Early Detection of Iron Overload Cardiomyopathy in Transfusion Dependent Thalassemia Patients in Sulaimaniyah City, Iraq

References

• Wood JC, Enriquez C, Ghugre N, et al. Physiology and pathophysiology of iron cardiomyopathy in thalassemia. Ann N Y Acad Sci. 2009;1054:386–395. doi:10.1196/annals.1345.047
   Web of Science ®Google Scholar
• Kremastinos DT, Farmakis D, Aessopos A, et al. β-thalassemia cardiomyopathy: history, present considerations, and future perspectives. Circ Heart Fail. 2010;3(3):451–458. doi:10.1161/CIRCHEARTFAILURE.109.913863
   PubMed Web of Science ®Google Scholar
• Pennell DJ, Udelson JE, Arai AE, et al. Cardiovascular function and treatment in β-thalassemia major: a consensus statement from the American Heart Association. Circulation. 2013;128(3):281–308. doi:10.1161/CIR.0b013e31829b2be6
   PubMed Web of Science ®Google Scholar
• Kontoghiorghe CN, Kontoghiorghes GJ. Efficacy and safety of iron-chelation therapy with deferoxamine, deferiprone, and deferasirox for the treatment of iron-loaded patients with non-transfusion-dependent thalassemia syndromes. Drug Des Devel Ther. 2016;10:465–481. doi:10.2147/DDDT.S79458
   PubMed Web of Science ®Google Scholar
• Kremastinos DT, Farmakis D. Iron overload cardiomyopathy in clinical practice. Circulation. 2011;124(20):2253–2263. doi:10.1161/CIRCULATIONAHA.111.050773
   PubMed Web of Science ®Google Scholar
• Kremastinos DT, Tsiapras DP, Tsetsos GA, Rentoukas EI, Vretou HP, Toutouzas PK. Left ventricular diastolic Doppler characteristics in beta-thalassemia major. Circulation. 1993;88(3):1127–1135. doi:10.1161/01.CIR.88.3.1127
   PubMed Web of Science ®Google Scholar
• Garadah TS, Kassab S, Mahdi N, Abu-Taleb A, Jamsheer A. QTc interval and QT dispersion in patients with thalassemia major: electrocardiographic (EKG) and echocardiographic evaluation. Clin Med Insights Cardiol. 2010;4:31–37. doi:10.4137/cmc.s4472
   PubMedGoogle Scholar
• Rose RA, Sellan M, Simpson JA, et al. Iron overload decreases CaV1. 3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation. Circ Arrhythm Electrophysiol. 2011;4(5):733–742. doi:10.1161/CIRCEP.110.960401
   PubMed Web of Science ®Google Scholar
• Ghanavat M, Haybar H, Pezeshki SMS, et al. Cardiomyopathy in thalassemia: quick review from cellular aspects to diagnosis and current treatments. Lab Med. 2020;51(2):143–150. doi:10.1093/labmed/lmz052
   PubMed Web of Science ®Google Scholar
• Lekawanvijit S, Chattipakorn N. Iron overload thalassemic cardiomyopathy: iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity. Can J Cardiol. 2009;25(4):213–218. doi:10.1016/S0828-282X(09)70064-9
   PubMed Web of Science ®Google Scholar
• Russo V, Melillo E, Papa AA, Rago A, Chamberland C, Nigro G. Arrhythmias and sudden cardiac death in beta-thalassemia major patients: noninvasive diagnostic tools and early markers. Cardiol Res Pract. 2019;2019:1–8. doi:10.1155/2019/9319832
   Web of Science ®Google Scholar
• McMurray JJV, Adamopoulos S, Anker SD, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2012;33(14):1787–1847. doi:10.1093/eurheartj/ehs104
   PubMed Web of Science ®Google Scholar
• Rubis P. The diagnostic work up of genetic and inflammatory dilated cardiomyopathy. E-J Cardiol Pract. 2015;13(19):1–11.
   Google Scholar
• Murphy CJ, Oudit GY. Iron-overload cardiomyopathy: pathophysiology, diagnosis, and treatment. J Card Fail. 2010;16(11):888–900. doi:10.1016/j.cardfail.2010.05.009
   PubMed Web of Science ®Google Scholar
• Ghandi Y, Eghbali A, Rafie F. Correlation between mean serum ferritin levels and atrial electrocardiographic markers in beta-thalassemia major. Iran J Blood Cancer. 2018;10(3):76–81.
   Google Scholar
• Wood JC. Cardiac complications in thalassemia major. Hemoglobin. 2009;33(sup1):S81–S86. doi:10.3109/03630260903347526
   PubMedGoogle Scholar
• Kirillova VV, Sokolova LA, Meshchaninov VN, Pershanova VI. The level of NT-proBNP in ambulatory patients with chronic heart failure with preserved ejection fraction of the left ventricle. Ter Arkh. 2018;90(9):68–72. doi:10.26442/terarkh201890968-72
   PubMed Web of Science ®Google Scholar
• Fan S, Huang H, Zhang D, et al. The dynamic change of serum cTnT and NT-ProBNP during the intervention therapy for congenital heart disease and the value for prognosis prediction. Int J Clin Exp Med. 2016;9(3):5842–5847.
   Web of Science ®Google Scholar
• Vlachou M, Kamperidis V, Giannakoulas G, Karamitsos T, Vlachaki E, Karvounis H. Biochemical and imaging markers in patients with thalassaemia. Hellenic J Cardiol. 2021;62(1):4–12. doi:10.1016/j.hjc.2020.04.012
   PubMed Web of Science ®Google Scholar
• Mozos I. Ventricular Arrhythmia Risk in Noncardiac Diseases. In Tech; 2014:89–109.
   Google Scholar
• Rago A, Russo V, Papa AA, et al. The role of the atrial electromechanical delay in predicting atrial fibrillation in beta-thalassemia major patients. J Interv Card Electrophysiol. 2017;48(2):147–157. doi:10.1007/s10840-016-0201-y
   PubMed Web of Science ®Google Scholar
• Siri-Angkul N, Xie L, Chattipakorn SC, Chattipakorn N. Cellular electrophysiology of iron-overloaded cardiomyocytes. Front Physiol. 2018;9:1–7. doi:10.3389/fphys.2018.01615
   PubMed Web of Science ®Google Scholar
• Yu CY, Lin CH, Yang YH. Human body surface area database and estimation formula. Burns. 2010;36(5):616–629. doi:10.1016/j.burns.2009.05.013
   PubMed Web of Science ®Google Scholar
• Kautsar A, Advani N, Andriastuti M. N-terminal-pro-b-type natriuretic peptide levels and cardiac hemosiderosis in adolescent β-thalassemia major patients. Ann Pediatr Cardiol. 2019;12(1):32. doi:10.4103/apc.APC_49_18
   PubMed Web of Science ®Google Scholar
• Patsourakos D, Gatzoulis KA, Aggeli C, et al. Twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients. J Arrhythm. 2020;36(5):920–928. doi:10.1002/joa3.12412
   PubMed Web of Science ®Google Scholar
• Detterich J, Noetzli L, Dorey F, et al. Electrocardiographic consequences of cardiac iron overload in thalassemia major. Am J Hematol. 2012;87(2):139–144. doi:10.1002/ajh.22205
   PubMed Web of Science ®Google Scholar
• Ramazzotti A, Pepe A, Positano V, et al. Standardized T2* map of a normal human heart to correct T2* segmental artefacts; myocardial iron overload and fibrosis in thalassemia intermedia versus thalassemia major patients and electrocardiogram changes in thalassemia major patients. Hemoglobin. 2008;32(1–2):97–107. doi:10.1080/03630260701879514
   PubMed Web of Science ®Google Scholar
• Ghadiri Anari A, Ghiliyan R, Rezaeian G. P-wave Dispersion in patients with major Thalassemia. Iran J Pediatr Hematol Oncol. 2012;2(2):67–71.
   Google Scholar
• Nisli K, Taner Y, Naci O, et al. Electrocardiographic markers for the early detection of cardiac disease in patients with beta-thalassemia major. J Pediatr. 2010;86:159–162. doi:10.2223/JPED.1982
   Web of Science ®Google Scholar
• Garadah TS, Mahdi N, Kassab S, Shoroqi IA, Abu-Taleb A, Jamsheer A. The pro-BNP serum level and echocardiographic tissue Doppler abnormalities in patients with beta thalassemia major. Clin Med Insights Cardiol. 2010;4:135–141. doi:10.4137/CMC.S6452
   PubMedGoogle Scholar
• Kremastinos DT, Tsiapras DP, Kostopoulou AG, Hamodraka ES, Chaidaroglou AS, Kapsali ED. NT‐proBNP levels and diastolic dysfunction in β‐Thalassaemia major patients. Eur J Heart Fail. 2007;9(5):531–536. doi:10.1016/j.ejheart.2006.11.004
   PubMed Web of Science ®Google Scholar
• Deraz SE, Abd El Naby SA, Mahmoud AA. Assessment of ventricular dysfunction in Egyptian children with Beta-thalassemia major. Hematol Oncol Stem Cell Ther. 2021;14(3):206–213. doi:10.1016/j.hemonc.2020.07.003
   PubMedGoogle Scholar
• Bosi G, Crepaz R, Gamberini MR, et al. Left ventricular remodelling, and systolic and diastolic function in young adults with β thalassaemia major: a Doppler echocardiographic assessment and correlation with haematological data. Heart. 2003;89(7):762–766. doi:10.1136/heart.89.7.762
   PubMed Web of Science ®Google Scholar
• Huttin O, Kobayashi M, Ferreira JP, et al. Circulating multimarker approach to identify patients with preclinical left ventricular remodelling and/or diastolic dysfunction. ESC Heart Failure. 2021;8(2):1700–1705. doi:10.1002/ehf2.13203
   PubMed Web of Science ®Google Scholar
• Nagueh SF. Left ventricular diastolic function: understanding pathophysiology, diagnosis, and prognosis with echocardiography. JACC Cardiovasc Imaging. 2020;13(1Part 2):228–244. doi:10.1016/j.jcmg.2018.10.038
   PubMed Web of Science ®Google Scholar
• Sahin C, Basaran O, Altun I, et al. Assessment of myocardial performance index and aortic elasticity in patients with beta-thalassemia major. J Clin Med Res. 2015;7(10):795–801. doi:10.14740/jocmr2293w
   PubMedGoogle Scholar
• Majd Z, Haghpanah S, Ajami GH, et al. Serum ferritin levels correlation with heart and liver MRI and LIC in patients with transfusion-dependent thalassemia. Iran Red Crescent Med J. 2015;17(4):e24959. doi:10.5812/ircmj.17(4)2015.24959
   PubMed Web of Science ®Google Scholar
• Eghbali A, Taherahmadi H, Shahbazi M, Bagheri B, Ebrahimi L. Association between serum ferritin level, cardiac and hepatic T2-star MRI in patients with major β-thalassemia. Iran J Pediatr Hematol Oncol. 2014;4(1):17–21.
   PubMedGoogle Scholar