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Review

Xerostomia induced by radiotherapy: an overview of the physiopathology, clinical evidence, and management of the oral damage

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Pages 171-188 | Published online: 04 Feb 2015

References

  • BivonaPLXerostomia. A common problem among the elderlyN Y State Dent J19986446529707984
  • CassolatoSFTurnbullRSXerostomia: clinical aspects and treatmentGerodontology200320647714697016
  • WaltimoTChristenSMeurmanJHFilippiADental care of patients with leukemiaSchweiz Monatsschr Zahnmed200511530831515901038
  • BrandHSBotsCPRaber-DurlacherEXerostomia and chronic oral complications among patients treated with haematopoietic stem cell transplantationBr Dent J2009207E1719893563
  • GuptaAEpsteinJBSroussiHHyposalivation in elderly patientsJ Can Dent Assoc20067284184617109806
  • VillaAAbatiSRisk factors and symptoms associated with xerostomia: a cross-sectional studyAust Dent J20115629029521884145
  • VillaAPolimeniAStrohmengerLCicciùDGherloneEAbatiSDental patients’ self-reports of xerostomia and associated risk factorsJ Am Dent Assoc201114281181621719803
  • BusatoIMIgnácioSABrancherJAGrégioAMMachadoMAAzevedo-AlanisLRImpact of xerostomia on the quality of life of adolescents with type 1 diabetes mellitusOral Surg Oral Med Oral Pathol Oral Radiol Endod200910837638219716505
  • MoorePGuggenheimerJEtzelJKWeyantRJTrevor orchard type 1 diabetes mellitus, xerostomia, and salivary flow ratesOral Surg Oral Med Oral Pathol Oral Radiol Endod20019228129111552145
  • JensenSBPedersenAMVissinkASalivary Gland Hypofunction/Xerostomia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of lifeSupport Care Cancer2010181039106020237805
  • FoxPCBunchKABaumBJSubjective reports of xerostomia and objective measures of salivary gland performanceJ Am Dent Assoc19871155815843477595
  • PorterSRScullyCHegartyAMAn update of the etiology and management of xerostomiaOral Surg Oral Med Oral Pathol Oral Radiol Endod200497284614716254
  • De GraeffADe LeeuwJRRosWJHordijkGJBlijhamGHWinnubstJAA prospective study on quality of life of patients with cancer of the oral cavity or oropharynx treated with surgery with or without radiotherapyOral Oncol199935273210211307
  • ArgirisAKaramouzisMVRabenDFerrisRLHead and neck cancerLancet20083711695170918486742
  • Globocaniarcfr [homepage on the Internet]LyonInternational Agency for Research on Cancer; World Health Organization2012 [updated January 9, 2014]. Available from: http://globocan.iarc.fr/Default.aspxAccessed May 1, 2014
  • MaciejewskiBZajuszAPileckiBSalivary Gland Hypofunction/Xerostomia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)Acute mucositis in the stimulated oral mucosa of patients during radiotherapy for head and neck cancerRadiother Oncol1991227111947216
  • ScullyCEpsteinJBOral health care for the cancer patientEur J Cancer B Oral Oncol1996322812928944831
  • SreebnyLMSaliva in health and disease: an appraisal and updateInt Dent J20005014016110967766
  • VissinkAKalicharanDS-GravenmadeEJAcute irradiation effects on morphology and function of rat submandibular glandsJ Oral Pathol Med1991204494561804990
  • BurlageFRCoppesRPMeertensHStokmanMAVissinkAParotid and submandibular/sublingual flow during high dose radiotherapyRadiother Oncol20016127127411730996
  • EpsteinJBRobertsonMEmertonSPhillipsNStevenson-MoorePQuality of life and oral function in patients treated with radiation therapy for head and neck cancerHead Neck20012338939811295813
  • FranzénLFunegårdUEricsonTHenrikssonRParotid gland function during and following radiotherapy of malignancies in the head and neck. A consecutive study of salivary flow and patient discomfortEur J Cancer1992284574621591063
  • DreizenSADalyTEDraneJBBrownLROral complications of cancer radiotherapyPostgrad Med1977618592834698
  • Ben-AryehHGutmanDSzargelRLauferDEffects of irradiation on saliva in cancer patientsInt J Oral Surg197514205210811576
  • DreizenSBrownLRHandlerSLevyBMRadiation-induced xerostomia in cancer patients. Effect on salivary and serum electrolytesCancer1976382732787352
  • MarksJEDavisCCGottsmanVLPurdyJELeeFThe effects of radiation of parotid salivary functionInt J Radiat Oncol Biol Phys19817101310197298398
  • Ben-AryehHMironDBerdicevskyISzargelRGutmanDXerostomia in the elderly: prevalence, diagnosis, complications and treatmentGerodontology1985477823867609
  • AbelsonDCMandelIDThe effect of saliva on plaque pH in vivoJ Dent Res198160163416386943155
  • LingströmPBirkhedDPlaque pH and oral retention after consumption of starchy snack products at normal and low salivary secretion rateActa Odontol Scand1993513793888304015
  • EliassonLBirkhedDOsterbergTCarlénAMinor salivary gland secretion rates and immunoglobulin A in adults and the elderlyEur J Oral Sci200611449449917184231
  • AlmståhlAWikströmMOral microflora in subjects with reduced salivary secretionJ Dent Res1998781410141610439028
  • ValdezIHWolffAAtkinsonJCMacynskiAAFoxPCUse of pilocarpine during head and neck radiation therapy to reduce xerostomia and salivary dysfunctionCancer199371184818518448748
  • MakkonenTATenovuoJViljaPHeimdahlAChanges in the protein composition of whole saliva during radiotherapy in patients with oral or pharyngeal cancerOral Surg Oral Med Oral Pathol1986622702752427987
  • IzutsuKTTrueloveELBleyerWAAndersonWMSchubertMMRiceJCWhole saliva albumin as an indicator of stomatitis in cancer therapy patientsCancer1981486145014547023657
  • BrownLRDreizenSHandlerSJohnstonDAEffect of radiation-induced xerostomia on human oral microfloraJ Dent Res19745447407501099136
  • KeeneHJDalyTBrownLRDental caries and Streptococcus mutans prevalence in cancer patients with irradiation-induced xerostomia: 1–13 years after radiotherapyCaries Res1981154164276942926
  • HaseJCBirkhedDSalivary glucose clearance, dry mouth and pH changes in dental plaque in manArch Oral Biol1988338758803256293
  • RavaldNListTCaries and periodontal conditions in patients with primary Sjögren’s syndromeSwed Dent J1998223971039768457
  • AlmståhlAWikströmMGroeninkJLactoferrin, amylase and mucin MUC5B and their relation to the oral microflora in hyposalivation of different originsOral Microbiol Immunol20011634535211737657
  • AlmståhlACarlénAEliassonLLingströmPLactobacillus species in supragingival plaque in subjects with hyposalivationArch Oral Biol20105525525920149344
  • RadvanskyLJPaceMBSiddiquiAPrevention and management of radiation-induced dermatitis, mucositis, and xerostomiaAm J Health Syst Pharm2013701025103223719879
  • WijersOBLevendagPCBraaksmaMMBoonzaaijerMVischLLSchmitzPIPatients with head and neck cancer cured by radiation therapy: a survey of the dry mouth syndrome in long-term survivorsHead Neck20022473774712203798
  • SherDJBalboniTAHaddadRIEfficacy and toxicity of chemoradiotherapy using intensity-modulated radiotherapy for unknown primary of head and neckInt J Radiat Oncol Biol Phys2011801405141121177045
  • SchoenfeldJDSherDJNorrisCMJrSalivary gland tumors treated with adjuvant intensity-modulated radiotherapy with or without concurrent chemotherapyInt J Radiat Oncol Biol Phys20128230831421075557
  • AtkinsonJCWuAJSalivary gland dysfunction: causes, symptoms, treatmentJ Am Dent Assoc19941254094168176076
  • SpielmanAIGustducin and its role in tasteJ Dent Res1998775395449539456
  • PedersenAMBardowAJensenSBNauntofteBSaliva and gastrointestinal functions of taste, mastication, swallowing and digestionOral Dis2002811712912108756
  • Ramirez-AmadorVSilvermanSJrMayerPTylerMQuiveyJCandidal colonization and oral candidiasis in patients undergoing oral and pharyngeal radiation therapyOral Surg Oral Med Oral Pathol Oral Radiol Endod1997841491539269016
  • ChenTYWebsterJHOral monilia study on patients with head and neck cancer during radiotherapyCancer1974342462494604859
  • SamaranayakeLPLameyPJOral candidosis: 1. clinicopathological aspectsDent Update19881562272282302313248658
  • KuntzRAllenMOsburnJXerostomiaInt J Pharm Compd2000411761177
  • AlmeidaJPKowalskiLPPilocarpine used to treat xerostomia in patients submitted to radioactive iodine therapy: a pilot studyBraz J Otorhinolaryngol201076565966220963353
  • KosekiMMakiYMatsukuboTOhashiYTsubotaKSalivary flow and its relationship to oral signs and symptoms in patients with dry eyesOral Dis2004102758014996276
  • TomiitaMTakeiSKuwadaNEfficacy and safety of orally administered pilocarpine hydrochloride for patients with juvenile-onset Sjögren’s syndromeMod Rheumatol201020548649020517630
  • Ramos-CasalsMTzioufasAGStoneJHSisóABoschXTreatment of primary Sjögren syndrome: a systematic reviewJAMA2010304445246020664046
  • HendricksonRGMoroccoAPGreenbergMIPilocarpine toxicity and the treatment of xerostomiaJ Emerg Med200426442943215093850
  • ChambersMSJonesCUBielMAOpen-label, long-term safety study of cevimeline in the treatment of postirradiation xerostomiaInt J Radiat Oncol Biol Phys20076951369137617855005
  • ChambersMSPosnerMJonesCUCevimeline for the treatment of postirradiation xerostomia in patients with head and neck cancerInt J Radiat Oncol Biol Phys20076841102110917379432
  • HamadaTNakaneTKimuraTTreatment of xerostomia with the bile secretion-stimulant drug anethole trithione: a clinical trialAm J Med Sci199931814615110487404
  • BagheriHSchmittLBerlanMMontastrucJLA comparative study of the effects of yohimbine and anetholtrithione on salivary secretion in depressed patients treated with psychotropic drugsEur J Clin Pharmacol1997523393429272401
  • DykeSClinical management and review of Sjögren’s syndromeInt J Pharm Compd2000433834123981695
  • JohnstonePAPengYPMayBCInouyeWSNiemtzowRCAcupuncture for pilocarpine-resistant xerostomia following radiotherapy for head and neck malignanciesInt J Radiat Oncol Biol Phys20015035335711380221
  • SagarSMAcupuncture as an evidence-based option for symptom control in cancer patientsCurr Treat Options Oncol2008911712618688727
  • JedelEAcupuncture in xerostomia – a systematic reviewJ Oral Rehabil20053239239615899016
  • JensenSBPedersenAMVissinkAA systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impactSupport Care Cancer20101881061107920333412
  • O’SullivanEMHigginsonIJClinical effectiveness and safety of acupuncture in the treatment of irradiation-induced xerostomia in patients with head and neck cancer: a systematic reviewAcupunct Med20102819119921062848
  • ZhuangLYangZZengXThe preventive and therapeutic effect of acupuncture for radiation-induced xerostomia in patients with head and neck cancer: a systematic reviewIntegr Cancer Ther20131219720522791311
  • Diaz-ArnoldAMMarekCAThe impact of saliva on patient care: a literature reviewJ Prosthet Dent20028833734312426506
  • MommFVolegova-NeherNJSchulte-MontingJGuttenbergerRDifferent saliva substitutes for treatment of xerostomia following radiotherapy. A prospective crossover studyStrahlenther Onkol200518123123615827692
  • DaviesAClinically proved treatments for xerostomia were ignoredBMJ199831612479583935