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Review

Neural circuits in anxiety and stress disorders: a focused review

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Pages 115-126 | Published online: 23 Jan 2015

References

  • KesslerRCBerglundPDemlerOJinRMerikangasKRWaltersEELifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey ReplicationArch Gen Psychiatry200562659360215939837
  • GreenbergPESisitskyTKesslerRCThe economic burden of anxiety disorders in the 1990sJ Clin Psychiatry199960742743510453795
  • WittchenH-UGeneralized anxiety disorder: prevalence, burden, and cost to societyDepress Anxiety200216416217112497648
  • KesslerRCThe impairments caused by social phobia in the general population: implications for interventionActa Psychiatr Scand Suppl2003108417192712950433
  • American Psychiatric AssociationThe Diagnostic and Statistical Manual of Mental Disorders5th edArlington, VAAmerican Psychiatric Association2013
  • BarlowDHUnraveling the mysteries of anxiety and its disorders from the perspective of emotion theoryAm Psychol200055111247126311280938
  • DavisMWalkerDLMilesLGrillonCPhasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxietyNeuropsychopharmacology201035110513519693004
  • McTeagueLMLangPJThe anxiety spectrum and the reflex physiology of defense: from circumscribed fear to broad distressDepress Anxiety201229426428122511362
  • SchmitzAGrillonCAssessing fear and anxiety in humans using the threat of predictable and unpredictable aversive events (the NPU-threat test)Nat Protoc20127352753222362158
  • LeeSKimS-JKwonO-BLeeJHKimJ-HInhibitory networks of the amygdala for emotional memoryFront Neural Circuits2013712923914157
  • MarenSNeurobiology of Pavlovian fear conditioningAnnu Rev Neurosci200124189793111520922
  • KumarVBhatZAKumarDAnimal models of anxiety: a comprehensive reviewJ Pharmacol Toxicol Methods201368217518323684951
  • ShinLMLiberzonIThe neurocircuitry of fear, stress, and anxiety disordersNeuropsychopharmacology201035116919119625997
  • SteinMBSimmonsANFeinsteinJSPaulusMPIncreased amygdala and insula activation during emotion processing in anxiety-prone subjectsAm J Psychiatry2007164231832717267796
  • ShankmanSAGorkaSMNelsonBDFitzgeraldDAPhanKLO’DalyOAnterior insula responds to temporally unpredictable aversiveness: an fMRI studyNeuroreport201425859660024614364
  • TaugherRJLuYWangYThe bed nucleus of the stria terminalis is critical for anxiety-related behavior evoked by CO2 and acidosisJ Neurosci20143431102471025525080586
  • Kollack-WalkerSWatsonSJAkilHSocial stress in hamsters: defeat activates specific neurocircuits within the brainJ Neurosci1997172288428855 Available from: http://www.ncbi.nlm.nih.gov/pubmed/9348352Accessed October 31, 20149348352
  • DamsaCKoselMMoussallyJCurrent status of brain imaging in anxiety disordersCurr Opin Psychiatry20092219611019122541
  • EngelKBandelowBGruberOWedekindDNeuroimaging in anxiety disordersJ Neural Transm2009116670371618568288
  • LangPJBradleyMMCuthbertBNEmotion, motivation, and anxiety: brain mechanisms and psychophysiologyBiol Psychiatry19984412124812639861468
  • DoehrmannOGhoshSSPolliFEPredicting treatment response in social anxiety disorder from functional magnetic resonance imagingJAMA Psychiatry2013701879722945462
  • KanwisherNMcDermottJChunMMThe fusiform face area: a module in human extrastriate cortex specialized for face perceptionJ Neurosci1997171143024311 Available from: http://www.ncbi.nlm.nih.gov/pubmed/9151747Accessed October 31, 20149151747
  • FrickAHownerKFischerHKristianssonMFurmarkTAltered fusiform connectivity during processing of fearful faces in social anxiety disorderTransl Psychiatry2013310e31224105443
  • BrühlABRuferMDelsignoreAKaffenbergerTJänckeLHerwigUNeural correlates of altered general emotion processing in social anxiety disorderBrain Res20111378728321215728
  • GiménezMPujolJOrtizHAltered brain functional connectivity in relation to perception of scrutiny in social anxiety disorderPsychiatry Res2012202321422322809740
  • CaserasXGiampietroVLamasAThe functional neuroanatomy of blood-injection-injury phobia: a comparison with spider phobics and healthy controlsPsychol Med201040112513419435544
  • HilbertKEvensRMaslowskiNIWittchenHULuekenUFear processing in dental phobia during crossmodal symptom provocation: an fMRI studyBiomed Res Int2014201419635324738049
  • SchweckendiekJKluckenTMerzCJWeaving the (neuronal) web: fear learning in spider phobiaNeuroimage201154168168820673801
  • LuekenUKruschwitzJDMuehlhanMSiegertJHoyerJWittchenH-UHow specific is specific phobia? Different neural response patterns in two subtypes of specific phobiaNeuroimage201156136337221316468
  • PatelRSprengRNShinLMGirardTANeurocircuitry models of posttraumatic stress disorder and beyond: a meta-analysis of functional neuroimaging studiesNeurosci Biobehav Rev20123692130214222766141
  • GiménezMOrtizHSoriano-MasCFunctional effects of chronic paroxetine versus placebo on the fear, stress and anxiety brain circuit in Social Anxiety Disorder: initial validation of an imaging protocol for drug discoveryEur Neuropsychopharmacol201424110511624332890
  • FerryATOngürDAnXPriceJLPrefrontal cortical projections to the striatum in macaque monkeys: evidence for an organization related to prefrontal networksJ Comp Neurol20004253447470 Available from: http://www.ncbi.nlm.nih.gov/pubmed/10972944Accessed October 31, 201410972944
  • HerryCFerragutiFSingewaldNLetzkusJJEhrlichILüthiANeuronal circuits of fear extinctionEur J Neurosci201031459961220384807
  • MarekRStrobelCBredyTWSahPThe amygdala and medial prefrontal cortex: partners in the fear circuitJ Physiol2013591Pt 102381239123420655
  • WhalenPJBushGMcNallyRJThe emotional counting Stroop paradigm: a functional magnetic resonance imaging probe of the anterior cingulate affective divisionBiol Psychiatry19984412121912289861465
  • BoehmeSRitterVTefikowSBrain activation during anticipatory anxiety in social anxiety disorderSoc Cogn Affect Neurosci2014991413141823938870
  • SripadaCAngstadtMLiberzonIMcCabeKPhanKLAberrant reward center response to partner reputation during a social exchange game in generalized social phobiaDepress Anxiety201330435336123576237
  • Del CasaleASerataDRapinesiCStructural neuroimaging in patients with panic disorder: findings and limitations of recent studiesPsychiatr Danub2013252108114 Available from: http://www.ncbi.nlm.nih.gov/pubmed/23793273Accessed October 31, 201423793273
  • KimJEDagerSRLyooIKThe role of the amygdala in the pathophysiology of panic disorder: evidence from neuroimaging studiesBiol Mood Anxiety Disord2012212023168129
  • PannekoekJNvan der WerffSJSteinDJvan der WeeNJAdvances in the neuroimaging of panic disorderHum Psychopharmacol201328660861124038132
  • FislerMSFederspielAHornHSpider phobia is associated with decreased left amygdala volume: a cross-sectional studyBMC Psychiatry20131317023442196
  • MoreyRajendra AGoldAndrea LLaBarKevin SAmygdala volume changes with posttraumatic stress disorder in a large case-controlled veteran groupArch Gen Psychiatry201269111169117823117638
  • SchienleAEbnerFSchäferALocalized gray matter volume abnormalities in generalized anxiety disorderEur Arch Psychiatry Clin Neurosci2011261430330720820793
  • KuoJRKaloupekDGWoodwardSHAmygdala volume in combat-exposed veterans with and without posttraumatic stress disorder: a cross-sectional studyArch Gen Psychiatry201269101080108623026958
  • IrleERuhlederMLangeCReduced amygdalar and hippocampal size in adults with generalized social phobiaJ Psychiatry Neurosci201035212613120184810
  • SyalSHattinghCJFouchéJ-PGrey matter abnormalities in social anxiety disorder: a pilot studyMetab Brain Dis201227329930922527992
  • Machado-de-SousaJPOsórioFLJackowskiAPIncreased amygdalar and hippocampal volumes in young adults with social anxietyPLoS ONE201492e8852324523911
  • LipkaJMiltnerWHRStraubeTVigilance for threat interacts with amygdala responses to subliminal threat cues in specific phobiaBiol Psychiatry201170547247821601831
  • LuekenUHilbertKStolyarVMaslowskiNIBeesdo-BaumKWittchenHUNeural substrates of defensive reactivity in two subtypes of specific phobiaSoc Cogn Affect Neurosci Epub20131114
  • BallTMSullivanSFlaganTSelective effects of social anxiety, anxiety sensitivity, and negative affectivity on the neural bases of emotional face processingNeuroimage20125921879188721920442
  • KlumppHAngstadtMNathanPJPhanKLAmygdala reactivity to faces at varying intensities of threat in generalized social phobia: an event-related functional MRI studyPsychiatry Res2010183216716920609570
  • SchmidtSMohrAMiltnerWHRStraubeTTask-dependent neural correlates of the processing of verbal threat-related stimuli in social phobiaBiol Psychol201084230431220227458
  • MiladMRPitmanRKEllisCBNeurobiological basis of failure to recall extinction memory in posttraumatic stress disorderBiol Psychiatry200966121075108219748076
  • ShvilERuschHLSullivanGMNeriaYNeural, psychophysiological, and behavioral markers of fear processing in PTSD: a review of the literatureCurr Psychiatry Rep201315535837423619614
  • LabuschagneIPhanKLWoodAOxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorderNeuropsychopharmacology201035122403241320720535
  • MånssonKNTCarlbringPFrickAAltered neural correlates of affective processing after internet-delivered cognitive behavior therapy for social anxiety disorderPsychiatry Res2013214322923724064198
  • PhanKLCoccaroEFAngstadtMCorticolimbic brain reactivity to social signals of threat before and after sertraline treatment in generalized social phobiaBiol Psychiatry201373432933623164370
  • TaylorCTAupperleRLFlaganTNeural correlates of a computerized attention modification program in anxious subjectsSoc Cogn Affect Neurosci2014991379138723934417
  • ZantvoordJBDiehleJLindauerRJLUsing neurobiological measures to predict and assess treatment outcome of psychotherapy in posttraumatic stress disorder: systematic reviewPsychother Psychosom201382314215123548778
  • HölzelBKHogeEAGreveDNNeural mechanisms of symptom improvements in generalized anxiety disorder following mindfulness trainingNeuroimage Clin2013244845824179799
  • NitschkeJBSarinopoulosIOathesDJAnticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment responseAm J Psychiatry2009166330231019122007
  • PalmMEElliottRMcKieSDeakinJFWAndersonIMAttenuated responses to emotional expressions in women with generalized anxiety disorderPsychol Med20114151009101820716396
  • BoutrosNNGallowayMPGhoshSGjiniKBowyerSMAbnormal coherence imaging in panic disorder: a magnetoencephalography investigationNeuroreport201324948749123612562
  • OttavianiCCevolaniDNuciforaVAmygdala responses to masked and low spatial frequency fearful faces: a preliminary fMRI study in panic disorderPsychiatry Res20122032–315916522944369
  • KlumppHPostDAngstadtMFitzgeraldDAPhanKLAnterior cingulate cortex and insula response during indirect and direct processing of emotional faces in generalized social anxiety disorderBiol Mood Anxiety Disord201331723547713
  • BrühlABHänggiJBaurVIncreased cortical thickness in a frontoparietal network in social anxiety disorderHum Brain Mapp20143572966297724039023
  • RossoIMMakrisNBrittonJCAnxiety sensitivity correlates with two indices of right anterior insula structure in specific animal phobiaDepress Anxiety201027121104111021132846
  • AhmedFSpottiswoodeBSCareyPDSteinDJSeedatSRelationship between neurocognition and regional brain volumes in traumatized adolescents with and without posttraumatic stress disorderNeuropsychobiology201266317418422948482
  • ChaoLWeinerMNeylanTRegional cerebral volumes in veterans with current versus remitted posttraumatic stress disorderPsychiatry Res2013213319320123816189
  • KroesMCWWhalleyMGRuggMDBrewinCRAssociation between flashbacks and structural brain abnormalities in posttraumatic stress disorderEur Psychiatry201126852553121592738
  • LipkaJHoffmannMMiltnerWHStraubeTEffects of Cognitive-Behavioral Therapy on Brain Responses to Subliminal and Supraliminal Threat and Their Functional Significance in Specific PhobiaBiol Psychiatry Epub20131114
  • CarréAGierskiFLemogneCLinear association between social anxiety symptoms and neural activations to angry faces: from subclinical to clinical levelsSoc Cogn Affect Neurosci20149688088623651705
  • KlumppHAngstadtMPhanKLInsula reactivity and connectivity to anterior cingulate cortex when processing threat in generalized social anxiety disorderBiol Psychol201289127327622027088
  • FonzoGASimmonsANThorpSRNormanSBPaulusMPSteinMBExaggerated and disconnected insular-amygdalar blood oxygenation level-dependent response to threat-related emotional faces in women with intimate-partner violence posttraumatic stress disorderBiol Psychiatry201068543344120573339
  • GarrettASCarrionVKletterHKarchemskiyAWeemsCFReissABrain activation to facial expressions in youth with PTSD symptomsDepress Anxiety201229544945922553009
  • Rougemont-BückingALinnmanCZeffiroTAAltered processing of contextual information during fear extinction in PTSD: an fMRI studyCNS Neurosci Ther201117422723620406268
  • NardoDHögbergGLaniusRAGray matter volume alterations related to trait dissociation in PTSD and traumatized controlsActa Psychiatr Scand2013128322223323113800
  • KlumppHFitzgeraldDAPhanKLNeural predictors and mechanisms of cognitive behavioral therapy on threat processing in social anxiety disorderProg Neuropsychopharmacol Biol Psychiatry201345839123665375
  • LinaresIMPJackowskiAPTrzesniakCMCortical thinning of the right anterior cingulate cortex in spider phobia: a magnetic resonance imaging and spectroscopy studyBrain Res20141576354224892191
  • KühnSGallinatJGray matter correlates of posttraumatic stress disorder: a quantitative meta-analysisBiol Psychiatry2013731707422840760
  • SchuffNZhangYZhanWPatterns of altered cortical perfusion and diminished subcortical integrity in posttraumatic stress disorder: an MRI studyNeuroimage201154Suppl 1S62S6820483375
  • ZhangJTanQYinHDecreased gray matter volume in the left hippocampus and bilateral calcarine cortex in coal mine flood disaster survivors with recent onset PTSDPsychiatry Res20111922849021498053
  • DuvalERHaleLRLiberzonIAnterior cingulate cortex involvement in subclinical social anxietyPsychiatry Res2013214345946124080515
  • RamageAELairdAREickhoffSBA coordinate-based meta-analytic model of trauma processing in posttraumatic stress disorderHum Brain Mapp201334123392339922936519
  • SartoryGCwikJKnuppertzHIn search of the trauma memory: a meta-analysis of functional neuroimaging studies of symptom provocation in posttraumatic stress disorder (PTSD)PLoS ONE201383e5815023536785
  • ShinLMDavisFCVanelzakkerMBDahlgrenMKDuboisSJNeuroimaging predictors of treatment response in anxiety disordersBiol Mood Anxiety Disord2013311523915782
  • ZivMGoldinPRJazaieriHHahnKSGrossJJEmotion regulation in social anxiety disorder: behavioral and neural responses to three socio-emotional tasksBiol Mood Anxiety Disord2013312024517388
  • CourtinJBienvenuTCMEinarssonEÖHerryCMedial prefrontal cortex neuronal circuits in fear behaviorNeuroscience201324021924223500092
  • Campbell-SillsLSimmonsANLoveroKLRochlinAAPaulusMPSteinMBFunctioning of neural systems supporting emotion regulation in anxiety-prone individualsNeuroimage201154168969620673804
  • LiaoWXuQMantiniDAltered gray matter morphometry and resting-state functional and structural connectivity in social anxiety disorderBrain Res2011138816717721402057
  • ChaJGreenbergTCarlsonJMDedoraDJHajcakGMujica-ParodiLRCircuit-wide structural and functional measures predict ventromedial prefrontal cortex fear generalization: implications for generalized anxiety disorderJ Neurosci201434114043405324623781
  • ChenYFuKFengCDifferent regional gray matter loss in recent onset PTSD and non PTSD after a single prolonged trauma exposurePLoS ONE2012711e4829823155380
  • WeberMKillgoreWDSRossoIMVoxel-based morphometric gray matter correlates of posttraumatic stress disorderJ Anxiety Disord201327441341923746489
  • JovanovicTNorrholmSDNeural mechanisms of impaired fear inhibition in posttraumatic stress disorderFront Behav Neurosci201154421845177
  • FelminghamKWilliamsLMKempAHNeural responses to masked fear faces: sex differences and trauma exposure in posttraumatic stress disorderJ Abnorm Psychol2010119124124720141261
  • BlairKSGeraciMOteroMAtypical modulation of medial prefrontal cortex to self-referential comments in generalized social phobiaPsychiatry Res20111931384521601433
  • SripadaCSAngstadtMBanksSNathanPJLiberzonIPhanKLFunctional neuroimaging of mentalizing during the trust game in social anxiety disorderNeuroreport2009201198498919521264
  • EtkinASchatzbergAFCommon abnormalities and disorder-specific compensation during implicit regulation of emotional processing in generalized anxiety and major depressive disordersAm J Psychiatry2011168996897821632648
  • PriceRBEldrethDAMohlmanJDeficient prefrontal attentional control in late-life generalized anxiety disorder: an fMRI investigationTransl Psychiatry2011110e4622833192
  • SchlundMWVerduzcoGCataldoMFHoehn-SaricRGeneralized anxiety modulates frontal and limbic activation in major depressionBehav Brain Funct201281822321875
  • LaniusRABrewinCRBremnerJDDoes neuroimaging research examining the pathophysiology of posttraumatic stress disorder require medication-free patients?J Psychiatry Neurosci2010352808920184804
  • GoldinPZivMJazaieriHGrossJJRandomized controlled trial of mindfulness-based stress reduction versus aerobic exercise: effects on the self-referential brain network in social anxiety disorderFront Hum Neurosci2012629523133411
  • GoldinPRZivMJazaieriHHahnKHeimbergRGrossJJImpact of cognitive behavioral therapy for social anxiety disorder on the neural dynamics of cognitive reappraisal of negative self-beliefs: randomized clinical trialJAMA Psychiatry201370101048105623945981
  • QiuCLiaoWDingJRegional homogeneity changes in social anxiety disorder: a resting-state fMRI studyPsychiatry Res20111941475321831605
  • WoonFLSoodSHedgesDWHippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: a meta-analysisProg Neuropsychopharmacol Biol Psychiatry20103471181118820600466
  • HettemaJKettenmannBAhluwaliaVPilot multimodal twin imaging study of generalized anxiety disorderDepress Anxiety201229320220921994092
  • ThomaesKDorrepaalEDraijerNIncreased anterior cingulate cortex and hippocampus activation in Complex PTSD during encoding of negative wordsSoc Cogn Affect Neurosci20138219020022156722
  • TalatiAPantazatosSPSchneierFRWeissmanMMHirschJGray matter abnormalities in social anxiety disorder: primary, replication, and specificity studiesBiol Psychiatry2013731758422748614
  • BrohawnKHOffringaRPfaffDLHughesKCShinLMThe neural correlates of emotional memory in posttraumatic stress disorderBiol Psychiatry201068111023103020855060
  • HayesJPVanelzakkerMBShinLMEmotion and cognition interactions in PTSD: a review of neurocognitive and neuroimaging studiesFront Integr Neurosci201268923087624
  • SchienleAScharmüllerWLeutgebVSchäferAStarkRSex differences in the functional and structural neuroanatomy of dental phobiaBrain Struct Funct2013218377978722644919
  • KreifeltsBBrückCRitterJThey are laughing at me: cerebral mediation of cognitive biases in social anxietyPLoS ONE201496e9981524918625
  • OffringaRHandwerger BrohawnKStaplesLKDiminished rostral anterior cingulate cortex activation during trauma-unrelated emotional interference in PTSDBiol Mood Anxiety Disord2013311023672953
  • EtkinAPraterKEHoeftFMenonVSchatzbergAFFailure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorderAm J Psychiatry2010167554555420123913
  • BaurVBrühlABHerwigUEvidence of frontotemporal structural hypoconnectivity in social anxiety disorder: A quantitative fiber tractography studyHum Brain Mapp201334243744622076860
  • DodhiaSHosanagarAFitzgeraldDAModulation of resting-state amygdala-frontal functional connectivity by oxytocin in generalized social anxiety disorderNeuropsychopharmacology20143992061206924594871
  • TrompDPGrupeDWOathesDJReduced structural connectivity of a major frontolimbic pathway in generalized anxiety disorderArch Gen Psychiatry201269992593422945621
  • StrawnJRBitterSMWeberWANeurocircuitry of generalized anxiety disorder in adolescents: a pilot functional neuroimaging and functional connectivity studyDepress Anxiety2012291193994722628125
  • StrawnJRWehryAMChuW-JNeuroanatomic abnormalities in adolescents with generalized anxiety disorder: a voxel-based morphometry studyDepress Anxiety201330984284823495075
  • RoyAKFudgeJLKellyCIntrinsic functional connectivity of amygdala-based networks in adolescent generalized anxiety disorderJ Am Acad Child Adolesc Psychiatry2013523290299.e223452685
  • MonkCSTelzerEHMoggKAmygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorderArch Gen Psychiatry200865556857618458208
  • PraterKEHosanagarAKlumppHAngstadtMPhanKLAberrant amygdala-frontal cortex connectivity during perception of fearful faces and at rest in generalized social anxiety disorderDepress Anxiety201330323424123184639
  • MaslowskyJMoggKBradleyBPA preliminary investigation of neural correlates of treatment in adolescents with generalized anxiety disorderJ Child Adolesc Psychopharmacol201020210511120415605
  • LiaoWQiuCGentiliCAltered effective connectivity network of the amygdala in social anxiety disorder: a resting-state FMRI studyPLoS ONE2010512e1523821203551
  • GreenbergTCarlsonJMChaJHajcakGMujica-ParodiLRVentromedial prefrontal cortex reactivity is altered in generalized anxiety disorder during fear generalizationDepress Anxiety201330324225023139148
  • SripadaRKKingAPGarfinkelSNAltered resting-state amygdala functional connectivity in men with posttraumatic stress disorderJ Psychiatry Neurosci201237424124922313617
  • FrickAGingnellMMarquandAFClassifying social anxiety disorder using multivoxel pattern analyses of brain function and structureBehav Brain Res201425933033524239689
  • AndersonMLNeural reuse: a fundamental organizational principle of the brainBehav Brain Sci201033424526620964882