References
- ChangLReview article: epidemiology and quality of life in functional gastrointestinal disordersAliment Pharmacol Ther200420Suppl 7313915521853
- Rome FoundationGuidelines – Rome III Diagnostic Criteria for Functional Gastrointestinal DisordersJ Gastrointestin Liver Dis20061530731217203570
- American College of Gastroenterology Task Force on Irritable Bowel SyndromeBrandtLJCheyWDAn evidence-based position statement on the management of irritable bowel syndromeAm J Gastroenterol2009104Suppl 1S1S3519521341
- HunginAPWhorwellPJTackJMearinFThe prevalence, patterns and impact of irritable bowel syndrome: an international survey of 40,000 subjectsAliment Pharmacol Ther20031764365012641512
- ChangJYTalleyNJAn update on irritable bowel syndrome: from diagnosis to emerging therapiesCurr Opin Gastroenterol201127727821099429
- MayerEANaliboffBDChangLBasic pathophysiologic mechanisms in irritable bowel syndromeDig Dis20011921221811752839
- HauserGPletikosicSTkalcicMCognitive behavioral approach to understanding irritable bowel syndromeWorld J Gastroenterol2014206744675824944466
- OhmanLSimrénMPathogenesis of IBS: role of inflammation, immunity and neuroimmune interactionsNat Rev Gastroenterol Hepatol2010716317320101257
- RagnarssonGBodemarGDivision of the irritable bowel syndrome into subgroups on the basis of daily recorded symptoms in two outpatient samplesScand J Gastroenterol199934993100010563669
- MearinFBalboaABadíaXIrritable bowel syndrome subtypes according to bowel habit: revisiting the alternating subtypeEur J Gastroenterol Hepatol20031516517212560761
- MearinFBaróERosetMBadíaXZárateNPérezIClinical patterns over time in irritable bowel syndrome: symptom instability and severity variabilityAm J Gastroenterol20049911312114687152
- HuliszDThe burden of illness of irritable bowel syndrome: current challenges and hope for the futureJ Manag Care Pharm20041029930915298528
- FrankLKleinmanLRentzACieslaGKimJJZackerCHealth-related quality of life associated with irritable bowel syndrome: comparison with other chronic diseasesClin Ther20022467568912017411
- LongstrethGFWilsonAKnightKIrritable bowel syndrome, health care use, and costs: a U.S. managed care perspectiveAm J Gastroenterol20039860060712650794
- DavisRHOvercoming barriers in irritable bowel syndrome with constipation (IBS-C)J Fam Pract200958S3S7
- DrossmanDAMorrisCBSchneckSInternational survey of patients with IBS: symptom features and their severity, health status, treatments, and risk taking to achieve clinical benefitJ Clin Gastroenterol20094354155019384249
- Müller-LissnerSTackJFengYSchenckFSpecht GrypRLevels of satisfaction with current chronic constipation treatment options in Europe – an internet surveyAliment Pharmacol Ther201337113714523126338
- AkehurstRKaltenthalerETreatment of irritable bowel syndrome: a review of randomised controlled trialsGut20014827228211156653
- DornSDKaptchukTJParkJBA meta-analysis of the placebo response in complementary and alternative medicine trials of irritable bowel syndromeNeurogastroenterol Motil20071963063717640177
- ElsenbruchSHow positive and negative expectations shape the experience of visceral painHandb Exp Pharmacol20142259711925304528
- LayerPStanghelliniVReview article: Linaclotide for the management of irritable bowel syndrome with constipationAliment Pharmacol Ther20143937138424433216
- SoaresRLIrritable bowel syndrome: a clinical reviewWorld J Gastroenterol201420121441216025232249
- KarantanosTMarkoutsakiTGazouliMAnagnouNPKaramanolisDGCurrent insights in to the pathophysiology of Irritable Bowel SyndromeGut Pathog20102320465787
- OhmanLSimrénMNew insights into the pathogenesis and pathophysiology of irritable bowel syndromeDig Liver Dis20073920121517267314
- SaitoYAThe role of genetics in IBSGastroenterol Clin North Am2011401456721333900
- LockeGR3rdZinsmeisterARTalleyNJFettSLMeltonLJFamilial association in adults with functional gastrointestinal disordersMayo Clin Proc200075990791210994826
- AdamBLiebregtsTHoltmannGMechanisms of disease: genetics of functional gastrointestinal disorders-searching the genes that matterNat Clin Pract Gastroenterol Hepatol20074210211017268545
- CamilleriMKatzkaDAIrritable bowel syndrome: methods, mechanisms, and pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndromeAm Physiol Gastrointest Liver Physiol2012302G10751084
- DrossmanDACamilleriMMayerEAWhiteheadWEAGA technical review on irritable bowel syndromeGastroenterology20021232108213112454866
- SerraJAzpirozFMalageladaJRImpaired transit and tolerance of intestinal gas in the irritable bowel syndromeGut200148141911115817
- ProttGShimLHansenRKellowJMalcolmARelationships between pelvic floor symptoms and function in irritable bowel syndromeNeurogastroenterol Motil20102276476920456760
- BarbaraGDe GiorgioRStanghelliniVCremonCSalvioliBCorinaldesiRNew pathophysiological mechanisms in irritable bowel syndromeAliment Pharmacol Ther200420Suppl 21915335408
- PosserudISyrousALindströmLTackJAbrahamssonHSimrenMAltered rectal perception in irritable bowel syndrome is associated with symptom severityGastroenterology20071331113112317919487
- BouinMPlourdeVBoivinMRectal distention testing in patients with irritable bowel syndrome: sensitivity, specificity, and predictive values of pain sensory thresholdsGastroenterology20021221771177712055583
- CostantiniMSturnioloGCZaninottoGAltered esophageal pain threshold in irritable bowel syndromeDig Dis Sci1993382062128093869
- TrimbleKCFaroukRPrydeADouglasSHeadingRCHeightened visceral sensation in functional gastrointestinal disease is not site-specific. Evidence for a generalized disorder of gut sensitivityDig Dis Sci199540160716137648957
- AccarinoAMAzpirozFMalageladaJRSelective dysfunction of mechanosensitive intestinal afferents in irritable bowel syndromeGastroenterology19951086366437875466
- SimrénMAbrahamssonHBjörnssonESAn exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndromeGut200148202711115818
- PosserudIAgerforzPEkmanRBjörnssonESAbrahamssonHSimrénMAltered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stressGut2004531102110815247175
- NaliboffBDBermanSSuyenobuBLongitudinal change in perceptual and brain activation response to visceral stimuli in irritable bowel syndrome patientsGastroenterology200613135236516890589
- Van OudenhoveLDemyttenaereKTackJAzizQCentral nervous system involvement in functional gastrointestinal disordersBest Pract Res Clin Gastroenterol20041866368015324706
- ElsenbruchSAbdominal pain in Irritable Bowel Syndrome: a review of putative psychological, neural and neuro-immune mechanismsBrain Behav Immun20112538639421094682
- Al OmranYAzizQThe brain-gut axis in health and diseaseAdv Exp Med Biol201481713515324997032
- MertzHROverview of functional gastrointestinal disorders: dysfunction of the brain-gut axisGastroenterol Clin North Am20033246347612858602
- ChitkaraDKVan TilburgMABlois-MartinNWhiteheadWEEarly life risk factors that contribute to irritable bowel syndrome in adults: a systematic reviewAm J Gastroenterol200810376577418177446
- HylandNPQuigleyEMBrintEMicrobiota-host interactions in irritable bowel syndrome: epithelial barrier, immune regulation and brain-gut interactionsWorld J Gastroenterol2014208859886625083059
- LongstrethGFThompsonWGCheyWDHoughtonLAMearinFSpillerRCFunctional bowel disordersGastroenterology20061301480149116678561
- FordACTalleyNJVeldhuyzen Van ZantenSJVakilNBSimelDLMoayyediPWill the history and physical examination help establish that irritable bowel syndrome is causing this patient’s lower gastrointestinal tract symptoms?JAMA20083001793180518854541
- EngsbroALBegtrupLMKjeldsenJPatients suspected of irritable bowel syndrome – crosssectional study exploring the sensitivity of Rome III criteria in primary careAm J Gastroenterol201310897298023419383
- DeepakPEhrenpreisEDConstipationDis Mon20115751151721944391
- QuigleyEMAbdel-HamidHBarbaraGA global perspective on irritable bowel syndrome: a consensus statement of the World Gastroenterology Organisation Summit Task Force on irritable bowel syndromeJ Clin Gastroenterol20124635636622499071
- SpillerRAzizQCreedFGuidelines on the irritable bowel syndrome: mechanisms and practical managementGut2007561770179817488783
- HammerJEslickGDHowellSCAltiparmakETalleyNJDiagnostic yield of alarm features in irritable bowel syndrome and functional dyspepsiaGut20045366667215082584
- FordACVeldhuyzen Van ZantenSJRodgersCCTalleyNJVakilNBMoayyediPDiagnostic utility of alarm features for colorectal cancer: systematic review and meta-analysisGut2008571545155318676420
- GunnarssonJSimrénMEfficient diagnosis of suspected functional bowel disordersNat Clin Pract Gastroenterol Hepatol2008549850718679389
- WaldAPathophysiology, diagnosis and current management of chronic constipationNat Clin Pract Gastroenterol Hepatol200639010016456575
- de BortoliNMartinucciIBelliniMOverlap of functional heartburn and gastroesophageal reflux disease with irritable bowel syndromeWorld J Gastroenterol2013195787579724124323
- TalleyNJDennisEHSchettler-DuncanVALacyBEOldenKWCrowellMDOverlapping upper and lower gastrointestinal symptoms in irritable bowel syndrome patients with constipation or diarrheaAm J Gastroenterol2003982454245914638348
- WongRKPalssonOSTurnerMJInability of the Rome III criteria to distinguish functional constipation from constipation-subtype irritable bowel syndromeAm J Gastroenterol20101052228223420502449
- ShekharCMonaghanPJMorrisJRome III functional constipation and irritable bowel syndrome with constipation are similar disorders within a spectrum of sensitization, regulated by serotoninGastroenterology201314574975723872499
- ReyEBalboaAMearinFChronic constipation, irritable bowel syndrome with constipation and constipation with pain/discomfort: similarities and differencesAm J Gastroenterol201410987688424589666
- FurnariMSavarinoEBruzzoneLReassessment of the role of methane production between irritable bowel syndrome and functional constipationJ Gastrointestin Liver Dis20122115716322720304
- GemignaniLSavarinoVGhioMLactulose breath test to assess oro-cecal transit delay and estimate esophageal dysmotility in scleroderma patientsSemin Arthritis Rheum201342552252923352249
- CremoniniFLemboAIBS with constipation, functional constipation, painful and non-painful constipation: e Pluribus…Plures?Am J Gastroenterol201410988588624896758
- CheyWDKurlanderJEswaranSIrritable bowel syndrome: a clinical reviewJAMA2015313994995825734736
- O’ConnorOJMcSweeneySEMcWilliamsSRole of radiologic imaging in irritable bowel syndrome: evidence-based reviewRadiology201226248549422156992
- McNallyMALockeGRZinsmeisterARSchleckCDPetersonJTalleyNJBiliary events and an increased risk of new onset irritable bowel syndrome: a population-based cohort studyAliment Pharmacol Ther200828333434319086237
- American College of Gastroenterology Task Force on Irritable Bowel SyndromeBrandtLJCheyWDAn evidence-based position statement on the management of irritable bowel syndromeAm J Gastroenterol2009104Suppl 1S1S3519521341
- KlauserAGVoderholzerWASchindlbeckNEMüller-LissnerSAFunctional diagnostic work-up in patients with irritable bowel syndromeZ Gastroenterol1996342732788686358
- KoideAYamaguchiTOdakaTQuantitative analysis of bowel gas using plain abdominal radiograph in patients with irritable bowel syndromeAm J Gastroenterol2000951735174110925977
- TörnblomHVan OudenhoveLSadikRAbrahamssonHTackJSimrénMColonic transit time and IBS symptoms: what’s the link?Am J Gastroenterol201210775476022334251
- HorikawaYMienoHInoueMKajiyamaGGastrointestinal motility in patients with irritable bowel syndrome studied by using radiopaque markersScand J Gastroenterol1999341190119510636065
- CosentinoMBeatiCFornariSDefaecography and colonic transit time for the evaluation of female patients with obstructed defaecationRadiol Med201411981381924846080
- SavarinoESavarinoVFoxMMeasurement of oro-caecal transit time by magnetic resonance imagingEur Radiol2015 Epub ahead of print25576231
- BrandãoACIanezPMR imaging of the pelvic floor: defecographyMagn Reson Imaging Clin N Am20132142744523642561
- CamilleriMReview article: new receptor targets for medical therapy in irritable bowel syndromeAliment Pharmacol Ther201031354619785622
- CorsettiMTackJFDA and EMA end points: which outcome end points should we use in clinical trials in patients with irritable bowel syndrome?Neurogastroenterol Motil20132545345723672677
- U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER)Guidance for Industry Irritable Bowel Syndrome – Clinical Evaluation of Drugs for Treatment2012 Available from: http://www.fda.gov/downloads/Drugs/Guidances/UCM205269.pdfAccessed March 23, 2015
- European Medicines AgencyGuideline on the evaluation of medicinal products for the treatment of irritable bowel syndrome EMA/CHMP/60337/2013. (CPMP/EWP/785/97 Rev. 1). Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2014/09/WC500173457.pdfAccessed March 23, 2015
- TackJCorsettiMPrucalopride: evaluation of the pharmacokinetics, pharmacodynamics, efficacy and safety in the treatment of chronic constipationExpert Opin Drug Metab Toxicol201281327133522985444
- TackJCamilleriMChangLSystematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disordersAliment Pharmacol Ther20123574576722356640
- Amitiza: FDA Product Information2013 Available from: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2008/ucm116889.htm
- Linaclotide: FDA Product Information2013 Available from: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm317505.htm
- Linaclotide: EMA Summary of Product Characteristics2013 Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002490/WC500135622.pdf
- JonesJBoormanJP CannPBritish Society of Gastroenterology guidelines for the management of the irritable bowel syndromeGut200047Suppl 2ii1ii1911053260
- AllerRde LuisDAIzaolaOEffects of a high-fiber diet on symptoms of irritable bowel syndrome: a randomized clinical trialNutrition20042073573715325678
- EswaranSMuirJCheyWDFiber and functional gastrointestinal disordersAm J Gastroenterol201310871872723545709
- ShepherdSJParkerFCMuirJGGibsonPRDietary triggers of abdominal symptoms in patients with irritable bowel syndrome: randomized placebo-controlled evidenceClin Gastroenterol Hepatol2008676577118456565
- ShepherdSJLomerMCGibsonPRShort-chain carbohydrates and functional gastrointestinal disordersAm J Gastroenterol201310870771723588241
- HalmosEPPowerVAShepherdSJGibsonPRMuirJGA diet low in FODMAPs reduces symptoms of irritable bowel syndromeGastroenterol20141466775
- HalmosEPChristophersonCTBirdARShepherdSJGibsonPRMuirJGDiets that differ in their FODMAP content alter the colonic luminal microenvironmentGut20156419310025016597
- AlaimoKMcDowellMABriefelRRDietary intake of vitamins, minerals, and fiber of persons ages 2 months and over in the United States: Third National Health and Nutrition Examination Survey, Phase 1, 1988–1991Adv Data199425812810138938
- BelliniMGambacciniDSalvadoriSManagement of chronic constipation in general practiceTech Coloproctol20141854354924272606
- BijkerkCJde WitNJMurisJWWhorwellPJKnottnerusJAHoesAWSoluble or insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo controlled trialBMJ2009339b315419713235
- GianniniEGMansiCDulbeccoPSavarinoVRole of partially hydrolyzed guar gum in the treatment of irritable bowel syndromeNutrition20062233434216413751
- TuohyKMKolidaSLustenbergerAMGibsonGRThe prebiotic effects of biscuits containing partially hydrolysed guar gum and fructo-oligosaccharides – a human volunteer studyBr J Nutr20018634134811570986
- TakahashiHWakoNOkuboTIshiharaNYamanakaJYamamotoTInfluence of partially hydrolysed guar gum on constipation in womenJ Nutr Sci Vitaminol (Tokyo)1994402512597965214
- FurnariMParodiAGemignaniLClinical trial: the combination of rifaximin with partially hydrolysed guar gum is more effective than rifaximin alone in eradicating small intestinal bacterial overgrowthAliment Pharmacol Ther2010321000100620937045
- MoayyediPQuigleyEMLacyBEThe effect of fiber supplementation on irritable bowel syndrome: a systematic review and meta-analysisAm J Gastroenterol20141091367137425070054
- JadallahKAKullabSMSandersDSConstipation-predominant irritable bowel syndrome: a review of current and emerging drug therapiesWorld J Gastroenterol2014208898890925083062
- American College of Gastroenterology Chronic Constipation Task ForceAn evidence-based approach to the management of chronic constipation in North AmericaAm J Gastroenterol2005100Suppl 1S1S416008640
- DipalmaJAClevelandMVMcGowanJHerreraJLA randomized, multicenter, placebo-controlled trial of polyethylene glycol laxative for chronic treatment of chronic constipationAm J Gastroenterol20071021436144117403074
- ChapmanRWStanghelliniVGeraintMHalphenMRandomized clinical trial: macrogol/PEG 3350 plus electrolytes for treatment of patients with constipation associated with irritable bowel syndromeAm J Gastroenterol20131081508151523835436
- CuppolettiJMalinowskaDHTewariKPSPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currentsAm J Physiol Cell Physiol2004287C1173C118315213059
- BarrettKEKeelySJChloride secretion by the intestinal epithelium: molecular basis and regulatory aspectsAnnu Rev Physiol20006253557210845102
- LacknerJJaccardJBaumCPatient-reported outcomes for irritable bowel syndrome are associated with patients’ severity ratings of gastrointestinal symptoms and psychological factorsClin Gastroenterol Hepatol2011995796421699821
- BharuchaAEWaldmanSATaking a lesson from microbial diarrheagenesis in the management of chronic constipationGastroenterology201013881381720114092
- GiannellaRAMannEAE. coli heatstable enterotoxin and guanylyl cyclase C: new functions and unsuspected actionsTrans Am Clin Climatol Assoc2003114678512813912
- SchlossmannJFeilRHofmannFInsights into cGMP signalling derived from cGMP kinase knockout miceFront Biosci2005101279128915769624
- BusbyRWBryantAPBartoliniWPLinaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transitEur J Pharmacol201064932833520863829
- EutameneHBradesiSLaraucheMGuanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral painNeurogastroenterol Motil2010223312e8419706070
- CastroJHarringtonAMHughesPALinaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3′,5′-monophosphateGastroenterology20131451334134623958540
- European Medicines AgencyCommittee for Medicinal Products for Human Use (CHMP) assessment report: Constella2012 Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002490/WC500135624.pdfAccessed December 23, 2012
- CheyWDLemboAJLavinsBJLinaclotide for irritable bowel syndrome with constipation: a 26-week, randomized, double-blind, placebo controlled trial to evaluate efficacy and safetyAm J Gastroenterol20121071702171222986437
- RaoSLemboAJShiffSJA 12- week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipationAm J Gastroenterol20121071714172422986440
- QuigleyEMTackJCheyWDRandomised clinical trials: linaclotide phase 3 studies in IBS-C – a prespecified further analysis based on European Medicines Agency-specified endpointsAliment Pharmacol Ther201337496123116208
- FordACQuigleyEMLacyBELemboAJSaitoYASchillerLREffect of antidepressant and psychological therapies, including hypnotherapy, in irritable bowel syndrome: systemic review and meta-analysisAm J Gastroenterol201410991350136524935275