Association of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Diabetic Kidney Disease in Chinese Patients with Type 2 Diabetes: A Cross-Sectional Study

References

• Alicic RZ, Rooney MT, Tuttle KR. Diabetic kidney disease: challenges, progress, and possibilities. Clin J Am Soc Nephrol. 2017;12(12):2032–2045. doi:10.2215/CJN.11491116
   PubMed Web of Science ®Google Scholar
• Pálsson R, Patel UD. Cardiovascular complications of diabetic kidney disease. Adv Chronic Kidney Dis. 2014;21(3):273–280. doi:10.1053/j.ackd.2014.03.003
   PubMed Web of Science ®Google Scholar
• Wada J, Makino H. Inflammation and the pathogenesis of diabetic nephropathy. Clin Sci. 2013;124(3):139–152. doi:10.1042/CS20120198
   PubMed Web of Science ®Google Scholar
• Yaribeygi H, Atkin SL, Sahebkar A. Interleukin-18 and diabetic nephropathy: a review. J Cell Physiol. 2019;234(5):5674–5682. doi:10.1002/jcp.27427
   PubMed Web of Science ®Google Scholar
• Matoba K, Takeda Y, Nagai Y, Kawanami D, Utsunomiya K, Nishimura R. Unraveling the role of inflammation in the pathogenesis of diabetic kidney disease. Int J Mol Sci. 2019;20(14):3393. doi:10.3390/ijms20143393
   PubMed Web of Science ®Google Scholar
• Jung SW, Moon JY. The role of inflammation in diabetic kidney disease. Korean J Intern Med. 2021;36(4):753–766. doi:10.3904/kjim.2021.174
   PubMed Web of Science ®Google Scholar
• Bilgin S, Aktas G, Zahid Kocak M, et al. Association between novel inflammatory markers derived from hemogram indices and metabolic parameters in type 2 diabetic men. Aging Male. 2020;23(5):923–927. doi:10.1080/13685538.2019.1632283
   PubMed Web of Science ®Google Scholar
• Boralkar KA, Kobayashi Y, Amsallem M, et al. Value of neutrophil to lymphocyte ratio and its trajectory in patients hospitalized with acute heart failure and preserved ejection fraction. Am J Cardiol. 2020;125(2):229–235. doi:10.1016/j.amjcard.2019.10.020
   PubMed Web of Science ®Google Scholar
• Chen W, Chen K, Xu Z, et al. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio predict mortality in patients with diabetic foot ulcers undergoing amputations. Diabetes Metab Syndr Obes. 2021;14:821–829. doi:10.2147/DMSO.S284583
   PubMed Web of Science ®Google Scholar
• Jeong Y, Jeon SR, Kim HG, et al. The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis. Intest Res. 2021;19(1):62–70. doi:10.5217/ir.2019.09156
   PubMed Web of Science ®Google Scholar
• Khalid A, Ali Jaffar M, Khan T, et al. Hematological and biochemical parameters as diagnostic and prognostic markers in SARS-COV-2 infected patients of Pakistan: a retrospective comparative analysis. Hematology. 2021;26(1):529–542. doi:10.1080/16078454.2021.1950898
   PubMed Web of Science ®Google Scholar
• Onalan E, Dönder E. Neutrophil and platelet to lymphocyte ratio in patients with hypothyroid Hashimoto’s thyroiditis. Acta Biomed. 2020;91(2):310–314. doi:10.23750/abm.v91i2.8592
   PubMedGoogle Scholar
• Aktas G. Hematological predictors of novel Coronavirus infection. Rev Assoc Med Bras. 2021;67(Suppl 1):1–2. doi:10.1590/1806-9282.67.suppl1.20200678
   PubMed Web of Science ®Google Scholar
• Atak B, Aktas G, Duman TT, Erkus E, Kocak MZ, Savli H. Diabetes control could through platelet-to-lymphocyte ratio in hemograms. Rev Assoc Med Bras. 2019;65(1):38–42. doi:10.1590/1806-9282.65.1.38
   PubMed Web of Science ®Google Scholar
• Hirahara T, Arigami T, Yanagita S, et al. Combined neutrophil-lymphocyte ratio and platelet-lymphocyte ratio predicts chemotherapy response and prognosis in patients with advanced gastric cancer. BMC Cancer. 2019;19(1):672. doi:10.1186/s12885-019-5903-y
   PubMed Web of Science ®Google Scholar
• Kosekli MA. Mean platelet volume and platelet to lymphocyte count ratio are associated with hepatitis B-related liver fibrosis. Eur J Gastroenterol Hepatol. 2022;34(3):324–327. doi:10.1097/MEG.0000000000002219
   PubMed Web of Science ®Google Scholar
• Caramori ML, Chan JC, Heerspink HJ. KDIGO 2020 clinical practice guideline for diabetes management in chronic kidney disease. Kidney Int. 2020;98(4s):S1–S115. doi:10.1016/j.kint.2020.06.019
   PubMedGoogle Scholar
• Sudchada P, Laehn S. Comparisons of GFR estimation using the CKD Epidemiology Collaboration (CKD-EPI) equation and other creatinine-based equations in Asian population: a systematic review. Int Urol Nephrol. 2016;48(9):1511–1517. doi:10.1007/s11255-016-1357-1
   PubMed Web of Science ®Google Scholar
• Bilgin S, Kurtkulagi O, Atak Tel BM, et al. Does C-reactive protein to serum Albumin Ratio correlate with diabEtic nephropathy in patients with Type 2 dIabetes MEllitus? The CARE TIME study. Prim Care Diabetes. 2021;15(6):1071–1074. doi:10.1016/j.pcd.2021.08.015
   PubMed Web of Science ®Google Scholar
• Wang K, Xu W, Zha B, Shi J, Wu G, Ding H. Fibrinogen to albumin ratio as an independent risk factor for type 2 diabetic kidney disease. Diabetes Metab Syndr Obes. 2021;14:4557–4567. doi:10.2147/DMSO.S337986
   PubMed Web of Science ®Google Scholar
• Kocak MZ, Aktas G, Duman TT, et al. Monocyte lymphocyte ratio as a predictor of diabetic kidney injury in type 2 diabetes mellitus; The MADKID Study. J Diabetes Metab Disord. 2020;19(2):997–1002. doi:10.1007/s40200-020-00595-0
   PubMed Web of Science ®Google Scholar
• Wang JR, Chen Z, Yang K, et al. Association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and diabetic retinopathy among diabetic patients without a related family history. Diabetol Metab Syndr. 2020;12:55. doi:10.1186/s13098-020-00562-y
   PubMed Web of Science ®Google Scholar
• Zahorec R. Neutrophil-to-lymphocyte ratio, past, present and future perspectives. Bratisl Lek Listy. 2021;122(7):474–488. doi:10.4149/BLL_2021_078
   PubMed Web of Science ®Google Scholar
• Ciray H, Aksoy AH, Ulu N, Cizmecioglu A, Gaipov A, Solak Y. Nephropathy, but not angiographically proven retinopathy, is associated with neutrophil to lymphocyte ratio in patients with type 2 diabetes. Exp Clin Endocrinol Diabetes. 2015;123(5):267–271. doi:10.1055/s-0035-1547257
   PubMed Web of Science ®Google Scholar
• Wan H, Wang Y, Fang S, et al. Associations between the neutrophil-to-lymphocyte ratio and diabetic complications in adults with diabetes: a cross-sectional study. J Diabetes Res. 2020;2020:6219545. doi:10.1155/2020/6219545
   PubMed Web of Science ®Google Scholar
• Huang W, Huang J, Liu Q, et al. Neutrophil-lymphocyte ratio is a reliable predictive marker for early-stage diabetic nephropathy. Clin Endocrinol. 2015;82(2):229–233. doi:10.1111/cen.12576
   PubMed Web of Science ®Google Scholar
• Onalan E, Gozel N, Donder E. Can hematological parameters in type 2 diabetes predict microvascular complication development? Pak J Med Sci. 2019;35(6):1511–1515. doi:10.12669/pjms.35.6.1150
   PubMed Web of Science ®Google Scholar
• Duan S, Sun L, Zhang C, et al. Association of platelet-to-lymphocyte ratio with kidney clinicopathologic features and renal outcomes in patients with diabetic kidney disease. Int Immunopharmacol. 2021;93:107413. doi:10.1016/j.intimp.2021.107413
   PubMed Web of Science ®Google Scholar
• Milas O, Gadalean F, Vlad A, et al. Pro-inflammatory cytokines are associated with podocyte damage and proximal tubular dysfunction in the early stage of diabetic kidney disease in type 2 diabetes mellitus patients. J Diabetes Complications. 2020;34(2):107479. doi:10.1016/j.jdiacomp.2019.107479
   PubMed Web of Science ®Google Scholar
• Liew PX, Kubes P. The neutrophil’s role during health and disease. Physiol Rev. 2019;99(2):1223–1248. doi:10.1152/physrev.00012.2018
   PubMed Web of Science ®Google Scholar
• Tesch GH. Diabetic nephropathy - is this an immune disorder? Clin Sci. 2017;131(16):2183–2199. doi:10.1042/CS20160636
   PubMed Web of Science ®Google Scholar
• Repsold L, Joubert AM. Platelet function, role in thrombosis, inflammation, and consequences in chronic myeloproliferative disorders. Cells. 2021;10(11):3034. doi:10.3390/cells10113034
   PubMed Web of Science ®Google Scholar
• Qin B, Ma N, Tang Q, et al. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients. Mod Rheumatol. 2016;26(3):372–376. doi:10.3109/14397595.2015.1091136
   PubMed Web of Science ®Google Scholar
• Targońska-Stępniak B, Zwolak R, Piotrowski M, Grzechnik K, Majdan M. The relationship between hematological markers of systemic inflammation (neutrophil-to-lymphocyte, platelet-to-lymphocyte, lymphocyte-to-monocyte ratios) and ultrasound disease activity parameters in patients with rheumatoid arthritis. J Clin Med. 2020;9(9):2760. doi:10.3390/jcm9092760
   PubMed Web of Science ®Google Scholar
• Zhang Y, Ma KL, Gong YX, et al. Platelet microparticles mediate glomerular endothelial injury in early diabetic nephropathy. J Am Soc Nephrol. 2018;29(11):2671–2695. doi:10.1681/ASN.2018040368
   PubMed Web of Science ®Google Scholar
• Kaur R, Kaur M, Singh J. Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies. Cardiovasc Diabetol. 2018;17(1):121. doi:10.1186/s12933-018-0763-3
   PubMed Web of Science ®Google Scholar
• Bharath LP, Nikolajczyk BS. The intersection of metformin and inflammation. Am J Physiol Cell Physiol. 2021;320(5):C873–C879. doi:10.1152/ajpcell.00604.2020
   PubMed Web of Science ®Google Scholar
• Heerspink HJL, Perco P, Mulder S, et al. Canagliflozin reduces inflammation and fibrosis biomarkers: a potential mechanism of action for beneficial effects of SGLT2 inhibitors in diabetic kidney disease. Diabetologia. 2019;62(7):1154–1166. doi:10.1007/s00125-019-4859-4
   PubMed Web of Science ®Google Scholar
• Kawanami D, Matoba K, Sango K, Utsunomiya K. Incretin-based therapies for diabetic complications: basic mechanisms and clinical evidence. Int J Mol Sci. 2016;17(8):1223. doi:10.3390/ijms17081223
   PubMed Web of Science ®Google Scholar