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Review

Adverse drug reactions and drug–drug interactions with over-the-counter NSAIDs

, &
Pages 1061-1075 | Published online: 15 Jul 2015

References

  • Naprelan® (naproxen sodium) [package insert]San Diego, CAVictory Pharma, Inc2009
  • Orudis® (ketoprofen) [package insert]Philadelphia, PAWyeth Pharmaceuticals Inc2007
  • HershEVMoorePARossGLOver-the-counter analgesics and antipyretics: a critical assessmentClin Ther200022550054810868553
  • SchiffMMinicMComparison of the analgesic efficacy and safety of nonprescription doses of naproxen sodium and Ibuprofen in the treatment of osteoarthritis of the kneeJ Rheumatol20043171373138315229960
  • RainsfordKDFifty years of ibuprofen: advancing pain and fever managementInt J Clin Pract Suppl20131781223163541
  • CooperSASchachtelBPGoldmanEGelbSCohnPIbuprofen and acetaminophen in the relief of acute pain: a randomized, double-blind, placebo-controlled studyJ Clin Pharmacol19892911102610302689471
  • SchachtelBPFillingimJMThodenWRLaneACBaybuttRISore throat pain in the evaluation of mild analgesicsClin Pharmacol Ther19884467047113197368
  • RaoPKnausEEEvolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyondJ Pharm Pharm Sci200811281s110s19203472
  • FreedmanMDDrug interactions: classification and systematic approachAm J Ther19952643344311850688
  • HaasDAAdverse drug interactions in dental practice: interactions associated with analgesics, Part III in a seriesJ Am Dent Assoc1999130339740710085663
  • DuongMSalvoFParienteAUsage patterns of ‘over-the-counter’ vs prescription-strength nonsteroidal anti-inflammatory drugs in FranceBr J Clin Pharmacol201477588789524102791
  • KoffemanARValkhoffVECelikSHigh-risk use of over-the-counter non-steroidal anti-inflammatory drugs: a population-based cross-sectional studyBr J Gen Pract201464621e191e19824686883
  • GutthannSPGarcía RodríguezLARaifordDSIndividual nonsteroidal antiinflammatory drugs and other risk factors for upper gastrointestinal bleeding and perforationEpidemiology19978118249116088
  • SchoenfeldPKimmeyMBScheimanJBjorkmanDLaineLReview article: nonsteroidal anti-inflammatory drug-associated gastrointestinal complications – guidelines for prevention and treatmentAliment Pharmacol Ther199913101273128510540041
  • HenryDLimLLGarcia RodriguezLAVariability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysisBMJ19963127046156315668664664
  • HenryDMcGettiganPEpidemiology overview of gastrointestinal and renal toxicity of NSAIDsInt J Clin Pract Suppl2003135434912723747
  • DerrySLokeYKRisk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysisBMJ200032172701183118711073508
  • WeilJColin-JonesDLangmanMProphylactic aspirin and risk of peptic ulcer bleedingBMJ199531069838278307711618
  • LewisSCLangmanMJLaporteJRMatthewsJNRawlinsMDWiholmBEDose-response relationships between individual nonaspirin nonsteroidal anti-inflammatory drugs (NANSAIDs) and serious upper gastrointestinal bleeding: a meta-analysis based on individual patient dataBr J Clin Pharmacol200254332032612236853
  • MooreNVanganseELeparcJ-MThe PAIN study: Paracetamol, Aspirin and Ibuprofen New tolerability study: a large-scale, randomised clinical trial comparing the tolerability of aspirin, ibuprofen and paracetamol for short-term analgesiaClin Drug Investig19991828998
  • MooreNCharlesworthAVan GanseERisk factors for adverse events in analgesic drug users: results from the PAIN studyPharmacoepidemiol Drug Saf200312760161014558184
  • FriesJFBruceBRates of serious gastrointestinal events from low dose use of acetylsalicylic acid, acetaminophen, and ibuprofen in patients with osteoarthritis and rheumatoid arthritisJ Rheumatol200330102226223314528521
  • RichyFBruyereOEthgenOTime dependent risk of gastrointestinal complications induced by non-steroidal anti-inflammatory drug use: a consensus statement using a meta-analytic approachAnn Rheum Dis200463775976615194568
  • BlotWJMcLaughlinJKOver the counter non-steroidal anti- inflammatory drugs and risk of gastrointestinal bleedingJ Epidemiol Biostat20005213714210890286
  • LewisJDKimmelSELocalioARRisk of serious upper gastrointestinal toxicity with over-the-counter nonaspirin nonsteroidal anti-inflammatory drugsGastroenterology200512961865187416344055
  • Hippisley-CoxJCouplandCLoganRRisk of adverse gastrointestinal outcomes in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysisBMJ200533175281310131616322018
  • MooreNSalvoFDuongMBlinPParienteACardiovascular risks associated with low-dose ibuprofen and diclofenac as used OTCExpert Opin Drug Saf201413216717924256349
  • Summary Minutes of the Joint Arthritis Advisory Committee and Drug Safety and Risk Management Advisory Committee Meeting February 10–11, 2014Silver Spring, MDFood and Drug Administration; Center for Drug Evaluation and Research2014 Available from: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/ArthritisAdvisoryCommittee/UCM395527.pdfAccessed September 10, 2014
  • Advil® (ibuprofen) [package insert]Madison, NJPfizer Consumer Healthcare2012
  • Aleve® (naproxen sodium) [package insert]Whippany, NJBayer HealthCare Consumer Care2014
  • Safety Alerts for Human Medical Products: Vioxx (rofecoxib) Sep 2004 [webpage on the Internet]Silver Spring, MDU.S. Food and Drug Administration [updated August 21, 2013]. Available from: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHu-manMedicalProducts/ucm166532.htmAccessed October 11, 2013
  • CaldwellBAldingtonSWeatherallMShirtcliffePBeasleyRRisk of cardiovascular events and celecoxib: a systematic review and meta-analysisJ R Soc Med200699313214016508052
  • SolomonDHAvornJStürmerTGlynnRJMogunHSchneeweissSCardiovascular outcomes in new users of coxibs and nonsteroidal antiinflammatory drugs: high-risk subgroups and time course of riskArthritis Rheum20065451378138916645966
  • FosbølELGislasonGHJacobsenSRisk of myocardial infarction and death associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) among healthy individuals: a nationwide cohort studyClin Pharmacol Ther200985219019718987620
  • Hippisley-CoxJCouplandCRisk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysisBMJ20053307504136615947398
  • GislasonGHRasmussenJNAbildstromSZIncreased mortality and cardiovascular morbidity associated with use of nonsteroidal anti-inflammatory drugs in chronic heart failureArch Intern Med2009169214114919171810
  • LipworthLFriisSBlotWJA population-based cohort study of mortality among users of ibuprofen in DenmarkAm J Ther200411315616315133529
  • WeirMRRenal effects of nonselective NSAIDs and coxibsCleve Clin J Med200269Suppl 1SI53SI5812086295
  • FarquharWBMorganALZambraskiEJKenneyWLEffects of acetaminophen and ibuprofen on renal function in the stressed kidneyJ Appl Physiol (1985)19998625986049931196
  • SchneiderVLévesqueLEZhangBHutchinsonTBrophyJMAssociation of selective and conventional nonsteroidal antiinflammatory drugs with acute renal failure: a population-based, nested case-control analysisAm J Epidemiol2006164988188917005625
  • FureySAVargasRMcMahonFGRenovascular effects of nonprescription ibuprofen in elderly hypertensive patients with mild renal impairmentPharmacotherapy19931321431488469621
  • GriffinMRYaredARayWANonsteroidal antiinflammatory drugs and acute renal failure in elderly personsAm J Epidemiol2000151548849610707917
  • LeskoSMMitchellAAAn assessment of the safety of pediatric ibuprofen. A practitioner-based randomized clinical trialJAMA1995273129299337884951
  • LeskoSMMitchellAARenal function after short-term ibuprofen use in infants and childrenPediatrics199710069549579374563
  • UlinskiTGuigonisVDunanOBensmanAAcute renal failure after treatment with non-steroidal anti-inflammatory drugsEur J Pediatr2004163314815014745553
  • WongWCowardRJMorrisMCIbuprofen induced acute renal failure in an infantN Z Med J2001114114043111700753
  • KovesiTASwartzRMacDonaldNTransient renal failure due to simultaneous ibuprofen and aminoglycoside therapy in children with cystic fibrosisN Engl J Med1998338165669424574
  • VolansGMonaghanJColbridgeMIbuprofen overdoseInt J Clin Pract Suppl2003135546012723749
  • VeltriJCRollinsDEA comparison of the frequency and severity of poisoning cases for ingestion of acetaminophen, aspirin, and ibuprofenAm J Emerg Med1988621041073355621
  • PalmerRWeissRZusmanRMHaigAFlavinSMacDonaldBEffects of nabumetone, celecoxib, and ibuprofen on blood pressure control in hypertensive patients on angiotensin converting enzyme inhibitorsAm J Hypertens200316213513912559680
  • GurwitzJHEverittDEMonaneMThe impact of ibuprofen on the efficacy of antihypertensive treatment with hydrochlorothiazide in elderly personsJ Gerontol A Biol Sci Med Sci1996512M74M798612107
  • HoustonMCWeirMGrayJThe effects of nonsteroidal anti-inflammatory drugs on blood pressures of patients with hypertension controlled by verapamilArch Intern Med199515510104910547748048
  • BhagatKEffects of non-steroidal anti-inflammatory drugs on hypertension control using angiotensin converting enzyme inhibitors and thiazide diureticsEast Afr Med J2001781050750911921591
  • ThakurVCookMEWallinJDAntihypertensive effect of the combination of fosinopril and HCTZ is resistant to interference by nonsteroidal antiinflammatory drugsAm J Hypertens1999129 Pt 192592810509552
  • MacDonaldTMRichardDLheritierKKrammerGThe effects of lumiracoxib 100 mg once daily vs ibuprofen 600 mg three times daily on the blood pressure profiles of hypertensive osteoarthritis patients taking different classes of antihypertensive agentsInt J Clin Pract201064674675520518950
  • LapiFAzoulayLYinHNessimSJSuissaSConcurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control studyBMJ2013346e852523299844
  • PavlicevićIGlavaskiMRumboldtMRumboldtZProhypertensive effects of non-steroidal anti-inflammatory drugs are mostly due to vasoconstrictionColl Antropol201135381782222053561
  • AyalasomayajulaSTchaloyanSYehCMA study of the pharmacokinetic interactions of the direct renin inhibitor aliskiren with allopurinol, celecoxib and cimetidine in healthy subjectsCurr Med Res Opin200824371772618234150
  • VerhammeKMosisGDielemanJStrickerBSturkenboomMSpironolactone and risk of upper gastrointestinal events: population based case-control studyBMJ2006333756333016840442
  • MascleeGMValkhoffVEColomaPMRisk of upper gastrointestinal bleeding from different drug combinationsGastroenterology2014147478479224937265
  • HoffmannWvan den BergNThyrianJRFissTFrequency and determinants of potential drug–drug interactions in an elderly population receiving regular home visits by GPs – results of the home medication review in the AGnES-studiesPharmacoepidemiol Drug Saf201120121311131821919114
  • KlassenDGoodfriendTLSchunaAAYoungDYPetersonCAAssessment of blood pressure during treatment with naproxen or ibuprofen in hypertensive patients treated with hydrochlorothiazideJ Clin Pharmacol199333109719788227469
  • PavlicevićIKuzmanićMRumboldtMRumboldtZInteraction between antihypertensives and NSAIDs in primary care: a controlled trialCan J Clin Pharmacol2008153e372e38218953082
  • PatersonCAJacobsDRasmussenSYoungbergSPMcGuinnessNRandomized, open-label, 5-way crossover study to evaluate the pharmacokinetic/pharmacodynamic interaction between furosemide and the non-steroidal anti-inflammatory drugs diclofenac and ibuprofen in healthy volunteersInt J Clin Pharmacol Ther201149847749021781648
  • WebsterJInteractions of NSAIDs with diuretics and beta-blockers mechanisms and clinical implicationsDrugs198530132412863124
  • DaviesJGRawlinsDCBussonMEffect of ibuprofen on blood pressure control by propranolol and bendrofluazideJ Int Med Res19881631731813044869
  • GroverSACoupalLZowallHTreating osteoarthritis with cyclooxygenase-2-specific inhibitors: what are the benefits of avoiding blood pressure destabilization?Hypertension2005451929715545508
  • Catella-LawsonFReillyMPKapoorSCCyclooxygenase inhibitors and the antiplatelet effects of aspirinN Engl J Med2001345251809181711752357
  • MackenzieISCoughtrieMWMacDonaldTMWeiLAntiplatelet drug interactionsJ Intern Med2010268651652921073556
  • SaxenaABalaramnavarVMHohlfeldTSaxenaAKDrug/drug interaction of common NSAIDs with antiplatelet effect of aspirin in human plateletsEur J Pharmacol20137211–321522424075938
  • KimmelSEBerlinJAReillyMThe effects of nonselective non-aspirin non-steroidal anti-inflammatory medications on the risk of nonfatal myocardial infarction and their interaction with aspirinJ Am Coll Cardiol200443698599015028354
  • KurthTGlynnRJWalkerAMInhibition of clinical benefits of aspirin on first myocardial infarction by nonsteroidal antiinflammatory drugsCirculation2003108101191119512939216
  • MacDonaldTMWeiLEffect of ibuprofen on cardioprotective effect of aspirinLancet2003361935757357412598144
  • PatelTNGoldbergKCUse of aspirin and ibuprofen compared with aspirin alone and the risk of myocardial infarctionArch Intern Med2004164885285615111370
  • FischerLMSchliengerRGMatterCMJickHMeierCRCurrent use of nonsteroidal antiinflammatory drugs and the risk of acute myocardial infarctionPharmacotherapy200525450351015977911
  • AntonicelliLTagliabracciAAsthma death induced by ibuprofenMonaldi Arch Chest Dis19955042762787550206
  • GorayaJSVirdiVSTo the editor: Exacerbation of asthma by ibuprofen in a very young childPediatr Pulmonol200132326211536457
  • MerrittGJSelleRIJrCross-reactivity between aspirin and ibuprofen in an asthmatic – a case reportAm J Hosp Pharm1978351012451248696734
  • SzczeklikANizankowskaEMastalerzLSzaboZAnalgesics and asthmaAm J Ther20029323324311941383
  • PalmerGMA teenager with severe asthma exacerbation following ibuprofenAnaesth Intensive Care200533226126515960412
  • DebleyJSCarterERGibsonRLRosenfeldMReddingGJThe prevalence of ibuprofen-sensitive asthma in children: a randomized controlled bronchoprovocation challenge studyJ Pediatr2005147223323816126056
  • MellemkjaerLBlotWJSørensenHTUpper gastrointestinal bleeding among users of NSAIDs: a population-based cohort study in DenmarkBr J Clin Pharmacol200253217318111851641
  • JohnsenSPSørensenHTMellemkjoerLHospitalisation for upper gastrointestinal bleeding associated with use of oral anticoagulantsThromb Haemost200186256356811522004
  • HirshJDalenJEDeykinDPollerLOral anticoagulants. Mechanism of action, clinical effectiveness, and optimal therapeutic rangeChest19921024 Suppl312S326S1345417
  • P450 Drug Interaction Table [webpage on the Internet]Indianapolis, INIndiana University [updated July 12, 2013; cited April 12, 2013]. Available from: http://medicine.iupui.edu/clinpharm/ddis/table.aspxAccessed March 21, 2015
  • GreenblattDJvon MoltkeLLInteraction of warfarin with drugs, natural substances, and foodsJ Clin Pharmacol200545212713215647404
  • ThijssenHHSouteBAVervoortLMClaessensJGParacetamol (acetaminophen) warfarin interaction: NAPQI, the toxic metabolite of paracetamol, is an inhibitor of enzymes in the vitamin K cycleThromb Haemost200492479780215467911
  • MahéICaulinCBergmannJFDoes paracetamol potentiate the effects of oral anticoagulants?: a literature reviewDrug Saf200427532533315061686
  • MahéIBertrandNDrouetLParacetamol: a haemorrhagic risk factor in patients on warfarinBr J Clin Pharmacol200559337137415752384
  • MahéIBertrandNDrouetLInteraction between paracetamol and warfarin in patients: a double-blind, placebo-controlled, randomized studyHaematologica200691121621162717145598
  • ZhangQBal-dit-SollierCDrouetLInteraction between acetaminophen and warfarin in adults receiving long-term oral anticoagulants: a randomized controlled trialEur J Clin Pharmacol201167330931421191575
  • MacDonaldTMWeiLIs there an interaction between the cardiovascular protective effects of low-dose aspirin and ibuprofen?Basic Clin Pharmacol Toxicol200698327528016611202
  • Information for Healthcare Professionals: Concomitant use of Ibuprofen and Aspirin [webpage on the Internet]Silver Spring, MDU.S. Food and Drug Administration2006 [updated August 14, 2013; cited April 12, 2013]. Available from: http://www.fda.gov/Drugs/Drug-Safety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm125222.htmAccessed March 21, 2015
  • SerebruanyVLSelective serotonin reuptake inhibitors and increased bleeding risk: are we missing something?Am J Med2006119211311616443409
  • HallbäckIHäggSErikssonACWhissPAIn vitro effects of serotonin and noradrenaline reuptake inhibitors on human platelet adhesion and coagulationPharmacol Rep201264497998323087151
  • Bismuth-EvenzalYGonopolskyYGurwitzDIancuIWeizmanARehaviMDecreased serotonin content and reduced agonist-induced aggregation in platelets of patients chronically medicated with SSRI drugsJ Affect Disord20121361–29910321893349
  • de AbajoFJRodríguezLAMonteroDAssociation between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control studyBMJ199931972171106110910531103
  • de JongJCvan den BergPBTobiHde Jong-van den BergLTCombined use of SSRIs and NSAIDs increases the risk of gastrointestinal adverse effectsBr J Clin Pharmacol200355659159512814454
  • SchaferAIEffects of nonsteroidal antiinflammatory drugs on platelet function and systemic hemostasisJ Clin Pharmacol19953532092197608308
  • ZullinoDFKhazaalYIncreased risk of gastrointestinal adverse effects under SSRI/NSAID combination may be due to pharmacokinetic interactionsBr J Clin Pharmacol200559111811915606451
  • AndradeCSandarshSChethanKBNageshKSSerotonin reuptake inhibitor antidepressants and abnormal bleeding: a review for clinicians and a reconsideration of mechanismsJ Clin Psychiatry201071121565157521190637
  • PhelanKMMosholderADLuSLithium interaction with the cyclooxygenase 2 inhibitors rofecoxib and celecoxib and other non-steroidal anti-inflammatory drugsJ Clin Psychiatry200364111328133414658947
  • FinleyPRWarnerMDPeabodyCAClinical relevance of drug interactions with lithiumClin Pharmacokinet19952931721918521679
  • RaghebMPowellALLithium interaction with sulindac and naproxenJ Clin Psychopharmacol1986631501543711365
  • RaghebMIbuprofen can increase serum lithium level in lithium-treated patientsJ Clin Psychiatry19874841611633558329
  • KaufmanDWKellyJPWiholmBEThe risk of acute major upper gastrointestinal bleeding among users of aspirin and ibuprofen at various levels of alcohol consumptionAm J Gastroenterol199994113189319610566713
  • Food and Drug Administration, HHSOrgan-specific warnings; internal analgesic, antipyretic, and antirheumatic drug products for over-the-counter human use; final monograph. Final ruleFed Regist20097481193851940919507324
  • MüllerWESingerAWonnemannMHafnerURolliMSchäferCHyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extractPharmacopsychiatry199831Suppl 116219684943
  • BorrelliFIzzoAAHerb-drug interactions with St John’s wort (Hypericum perforatum): an update on clinical observationsAAPS J200911471072719859815
  • BellECRavisWRLloydKBStokesTJEffects of St John’s wort supplementation on ibuprofen pharmacokineticsAnn Pharmacother200741222923417284505
  • IzzoAAErnstEInteractions between herbal medicines and prescribed drugs: an updated systematic reviewDrugs200969131777179819719333
  • MeiselCJohneARootsIFatal intracerebral mass bleeding associated with Ginkgo biloba and ibuprofenAtherosclerosis2003167236712818420
  • SavovicJWiderBErnstEEffects of Ginkgo biloba on blood coagulation parameters: a systematic review of randomised clinical trialsEvidence-Based Integrative Medicine200523167176
  • ChavezMLJordanMAChavezPIEvidence-based drug – herbal interactionsLife Sci200678182146215716427091
  • Methotrexate sodium [package insert]Lake Zurich, ILFresenlus Kabi USA, LLC2013
  • TracyTSKrohnKJonesDRBradleyJDHallSDBraterDCThe effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritisEur J Clin Pharmacol19924221211251618240
  • KremerJMHamiltonRAThe effects of nonsteroidal antiinflammatory drugs on methotrexate (MTX) pharmacokinetics: impairment of renal clearance of MTX at weekly maintenance doses but not at 7.5 mgJ Rheumatol19952211207220778596147
  • EganLJDrug interactions in gastroenterology: mechanisms, consequences, and how to avoidClin Gastroenterol Hepatol20042972573015354272
  • MurrayMDBlackPKKuzmikDDAcute and chronic effects of nonsteroidal antiinflammatory drugs on glomerular filtration rate in elderly patientsAm J Med Sci199531051881977485222
  • BrooksCDUlrichJEEffect of ibuprofen or aspirin on probenecid-induced uricosuriaJ Int Med Res1980842832857409302
  • García RodríguezLAEganKFitzGeraldGATraditional nonsteroidal anti-inflammatory drugs and postmenopausal hormone therapy: a drug–drug interaction?PLoS Med200745e15717518513
  • HeissGWallaceRAndersonGLWHI InvestigatorsHealth risks and benefits 3 years after stopping randomized treatment with estrogen and progestinJAMA200829991036104518319414
  • RossouwJEAndersonGLPrenticeRLWriting Group for the Women’s Health Initiative InvestigatorsRisks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trialJAMA2002288332133312117397
  • MansonJEChlebowskiRTStefanickMLMenopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women’s Health Initiative randomized trialsJAMA2013310131353136824084921
  • SchierbeckLLRejnmarkLToftengCLEffect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomised trialBMJ2012345e640923048011
  • MendonçaLLKhamashtaMANelson-PiercyCHuntBJHughesGRNon-steroidal anti-inflammatory drugs as a possible cause for reversible infertilityRheumatology (Oxford)200039888088210952743
  • NielsenGLSørensenHTLarsenHPedersenLRisk of adverse birth outcome and miscarriage in pregnant users of non-steroidal anti-inflammatory drugs: population based observational study and case-control studyBMJ2001322728126627011157526
  • NielsenGLSkriverMVPedersenLSørensenHTDanish group reanalyses miscarriage in NSAID usersBMJ2004328743110914715618
  • HorwitzRIFeinsteinARThe problem of “protopathic bias” in case-control studiesAm J Med19806822552587355896
  • LiDKLiuLOdouliRExposure to non-steroidal anti-inflammatory drugs during pregnancy and risk of miscarriage: population based cohort studyBMJ2003327741136812919986
  • MajedBHKhalilRAMolecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newbornPharmacol Rev201264354058222679221
  • PiperJMRayWADaughertyJRGriffinMRCorticosteroid use and peptic ulcer disease: role of nonsteroidal anti-inflammatory drugsAnn Intern Med199111497357402012355
  • KataokaHHorieYKoyamaRNakatsugiSFurukawaMInteraction between NSAIDs and steroid in rat stomach: safety of nimesulide as a preferential COX-2 inhibitor in the stomachDig Dis Sci20004571366137510961716
  • JacubeitTDrischDWeberERisk factors as reflected by an intensive drug monitoring systemAgents Actions Suppl1990291171252316432
  • LaFleurJMcBethCGunningKOderdaLSteinvoortCOderdaGMPrevalence of drug-related problems and cost-savings opportunities in medicaid high utilizers identified by a pharmacist-run drug regimen review centerJ Manag Care Pharm200612867768517269846