New advances in the treatment of generalized lipodystrophy: role of metreleptin

References

• FiorenzaCGChouSHMantzorosCSLipodystrophy: pathophysiology and advances in treatmentNat Rev Endocrinol20117313715021079616
   PubMed Web of Science ®Google Scholar
• GargAClinical review: lipodystrophies: genetic and acquired body fat disordersJ Clin Endocrinol Metab201196113313332521865368
   PubMed Web of Science ®Google Scholar
• TsoukasMAFarrOMMantzorosCSLeptin in congenital and HIV-associated lipodystrophyMetabolism2015641475925267014
   PubMed Web of Science ®Google Scholar
• CintiSFrederichRCZingarettiMCDe MatteisRFlierJSLowellBBImmunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissueEndocrinology199713827978049003017
   PubMed Web of Science ®Google Scholar
• GargAKircherMDel CampoMAmatoRSAgarwalAKUniversity of Washington Center for Mendelian GWhole exome sequencing identifies de novo heterozygous CAV1 mutations associated with a novel neonatal onset lipodystrophy syndromeAm J Med Genet A201516781796180625898808
   PubMed Web of Science ®Google Scholar
• VigourouxCCaron-DebarleMLe DourCMagreJCapeauJMolecular mechanisms of human lipodystrophies: from adipocyte lipid droplet to oxidative stress and lipotoxicityInt J Biochem Cell Biol201143686287621392585
   PubMed Web of Science ®Google Scholar
• ChanJLOralEAClinical classification and treatment of congenital and acquired lipodystrophyEndocr Pract201016231032320061300
   PubMed Web of Science ®Google Scholar
• CortesVAFernandez-GalileaMLipodystrophies: adipose tissue disorders with severe metabolic implicationsJ Physiol Biochem Epub201542
   PubMed Web of Science ®Google Scholar
• Paz-FilhoGMastronardiCFrancoCBWangKBWongMLLicinioJLeptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implicationsArq Bras Endocrinol Metabol201256959760723329181
   PubMedGoogle Scholar
• GordenPLupsaBCChongAYLunguAOIs there a human model for the ‘metabolic syndrome’ with a defined aetiology?Diabetologia20105371534153620401463
   PubMed Web of Science ®Google Scholar
• Paz-FilhoGMastronardiCALicinioJLeptin treatment: facts and expectationsMetabolism201564114615625156686
   PubMed Web of Science ®Google Scholar
• ChouKPerryCMMetreleptin: first global approvalDrugs201373998999723740412
   PubMed Web of Science ®Google Scholar
• SinhaGLeptin therapy gains FDA approvalNat Biotechnol201432430030224714458
   PubMed Web of Science ®Google Scholar
• Paz-FilhoGMastronardiCAParkerBJMolecular pathways involved in the improvement of non-alcoholic fatty liver diseaseJ Mol Endocrinol201351116717923718963
   PubMed Web of Science ®Google Scholar
• RodriguezAJNeemanTGilesAGMastronardiCAPaz FilhoGLeptin replacement therapy for the treatment of non-HAART associated lipodystrophy syndromes: a meta-analysis into the effects of leptin on metabolic and hepatic endpointsArq Bras Endocrinol Metabol201458878379725465598
   PubMed Web of Science ®Google Scholar
• Diker-CohenTCochranEGordenPBrownRJPartial and generalized lipodystrophy: comparison of baseline characteristics and response to metreleptinJ Clin Endocrinol Metab201510051802181025734254
   PubMed Web of Science ®Google Scholar
• AgarwalAKGargAGenetic basis of lipodystrophies and management of metabolic complicationsAnnu Rev Med20065729731116409151
   PubMed Web of Science ®Google Scholar
• BarraCBSavoldelliRDMannaTDGenetic and metabolic description of five patients with Berardinelli-Seip syndromeArq Bras Endocrinol Metabol2011551545921468520
   PubMedGoogle Scholar
• AgarwalAKAriogluEDe AlmeidaSAGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34Nat Genet2002311212311967537
   PubMed Web of Science ®Google Scholar
• MagreJDelepineMKhalloufEIdentification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13Nat Genet200128436537011479539
   PubMed Web of Science ®Google Scholar
• KimCADelepineMBoutetEAssociation of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophyJ Clin Endocrinol Metab20089341129113418211975
   PubMed Web of Science ®Google Scholar
• HayashiYKMatsudaCOgawaMHuman PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophyJ Clin Invest200911992623263319726876
   PubMed Web of Science ®Google Scholar
• NolisTExploring the pathophysiology behind the more common genetic and acquired lipodystrophiesJ Hum Genet2014591162324152769
   PubMed Web of Science ®Google Scholar
• BillingsJKMilgraumSSGuptaAKHeadingtonJTRasmussenJELipoatrophic panniculitis: a possible autoimmune inflammatory disease of fat. Report of three casesArch Dermatol198712312166216663688906
   PubMedGoogle Scholar
• HublerAAbendrothKKeinerTDysregulation of insulin-like growth factors in a case of generalized acquired lipoatrophic diabetes mellitus (Lawrence Syndrome) connected with autoantibodies against adipocyte membranesExp Clin Endocrinol Diabetes1998106179849516065
   PubMed Web of Science ®Google Scholar
• Safar ZadehELunguAOCochranEKThe liver diseases of lipodystrophy: the long-term effect of leptin treatmentJ Hepatol201359113113723439261
   PubMed Web of Science ®Google Scholar
• TchangBGShuklaAPAronneLJMetreleptin and generalized lipodystrophy and evolving therapeutic perspectivesExpert Opin Biol Ther20151571061107526063386
   PubMed Web of Science ®Google Scholar
• HillRAMargeticSPeggGGGazzolaCLeptin: its pharmacokinetics and tissue distributionInt J Obes Relat Metab Disord19982287657709725636
   PubMed Web of Science ®Google Scholar
• Bristol-Myers Squibb CompanyEndocrinologic and Metabolic Drugs Advisory Committee Briefing Document 20132013 Available from: http://www.fda.gov/downloads/AdvisoryCommittees/Committees-MeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM377929.pdfAccessed July 8, 2015
   Google Scholar
• WatsonAMPoloyacSMHowardGBlouinRAEffect of leptin on cytochrome P-450, conjugation, and antioxidant enzymes in the ob/ob mouseDrug Metab Dispos199927669570010348799
   PubMed Web of Science ®Google Scholar
• BoguszewskiCLPaz-FilhoGVellosoLANeuroendocrine body weight regulation: integration between fat tissue, gastrointestinal tract, and the brainEndokrynol Pol201061219420620464707
   PubMed Web of Science ®Google Scholar
• Paz-FilhoGWongMLLicinioJTen years of leptin replacement therapyObes Rev2011125e315e32321410864
   PubMedGoogle Scholar
• OralEASimhaVRuizELeptin-replacement therapy for lipodystrophyN Engl J Med2002346857057811856796
   PubMed Web of Science ®Google Scholar
• DaherESilva JuniorGBenevidesVBerardinelli syndrome. A case report with fatal outcomeInvest Clin200849225125518717270
   PubMed Web of Science ®Google Scholar
• SeipMTrygstadOGeneralized lipodystrophy, congenital and acquired (lipoatrophy)Acta Paediatr Suppl19964132288783769
   PubMedGoogle Scholar
• BeltrandJBeregszasziMChevenneDMetabolic correction induced by leptin replacement treatment in young children with Berardinelli-Seip congenital lipoatrophyPediatrics20071202e291e29617671040
   PubMed Web of Science ®Google Scholar
• BeltrandJLahlouNLe CharpentierTResistance to leptin-replacement therapy in Berardinelli-Seip congenital lipodystrophy: an immunological originEur J Endocrinol201016261083109120236991
   PubMed Web of Science ®Google Scholar
• ChanJLLutzKCochranEClinical effects of long-term metre-leptin treatment in patients with lipodystrophyEndocr Pract201117692293222068254
   PubMed Web of Science ®Google Scholar
• ChongAYLupsaBCCochranEKGordenPEfficacy of leptin therapy in the different forms of human lipodystrophyDiabetologia2010531273519727665
   PubMed Web of Science ®Google Scholar
• EbiharaKKusakabeTHirataMEfficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophyJ Clin Endocrinol Metab200792253254117118991
   PubMed Web of Science ®Google Scholar
• JavorEDCochranEKMussoCYoungJRDepaoliAMGordenPLong-term efficacy of leptin replacement in patients with generalized lipodystrophyDiabetes20055471994200215983199
   PubMed Web of Science ®Google Scholar
• JavorEDGhanyMGCochranEKLeptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophyHepatology200541475376015791619
   PubMed Web of Science ®Google Scholar
• MoranSAPattenNYoungJRChanges in body composition in patients with severe lipodystrophy after leptin replacement therapyMetabolism200453451351915045701
   PubMed Web of Science ®Google Scholar
• OralEARuizEAndeweltAEffect of leptin replacement on pituitary hormone regulation in patients with severe lipodystrophyJ Clin Endocrinol Metab20028773110311712107209
   PubMed Web of Science ®Google Scholar
• ParkJYJavorEDCochranEKDePaoliAMGordenPLong-term efficacy of leptin replacement in patients with Dunnigan-type familial partial lipodystrophyMetabolism200756450851617379009
   PubMed Web of Science ®Google Scholar
• PetersenKFOralEADufourSLeptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophyJ Clin Invest2002109101345135012021250
   PubMed Web of Science ®Google Scholar
• SimhaVSubramanyamLSzczepaniakLComparison of efficacy and safety of leptin replacement therapy in moderately and severely hypoleptinemic patients with familial partial lipodystrophy of the Dunnigan varietyJ Clin Endocrinol Metab201297378579222170723
   PubMed Web of Science ®Google Scholar
• MuniyappaRBrownRJMariAEffects of leptin replacement therapy on pancreatic beta-cell function in patients with lipodystrophyDiabetes Care20143741101110724496806
   PubMed Web of Science ®Google Scholar
• ChristensenJDLunguAOCochranEBone mineral content in patients with congenital generalized lipodystrophy is unaffected by metreleptin replacement therapyJ Clin Endocrinol Metab2014998E1493E150025070319
   PubMed Web of Science ®Google Scholar
• BrownRJChanJLJaffeESLymphoma in acquired generalized lipodystrophyLeuk Lymphoma Epub2015213
   Web of Science ®Google Scholar
• AslamASavageDBCoulsonIHAcquired generalized lipodystrophy associated with peripheral T cell lymphoma with cutaneous infiltrationInt J Dermatol201554782782924168394
   PubMed Web of Science ®Google Scholar
• YianniasJADiCaudoDJMaskinEPeripheral T-cell lymphoma presenting as lipoatrophy and nodulesInt J Dermatol200645121415141917184242
   PubMed Web of Science ®Google Scholar
• SienkiewiczEMagkosFAronisKNLong-term metreleptin treatment increases bone mineral density and content at the lumbar spine of lean hypoleptinemic womenMetabolism20116091211122121741057
   PubMed Web of Science ®Google Scholar
• MarkALSelective leptin resistance revisitedAm J Physiol Regul Integr Comp Physiol20133056R566R58123883674
   PubMed Web of Science ®Google Scholar
• ZelissenPMStenlofKLeanMEEffect of three treatment schedules of recombinant methionyl human leptin on body weight in obese adults: a randomized, placebo-controlled trialDiabetes Obes Metab20057675576116219020
   PubMed Web of Science ®Google Scholar
• HeymsfieldSBGreenbergASFujiokaKRecombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trialJ Am Med Assoc19992821615681575
   PubMed Web of Science ®Google Scholar
• MoonHSMatareseGBrennanAMEfficacy of metreleptin in obese patients with type 2 diabetes: cellular and molecular pathways underlying leptin toleranceDiabetes20116061647165621617185
   PubMed Web of Science ®Google Scholar
• RavussinESmithSRMitchellJAEnhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapyObesity (Silver Spring)20091791736174319521351
   PubMed Web of Science ®Google Scholar
• TamCSLecoultreVRavussinENovel strategy for the use of leptin for obesity therapyExpert Opin Biol Ther201111121677168521910668
   PubMed Web of Science ®Google Scholar
• MittendorferBHorowitzJFDePaoliAMMcCamishMAPattersonBWKleinSRecombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetesDiabetes20116051474147721411512
   PubMed Web of Science ®Google Scholar
• FarrOMTsoukasMAMantzorosCSLeptin and the brain: influences on brain development, cognitive functioning and psychiatric disordersMetabolism201564111413025092133
   PubMed Web of Science ®Google Scholar
• RodríguezAJMastronardiCAPaz-FilhoGClinical perspectives: leptin replacement therapy for the treatment of lipodystrophy-associated non-alcoholic fatty liver diseaseTransl Gastrointest Cancer20144198107
   Google Scholar