Neurogenic orthostatic hypotension – management update and role of droxidopa

References

• FreemanRWielingWAxelrodFBConsensus statement on the definition of orthostatic hypotension, neutrally mediated syncope and the postural tachycardia syndromeClin Auton Res2011212697121431947
   PubMed Web of Science ®Google Scholar
• SoteriadesESEvansJCLarsonMGIncidence and prognosis of syncopeN Engl J Med20023471287888512239256
   PubMed Web of Science ®Google Scholar
• FreemanRNeurogenic Orthostatic HypotensionN Engl J Med2008358661562418256396
   PubMed Web of Science ®Google Scholar
• ShibaoCGrijalvaCGRajSRBiaggioniIGriffinMROrthostatic hypotension-related hospitalizations in the United SatesAm J Med20071201197598017976425
   PubMed Web of Science ®Google Scholar
• OoiWlHossainMLipsitzLAThe association between orthostatic hypotension and recurrent falls in nursing home residentsAm J Med2000108210611111126303
   PubMed Web of Science ®Google Scholar
• BerrySDMillerRRFalls: Epidemiology, pathophysiology and relationship to fractureCurr Osteoporos Rep20086414915419032925
   PubMedGoogle Scholar
• RoseKMEigenbrodtMLBigaRLOrthostatic hypotension predicts mortality in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) StudyCirculation2006114763063616894039
   PubMed Web of Science ®Google Scholar
• RutanGHHermansonBBildDEKittnerSJOrthostatic hypotension in older adults. The Cardiovascular Health Study. CHS Collaborative Research GroupHypertension1992196 Pt 15085191592445
   PubMed Web of Science ®Google Scholar
• VeroneseNDe RuiMBolzettaFOrthostatic changes in blood pressure and mortality in the elderly: the Pro.V.A StudyAm J Hypertens2015311 pii: hpv022 [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• BerrySDMillerRRFalls: Epidemiology, pathophysiology, and relationship to FractureCurr Osteoporos Rep20086414915419032925
   PubMedGoogle Scholar
• JoynerMSheppardTAutonomic regulation of the circulationLowPClinical Autonomic disorders2ndPhiladelphia, PaLippincott-Raven19976171
   Google Scholar
• WielingWVanLieshoutJJMaintenance of postural normotension in humansLowClinical Autonomic disordersPhiladelphia, PaLippincott-Raven19977382
   Google Scholar
• GrubbBPNeurocardiogenic syncope and related disorders of orthostatic intoleranceCirculation2005111222997300615939833
   PubMed Web of Science ®Google Scholar
• BenarrochEFreemanRKaufmannHAutonomic nervous system Textbook of Clinical Neurology3rdPhiladelphia, PAElsevier2007383404
   Google Scholar
• BennarochEThe central autonomic network: functional organization and clinical correlationsArmonk, NYFutura press19973178
   Google Scholar
• GolsteinDSSharabiYNeurogenic orthostatic hypotension: a pathophysiological approachCirculation2009119113914619124673
   PubMed Web of Science ®Google Scholar
• FreemanRKaufmannHDisorders of Orthostatic tolerance-Orthostatic hypotension, postural tachycardia syndrome, and syncopeContinuum20071365088
   Google Scholar
• WielingWKredietCTvan DijkNLinzerMTschakovskyMEInitial orthostatic hypotension: review of a forgotten conditionClin Sci (Lond)2007112315716517199559
   PubMed Web of Science ®Google Scholar
• GibbonsCHFreemanRDelayed orthostatic hypotension: a frequent cause of orthostatic intoleranceNeurology2006671283216832073
   PubMed Web of Science ®Google Scholar
• The task force for the management diagnosis and management of syncope of the European Society of Cardiology (ESC)Guidelines for the diagnosis and management of syncope (version 2009)Eur Heart J2009302631267119713422
   PubMed Web of Science ®Google Scholar
• RavitsJMAAEM minimonograph #48. Autonomic nervous testingMuscle Nerve19972089199379236782
   PubMed Web of Science ®Google Scholar
• LowPATomaliaVAParkKJAutonomic function tests: some clinical applicationsJ Clin Neurol2013911823346153
   PubMed Web of Science ®Google Scholar
• LowPASingerWUpdate on management of neurogenic orthostatic hypotensionLancet Neurol20087545145818420158
   PubMed Web of Science ®Google Scholar
• KaufmannHBrannanTKrakoffLYahrMDMandeliJTreatment of orthostatic hyotension due to autonomic failure with a peripheral alpha-adrenergic agonist (midodrine)Neurology19883869519562452997
   PubMed Web of Science ®Google Scholar
• LowPAGildenJlFreemanRShengKNMcElligottMAEfficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study. Midodrine Study GroupJAMA199727713104610519091692
   PubMed Web of Science ®Google Scholar
• WrightRAKaufmannHCPereraRA double-blind, dose-response study of midodrine in neurogenic orthostatic hypotensionNeurology19985111201249674789
   PubMed Web of Science ®Google Scholar
• IzcovichAGonzalez MallaCManzottiMCatalanoHNGuyattGMidodrine for orthostatic hypotension ad recurrent reflex syncopre: A systematic reviewNeurology201483131170117725150287
   PubMed Web of Science ®Google Scholar
• KaufmannHL-dihydoxyphenylserine (droxidopa): a new therapy for neurogenic orthostatic hypotension: US expereinceClin Auton Res200818Suppl 1192418368303
   PubMed Web of Science ®Google Scholar
• GolsteinDSHomesCKaufmannHFreemanRClinical pharmacokinetics of the norepinephrine precursor L-threo-DOPS in primary chronic autonomic failureClin Auton Res200414636336815666063
   PubMed Web of Science ®Google Scholar
• Man in ‘t VeldAJBoomsmaFvan den MeirackerAHSchalekampMAEffect of unnatural noradrenaline precurosor on sympathetic control and orthostatic hypotension in dopamine-beta-hydroxylase deficiencyLancet198728569117211752890807
   PubMed Web of Science ®Google Scholar
• KaufmannHMalamutRNorcliffe-KaufmannLRosaKFreemanRThe Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scaleClin Auton Res2012222799022045363
   PubMed Web of Science ®Google Scholar
• KaufmanHFreemanRBiaggioniIDroxidopa for neurogenic hypotension: a randomized, placebo-controlled, phase 3 trialNeurology201483432833524944260
   PubMed Web of Science ®Google Scholar
• BiaggioniIFreemanRMathiasCJRandomized withdrawal study of patients with symptomatic neurogenic orthostatic hypotension responsive to droxidopaHypertension201565110011007
   Web of Science ®Google Scholar
• FreemanRlandsbergLYoungJThe treatment of neurogenic orthostatic hypotension with 3,4-DL-Threo-dihydroxyphenylserine: a randomized, placebo-controlled, crossover trialNeurology19995392151215710599797
   PubMed Web of Science ®Google Scholar
• MathiasCJSenardJMBrauneSL-threo-dihydroxyphenylserine (L-threo-DOPS; Droxidopa) in the management of neurogenic orthostatic hypotension: a multi-national, multi-center, dose-ranging study in multiple system atrophy and pure autonomic failureClin Auton Res200111423524211710796
   PubMed Web of Science ®Google Scholar
• KaaufmannHSaadiaDVoustianioukANorepinephrine precursor therapy in neurogenic orthostatic hypotensionCirculation2003108672472812885750
   PubMed Web of Science ®Google Scholar
• VannorsdallMDHariacharSHewittLAA randomized, placebo-controlled, phase 2 study of the efficacy and safety of droxidopa in patients with intradialytic hypotensionPostgrad Med2015127213314325708022
   PubMed Web of Science ®Google Scholar
• FukadaKEndoTYokoeML-threo-3,4-dihydroxyphenylserine (L-DOPS) co-administered with entacapone improves freezing of gait in Parkinson’s diseaseMed Hypotheses201380220921223265352
   PubMed Web of Science ®Google Scholar
• RobertsonDDavisTJRecent advances in the treatment of orthostatic hypotensionNeurology199545S26S327746370
   PubMed Web of Science ®Google Scholar
• LimPOFarquharsonCAShielsPAdverse cardiac effects of salt with fludrocortisone in hyperensionHypertension20013785686111244008
   PubMed Web of Science ®Google Scholar
• HoeldtkeRDStreetenDHTreatment of orthostatic hypotension with erythropoietinNew Eng J Med19993296116158341335
   PubMedGoogle Scholar