63
Views
7
CrossRef citations to date
0
Altmetric
Review

Profile of saxagliptin in the treatment of type 2 diabetes: focus on Japanese patients

, , , , , , , , , , & show all
Pages 547-558 | Published online: 11 Jul 2014

References

  • International Diabetes AssociationThe global burden, diabetes and impaired glucose tolerance Available from: https://www.idf.org/sites/default/files/The_Global_Burden.pdfAccessed June 9, 2014
  • International Diabetes AssociationThe global burden, mortalityIDF Diabetes Atlas6th ed Available from: http://www.idf.org/diabetesatlas/global-burdenAccessed June 9, 2014
  • HolzGG4thKühtreiberWMHabenerJFPancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1 (7–37)Nature199336164103623658381211
  • FreemanJSThe pathophysiologic role of incretinsJ Am Osteopath Assoc2007107 SupplS6S917724014
  • NauckMABallerBMeierJJGastric inhibitory polypeptide and glucagon-like peptide-1 in the pathogenesis of type 2 diabetesDiabetes200453 Suppl 3S190S19615561910
  • AhrénBFoleyJEThe islet enhancer vildagliptin: mechanisms of improved glucose metabolismInt J Clin Pract Suppl200815981418269436
  • BanerjeeMYounisNSoranHVildagliptin in clinical practice: a review of literatureExpert Opin Pharmacother200910162745275719874253
  • PalalauAITahraniAAPiyaMKBarnettAHDPP-4 inhibitors in clinical practicePostgrad Med200912167010019940419
  • NambaMKatsunoTKusunokiYMatsuoTMiuchiMMiyagawaJNew strategy for the treatment of type 2 diabetes mellitus with incretin-based therapyClin Exp Nephrol2013171101523135865
  • KonyaHTsunodaTKamitaniMAdd-on effect of sitagliptin in an obese type 2 diabetic patient with glimepiride and metformin on blood glucose control and incretin responseJ Diabetes Invest20123 Suppl 1S206
  • KatsunoTIkedaHIdaKMiyagawaJNambaMAdd-on therapy with the DPP-4 inhibitor sitagliptin improves glycemic control in insulin-treated Japanese patients with type 2 diabetes mellitusEndocr J201360673374223386390
  • KusunokiYKatsunoTMyojinMEffect of additional administration of acarbose on blood glucose fluctuations and postprandial hyperglycemia in patients with type 2 diabetes mellitus under treatment with alogliptinEndocr J201360443143923220949
  • ThornberryNAGallwitzBMechanism of action of inhibitors of dipeptidyl-peptidase-4 (DPP-4)Best Pract Res Clin Endocrinol Metab200923447948619748065
  • Onglyza® (saxagliptin) Full prescribing informationPrinceton, NJ, USAWilmington, DE. Bristol-Myers Sqibb/AstraZeneca Pharmaceuticals LP2009
  • RosenstockJAguilar-SalinasCKleinENepalSListJChenREffect of saxagliptin monotherapy in treatment-naive patients with type 2 diabetesCurr Med Res Opin200925102401241119650754
  • DeFronzoRHissaMNGarberAJOnce-daily saxagliptin added to metformin provides sustained glycemic control and is well tolerated over 102 weeks in patients with type 2 diabetesDiabetes200958 Suppl 1547P
  • ChacraARTanGHRavichandranSListJChenRCV181-040 InvestigatorsSafety and efficacy of saxagliptin in combination with submaximal sulphonylurea versus up-titrated sulphonylurea over 76 weeksDiab Vasc Dis Res20118215015921562067
  • HollanderPLLiJFrederichRAllenEChenRCV181-013 InvestigatorsSafety and efficacy of saxagliptin added to thiazolidinedione over 76 weeks in patients with type 2 diabetes mellitusDiab Vasc Dis Res20118212513521562064
  • PfütznerAPaz-PachecoEAllenEFrederichBChenRCV181039 InvestigatorsInitial combination therapy with saxagliptin and metformin provides sustained glycaemic control and is well tolerated for up to 76 weeksDiabetes Obes Metab201113656757621342412
  • FrederichRMcNeillRBerglindNFlemingDChenRThe efficacy and safety of the dipeptidyl peptidase-4 inhibitor saxagliptin in treatment-naïve patients with type 2 diabetes mellitus: a randomized controlled trialDiabetol Metab Syndr2012413622828124
  • PoolsupNSuksomboonNSetwiwattanakulWEfficacy of various antidiabetic agents as add-on treatments to metformin in type 2 diabetes mellitus: systematic review and meta-analysisISRN Endocrinol2012201279814622619731
  • GrossJLKramerCKLeitãoCBEffect of antihyperglycemic agents added to metformin and a sulfonylurea on glycemic control and weight gain in type 2 diabetes: a network meta-analysisAnn Intern Med20111541067267921576535
  • PhungOJSobierajDMEngelSSRajpathakSNEarly combination therapy for the treatment of type 2 diabetes mellitus: systematic review and meta-analysisDiabetes Obes Metab201416541041724205921
  • KahnSEThe relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetesDiabetologia200346131912637977
  • MatsumotoKMiyakeSYanoMGlucose tolerance, insulin secretion, and insulin sensitivity in nonobese and obese Japanese subjectsDiabetes Care19972010156215689314636
  • PratleyREWeyerCThe role of impaired early insulin secretion in the pathogenesis of type II diabetes mellitusDiabetologia200244892994511484070
  • FukushimaMSuzukiHSeinoYInsulin secretion capacity in the development from glucose tolerance to type 2 diabetesDiabetes Res Clin Pract200466 Suppl 1S37S4315563978
  • Fukuda-AkitaEOkitaKOkauchiYImpaired early insulin secretion in Japanese type 2 diabetes with metabolic syndromeDiabetes Res Clin Pract200879348248918006169
  • MandavilliACyranoskiDNews feature: Asia’s big problemNat Med200410432532715057217
  • IwahashiHOkauchiYRyoMInsulin-secretion capacity in normal glucose tolerance, impaired glucose tolerance, and diabetes in obese and non-obese Japanese patientsJ Diabetes Invest201233271275
  • IwaoTSakaiKAndoERelative contribution of insulin secretion and sensitivity at different stages of glucose tolerance: non-obese versus obese Japanese subjectsIntern Med201453538339024583424
  • SeinoYFukushimaMYabeDGIP and GLP-1, the two incretin hormones: similarities and differencesJ Diabetes Invest201011–2923
  • ChanCNMalikVJiaWDiabetes in Asia epidemiology, risk factors, and pathophysiologyJAMA2009301202129214019470990
  • ParkHParkCKimYRascatiKLEfficacy and safety of dipeptidyl peptidase-4 inhibitors in type 2 diabetes: meta-analysisAnn Pharmacother201246111453146923136353
  • KimYGHahnSOhTJKwakSHParkKSChoYMDifferences in the glucose-lowering efficacy of dipeptidyl peptidase-4 inhibitors between Asians and non-Asians: a systematic review and meta-analysisDiabetologia201356469670823344728
  • AsoYOzekiNTerasawaTSerum level of soluble CD26/dipeptidyl peptidase-4 (DPP-4) predicts the response to sitagliptin, a DPP-4 inhibitor, in patients with type 2 diabetes controlled inadequately by metformin and/or sulfonylureaTransl Res20121591253122153807
  • HorikawaCYoshimuraYKamadaCDietary intake in Japanese patients with type 2 diabetes: analysis from Japan Diabetes Complications StudyJ Diabetes Investig201452176187
  • WongMCWangHHKwanMWComparative effectiveness of dipeptidyl peptidase-4 (DPP-4) inhibitors and human glucagon-like peptide-1 (GLP-1) analogue as add-on therapies to sulphonylurea among diabetes patients in the Asia-Pacific region: a systematic reviewPLoS One201493e9096324614606
  • KawamoriRDiabetes trends in JapanDiabetes Metab Res Rev200218 Suppl 3S9S1312324979
  • KobayashiMYamazakiKHiraoKThe status of diabetes control and antidiabetic drug therapy in Japan – a cross-sectional survey of 17,000 patients with diabetes mellitus (JDDM 1)Diabetes Res Clin Pract200673219820416621117
  • KozawaJKitamuraTNishizawaHDipeptidyl peptidase-4 inhibitors are effective in Japanese type 2 diabetic patients with sustained endogenous insulin-secreting capacity, a higher body mass index and insulin resistanceJ Diabetes Invest201342190194
  • KadowakiTEfficacy and safety of a novel DPP-4 inhibitor saxagliptin in patients with type 2 diabetes mellitus – the results of clinical trials in JapanJap Pharmacol Ther2013418803815
  • Onglyza® (saxagliptin)A Phase II multiple dose study in Japanese patients. Summary of Product CharacteristicsTokyo, JapanKyowa Hakko Kirin Co, Ltd2009 Available from http://www.kksmile.com/druginfo/interv/ong_in.pdfAccessed June 30, 2014
  • Onglyza® (saxagliptin)A Phase III long-term monotherapy trial in Japanese patients. Summary of Product CharacteristicsTokyo, JapanKyowa Hakko Kirin Co, Ltd2011 Available from http://www.kksmile.com/druginfo/interv/ong_in.pdfAccessed June 30, 2014
  • Onglyza® (saxagliptin)A phase III long-term combination therapy trial in Japanese patients. Summary of Product CharacteristicsTokyo, JapanKyowa Hakko Kirin Co, Ltd2012 Available from http://www.kksmile.com/druginfo/interv/ong_in.pdfAccessed June 30, 2014
  • FrederichRAlexanderJHFiedorekFTA systematic assessment of cardiovascular outcomes in the saxagliptin drug development program for type 2 diabetesPostgrad Med20101223162720463410
  • MosenzonORazISciricaBMBaseline characteristics of the patient population in the Saxagliptin Assessment of Vascular Outcomes Recorded in patients with diabetes mellitus (SAVOR)-TIMI 53 trialDiabetes Metab Res Rev201329541742623564755
  • SciricaBMBhattDLBraunwaldESaxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitusN Engl J Med2013369141317132623992601
  • WhiteWBCannonCPHellerSRAlogliptin after acute coronary syndrome in patients with type 2 diabetesN Engl J Med2013369141327133523992602
  • SchernthanerGSattarNLessons from SAVOR and EXAMINE: some important answers, but many open questionsJ Diabetes Complications2262014 [Epub ahead of print.]
  • ScheenAJCardiovascular effects of dipeptidyl peptidase-4 inhibitors: from risk factors to clinical outcomesPostgrad Med2013125372023748503
  • OuXO’LearyHABroxmeyerHEImplications of DPP4 modification of proteins that regulate stem/progenitor and more mature cell typesBlood2013122216116923637126