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Review

The limits of oral therapy in pulmonary arterial hypertension management

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Pages 1731-1741 | Published online: 23 Nov 2015

References

  • RubinLJPrimary pulmonary hypertension[J]N Engl J Med199733621111178988890
  • SimonneauGGatzoulisMAAdatiaIUpdated clinical classification of pulmonary hypertension[J]J Am Coll Cardiol20136225 SupplD34D4124355639
  • RichSDantzkerDRAyresSMPrimary pulmonary hypertension. A national prospective study[J]Ann Intern Med198710722162233605900
  • D’AlonzoGEBarstRJAyresSMSurvival in patients with primary pulmonary hypertension. Results from a national prospective registry[J]Ann Intern Med199111553433491863023
  • GalieNHoeperMMHumbertMGuidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT) [J]Eur Heart J200930202493253719713419
  • HumbertMSitbonOChaouatASurvival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era[J]Circulation2010122215616320585011
  • GalieNCorrisPAFrostAUpdated treatment algorithm of pulmonary arterial hypertension[J]J Am Coll Cardiol20136225 SupplD60D7224355643
  • GalieNManesANegroLA meta-analysis of randomized controlled trials in pulmonary arterial hypertension[J]Eur Heart J200930439440319155250
  • RubinLJMendozaJHoodMTreatment of primary pulmonary hypertension with continuous intravenous prostacyclin (epoprostenol). Results of a randomized trial[J]Ann Intern Med199011274854912107780
  • BarstRJRubinLJLongWAA comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension[J]N Engl J Med199633452963018532025
  • BadeschDBTapsonVFMcgoonMDContinuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial[J]Ann Intern Med2000132642543410733441
  • GalieNSeegerWNaeijeRComparative analysis of clinical trials and evidence-based treatment algorithm in pulmonary arterial hypertension[J]J Am Coll Cardiol20044312 Suppl S81S88S15194183
  • ChannickRNSimonneauGSitbonOEffects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study[J]Lancet200135892881119112311597664
  • GalieNBadeschDOudizRAmbrisentan therapy for pulmonary arterial hypertension[J]J Am Coll Cardiol200546352953516053970
  • GalieNOlschewskiHOudizRJAmbrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2[J]Circulation2008117233010301918506008
  • McgoonMDFrostAEOudizRJAmbrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities[J]Chest2009135112212918812445
  • BolliMHBossCBinkertCThe discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N′-p ropylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist[J]J Med Chem201255177849786122862294
  • IglarzMBinkertCMorrisonKPharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist[J]J Pharmacol Exp Ther2008327373674518780830
  • PulidoTAdzerikhoIChannickRNMacitentan and morbidity and mortality in pulmonary arterial hypertension[J]N Engl J Med2013369980981823984728
  • LavelleASugrueRLawlerGSitaxentan-induced hepatic failure in two patients with pulmonary arterial hypertension[J]Eur Respir J200934377077119720812
  • JingZCYuZXShenJYVardenafil in pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled study[J]Am J Respir Crit Care Med2011183121723172921471085
  • JingZCJiangXWuBXVardenafil treatment for patients with pulmonary arterial hypertension: a multicentre, open-label study[J]Heart200995181531153619549620
  • GhofraniHAVoswinckelRReichenbergerFDifferences in hemodynamic and oxygenation responses to three different phospho-diesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study[J]J Am Coll Cardiol20044471488149615464333
  • GalieNGhofraniHATorbickiASildenafil citrate therapy for pulmonary arterial hypertension[J]N Engl J Med2005353202148215716291984
  • GalieNBrundageBHGhofraniHATadalafil therapy for pulmonary arterial hypertension[J]Circulation2009119222894290319470885
  • GhofraniHAGalieNGrimmingerFRiociguat for the treatment of pulmonary arterial hypertension[J]N Engl J Med2013369433034023883378
  • MielniczukLMSwistonJRMehtaSRiociguat: a novel therapeutic option for pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension[J]Can J Cardiol201430101233124025154043
  • BishopBMRiociguat for pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension[J]Am J Health Syst Pharm201471211839184425320133
  • BarstRJRubinLJLongWAA comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension[J]N Engl J Med199633452963018532025
  • MclaughlinVVShillingtonARichSSurvival in primary pulmonary hypertension: the impact of epoprostenol therapy[J]Circulation2002106121477148212234951
  • SitbonOHumbertMNunesHLong-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival[J]J Am Coll Cardiol200240478078812204511
  • BadeschDBMclaughlinVVDelcroixMProstanoid therapy for pulmonary arterial hypertension[J]J Am Coll Cardiol20044312 Suppl S56S61S15194179
  • TapsonVFTorresFKermeenFOral treprostinil for the treatment of pulmonary arterial hypertension in patients on background endothelin receptor antagonist and/or phosphodiesterase type 5 inhibitor therapy (the FREEDOM-C study): a randomized controlled trial[J]Chest201214261383139022628490
  • TapsonVFJingZCXuKFOral treprostinil for the treatment of pulmonary arterial hypertension in patients receiving background endothelin receptor antagonist and phosphodiesterase type 5 inhibitor therapy (the FREEDOM-C2 study): a randomized controlled trial[J]Chest2013144395295823669822
  • JingZCParikhKPulidoTEfficacy and safety of oral treprostinil monotherapy for the treatment of pulmonary arterial hypertension: a randomized, controlled trial[J]Circulation2013127562463323307827
  • BarstRJMcgoonMMclaughlinVBeraprost therapy for pulmonary arterial hypertension[J]J Am Coll Cardiol200341122119212512821234
  • GalieNHumbertMVachieryJLEffects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial[J]J Am Coll Cardiol20023991496150211985913
  • MontaniDPerrosFGambaryanNC-kit-positive cells accumulate in remodeled vessels of idiopathic pulmonary arterial hypertension[J]Am J Respir Crit Care Med2011184111612321471108
  • PerrosFMontaniDDorfmullerPPlatelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension[J]Am J Respir Crit Care Med20081781818818420966
  • SchermulyRTDonyEGhofraniHAReversal of experimental pulmonary hypertension by PDGF inhibition[J]J Clin Invest2005115102811282116200212
  • GhofraniHAMorrellNWHoeperMMImatinib in pulmonary arterial hypertension patients with inadequate response to established therapy[J]Am J Respir Crit Care Med201018291171117720581169
  • HoeperMMBarstRJBourgeRCImatinib mesylate as add-on therapy for pulmonary arterial hypertension: results of the randomized IMPRES study[J]Circulation2013127101128113823403476
  • SimonneauGTorbickiAHoeperMMSelexipag: an oral, selective prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension[J]Eur Respir J201240487488022362844
  • LiuCChenJEndothelin receptor antagonists for pulmonary arterial hypertension[J]Cochrane Database Syst Rev20063D4434
  • MclaughlinVVSitbonOBadeschDBSurvival with first-line bosentan in patients with primary pulmonary hypertension[J]Eur Respir J200525224424915684287
  • RubinLJBadeschDBBarstRJBosentan therapy for pulmonary arterial hypertension[J]N Engl J Med20023461289690311907289
  • GalieNRubinLHoeperMTreatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial[J]Lancet200837196302093210018572079
  • OwenKCrossDMDerziMAn overview of the preclinical toxicity and potential carcinogenicity of sitaxentan (Thelin(R)), a potent endothelin receptor antagonist developed for pulmonary arterial hypertension[J]Regul Toxicol Pharmacol20126419510322683289
  • McgoonMDFrostAEOudizRJAmbrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities[J]Chest2009135112212918812445
  • SastryBKNarasimhanCReddyNKClinical efficacy of sildenafil in primary pulmonary hypertension: a randomized, placebo-controlled, double-blind, crossover study[J]J Am Coll Cardiol20044371149115315063421
  • BarstRJIvyDDGaitanGA randomized, double-blind, placebo-controlled, dose-ranging study of oral sildenafil citrate in treatment-naive children with pulmonary arterial hypertension[J]Circulation2012125232433422128226
  • BarstRJBeghettiMPulidoTSTARTS-2: long-term survival with oral sildenafil monotherapy in treatment-naive pediatric pulmonary arterial hypertension[J]Circulation2014129191914192324637559
  • YungDWidlitzACRosenzweigEBOutcomes in children with idiopathic pulmonary arterial hypertension[J]Circulation2004110666066515289375
  • LammersAEHislopAAFlynnYEpoprostenol treatment in children with severe pulmonary hypertension[J]Heart200793673974317065181
  • HislopAAMoledinaSFosterHLong-term efficacy of bosentan in treatment of pulmonary arterial hypertension in children[J]Eur Respir J2011381707721177841
  • IvyDDRosenzweigEBLemarieJCLong-term outcomes in children with pulmonary arterial hypertension treated with bosentan in real-world clinical settings[J]Am J Cardiol201010691332133821029834
  • HaworthSGHislopAATreatment and survival in children with pulmonary arterial hypertension: the UK Pulmonary Hypertension Service for Children 2001–2006[J]Heart200995431231718952635
  • BarstRJMcgoonMDElliottCGSurvival in childhood pulmonary arterial hypertension: insights from the registry to evaluate early and long-term pulmonary arterial hypertension disease management[J]Circulation2012125111312222086881
  • van LoonRLRoofthooftMTDelhaasTOutcome of pediatric patients with pulmonary arterial hypertension in the era of new medical therapies[J]Am J Cardiol2010106111712420609658
  • BarstRJRubinLJMcgoonMDSurvival in primary pulmonary hypertension with long-term continuous intravenous prostacyclin[J]Ann Intern Med199412164094158053614
  • PrakashAPerryCMBosentan[J]Am J Cardiovasc Drugs20022533534314727963
  • BillmanGEAmbrisentan (Myogen)[J]Curr Opin Investig Drugs200231014831486
  • ShapiroSMOudizRJCaoTPrimary pulmonary hypertension: improved long-term effects and survival with continuous intravenous epoprostenol infusion[J]J Am Coll Cardiol19973023433499247503
  • Gomberg-MaitlandMOlschewskiHProstacyclin therapies for the treatment of pulmonary arterial hypertension[J]Eur Respir J200831489190118378784
  • LaliberteKArnesonCJeffsRPharmacokinetics and steady-state bioequivalence of treprostinil sodium (Remodulin) administered by the intravenous and subcutaneous route to normal volunteers[J]J Cardiovasc Pharmacol200444220921415243302
  • WalkerDKAcklandMJJamesGCPharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man[J]Xenobiotica199929329731010219969
  • PalmieriEAAffusoFFazioSTadalafil in primary pulmonary arterial hypertension[J]Ann Intern Med2004141974374415520445
  • FreyRMuckWUngerSSingle-dose pharmacokinetics, pharmacodynamics, tolerability, and safety of the soluble guanylate cyclase stimulator BAY 63-2521: an ascending-dose study in healthy male volunteers[J]J Clin Pharmacol200848892693418519919
  • WarrenJBHigenbottamTCaution with use of inhaled nitric oxide[J]Lancet199634890286296308782748
  • HoeperMMOlschewskiHGhofraniHAA comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolized iloprost in primary pulmonary hypertension. German PPH study group[J]J Am Coll Cardiol200035117618210636277
  • OlschewskiHWalmrathDSchermulyRAerosolized prostacyclin and iloprost in severe pulmonary hypertension[J]Ann Intern Med199612498208248610951
  • OlschewskiHGhofraniHAWalmrathDInhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis[J]Am J Respir Crit Care Med1999160260060710430735
  • GesslerTSchmehlTHoeperMMUltrasonic versus jet nebulization of iloprost in severe pulmonary hypertension[J]Eur Respir J2001171141911307743
  • VoswinckelREnkeBReichenbergerFFavorable effects of inhaled treprostinil in severe pulmonary hypertension: results from randomized controlled pilot studies[J]J Am Coll Cardiol20064881672168117045906
  • SimonneauGBarstRJGalieNContinuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: a double-blind, randomized, placebo-controlled trial[J]Am J Respir Crit Care Med2002165680080411897647
  • GalieNManesABranziAProstanoids for pulmonary arterial hypertension[J]Am J Respir Med20032212313714720012
  • Lopez-MeseguerMBerasteguiCMonforteVInhaled iloprost plus oral sildenafil in patients with severe pulmonary arterial hypertension delays the need for lung transplantation[J]Transplant Proc20134562347235023953548
  • OnenZPSayinTAkkocaYO[Efficacy of long-term oral mono-therapy and additional effect of inhaled iloprost in patients with severe idiopathic pulmonary arterial hypertension][J]Anadolu Kardiyol Derg201010545846020929705
  • BaldiFFusoLArrighiEOptimal management of pulmonary arterial hypertension: prognostic indicators to determine treatment course[J]Ther Clin Risk Manag20141082583925328398
  • MacchiaAMarchioliRMarfisiRA meta-analysis of trials of pulmonary hypertension: a clinical condition looking for drugs and research methodology[J]Am Heart J200715361037104717540207
  • OlschewskiHSimonneauGGalieNInhaled iloprost for severe pulmonary hypertension[J]N Engl J Med2002347532232912151469
  • RubinLJBadeschDBFlemingTRLong-term treatment with sildenafil citrate in pulmonary arterial hypertension: the SUPER-2 study[J]Chest201114051274128321546436
  • LangIGomez-SanchezMKneusslMEfficacy of long-term subcutaneous treprostinil sodium therapy in pulmonary hypertension[J]Chest200612961636164316778286
  • BarstRJGalieNNaeijeRLong-term outcome in pulmonary arterial hypertension patients treated with subcutaneous treprostinil[J]Eur Respir J20062861195120316899485
  • BadeschDBChampionHCSanchezMADiagnosis and assessment of pulmonary arterial hypertension[J]J Am Coll Cardiol2009541 SupplS55S6619555859
  • HumbertMLauEMMontaniDAdvances in therapeutic interventions for patients with pulmonary arterial hypertension[J]Circulation2014130242189220825602947
  • MclaughlinVVOudizRJFrostARandomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension[J]Am J Respir Crit Care Med2006174111257126316946127
  • HoeperMMLeuchteHHalankMCombining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension[J]Eur Respir J200628469169417012628
  • HumbertMBarstRJRobbinsIMCombination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2[J]Eur Respir J200424335335915358690
  • MclaughlinVVBenzaRLRubinLJAddition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trial[J]J Am Coll Cardiol201055181915192220430262
  • SimonneauGRubinLJGalieNAddition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: a randomized trial[J]Ann Intern Med2008149852153018936500
  • KempKSavaleLO’CallaghanDSUsefulness of first-line combination therapy with epoprostenol and bosentan in pulmonary arterial hypertension: an observational study[J]J Heart Lung Transplant201231215015822138355
  • SitbonOJaisXSavaleLUpfront triple combination therapy in pulmonary arterial hypertension: a pilot study[J]Eur Respir J20144361691169724627535
  • KeoghAMMayerEBenzaRLInterventional and surgical modalities of treatment in pulmonary hypertension[J]J Am Coll Cardiol2009541 SupplS67S7719555860
  • LordanJLCorrisPAPulmonary arterial hypertension and lung transplantation[J]Expert Rev Respir Med20115344145421702664
  • GrantonJMercierODe PerrotMManagement of severe pulmonary arterial hypertension[J]Semin Respir Crit Care Med201334570071324037636
  • HoeperMMGrantonJIntensive care unit management of patients with severe pulmonary hypertension and right heart failure[J]Am J Respir Crit Care Med2011184101114112421700906