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Review

Role of tipranavir in treatment of patients with multidrug-resistant HIV

, , , &
Pages 431-441 | Published online: 23 Sep 2010

References

  • World Health OrganizationWorld Health Statistics 2009: Cause of specific mortality and morbidity Available at: http://www.who.int/whosis/whostat/EN_WHS09_Table2.pdfAccessed on Dec 6, 2009
  • Department of Health and Human Services, Centers for Disease Control and PreventionCases of HIV infection and AIDS in the United States and Dependent Areas, 2007HIV/AIDS surveillance report200719163
  • WheelerWMahleKBodnarUAntiretroviral drug resistance mutations and subtypes in drug-naïve persons newly diagnosed with HIV-1 infection, United States, Mar 2003–Oct 200614th Conference on Retroviruses and Opportunistic Infections (CROI 2007)2007 Feb 25–28Los Angeles, CA
  • VianiRPeraltaAAldrovandiGPrevalence of primary HIV drug resistance among recently infected adolescents; a multicenter adolescent trials network study: ATN02913th Conference on Retroviruses and Opportunistic Infections (CROI 2007)2006 Feb 5–8Denver, CO
  • HuDJDonderoTJRayfieldMAThe emerging genetic diversity of HIV-the importance of global surveillance for diagnostics, research, and preventionJAMA1996275932102168604174
  • Panel on Antiretroviral Guidelines for Adults and AdolescentsGuidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescentsDepartment of Health and Human Services20091211161 Available at: http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdfAccessed on: Apr 14, 2009
  • Working Group on Antiretroviral Therapy and Medical Management of HIV-Infected ChildrenGuidelines for the use of antiretroviral agents in pediatric HIV infection20092231139 Available at: http://aidsinfo.nih.gov/ContentFiles/PediatricGuidelines.pdfAccessed on Apr 20, 2009
  • JohnsonVABrun-VézinetFClotetBUpdate of the drug resistance mutations in HIV-1: Dec 2008Top HIV Med200816513814519106428
  • SchmidtBWalterHMoschikBSimple algorithm derived from a geno-/phenotypic database to predict HIV-1 protease inhibitor resistanceAIDS200014121731173810985309
  • MeynardJLVrayMMorand-JoubertLPhenotypic or genotypic resistance testing for choosing antiretroviral therapy after treatment failure: A randomized trialAIDS200216572773611964529
  • VrayMMeynardJLDalbanCPredictors of the virological response to a change in the antiretroviral treatment regimen in HIV-1-infected patients enrolled in a randomized trial comparing genotyping, phenotyping and standard of care (Narval trial, ANRS 088)Antivir Ther20038542743414640390
  • HalesGBirchCCroweSA randomised trial comparing genotypic and virtual phenotypic interpretation of HIV-drug resistance: The CREST StudyPLoS Clin Trials20061319
  • RomanelliFPomeroyCHuman immunodeficiency virus drug resistance testing: State of the art in genotypic and phenotypic testing of antiretroviralsPharmacotherapy200020215115710678293
  • ReevesJDPieferAJEmerging drug targets for antiretroviral therapyDrugs200565131747176616114975
  • DomsRWPeiperSCUnwelcomed guests with master keys: How HIV uses chemokine receptors for cellular entryVirology199723521791909281497
  • GulickRMLelezariJGoodrichJMaraviroc for previously treated patients with R5 HIV-1 infectionN Engl J Med200835914142944118832244
  • WoodAArmourDThe discovery of the CCR5 receptor antagonist, UK-427,857, a new agent for the treatment of HIV infection and AIDSProg Med Chem20054323927115850827
  • Fda.gov [homepage on Internet]Silver Spring, MDU.S. Food and Drug Administration Available from: http://www.fda.gov/Accessed on Jun 16, 2010
  • Emea.europa.eu [homepage on the Internet]LondonEuropean Medicines Agencyc1995 [updated 2009 Apr 30]. Available from: http://www.emea.europa.eu/Accessed on May 6, 2009
  • PfizerAn open label pharmacokinetic, safety and efficacy study of maraviroc in combination with background therapy for the treatment of HIV-1 infected, CCR5ClinicalTrials.gov [Internet]Bethesda, MDNational Library of Medicine (US)c2000 [updated 2009 May 5]. Available from: http://clinicaltrials.gov/ct2/show/NCT00791700: NCT00791700Accessed on May 8, 2009
  • YoungWMonogram Biosciences introduces new co-receptor tropism assay, profile, availability82007 Available from: http://www.natap.org/2007/HIV/082107_04.htmAccessed on Jun 21, 2009
  • WildCTShugarsDCGreenwellTKMcDanalCBMatthewsTJPeptides corresponding to a predictive α–helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infectionProc Natl Acad Sci U S A19949121977097747937889
  • LalezariJPHenryKO’HearnMEnfuvirtide, an HIV-1 fusion inhibitor for drug-resistant HIV infection in North and South AmericaN Engl J Med2003348222175218512637625
  • LazzarinAClotetBCooperDEfficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and AustraliaN Engl J Med2003348222186219512773645
  • NelsonMArastéhKClotetBDurable efficacy of enfuvirtide over 48 weeks in heavily treatment-experienced HIV-1 infected patients in the T-20 versus optimized background regimen only 1 and 2 clinical trialsJ Acquir Immune Defic Syndr200540440441216280694
  • XuLPozniakAWildfireAEmergence and evolution of enfuvirtide resistance following long-term therapy involves heptad repeat 2 mutations within gp41Antimicrob Agents Chemother20054931113111915728911
  • SuCMelbyTDeMasiRRavindranPHeilek-SnyderGGenotypic changes in human immunodeficiency virus type 1 envelope glycoproteins on treatment with the fusion inhibitor enfuvirtide and their influence on changes in drug susceptibility in vitroJ Clin Virol200636424925716765082
  • TrottierBWalmsleySReynesJSafety of enfuvirtide in combination with an optimized background of antiretrovirals in treatment-experienced HIV-1infected adults over 48 weeksJ Acquir Immune Defic Syndr200540441342116280695
  • MitsuyaHWeinholdKJFurmanPA3′-Azido-3′-deoxythymidine (BW A509U): An antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy- associated virus in vitroProc Natl Acad Sci U S A19858220709671002413459
  • TramontanoEPirasGMellorsJWPutzoluMBazmiHZLa CollaPBiochemical characterization of HIV-1 reverse transcriptases encoding mutations at amino acid residues 161 and 208 involved in resistance to phosphonoformateBiochem Pharmacol19985612158315899973178
  • RahimSFredrickLMda SilvaBABernsteinBKingMSGeographic and temporal trends of transmitted HIV-1 drug resistance among antiretroviral-naïve subjects screening for two clinical trials in North America and Western EuropeHIV Clin Trials20091029410319487179
  • MerluzziVJHargraveKDLabadiaMInhibition of replication by a non-nucleoside reverse transcriptase inhibitorScience19902504986141114131701568
  • RenJStammersDKStructural basis for drug resistance mechanisms for non-nucleoside inhibitors of HIV reverse transcriptaseVirus Res200813415717018313784
  • NadlerJPBergerDSBlickGEfficacy and safety of etravirine (TMC125) in patients with highly resistant HIV-1: Primary 24-week analysisAIDS200721611017148962
  • MadrugaJVCahnPGrinsztejnBEfficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomized, double-blind, placebo-controlled trialLancet20073709581293817617270
  • CohenCJBergerDSBlickGEfficacy and safety of etravirine (TMC125) in treatment-experienced HIV-1-infected patients: 48-week results of a phase IIb trialAIDS200923342343119114852
  • LazzarinACampbellTClotetBEfficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomized, double-blind, placebocontrolled trialLancet20073709581394817617271
  • LatailladeMKozalMJThe hunt for HIV-1 integrase inhibitorsAIDS Patient Care STDS200620748950116839248
  • JegedeOBabuJdi SantoRHIV type 1 integrase inhibitors: From basic research to clinical implicationsAIDS Rev200810317218918820719
  • SteigbigelRTCooperDAKumarPNRaltegravir with optimized background therapy for resistant HIV-1 infectionN Engl J Med2008359433935418650512
  • CooperDASteigbigelRTGatellJMSubgroup and resistance analyses of raltegravir for resistant HIV-1 infectionN Engl J Med2008359435536518650513
  • SiskindRClinicalTrials.gov [Internet]Safety and effectiveness of raltegravir (MK-0518) in treatment-experienced, HIV-infected children and adolescentsBethesda, MDNational Library of Medicine (US)c2000 [updated March 9, 2009]. Available from: http://clinicaltrials.gov/ct2/show/NCT00485264Accessed on May 6, 2009
  • RobertsNAMartinJAKinchingtonDRational design of peptide-based HIV proteinase inhibitorsScience199024849533583612183354
  • PetersonMLWangYvan der LaanMJVirologic efficacy of boosted double versus boosted single protease inhibitor therapyAIDS200721121547155417630549
  • GallantJEProtease-inhibitor boosting in the treatment-experienced patientsAIDS Rev20046422623315700621
  • SensionMPilieroPJRitonavir-boosted protease inhibitors: Impact of ritonavir on toxicities in treatment-experienced patientsJ Assoc Nurses AIDS Care2007181364717338984
  • ChenZLiYSchockHBHallDChenEKuoLCThree-dimensional structure of a mutant HIV-1 protease displaying cross-resistance to all protease inhibitors in clinical trialsJ Biol Chem19952703721433214367665551
  • ClotetBBellosNMolinaJEfficacy and safety of darunavirritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: A pooled subgroup analysis of data from two randomised trialsLancet200736995681169117817416261
  • de MeyerSVangeneugdenTvan BaelenBResistance profile of darunavir: Combined 24-week results from the POWER trialsAIDS Res Hum Retroviruses200824337938818327986
  • KingNMPrabu-JeyabalanMNalivaikaEAWigerinckPde BéthuneMPSchifferCAStructural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitorJ Virol20047821120121202115479840
  • TieYBorossPIWangYFHigh resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strainsJ Mol Biol2004338234135215066436
  • Prestiza® healthcare professionals full prescribing information32009 Available from: http://www.prezista.com/prezista/hcp/full_prescribing_information.htmlAccessed on Jul 31, 2009
  • MadrugaJVBergerDMcMurchieMEfficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: A randomised controlled phase III trialLancet20073709581495817617272
  • TurnerSRStrobachJWTommasiRATipranavir (PNU-140690): A potent, orally bioavailable nonpeptidic HIV protease inhibitor of the 5,6-dihydro-4-hydroxy-2-pyrone sulfonamide classJ Med Chem19984118346734769719600
  • KohYDasDAmanoMNon-peptidyl small molecule protease dimerization inhibitors (PDIs): Molecular and structural ananlysis of their HIV-1 inhibition and interactions with protease monomer subunit15th Conference on Retroviruses and Opportunistic Infections (CROI 2008)2008 Feb 3–6Boston, MA
  • PoppeSMSladeDEChongKTAntiviral activity of the dihydropyrone PNU-140690, a new nonpeptidic human immunodeficiency virus protease inhibitorAntimicrob Agents Chemother1997415105810639145869
  • MazzaFTronconiEValeroAThe non-peptidic HIV protease inhibitor tipranavir and two synthetic peptidomimetics (TS98 and TS102) modulate Pneumocystis carinii growth and proteasome activity of HEL299 cell lineJ Eukaryot Microbiol200653Suppl 1S144S14617169036
  • SquiresKMcCallisterSLazzarinATipranavir/ritonavir (TPV/r) demonstrates a robust resistance profile in multiple protease inhibitor-experienced patients: Correlation of baseline genotype and antiviral activity in BI 1182.52The 2nd IAS conference on HIV pathogenesis and treatment (IAS 2003)2003 Jul 13–16Paris, France
  • MacArthurRDRichmondDCraneLRTipranavir/ritonavir: Derivation of doses that achieve effective plasma concentrations above the IC50 for multiple PI-resistantHIV-1 viruses8th International Congress on Drug Therapy in HIV Infection (HIV 2006)2006 Nov 12–16Glasgow, Scotland
  • ParkinNChappeyCProtease mutations associated with higher or lower than expected tipranavir (TPV) susceptibility based on the TPV mutation score13th Conference on Retroviruses and Opportunistic Infections (CROI 2006)2006 Feb 5Denver, CO
  • YeniPMacGregorTGatheJCorrelation of viral load reduction and plasma levels in multiple protease inhibitor experienced patients taking tipranavir/ritonavir in a Phase IIB trial: BI 1182.5210th Conference on Retroviruses and Opportunistic Infections (CROI 2003)2003 Feb 10–14Boston, MA
  • MorelloJGarcía-GascóPRodríguez-NovoaSUsefulness of the genotypic inhibitory quotient in HIV patients treated with tipranavirThe 4th IAS conference on HIV pathogenesis and treatment (IAS 2007)2007 Jul 22–25Sydney, Australia
  • BonoraSde RequenaDGCalcagnoATipranavir (TPV) genotypic inhibitory quotient (gIQ) predicts early virological response to TPV-based salvage regimens13th Conference on Retroviruses and Opportunistic Infections (CROI 2006)2006 Feb 5–8Denver, CO
  • MorseGDCatanzaroLMAcostaEPClinical pharmacodynamics of HIV-1 protease inhibitors: Use of inhibitory quotients to optimize pharmacotherapyLancet200664215225
  • HicksCBCahnPCooperDADurable efficacy of tipranavir-ritonavir in combination with an optimised background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at 48 weeks in the Randomized Evaluation of Strategic Intervention in multi-drug reSistant patients with Tipranavir (RESIST) studies: An analysis of combined data from two randomised open-label trialsLancet2006368953446647516890833
  • de RequenaDGBonoraSCalcagnoATipranavir (TPV) genotypic inhibitory quotient predicts virological response at 48 weeks to TPV-based salvage regimensAntimicrob Agents Chemother20085231066107118160524
  • SalazarJCCahnPNegraMDPredictors of response to TPV/r in pediatric patients: Results of BI1182.14/PACTG105114th Conference on Retroviruses and Opportunistic Infections (CROI 2007)2006 Feb 25–28Los Angeles, CA
  • MayersDLKohlbrennerVMDohnanyilCThe inhibitory quotient (IQ) of tipranavir/ritonavir (tpv/r) in triple class experienced HIV+ patients: Results from bi 1182.52The 2nd IAS conference on HIV pathogenesis and treatment (IAS 2003)2003 Jul 13–16Paris, France
  • ValdezHMcCallisterSKohlbrennerVMayersDTipranavir/ritonavir (TPV/r) 500 mg/200 mg BID drives week 24 viral load (VL) below 400 copies/mL when combined with a second active drug (T-20) in protease inhibitor experienced HIV+ patientsThe 3rd IAS conference on HIV pathogenesis and treatment (IAS 2005)2005 Jul 24–27Rio de Janeiro, Brazil
  • NaegerLKZhengJJStrubleKAVirologic response to tipranavir based on plasma concentration (Cmin) and baseline resistance parameters13th Conference on Retroviruses and Opportunistic Infections (CROI 2006)2006 Feb 5–8Denver, CO
  • FlexnerCBateGKirkpatrickPTipranavirNat Rev Drug Discov200541295595616370086
  • McCallisterSValdezHCurryKA 14-day dose-response study of the efficacy, safety, and pharmacokinetics of the nonpeptidic protease inhibitor tipranavir in treatment-naive HIV-1-infected patientsJ Acquir Immune Defic Syndr200435437638215097154
  • VourvahisMDumondJPattersonKEffects of tipranavir/ritonavir (TPV/r) on the activity of hepatic and intestinal cytochrome P450 3A4/5 and P-glycoprotein (P-gp): Implications for drug interactions14th Conference on Retroviruses and Opportunistic Infections (CROI 2007)2007 Feb 25–28Los Angeles, CA
  • BaldwinJRBoronMTWangJSchneckDWHopkinsNKEffects of food and antacid on bioavailability of the protease inhibitor PNU- 140690 in healthy volunteers5th Conference on Retroviruses and Opportunistic Infections (CROI 1998)1998 Feb 1–5Chicago, IL
  • SaboJPHuettnerSMacGregorTRWruckJEvaluation of the bioavailability of tipranavir/ritonavir (TPV/r) 500 mg/200 mg oral solution (OS): Comparison to TPV capsules and the influence of food intake in healthy volunteers6th International Workshop on Clinical Pharmacology of HIV Therapy (NATP 2005)2005 Apr 28–30Québec City, Canada
  • GatheJCooperDAFarthingCEfficacy of the protease inhibitors tipranavir plus ritonavir in treatment-experienced patients: 24-week analysis from the RESIST-1 trialClin Infect Dis200643101337134617051503
  • CahnPVillacianJLazzarinARitonavir-boosted tipranavir demonstrates superior efficacy to ritonavir-boosted protease inhibitors in treatment-experienced HIV-infected patients: 24-week results of the RESIST-2 trial2006431013471356
  • SalazarJCCahnPYogevREfficacy, safety and tolerability of tipranavir coadministered with ritonavir in HIV-1 infected children and adolescentsAIDS200822141789179818753862
  • SalazarJCCahnPGiaquintoCYogevRMiklJEfficacy and safety profile of APTIVUS oral solution or capsules co-administered with low dose ritonavir (APTIVUS/r) in treatment experienced children and teenagers after two years of treatment (Phase I/IIa study)XVII International AIDS Conference (AIDS 2008)2008 Aug 3–8Mexico City, Mexico
  • Division of AIDS table for grading the severity of adult and pediatric adverse events version 1.0122004 Available from: http://www3.niaid.nih.gov/LabsAndResources/resources/DAIDSClinRsrch/PDF/DAIDSAEGradingTable.pdfAccessed on May 5, 2009
  • HuangICWuAWFinnernHWThijsHGatheJCFaircloughDLHealth-related quality of life and tolerability in treatment-experienced HIV-1-infected patients on tipranavir versus comparator regimensAntivir Ther2008131152518389895