosis. 2007;192:131–137. doi:10.1016/j.atherosclerosis.2006.04.016
  • Fang J-I, Wu J-S, Yang Y-C, Wang R-H, Lu F-H, Chang C-J. High uric acid level associated with increased arterial stiffness in apparently healthy women. Atherosclerosis. 2014;236(2):389–393. doi:10.1016/j.atherosclerosis.2014.07.024
  • Chou P, Lin KC, Lin HY, Tsai ST. Gender differences in the relationships of serum uric acid with fasting serum insulin and plasma glucose in patients without diabetes. J Rheumatol. 2001;28(3):571–576.
  • Hoieggen A, Alderman MH, Kjeldsen SE, et al. The impact of uric acid on cardiovascular outcomes in the LIFE study. Kidney Int. 2004;65:1041–1049. doi:10.1111/j.1523-1755.2004.00484.x
  • Heo SH, Lee SH. High levels of serum uric acid are associated with silent brain infarction. J Neurol Sci. 2010;297:6–10. doi:10.1016/j.jns.2010.07.007
  • Kim SY, Guevara JP, Kim KM, Choi HK, Heitjan DF, Albert DA. Hyperuricemia and coronary heart disease: a systematic review and meta-analysis. Arthritis Care Res (Hoboken). 2010;62:170–180. doi:10.1002/acr.20065
  • Chen X, Li Y, Sheng C-S, Huang Q-F, Zheng Y, Wang J-G. Association of serum uric acid with aortic stiffness and pressure in a Chinese workplace setting. Am J Hypertens. 2010;23(4):387–392. doi:10.1038/ajh.2009.277
  • Shin JY, Lee HR, Shim JY. Significance of high-normal serum uric acid level as a risk factor for arterial stiffness in healthy Korean men. Vasc Med. 2012;17(1):37–43. doi:10.1177/1358863X11434197
  • Baena CP, Lotufo PA, Mill JG, et al. Serum uric acid and pulse wave velocity among healthy adults: baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Am J Hypertens. 2015;28:966–970. doi:10.1093/ajh/hpu298
  • Liang J, Li Y, Zhou N, et al. Synergistic effects of serum uric acid and cardiometabolic risk factors on early stage atherosclerosis: the cardiometabolic risk in Chinese study. PLoS One. 2012;7(12):e51101. doi:10.1371/journal.pone.0051101
  • Sull JW, Koh EN, Cho SK, Bae H-J, Jee SH. Association of uric acid levels with arterial stiffness in Korean women and non-smoking men. Biomed Sci Letters. 2017;23(3):201–207. doi:10.15616/BSL.2017.23.3.201
  • Cicero AFG, Salvi P, D’Addato S, Rosticci M, Borghi C, for the Brisighella Heart Study group. Association between serum uric acid, hypertension, vascular stiffness and subclinical atherosclerosis: data from the Brisighella Heart Study. J Hypertens. 2014;32(1):57–64. doi:10.1097/HJH.0b013e328365b916
  • Fu S, Luo L, Ye P, Xiao W. Multimarker analysis for new biomarkers in relation to central arterial stiffness and hemodynamics in a Chinese community-dwelling population. Angiology. 2015;66:950–956. doi:10.1177/0003319715573910
  • Li Y, Lu J, Wu X, Yang C. Serum uric acid concentration and asymptomatic hyperuricemia with subclinical organ damage in general population. Angiology. 2014;65:634–640. doi:10.1177/0003319713513143
  • Lim JH, Kim YK, Kim YS, Na SH, Rhee MY, Lee MM. Relationship between serum uric acid levels, metabolic syndrome, and arterial stiffness in Korean. Korean Circ J. 2010;40:314–320. doi:10.4070/kcj.2010.40.7.314
  • Canepa M, Viazzi F, Strait JB, et al. Longitudinal association between serum uric acid and arterial stiffness: results from the Baltimore longitudinal study of aging. Hypertension. 2017;69(2):228–235. doi:10.1161/HYPERTENSIONAHA.116.08114
  • Nagano S, Takahashi M, Miyai N, et al. Association of serum uric acid with subsequent arterial stiffness and renal function in normotensive subjects. Hypertension. 2017;40:620–624. doi:10.1038/hr.2017.10
  • Ding X, Ye P, Wang X, et al. Peripheral arterial stiffness is associated with basal plasma uric acid: a prospective cohort study. Saudi J Biol Sci. 2017;24:574–581. doi:10.1016/j.sjbs.2017.01.028
  • Feig DI, Kang DH, Nakagawa T, Mazzali M, Johnson RJ. Uric acid and hypertension. Curr Hypertens Rep. 2006;8:111–115. doi:10.1007/s11906-006-0005-z
  • Feig DI, Johnson RJ. Hyperuricemia in childhood primary hypertension. Hypertension. 2003;42:247–252. doi:10.1161/01.HYP.0000085858.66548.59
  • Kuwabara M. Hyperuricemia, cardiovascular disease, and hypertension. Pulse (Basel). 2016;3:242–252. doi:10.1159/000443769
  • Mazzali M, Hugues J, Kim YG, et al. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension. 2001;38:1101–1106. doi:10.1161/hy1101.092839
  • Tsai WC, Huang YY, Lin CC, et al. Uric acid is an independent predictor of arterial stiffness in hypertensive patients. Heart Vessels. 2009;24(5):371–375. doi:10.1007/s00380-008-1127-9
  • Ramirez AJ, Christen AI, Sanchez RA. Serum acid uric elevation is associated to arterial stiffness in hypertension patients with metabolic disturbances. Curr Hypertens Rev. 2018;14(2):154–160. doi:10.2174/1573402114666180413143312
  • Vlachopoulos C, Xaplanteris P, Vyssoulis G, et al. Association of serum uric acid level with aortic stiffness and arterial wave reflections in newly diagnosed, never-treated hypertension. Am J Hypertens. 2011;24:33–39. doi:10.1038/ajh.2010.111
  • Hsu P-F, Chuang S-Y, Cheng H-M, et al. Associations of serum uric acid levels with arterial wave reflections and central systolic blood pressure. Int J Cardiol. 2013;168(3):2057–2063. doi:10.1016/j.ijcard.2013.01.164
  • Mulè G, Riccobene R, Castiglia A, et al. Relationship between mild hyperuricemia and aortic stiffness in untreated hypertensive patients. Nutr Metab Cardiovasc Dis. 2014;24:744–750. doi:10.1016/j.numecd.2014.01.014
  • Tsioufis C, Chatzis D, Vezali E, et al. The controversial role of serum uric acid in essential hypertension: relationships with indices of target organ damage. J Hum Hypertens. 2005;19:211–217. doi:10.1038/sj.jhh.1001810
  • Tsioufis C, Kyvelou S, Dimitriadis K, et al. The diverse associations of uric acid with low-grade inflammation, adiponectin and arterial stiffness in never-treated hypertensives. J Human Hypertens. 2011;25:554–559. doi:10.1038/jhh.2010.98
  • Saladini F, Benetti E, Fania C, et al. Association between uric acid, metabolic variables and arterial stiffness in the early phase of hypertension. J Hypertens. 2016; e208. doi:10.1097/01.hjh.0000467906.49825.ad.
  • Cipolli JAA, Ferreira-Sae MC, Martins RP, et al. Relationship between serum uric acid and internal carotid resistive index in hypertensive women: a cross-sectional study. BMC Cardiovasc Disord. 2012;12:52. doi:10.1186/1471-2261-12-52
  • Frauchiger B, Schmid HP, Roedel C, Moosmann P, Staub D. Comparison of carotid arterial resistive indices with intima-media thickness as sonographic markers of atherosclerosis. Stroke. 2001;32:836–841. doi:10.1161/01.STR.32.4.836
  • Gomez-Marcos MA, Recio-Rodríguez JI, Patino-Alonso MC, et al.; Vasorisk group. Relationship between uric acid and vascular structure and function in hypertensive patients and sex-related differences. Am J Hypertens. 2013;26(5):599–607. doi:10.1093/ajh/hps097.
  • Alper AB Jr, Chen W, Yau L, Srinivasan SR, Berenson GS, Hamm LL. Childhood uric acid predicts adult blood pressure: the Bogalusa Heart Study. Hypertension. 2005;45:34–38. doi:10.1161/01.HYP.0000150783.79172.bb
  • Sundström J, Sullivan L, D’Agostino RB, Levy D, Kannel WB, Vasan RS. Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence. Hypertension. 2005;45:28–33. doi:10.1161/01.HYP.0000150784.92944.9a
  • Perlstein TS, Gumieniak O, Williams GH, et al. Uric acid and the development of hypertension: the normative aging study. Hypertension. 2006;48:1031–1036. doi:10.1161/01.HYP.0000248752.08807.4c
  • Mellen PB, Bleyer AJ, Erlinger TP, et al. Serum uric acid predicts incident hypertension in a biethnic cohort: the atherosclerosis risk in communities study. Hypertension. 2006;48:1037–1042. doi:10.1161/01.HYP.0000249768.26560.66
  • Nakanishi N, Okamoto M, Yoshida H, Matsuo Y, Suzuki K, Tatara K. Serum uric acid and risk for development of hypertension and impaired fasting glucose or type II diabetes in Japanese male office workers. Eur J Epidemiol. 2003;18:523–530. doi:10.1023/a:1024600905574
  • Masuo K, Kawaguchi H, Mikami H, Ogihara T, Tuck ML. Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation. Hypertension. 2003;42:474–480. doi:10.1161/01.HYP.0000091371.53502.D3
  • Kuwabara M, Niwa K, Hisatome I, et al. Asymptomatic hyperuricemia without comorbidities predicts cardiometabolic diseases: five year Japanese cohort study. Hypertension. 2017;69:1036–1044. doi:10.1161/HYPERTENSIONAHA.116.08998
  • Kuwabara M, Hisatome I, Niwa K, et al. Uric acid is a strong risk marker for developing hypertension from prehypertension: a 5-year Japanese cohort study. Hypertension. 2018;71:78–86. doi:10.1161/HYPERTENSIONAHA.117.10370
  • Tomiyama H, Shiina K, Vlachopoulos C, et al. Involvement of arterial stiffness and inflammation in hyperuricemia-related development of hypertension. Hypertension. 2018;72:739–745. doi:10.1161/HYPERTENSIONAHA.118.11390
  • Tanaka A, Kawaguchi A, Tomiyama H, et al. Cross-sectional and longitudinal associations between serum uric acid and endothelial function in subjects with treated hypertension. Int J Cardiol. 2018;272:308–313. doi:10.1016/j.ijcard.2018.06.017
  • Kodama S, Saito K, Yachi Y, et al. Association between serum uric acid and development of type 2 diabetes. Diabetes Care. 2009;32:1737–1742. doi:10.2337/dc09-0288
  • Lv Q, Meng XF, He FF, et al. High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies. PLoS One. 2013;8:e56864. doi:10.1371/journal.pone.0056864
  • Xu Y, Zhu J, Gao L, et al. Hyperuricemia as an independent predictor of vascular complications and mortality in type 2 diabetes patients: a meta-analysis. PLoS One. 2013;8(10):e78206. doi:10.1371/journal.pone.0078206
  • Rizzo M, Obradovic M, Labudovic-Borovic M, et al. Uric acid metabolism in pre-hypertension and the metabolic syndrome. Curr Vasc Pharmacol. 2014;12:572–585. doi:10.2174/1570161111999131205160756
  • Tsushima Y, Nishizawa H, Tochinoet Y, et al. Uric acid secretion from adipose tissue and its increase in obesity. J Biol Chem. 2013;288:27138–27149. doi:10.1074/jbc.M113.485094
  • Stehouwer CDA, Henry RMA, Ferreira I. Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease. Diabetologia. 2008;51:527–539. doi:10.1007/s00125-007-0918-3
  • Zhang J, Xiang G, Xiang L, Sun H. Serum uric acid is associated with arterial stiffness in men with newly diagnosed type 2 diabetes mellitus. J Endocrinol Investig. 2014;37(5):441–447. doi:10.1007/s40618-013-0034-9
  • Sun N, Zhang Y, Tian J-L WH. Relationship between uric acid and arterial stiffness in the elderly with metabolic syndrome components. Chin Med J (Engl). 2013;126(16):3097–3102. doi:10.3760/cma.j.issn.0366-6999.20130215
  • Wijnands JM, Boonen A, van Sloten TT, et al. Association between serum uric acid, aortic, carotid and femoral stiffness among adults aged 40–75 years without and with type 2 diabetes mellitus: the Maastricht Study. J Hypertens. 2015;33(8):1642–1650. doi:10.1097/HJH.0000000000000593
  • Wang MC, Tsai WC, Chen JY, Huang JJ. Stepwise increase in arterial stiffness corresponding with the stages of chronic kidney disease. Am J Kidney Dis. 2005;45:494–501. doi:10.1053/j.ajkd.2004.11.011
  • Nemcsik J, Kiss I, Tisler A. Arterial stiffness, vascular calcification and bone metabolism in chronic kidney disease. World J Nephrol. 2012;1(1):25–34. doi:10.5527/wjn.v1.i1.25
  • Briet M, Boutouyrie P, Laurent S, London GM. Arterial stiffness and pulse pressure in CKD and ESRD. Kidney Int. 2012;82:388–400. doi:10.1038/ki.2012.131
  • Xia X, He F, Wu X, Peng F, Huang F, Yu X. Relationship between serum uric acid and all-cause and cardiovascular mortality in patients treated with peritoneal dialysis. Am J Kidney Dis. 2014;64:257–264. doi:10.1053/j.ajkd.2013.08.027
  • Bellomo G. Asymptomatic hyperuricemia following renal transplantation. World J Nephrol. 2015;4(3):324–329. doi:10.5527/wjn.v4.i3.324.
  • Madero M, Sarnak MJ, Wang X, et al. Uric acid and long term outcomes in CKD. Am J Kidney Dis. 2009;53:796–803. doi:10.1053/j.ajkd.2008.12.021
  • Elsurer R, Afsar B. Serum uric acid and arterial stiffness in hypertensive chronic kidney disease patients: sex-specific variations. Blood Press Monit. 2014;19:271–279. doi:10.1097/MBP.0000000000000056
  • Liu X, Wu J, Wu H, et al. Association of serum uric acid with arterial stiffness in peritoneal dialysis patients. Kidney Blood Res. 2018;43:1451–1458. doi:10.1159/000493659
  • Bauer F, Pagonas N, Seibert FS, et al. Serum uric acid and arterial function after renal transplantation. Ann Transplant. 2017;14(22):431–439. doi:10.12659/aot.901657
  • Tanindi A, Erkan AF, Alhan A, Tör HF. Arterial stiffness and central arterial wave reflection are associated with serum uric acid, total bilirubin, and neutrophil-to-lymphocyte ratio in patients with coronary artery disease. Anatol J Cardiol. 2015;15:396–403. doi:10.5152/akd.2014.5447
  • Khan F, George J, Wong K, McSwiggan S, Struthers AD, Belch JJF. The association between serum urate levels and arterial stiffness/endothelial function in stroke survivors. Atherosclerosis. 2000;200(2):374–379. doi:10.1016/j.atherosclerosis.2007.12.023
  • Park JS, Kang S, Ahn CW, Cha BS, Kim KR, Lee HC. Relationships between serum uric acid, adiponectin and arterial stiffness in postmenopausal women. Maturitas. 2012;73:344–348. doi:10.1016/j.maturitas.2012.09.009
  • Lee H, Jung Y-H, Kwon Y-J, Park B. Uric acid level has a J-shaped association with arterial stiffness in Korean postmenopausal women. Korean J Fam Med. 2017;38:333–337. doi:10.4082/kjfm.2017.38.6.333
  • McDonagh EM, Thorn CF, Callaghan JT, Altman RB, Klein TE. PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics. Pharmacogenet Genomics. 2014;24(9):464–476. doi:10.1097/FPC.0000000000000058
  • Grimaldi-Bensouda L, Alperovitch A, Aubrun E, et al. Impact of allopurinol on risk of myocardial infarction. Ann Rheum Dis. 2015;74:836–842. doi:10.1136/annrheumdis-2012-202972
  • MacIsaac RL, Salatzki J, Higgins P, et al. Allopurinol and cardiovascular outcomes in adults with hypertension. Hypertension. 2016;67:535–540. doi:10.1161/HYPERTENSIONAHA.115.06344
  • Struthers AD, Donnan PT, Lindsay P, McNaughton D, Broomhall J, MacDonald TM. Effect of allopurinol on mortality and hospitalisations in chronic heart failure: a retrospective cohort study. Heart. 2002;87:229–234. doi:10.1136/heart.87.3.229
  • Luk AJ, Levin GP, Moore EE, Zhou XH, Kestenbaum BR, Choi HK. Allopurinol and mortality in hyperuricaemic patients. Rheumatology (Oxford). 2009;48:804–806. doi:10.1093/rheumatology/kep069
  • Bredemeier M, Lopes LM, Eisenreich MA, et al. Xanthine oxidase inhibitors for prevention of cardiovascular events: a systematic review and meta-analysis of randomized controlled trial. BMC Cardiovasc Disord. 2018;18:24. doi:10.1186/s12872-018-0757-9
  • Deng G, Qiu Z, Li D, Fang Y, Zhang S. Effects of allopurinol on arterial stiffness: a meta-analysis of randomized controlled trials. Med Sci Monit. 2016;22:1389–1397. doi:10.12659/msm.898370
  • Alem MM, Alshehri AM, Cahusac PMB, Walters MR. Effect of xanthine oxidase inhibition on arterial stiffness in patients with chronic heart failure. Clin Med Insights Cardiol. 2018;12:1–10. doi:10.1177/1179546818779584
  • George J, Carr E, Davies J, Belch JJ, Struthers A. High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid. Circulation. 2006;114:2508–2516. doi:10.1161/CIRCULATIONAHA.106.651117
  • Higgins P, Dawson J, Lees KR, McArthur K, Quinn TJ, Walters MR. Xanthine oxidase inhibition for the treatment of cardiovascular disease: a systematic review and meta-analysis. Cardiovasc Ther. 2012;30(4):217–226. doi:10.1111/j.1755-5922.2011.00277
  • Rajendra NS, Ireland S, George J, Belch JJ, Lang CC, Struthers AD. Mechanistic insights into the therapeutic use of high-dose allopurinol in angina pectoris. J Am Coll Cardiol. 2011;58:820–828. doi:10.1016/j.jacc.2010.12.052
  • Kanbay M, Ozkara A, Selcoki Y, et al. Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearance, and proteinuria in patients with normal renal functions. Int Urol Nephrol. 2007;39:1227–1233. doi:10.1007/s11255-007-9253-3
  • Ng KP, Stringer SJ, Jesky MD, et al. Allopurinol is an independent determinant of improved arterial stiffness in chronic kidney disease: a cross sectional study. PLoS One. 2014;9(3):e91961. doi:10.1371/journal.pone.0091961
  • Agarwal V, Hans N, Messerli FH. Effect of allopurinol on blood pressure: a systematic review and meta-analysis. J Clin Hypertens (Greenwich). 2013;15:435–442. doi:10.1111/j.1751-7176.2012.00701.x
  • Kamatani N, Fujimori S, Hada T, et al. An allopurinol-controlled, randomized, double-dummy, double-blind, parallel between-group, comparative study of febuxostat (TMX-67), a non-purine-selective inhibitor of xanthine oxidase, in patients with hyperuricemia including those with gout in Japan: Phase 3 clinical study. J Clin Rheumatol. 2011;17:S13–S18. doi:10.1097/RHU.0b013e31821d36cc
  • Malik UZ, Hundley NJ, Romero G, et al. Febuxostat inhibition of endothelial-bound XO: implications for targeting vascular ROS production. Free Radic Biol Med. 2011;51:179–184. doi:10.1016/j.freeradbiomed.2011.04.004
  • Sezai A, Soma M, Nakata K, et al. Comparison of febuxostat and allopurinol for hyperuricemia in cardiac surgery patients (NU‑FLASH Trial). Circ J. 2013;77:2043–2049. doi:10.1253/circj.cj-13-0082
  • Sezai A, Soma M, Nakata K, et al. Comparison of febuxostat and allopurinol for hyperuricemia in cardiac surgery patients with chronic kidney disease (NU‑FLASH trial for CKD). J Cardiol. 2015;66:298–303. doi:10.1016/j.jjcc.2014.12.017
  • Tausche AK, Christoph M, Forkmann M, et al. As compared to allopurinol, urate-lowering therapy with febuxostat has superior effects on oxidative stress and pulse wave velocity in patients with severe chronic tophaceous gout. Rheumatol Int. 2014;34(1):101–109. doi:10.1007/s00296-013-2857-2
  • Zhang T, Pope JE. Cardiovascular effects of urate-lowering therapies in patients with chronic gout: a systematic review and meta-analysis. Rheumatology. 2017;56:1144–1153. doi:10.1093/rheumatology/kex065
  • White WB, Saag KG, Becker MA, et al.; for the CARES Investigators. Cardiovascular safety of febuxostat or allopurinol in patients with gout. N Engl J Med. 2018;378:1200–1210. doi:10.1056/NEJMoa1710895
  • Cuenca JA, Balda J, Palacio A, Young L, Pillinger MH, Tamari L. Febuxostat and cardiovascular events: a systematic review and meta-analysis. Int J Rheumatol. 2019;2019:1–10. doi:10.1155/2019/1076189
  • Pancholia AK. Sodium-glucose cotransporter-2 inhibition for the reduction of cardiovascular events in high-risk patients with diabetes mellitus. Indian Heart J. 2018;70(6):915–921. doi:10.1016/j.ihj.2018.08.022
  • Sanchez RA, Sanchez MJ, Ramirez AJ. Canagliflozin ameliorates arterial stiffness by reducing serum uric acid in type 2 diabetic patients. Diabetes. 2018;67(Supplement 1):1216–P. doi:10.2337/db18-1216-P
  • Bekki M, Tahara N, Tahara A, et al. Switching dipeptidyl peptidase-4 inhibitors to tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2 improves arterial stiffness evaluated by cardio-ankle vascular index in patients with type 2 diabetes: a pilot study. Curr Vasc Pharmacol. 2018. doi:10.2174/1570161116666180515154555
  • Chilton R, Tikkanen I, Cannon CP, et al. Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes. Diabetes, Obes Metab. 2015;17:1180–1193. doi:10.1111/dom.12572
  • Aroor AR, Das NA, Carpenter AJ, et al. Glycemic control by the SGLT2 inhibitor empagliflozin decreases aortic stiffness, renal resistivity index and kidney injury. Cardiovasc Diabetol. 2018;17:108. doi:10.1186/s12933-018-0750-8
  • Striepe K, Jumar A, Ott C, et al. Effects of the selective sodium-glucose cotransporter 2 inhibitor empagliflozin on vascular function and central hemodynamics in patients with type 2 diabetes mellitus. Circulation. 2017;136(12):1167–1169. doi:10.1161/CIRCULATIONAHA.117.029529
  • Singh M, Kumar A. Risks associated with SGLT2 inhibitors: an overview. Curr Drug Saf. 2018;13(2):84–91. doi:10.2174/1574886313666180226103408
  • Waring WS, McKnight JA, Webb DJ, Maxwell SR. Lowering serum urate does not improve endothelial function in patients with type 2 diabetes. Diabetologia. 2007;50(12):2572–2579. doi:10.1007/s00125-007-0817-7