Non-Surgical Treatment of Knee Osteoarthritis: Multidisciplinary Italian Consensus on Best Practice

References

• Moskowitz RW, Howell DS, Altman RD, Buckwalter JA, Goldberg VM. Osteoarthritis: Diagnosis and Medical/Surgical Management. 3rd ed. 2001:69–99.
   Google Scholar
• Piscitelli P, Iolascon G, Di Tanna G, et al. Socioeconomic burden of total joint arthroplasty for symptomatic hip and knee osteoarthritis in the Italian population: a 5-year analysis based on hospitalization records. Arthritis Care Res. 2012;64(9):1320–1327. doi:10.1002/acr.21706
   Web of Science ®Google Scholar
• Michelle H. Physical Agents in Rehabilitation. An Evidence-Based Approach to Practice. 5th ed. Canada: Elsevier; 2008.
   Google Scholar
• Santilli V. Linee guida ed evidenze scientifiche in medicina fisica e riabilitativa, Roma. Centro Stampa Università di Roma “La Sapienza”; 2018:1–736. Available from: http://www.formazionesostenibile.it/2017/RomeRehabilitation/libro_per_sito.pdf. Accessed April 8,2021.
   Google Scholar
• Zeng C, Li H, Yang T, et al. Electrical stimulation for pain relief in knee osteoarthritis: systematic review and network meta-analysis. Osteoarthr Cartil. 2015;23(2):189–202. doi:10.1016/j.joca.2014.11.014
   PubMed Web of Science ®Google Scholar
• Wang H, Zhang C, Gao C, et al. Effects of short-wave therapy in patients with knee osteoarthritis: a systematic review and meta-analysis. Clin Rehabil. 2017;31(5):660–671. doi:10.1177/0269215516683000
   PubMed Web of Science ®Google Scholar
• Giggins O, Fullen B, Coughlan G. Neuromuscular electrical stimulation in the treatment of knee osteoarthritis: a systematic review and meta-analysis. Clin Rehabil. 2012;26(10):867–881. doi:10.1177/0269215511431902
   PubMed Web of Science ®Google Scholar
• Benedetti MG, Boccia G, Cavazzuti L, et al. Localized muscle vibration reverses quadriceps muscle hypotrophy and improves physical function: a clinical and electrophysiological study. Int J Rehabil Res. 2017;40(4):339–346. doi:10.1097/mrr.0000000000000242
   PubMed Web of Science ®Google Scholar
• Rayegani SM, Raeissadat SA, Heidari S, Moradi-Joo M. Safety and effectiveness of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis. J Lasers Med Sci. 2017;8(Suppl 1):S12–s19. doi:10.15171/jlms.2017.s3
   PubMedGoogle Scholar
• Li S, Yu B, Zhou D, He C, Zhuo Q, Hulme JM. Electromagnetic fields for treating osteoarthritis. Cochrane Database Syst Rev. 2013;12:Cd003523. doi:10.1002/14651858.CD003523.pub2
   PubMed Web of Science ®Google Scholar
• Ryang We S, Koog YH, Jeong KI, Wi H. Effects of pulsed electromagnetic field on knee osteoarthritis: a systematic review. Rheumatology. 2013;52(5):815–824. doi:10.1093/rheumatology/kes063
   PubMed Web of Science ®Google Scholar
• Alayat MSM, Aly THA, Elsayed AEM, Fadil ASM. Efficacy of pulsed Nd:YAG laser in the treatment of patients with knee osteoarthritis: a randomized controlled trial. Lasers Med Sci. 2017;32(3):503–511. doi:10.1007/s10103-017-2141-x
   PubMed Web of Science ®Google Scholar
• Rutjes AW, Nüesch E, Sterchi R, et al. Transcutaneous electrostimulation for osteoarthritis of the knee. Cochrane Database Syst Rev. 2009;2009(4):Cd002823. doi:10.1002/14651858.CD002823.pub2
   PubMedGoogle Scholar
• Rutjes AW, Nüesch E, Sterchi R, Jüni P. Therapeutic ultrasound for osteoarthritis of the knee or hip. Cochrane Database Syst Rev. 2010;1:Cd003132. doi:10.1002/14651858.CD003132.pub2
   Web of Science ®Google Scholar
• Zhang C, Xie Y, Luo X, et al. Effects of therapeutic ultrasound on pain, physical functions and safety outcomes in patients with knee osteoarthritis: a systematic review and meta-analysis. Clin Rehabil. 2016;30(10):960–971. doi:10.1177/0269215515609415
   PubMed Web of Science ®Google Scholar
• National Cancer Institute. Dictionary of cancer terms. Available from: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/mind-body-exercise. Accessed April 7, 2021.
   Google Scholar
• The Royal Australian College of General Practitioners. Guideline for the Management of Knee and Hip Osteoarthritis. 2nd. East Melbourne, Vic: RACGP; 2018:1–71. Available from: https://www.racgp.org.au/download/Documents/Guidelines/Musculoskeletal/guideline-for-the-management-of-knee-and-hip-oa-2nd-edition.pdf. Accessed April 8, 2021.
   Google Scholar
• Department of Veterans Affairs Department of Defense. VA/DoD clinical practice guideline for the non-surgical management of hip & knee osteoarthritis. Version 1.0; 2014:1–126. Available from: https://www.healthquality.va.gov/guidelines/CD/OA/VADoDOACPGFINAL090214.pdf. Accessed April 8, 2021.
   Google Scholar
• Forestier R, Desfour H, Tessier JM, et al. Spa therapy in the treatment of knee osteoarthritis: a large randomised multicentre trial. Ann Rheum Dis. 2010;69(4):660–665. doi:10.1136/ard.2009.113209
   PubMed Web of Science ®Google Scholar
• Antonelli M, Donelli D, Fioravanti A. Effects of balneotherapy and spa therapy on quality of life of patients with knee osteoarthritis: a systematic review and meta-analysis. Rheumatol Int. 2018;38(10):1807–1824. doi:10.1007/s00296-018-4081-6
   PubMed Web of Science ®Google Scholar
• Fioravanti A, Karagülle M, Bender T, Karagülle MZ. Balneotherapy in osteoarthritis: facts, fiction and gaps in knowledge. Eur J Integr Med. 2017;9:148–150. doi:10.1016/j.eujim.2017.01.001
   Web of Science ®Google Scholar
• Forestier R, Erol forestier FB, Francon A. Spa therapy and knee osteoarthritis: a systematic review. Ann Phys Rehabil Med. 2016;59(3):216–226. doi:10.1016/j.rehab.2016.01.010
   PubMed Web of Science ®Google Scholar
• Matsumoto H, Hagino H, Hayashi K, et al. The effect of balneotherapy on pain relief, stiffness, and physical function in patients with osteoarthritis of the knee: a meta-analysis. Clin Rheumatol. 2017;36(8):1839–1847. doi:10.1007/s10067-017-3592-y
   PubMed Web of Science ®Google Scholar
• Fraioli A, Mennuni G, Fontana M, et al. Efficacy of spa therapy, mud-pack therapy, balneotherapy, and mud-bath therapy in the management of knee osteoarthritis. a systematic review. Biomed Res Int. 2018;2018:1042576. doi:10.1155/2018/1042576
   PubMed Web of Science ®Google Scholar
• Jevsevar DS. Treatment of osteoarthritis of the knee: evidence-based guideline, 2nd edition. J Am Acad Orthop Surg. 2013;21(9):571–576. doi:10.5435/jaaos-21-09-571
   PubMed Web of Science ®Google Scholar
• McAlindon TE, Bannuru RR, Sullivan MC, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthr Cartil. 2014;22(3):363–388. doi:10.1016/j.joca.2014.01.003
   PubMed Web of Science ®Google Scholar
• National Clinical Guideline C. National institute for health and clinical excellence: guidance. Osteoarthritis: care and management in adults. National Institute for Health and Care Excellence (UK).
   Google Scholar
• National Institute for Health and Care Excellence. Platelet-rich plasma injections for knee osteoarthritis. Interventional procedures guidance [IPG637]; 2019:1–4. Available from: https://www.nice.org.uk/guidance/ipg637. Accessed April 8, 2021.
   Google Scholar
• Gregori D, Giacovelli G, Minto C, et al. Association of pharmacological treatments with long-term pain control in patients with knee osteoarthritis: a systematic review and meta-analysis. JAMA. 2018;320(24):2564–2579. doi:10.1001/jama.2018.19319
   PubMed Web of Science ®Google Scholar
• Liu X, Machado GC, Eyles JP, Ravi V, Hunter DJ. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. Br J Sports Med. 2018;52(3):167–175. doi:10.1136/bjsports-2016-097333
   PubMed Web of Science ®Google Scholar
• Runhaar J, Rozendaal RM, van Middelkoop M, et al. Subgroup analyses of the effectiveness of oral glucosamine for knee and hip osteoarthritis: a systematic review and individual patient data meta-analysis from the OA trial bank. Ann Rheum Dis. 2017;76(11):1862–1869. doi:10.1136/annrheumdis-2017-211149
   PubMed Web of Science ®Google Scholar
• Bhandari M, Bannuru RR, Babins EM, et al. Intra-articular hyaluronic acid in the treatment of knee osteoarthritis: a Canadian evidence-based perspective. Ther Adv Musculoskelet Dis. 2017;9(9):231–246. doi:10.1177/1759720x17729641
   PubMed Web of Science ®Google Scholar
• Vannabouathong C, Bhandari M, Bedi A, et al. Nonoperative treatments for knee osteoarthritis: an evaluation of treatment characteristics and the intra-articular placebo effect: a systematic review. JBJS Rev. 2018;6(7):e5. doi:10.2106/jbjs.Rvw.17.00167
   PubMed Web of Science ®Google Scholar
• Altman R, Hackel J, Niazi F, Shaw P, Nicholls M. Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: a systematic review. Semin Arthritis Rheum. 2018;48(2):168–175. doi:10.1016/j.semarthrit.2018.01.009
   PubMed Web of Science ®Google Scholar
• Brosseau L, Taki J, Desjardins B, et al. The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part one: introduction, and mind-body exercise programs. Clin Rehabil. 2017;31(5):582–595. doi:10.1177/0269215517691083
   PubMed Web of Science ®Google Scholar
• Brosseau L, Taki J, Desjardins B, et al. The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part two: strengthening exercise programs. Clin Rehabil. 2017;31(5):596–611. doi:10.1177/0269215517691084
   PubMed Web of Science ®Google Scholar
• Brosseau L, Taki J, Desjardins B, et al. The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part three: aerobic exercise programs. Clin Rehabil. 2017;31(5):612–624. doi:10.1177/0269215517691085
   PubMed Web of Science ®Google Scholar
• American Academy of Orthopaedic Surgeons. Athletic Training and Sports Medicine. 2nd ed. Park Ridge, Ill: American Academy of Orthopaedic Surgery; 1991.
   Google Scholar
• Beckham-Burnett S, Grang WA. Safe and effective weight training for fitness and sport. J Musculoskelet Med. 1987;4(11):26–36.
   Google Scholar
• Brotzman SB, Wilk KE. La Riabilitazione in Ortopedia. 2nd ed. San Donato Milanese: MI: Excerpta Medica Italia Srl; 2004.
   Google Scholar
• Kisner C, Colby LA. Therapeutic exercise: foundations and techniques. Philadelphia: F.A. Davis; 1996:1–991. Availablefrom: https://www.academia.edu/43265538/Colby_Lynn_Allen_Kisner_Carolyn_Therapeutic_exercise_Foundations_and_techniques_F_A_Davis. Accessed April 8, 2021.
   Google Scholar
• Richards DB, Kibler B. Sports-related rehabilitation: an overview of concepts. J Musculoskelet Med. 1997;14(8):44–63.
   Google Scholar
• McAlindon TE, Felson DT, Zhang Y, et al. Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham study. Ann Intern Med. 1996;125(5):353–359. doi:10.7326/0003-4819-125-5-199609010-00001
   PubMed Web of Science ®Google Scholar
• Lane NE, Gore LR, Cummings SR, et al. Serum vitamin D levels and incident changes of radiographic hip osteoarthritis: a longitudinal study. Study of osteoporotic fractures research group. Arthritis Rheum. 1999;42(5):854–860. doi:10.1002/1529-0131(199905)42:5<854::aid-anr3>3.0.Co;2-i
   PubMed Web of Science ®Google Scholar
• Bergink AP, Uitterlinden AG, Van Leeuwen JP, et al. Vitamin D status, bone mineral density, and the development of radiographic osteoarthritis of the knee: the Rotterdam study. J Clin Rheumatol. 2009;15(5):230–237. doi:10.1097/RHU.0b013e3181b08f20
   PubMed Web of Science ®Google Scholar
• Huhtakangas JA, Veijola J, Turunen S, et al. Cytokine data obtained from synovial stromal cells of patients with rheumatoid arthritis or osteoarthritis. Data Brief. 2017;12:593–602. doi:10.1016/j.dib.2017.04.041
   PubMed Web of Science ®Google Scholar
• Brennan-Speranza TC, Mor D, Mason RS, et al. Skeletal muscle vitamin D in patients with end stage osteoarthritis of the knee. J Steroid Biochem Mol Biol. 2017;173:180–184. doi:10.1016/j.jsbmb.2017.01.022
   PubMed Web of Science ®Google Scholar
• Heidari B, Javadian Y, Babaei M, Yousef-Ghahari B. Restorative effect of vitamin D deficiency on knee pain and quadriceps muscle strength in knee osteoarthritis. Acta Med Iran. 2015;53(8):466–470.
   PubMedGoogle Scholar
• McAlindon T, LaValley M, Schneider E, et al. Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA. 2013;309(2):155–162. doi:10.1001/jama.2012.164487
   PubMed Web of Science ®Google Scholar
• Arden NK, Cro S, Sheard S, et al. The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: a randomised controlled trial. Osteoarthr Cartil. 2016;24(11):1858–1866. doi:10.1016/j.joca.2016.05.020
   PubMed Web of Science ®Google Scholar
• Jin X, Jones G, Cicuttini F, et al. Effect of vitamin D supplementation on tibial cartilage volume and knee pain among patients with symptomatic knee osteoarthritis: a randomized clinical trial. JAMA. 2016;315(10):1005–1013. doi:10.1001/jama.2016.1961
   PubMed Web of Science ®Google Scholar
• Hussain S, Singh A, Akhtar M, Najmi AK. Vitamin D supplementation for the management of knee osteoarthritis: a systematic review of randomized controlled trials. Rheumatol Int. 2017;37(9):1489–1498. doi:10.1007/s00296-017-3719-0
   PubMed Web of Science ®Google Scholar
• Gao XR, Chen YS, Deng W. The effect of vitamin D supplementation on knee osteoarthritis: a meta-analysis of randomized controlled trials. Int J Surg. 2017;46:14–20. doi:10.1016/j.ijsu.2017.08.010
   PubMed Web of Science ®Google Scholar
• Perry TA, Parkes MJ, Hodgson R, Felson DT, O’Neill TW, Arden NK. Effect of vitamin D supplementation on synovial tissue volume and subchondral bone marrow lesion volume in symptomatic knee osteoarthritis. BMC Musculoskelet Disord. 2019;20(1):76. doi:10.1186/s12891-019-2424-4
   PubMed Web of Science ®Google Scholar
• Thorlund JB, Juhl CB, Roos EM, Lohmander LS. Arthroscopic surgery for degenerative knee: systematic review and meta-analysis of benefits and harms. BMJ. 2015;350:h2747. doi:10.1136/bmj.h2747
   PubMed Web of Science ®Google Scholar
• Abram SGF, Judge A, Beard DJ, Price AJ. Adverse outcomes after arthroscopic partial meniscectomy: a study of 700 000 procedures in the national hospital episode statistics database for England. Lancet. 2018;392(10160):2194–2202. doi:10.1016/s0140-6736(18)31771-9
   PubMed Web of Science ®Google Scholar
• Carr A. Arthroscopic surgery for degenerative knee. BMJ. 2015;350:h2983. doi:10.1136/bmj.h2983
   PubMed Web of Science ®Google Scholar
• Lohmander LS, Thorlund JB, Roos EM. Routine knee arthroscopic surgery for the painful knee in middle-aged and old patients–time to abandon ship. Acta orthopaedica. 2016;87(1):2–4. doi:10.3109/17453674.2015.1124316
   PubMed Web of Science ®Google Scholar
• Beaufils P, Becker R, Kopf S, et al. Surgical management of degenerative meniscus lesions: the 2016 ESSKA meniscus consensus. Knee Surg Sports Traumatol Arthrosc. 2017;25(2):335–346. doi:10.1007/s00167-016-4407-4
   PubMed Web of Science ®Google Scholar
• Buldu MT, Marsh JL, Arbuthnot J. Mechanical symptoms of osteoarthritis in the knee and arthroscopy. J Knee Surg. 2016;29(5):396–402. doi:10.1055/s-0035-1564592
   PubMed Web of Science ®Google Scholar
• Lamplot JD, Brophy RH. The role for arthroscopic partial meniscectomy in knees with degenerative changes: a systematic review. Bone Joint J. 2016;98-b(7):934–938. doi:10.1302/0301-620x.98b7.37410
   PubMed Web of Science ®Google Scholar
• Khan M, Khanna V, Adili A, Ayeni OR, Bedi A, Bhandari M. Knee osteoarthritis: when arthroscopy can help. Pol Arch Intern Med. 2018;128(2):121–125. doi:10.20452/pamw.4186
   PubMedGoogle Scholar
• Price AJ, Alvand A, Troelsen A, et al. Knee replacement. Lancet. 2018;392(10158):1672–1682. doi:10.1016/s0140-6736(18)32344-4
   PubMed Web of Science ®Google Scholar
• Schmitt J, Lange T, Günther KP, et al. Indication criteria for total knee arthroplasty in patients with osteoarthritis - a multi-perspective consensus study. Z Orthop Unfall. 2017;155(5):539–548. doi:10.1055/s-0043-115120
   PubMed Web of Science ®Google Scholar
• Gademan MG, Hofstede SN, Vliet Vlieland TP, Nelissen RG, Marang-van de Mheen PJ. Indication criteria for total hip or knee arthroplasty in osteoarthritis: a state-of-the-science overview. BMC Musculoskelet Disord. 2016;17(1):463. doi:10.1186/s12891-016-1325-z
   PubMed Web of Science ®Google Scholar
• van Blitterswijk WJ, van de Nes JC, Wuisman PI. Glucosamine and chondroitin sulfate supplementation to treat symptomatic disc degeneration: biochemical rationale and case report. BMC Complement Altern Med. 2003;3:2. doi:10.1186/1472-6882-3-2
   PubMedGoogle Scholar
• Martí-Bonmatí L, Sanz-Requena R, Rodrigo JL, Alberich-Bayarri A, Carot JM. Glucosamine sulfate effect on the degenerated patellar cartilage: preliminary findings by pharmacokinetic magnetic resonance modeling. Eur Radiol. 2009;19(6):1512–1518. doi:10.1007/s00330-008-1286-1
   PubMed Web of Science ®Google Scholar
• Wildi LM, Raynauld JP, Martel-Pelletier J, et al. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI. Ann Rheum Dis. 2011;70(6):982–989. doi:10.1136/ard.2010.140848
   PubMed Web of Science ®Google Scholar
• Railhac JJ, Zaim M, Saurel AS, Vial J, Fournie B. Effect of 12 months treatment with chondroitin sulfate on cartilage volume in knee osteoarthritis patients: a randomized, double-blind, placebo-controlled pilot study using MRI. Clin Rheumatol. 2012;31(9):1347–1357. doi:10.1007/s10067-012-2022-4
   PubMed Web of Science ®Google Scholar
• Durmus D, Alayli G, Bayrak IK, Canturk F. Assessment of the effect of glucosamine sulfate and exercise on knee cartilage using magnetic resonance imaging in patients with knee osteoarthritis: a randomized controlled clinical trial. J Back Musculoskelet Rehabil. 2012;25(4):275–284. doi:10.3233/bmr-2012-0336
   PubMed Web of Science ®Google Scholar
• Wilkens P, Storheim K, Scheel I, Berg L, Espeland A. No effect of 6-month intake of glucosamine sulfate on Modic changes or high intensity zones in the lumbar spine: sub-group analysis of a randomized controlled trial. J Negat Results Biomed. 2012;11:13. doi:10.1186/1477-5751-11-13
   PubMedGoogle Scholar
• Raynauld JP, Martel-Pelletier J, Dorais M, et al. Total knee replacement as a knee osteoarthritis outcome: predictors derived from a 4-year long-term observation following a randomized clinical trial using chondroitin sulfate. Cartilage. 2013;4(3):219–226. doi:10.1177/1947603513483547
   PubMed Web of Science ®Google Scholar
• Jacobs L, Vo N, Coelho JP, et al. Glucosamine supplementation demonstrates a negative effect on intervertebral disc matrix in an animal model of disc degeneration. Spine. 2013;38(12):984–990. doi:10.1097/BRS.0b013e318286b31e
   PubMed Web of Science ®Google Scholar
• Kwoh CK, Roemer FW, Hannon MJ, et al. Effect of oral glucosamine on joint structure in individuals with chronic knee pain: a randomized, placebo-controlled clinical trial. Arthritis Rheum. 2014;66(4):930–939. doi:10.1002/art.38314
   PubMed Web of Science ®Google Scholar
• Armagan O, Yilmazer S, Calısir C, et al. Comparison of the symptomatic and chondroprotective effects of glucosamine sulphate and exercise treatments in patients with knee osteoarthritis. J Back Musculoskelet Rehabil. 2015;28(2):287–293. doi:10.3233/bmr-140516
   PubMed Web of Science ®Google Scholar
• Landsmeer ML, Runhaar J, van der Plas P, et al. Reducing progression of knee OA features assessed by MRI in overweight and obese women: secondary outcomes of a preventive RCT. Osteoarthr Cartil. 2016;24(6):982–990. doi:10.1016/j.joca.2015.12.016
   PubMed Web of Science ®Google Scholar
• Martel-Pelletier J, Roubille C, Abram F, et al. First-line analysis of the effects of treatment on progression of structural changes in knee osteoarthritis over 24 months: data from the osteoarthritis initiative progression cohort. Ann Rheum Dis. 2015;74(3):547–556. doi:10.1136/annrheumdis-2013-203906
   PubMed Web of Science ®Google Scholar
• Roubille C, Martel-Pelletier J, Abram F, et al. Impact of disease treatments on the progression of knee osteoarthritis structural changes related to meniscal extrusion: data from the OAI progression cohort. Semin Arthritis Rheum. 2015;45(3):257–267. doi:10.1016/j.semarthrit.2015.05.001
   PubMed Web of Science ®Google Scholar
• Pelletier JP, Raynauld JP, Beaulieu AD, et al. Chondroitin sulfate efficacy versus celecoxib on knee osteoarthritis structural changes using magnetic resonance imaging: a 2-year multicentre exploratory study. Arthritis Res Ther. 2016;18(1):256. doi:10.1186/s13075-016-1149-0
   PubMed Web of Science ®Google Scholar
• Martel-Pelletier J, Raynauld JP, Mineau F, et al. Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study. Arthritis Res Ther. 2017;19(1):169. doi:10.1186/s13075-017-1377-y
   PubMed Web of Science ®Google Scholar
• Raynauld JP, Pelletier JP, Abram F, Dodin P, Delorme P, Martel-Pelletier J. Long-term effects of glucosamine and chondroitin sulfate on the progression of structural changes in knee osteoarthritis: six-year followup data from the osteoarthritis initiative. Arthritis Care Res. 2016;68(10):1560–1566. doi:10.1002/acr.22866
   Web of Science ®Google Scholar
• Altman RD, Bedi A, Karlsson J, Sancheti P, Schemitsch E. Product differences in intra-articular hyaluronic acids for osteoarthritis of the knee. Am J Sports Med. 2016;44(8):2158–2165. doi:10.1177/0363546515609599
   PubMed Web of Science ®Google Scholar
• Bannuru RR, Natov NS, Dasi UR, Schmid CH, McAlindon TE. Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis–meta-analysis. Osteoarthr Cartil. 2011;19(6):611–619. doi:10.1016/j.joca.2010.09.014
   PubMed Web of Science ®Google Scholar
• Gaasbeek RD, Groen BE, Hampsink B, van Heerwaarden RJ, Duysens J. Valgus bracing in patients with medial compartment osteoarthritis of the knee. A gait analysis study of a new brace. Gait Posture. 2007;26(1):3–10. doi:10.1016/j.gaitpost.2006.07.007
   PubMed Web of Science ®Google Scholar
• Mont MA, Cherian JJ, Bhave A, et al. Unloader bracing for knee osteoarthritis: a pilot study of gait and function. Surg Technol Int. 2015;27:287–293.
   PubMedGoogle Scholar
• Yu SP, Williams M, Eyles JP, Chen JS, Makovey J, Hunter DJ. Effectiveness of knee bracing in osteoarthritis: pragmatic trial in a multidisciplinary clinic. Int J Rheum Dis. 2016;19(3):279–286. doi:10.1111/1756-185x.12796
   PubMed Web of Science ®Google Scholar
• Steadman JR, Briggs KK, Pomeroy SM, Wijdicks CA. Current state of unloading braces for knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2016;24(1):42–50. doi:10.1007/s00167-014-3305-x
   PubMed Web of Science ®Google Scholar
• Ostrander RV, Leddon CE, Hackel JG, O’Grady CP, Roth CA. Efficacy of unloader bracing in reducing symptoms of knee osteoarthritis. Am J Orthop. 2016;45(5):306–311.
   PubMedGoogle Scholar
• Kapadia BH, Cherian JJ, Starr R, et al. Gait using pneumatic brace for end-stage knee osteoarthritis. J Knee Surg. 2016;29(3):218–223. doi:10.1055/s-0036-1579790
   PubMed Web of Science ®Google Scholar
• Petersen W, Ellermann A, Zantop T, et al. Biomechanical effect of unloader braces for medial osteoarthritis of the knee: a systematic review (CRD 42015026136). Arch Orthop Trauma Surg. 2016;136(5):649–656. doi:10.1007/s00402-015-2388-2
   PubMed Web of Science ®Google Scholar
• Fantini Pagani CH, Potthast W, Bruggemann GP. The effect of valgus bracing on the knee adduction moment during gait and running in male subjects with varus alignment. Clin Biomech. 2010;25(1):70–76. doi:10.1016/j.clinbiomech.2009.08.010
   PubMed Web of Science ®Google Scholar
• Haladik JA, Vasileff WK, Peltz CD, Lock TR, Bey MJ. Bracing improves clinical outcomes but does not affect the medial knee joint space in osteoarthritic patients during gait. Knee Surg Sports Traumatol Arthrosc. 2014;22(11):2715–2720. doi:10.1007/s00167-013-2596-7
   PubMed Web of Science ®Google Scholar
• Duivenvoorden T, Brouwer RW, van Raaij TM, Verhagen AP, Verhaar JA, Bierma-Zeinstra SM. Braces and orthoses for treating osteoarthritis of the knee. Cochrane Database Syst Rev. 2015;3:Cd004020. doi:10.1002/14651858.CD004020.pub3
   PubMed Web of Science ®Google Scholar
• Hochberg MC, Altman RD, April KT, et al. American college of rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res. 2012;64(4):465–474. doi:10.1002/acr.21596
   PubMed Web of Science ®Google Scholar
• Nussbaum EL, Houghton P, Anthony J, Rennie S, Shay BL, Hoens AM. Neuromuscular electrical stimulation for treatment of muscle impairment: critical review and recommendations for clinical practice. Physiother Can. 2017;69(5):1–76. doi:10.3138/ptc.2015-88
   PubMed Web of Science ®Google Scholar
• Bruyère O, Cooper C, Pelletier JP, et al. A consensus statement on the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis-From evidence-based medicine to the real-life setting. Semin Arthritis Rheum. 2016;45(4 Suppl):S3–S11. doi:10.1016/j.semarthrit.2015.11.010
   PubMed Web of Science ®Google Scholar