References
- AllenAPEarleyCJRestless legs syndrome: A review of clinical and pathophysiologic featuresJ Clin Neurophysiol20011812814711435804
- AllenRPPicchiettiDHeningWATrenkwalderCWaltersASMontplaisiJRestless legs syndrome: diagnostic criteria, special considerations, and epidemiology A report from restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of HealthSleep Med2003410111914592341
- TrenkwalderCHoglBWinkelmannJRecent advances in the diagnosis, genetics and treatment of resltess legs syndromeJ Neurol200925653955319444530
- SimakajornboonHNKheirandish-GozalLGozalDDiagnosis and management of restless legs syndrome in childrenSleep Med Rev20091314915619186083
- McRaeANeurotransmitters and pharmacology of the basal gangliaJankovicJTolosaEParkinson’s Disease and Movement DisordersBaltimoreWilliams and Wilkins1998491592
- BrooksDJFunctional imaging of movement disordersJankovicJTolosaEParkinson’s Disease and Movement DisordersBaltimoreWilliams and Wilkins19989911016
- LeWittPAPfeifferRENeurologic aspects of Wilson’s disease: clinical manifestations and treatment considerationsJankovicJTolosaEParkinson’s Disease and Movement DisordersBaltimoreWilliams and Wilkin19984766
- BagettaGDe SarroGPrioloENisticòGVentral tegmental area: site through which dopamine D2-receptor agonists evoke behavioural and electrocortical sleep in ratsBr J Pharmacol1988958608662974741
- WinkelmanJWConsidering the causes of RLSEur J Neurol200613Suppl 3S8S14
- MontplaisirJBoucherSPoirierGLavigneGLapierreOLespérancePClinical, polysomnographic, and genetic characteristics of restless legs syndrome: a study of 133 patients diagnosed with new standard criteriaMov Disorders2004126165
- AllenRDopamine and iron in the pathophysiology of restless legs syndrome (RLS)Sleep Med2004538539115222997
- StaedtJStoppeGKoglerADopamine D2 receptor alteration in patients with periodic movements in sleep (nocturnal myoclonus)J Neurol Transm1993937174
- StaedtJStoppeGKoglerANocturnal myoclonus syndrome (periodic movements in sleep) related to central dopamine D2-receptor alterationsEur Arch Psychiatry Clin Neurosci19952458107786913
- TurjanskiNLeesAJBrooksDJStriatal dopaminergic function in restless legs syndrome: 18F-dopa and 11C-raclopride PET studiesNeurology19995293293710102408
- MichaudMSoucyJPChabliALavigneGMontplaisirJSPECT imaging of striatal pre- and postsynaptic dopaminergic status in restless legs syndrome with periodic leg movements in sleepJ Neurol20022491647011985381
- PatrickLRRestless legs syndrome: pathophysiology and the role of iron and folateAltern Med RBev20071210112
- O’KeeffeSTGavinKLavanJNIron status and restless legs syndrome in the elderlyAge Ageing1994232002038085504
- SunERChenCAHoGEarleyCJAllenRPIron and the restless legs syndromeSleep1998213713779646381
- BergerKvon EckardsteinATrenkwalderCRothdachAJunkerRWeilandSKIron metabolism and the risk of restless legs syndrome in an elderly general population – the MEMO studyJ Neurol20022491195119912242538
- EarleyCJHecklerDAllenRPIV iron treatment for RLSSleep200024359
- AllenRPBarkerPBWehrlFSongHKEarleyCJMRI measurement of brain iron in patients with restless legs syndromeNeurology20015626326511160969
- ConnorJRBoyerPJMenziesSLNeuropathological examination suggests impaired brain iron acquisition in restless legs syndromeNeurology19996130430912913188
- SnyderAMWangXPattonSMMitochondrial ferritin in the substantia nigra in restless legs syndromeJ Neuropathol Exp Neurol2009681193119919816198
- EarleyCJHecklerDAllenRPRepeated IV doses of iron provides effective supplemental treatment of restless legs syndromeSleep Med2005630130515978514
- GroteLLeissnerLHednerJUlfbergJA randomized, double-blind, placebo controlled, multi-center study of intravenous iron sucrose and placebo in the treatment of restless legs syndromeMov Disord2009241445145219489063
- EarleyCJHorskÃAMohamedMABarkerPBBeardJLAllenRPA randomized, double-blind, placebo-controlled trial of intravenous iron sucrose in restless legs syndromeSleep Med20091020621118280205
- UngerELEarleyCJBeardJLDiurnal cycle influences peripheral and brain iron levels in miceJ Appl Physiol200910618719318988764
- EarleyCJPonnuruPWangXAltered iron metabolism in lymphocytes from subjects with restless legs syndromeSleep20083184785218548829
- O’KeeffeSTIron deficiency with normal ferritin levels in restless legs syndromeSleep Med2005628128215854860
- ConnorJRWangXSAllenRPAltered dopaminergic profile in the putamen and substantia nigra in restless leg syndromeBrain20091322403241219467991
- AllenRPEarleyCJRestless legs syndrome: A review of clinical and pathophysiologic featuresJ Clin Neurophysiol20011812814711435804
- WinkelmannJSchadrackJWetterTCZieglgänsbergerWTrenkwalderCOpioid and dopamine antagonist drug challenges in untreated restless legs syndrome patientsSleep Med200125661
- WetterTCStiasnyKWinkelmanJA randomized controlled study of pergolide in patients with restless legs syndromeNeurology19995294495010102410
- BucherSSeelosyKTrenkwalderCActivation mapping of involuntary limb movements in the restless legs syndrome using functional magnetic resonance imagingProceedings of the 4th International Society for Magnetic Imaging in Medicine1996 April 27-MayNew York, USADallasWiley19961331
- OndoWGVuongKDWangQRestless legs syndrome in monozygotic twins: clinical correlatesNeurology2000551404140611087794
- LazzariniAWaltersASHickeyKStudies of penetrance and anticipation in five autosomal-dominant restless legs syndrome pedigreesMov Disord1999141111169918352
- AllenRPLa BudaMCBeckerPEarleyCJFamily history study of the restless legs syndromeSleep Med20023SupplS3S714592159
- WinkelmanJWetterTCCollado-SeidelVClinical characteristics and frequency of the hereditary restless legs syhdrome in a population of 300 patientsSleep20002359760210947027
- BonatiMTFerini-StrambiLAridonPOldaniAZucconiMCasariGAutosomal dominant restless legs syndrome maps on chromosome 14qBrain20031261485149212764067
- PichlerIMarroniFVolpatoCBLinkage analysis identifies a novel locus for restless legs syndrome on chromosome 2q in a South Tyrolean populatio isolateAm J Hum Genet20067971672316960808
- ChenSOndoWGRaoSLiLChenQWangQGenomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9pAm J Hum Genet20047487688515077200
- WinkelmannJLichtnerPKemLinkDNew loci for restless legs syndrome map to Chromosome 4q and 17p [abstract]Mov Disord200621304
- StefanssonHRyeDBHicksAA genetic risk factor for periodic limb movements in sleepN Engl J Med200735763964717634447
- WinkelmannJSchormairBLichtnerPGenome-wide association study of restless legs syndrome identifies common variants in three genomic regionsNat Geneet20073910001006
- VetrugnoRD’angeloRMontagnaPPeriodic limb movements in sleep and periodic limb movement disorderNeruol Sci200728SupplS9S14
- BaranASRichertACDouglassABMayWAnsarinKChange in periodic limb movements index during treatment of obstructive sleep apnea with continuous positive airway pressureSleep20032671772014572125
- ColemanRMPollackCPWeitzmanEDPeriodic movements in sleep (nocturnal myoclonus): relation to sleep disordersAnn Neurol198084164217436384
- HornyakMFeigeBRiemannDVoderholzerUPeriodic leg movements in sleep and periodic limb movement disorder: prevalence, clinical significance and treatmentSleep Med Rev20061016917716762807
- American Sleep Disorders AssociationRecording and scoring leg movements. The Atlas Task ForceSleep1993167487598165390
- ZucconiMFerriRAllenRThe official World Association of Sleep Medicine (WASM) standards for recording and scoring periodic leg movements in sleep (PLMS) and wakefulness (PLMW) developed in collaboration with a task force from the International Restless Legs Syndrome Study Group (IRLSSG)Sleep Med2006717518316459136
- AllenRPPicchiettiDHeningWARestless legs syndrome: diagnostic criteria, special considerations, and epidemiology A report from restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of HealthSleep Med2003410111914592341
- American Academy of Sleep MedicineInternational Classification of Sleep Disorders2nd edDiagnostic and Coding ManualWestchester, IllinoisAmerican Academy of Sleep Medicine2005
- EarleyCJAllenRPBeardJLConnorJRInsight into the pathophysiology of resless legs syndromeJ Neurosci Res20006262362811104500
- PicchiettiDAllenRPWaltersASDavidsonJEMyersAFerini-StrambiLRestless legs syndrome: prevalence and impact in children and adolescents-the Peds REST studyPediatrics200712025326617671050
- KirkVGBohnSPeriodic limb movements in children: prevalence in a referred populationSleep20042731331515124728
- Ancoli-IstraelSKripkeDFKlauberMRPeriodic limb movements in sleep in community-dwelling elderlySleep1991144965001798881
- FerriRGschliesserVFrauscherBPoeweWHöglBPeriodic leg movements and periodic leg movement disorder in patients presenting with unexplained insomniaClin Neurophysiol200912025726319109055
- LeeMSChoiYCLeeSHLeeSBSleep related periodic leg movements associated with spinal cord lesionsMov Disord1996117197228914100
- LugaresiECirignottaFCoccagnaGMontagnaPNocturnal myoclonus and restless legs syndromeAdv Neurol1986432953073946114
- TrenkwalderCBucherSFOertelWHBereitschaftspotential in idiopathic and symptomatic restless legs syndromeElectroencephalogr Clin Neurophysiol199389951037683607
- FerriRZucconiMRundoFSpruytKManconiMFerini-StrambiLHeart rate and spectral EEG changes accompanying periodic and non-periodic leg movements during sleepClin Neurophysiol200711843844817140849
- FerrilloFBeelkeMCanovaroPChanges in cerebral and autonomic activity heralding periodic limb movements in sleepSleep Med2004540741215223001
- SforzaENicolasALavigneGGosselinAPetitDMontplaisirJEEG and cardiac activation during periodic leg movements in sleep: support for a hierarchy of arousal responsesNeurology19995278679110078729
- GuggisbergAGHessCWMathisJThe significance of the sympathetic nervous system in the pathophysiology of periodic leg movements in sleepSleep20073075576617580597
- PennestriMHMontplaisirJColomboRLavigneGLanfranchiPANocturnal blood pressure changes in patients with restless legs syndromeNeurology2007681213121817420405
- SiddiquiFStrusJMingXLeeIAChokrovertySWaltersASRise of blood pressure with periodic limb movements in sleep and wakefulnessClin Neurophysiol20071181923193017588809
- WaltersASRyeDBReview of the relationship of restless legs syndrome and periodic limb movements in sleep to hypertension, heart disease, and strokeSleep20093258959719480225
- AllenRDopamine and iron in the pathophysiology of restless legs syndrome (RLS)Sleep Med2004538539115222997
- HeningWAWaltersASWagnerMCircadian rhythm of motor restlessness and sensory symptoms in idiopathic restless legs syndromeSleep19992290191210566908
- KhaldyHLeónJEscamesGBikjdaoueneLGarcíaJJAcuña-CastroviejoDCircadian rhythms of dopamine and dihydroxyphenyl acetic acid in the mouse striatum: effects of pinealectomy and melatonin treatmentNeuroendocrinology20027520120811914592
- OndoWGHeYRajasekaranSLeWDClinical correlates of 6-hydroxydopamine injections into A11 dopaminergic neurons in rats: a possible model for restless legs syndromeMov Disord199813271275
- KushidaCARopinirole for the treatment of restless legs syndromeNeuropsychiatr Dis Treat2006240741919412490
- EdenRJCostallBDomeneyAMPreclinical pharmacology of ropinirole (SK&F101468-A), a novel dopamine D2 agonistPharmacol Biochem Behav1991381471541673248
- ColdwellMCBoyfieldIBrownTHaganJJMiddlemissDNComparison of the functional potencies of ropinirole and other dopamine receptor agonists at human D2(long), D3 and D4 receptors expressed in Chinese hamster ovary cellsBr J Pharmacol19991271696170210455328
- LevantBLingZDCarveyPMDopamine D3 receptors: relevance for drug treatment of Parkinson’s diseaseCNS Drugs199912391402
- JennerPThe rationale for the use of dopamine agonists in Parkinson’s diseaseNeurology199545SupplS6S127715795
- BrooksDJTorjanskiNBurnDJRopinirole in the symptomatic treatment of Parkinson’s diseaseJ Neural Transm Suppl1995452312388748630
- RamjiJVKeoghJPBlakeTJDisposition of ropinirole in animals and manXenobiotica19992931132510219970
- DolleryCRopinirole hydrochlorideDolleryCTherapeutic drugs22nd edEdinburghChurchill Livingstone19995054
- SwagzdisJEWittendorfRWDeMarinisRMMicoBAPharmacokinetics of dopamine-2 agonists in rats and dogsJ Pharm Sci1986759259283795020
- JennerPTullochIThe preclinical pharmacology of ropinirole-receptro interactions, antiparkinsonian activity and potential to induce dyskinesiaOlanowCWObesoJABeyond the Decade of the Brain Dopamine agonists in early Parkinson’s diseaseRoyal Tunbridge WellsWells Medical1997115128
- BloomerJCClarkeSEHeneryRJIn vitro identification of the P450 enzymes responsible for the metabolism of ropiniroleDrug Metab Dispos1997258408449224778
- BeeraheeANicholsAAluriJPopulation pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of ropinirole in Parkinson patientsReport number BF-1019Harlow (UK)SmithKline Beecham Pharmaceuticals1995
- ZevinSBenowitzNLDrug interactions with tobacco smoking: an updateClin Pharmacokinet19993642543810427467
- HubbleJKollerWCAtchinsonPLinear pharmaceuticals behavior of ropinirole during multople dosing in patients with Parkinson’s diseaseClin Pharmacol200036641646
- BrefelCThalamusCRayetSEffect on food on the pharmacokinetics of ropinirole in parkinsonian patientsBr J Clin Pharmacol1998454124259578193
- TullochIFPharmacologic profile of ropinirole: a nonergolinic dopamine agonistNeurology199749Suppl 1S58S629222275
- JostWHRopinirole: current status of the studiesJ Neurol2004251Suppl 6S13S18
- AllenRBeckerPMBoganRRopinirole decrease periodic letg movements and improves sleep parameters in patients with restless legs syndromeSleep20042790791415453549
- AdlerCHHauserRASethiKRopnirole for restless legs syndrome: a placebo-controlled crossover trialNeurology2004621405140715111683
- WaltersASOndoWGDreykluftTRopinirole is effective in the treatment of resless legs syndrome. TREAT RLS 2: a 12-week, double-blind, randomized, parallel-group, placebo-controlled studyMov Disord2004191414142315390050
- TrenkwalderCGarcia-BorregueroDMontagnaPRopinirole in the treatment of restless legs syndrome: results from a 12-week, randomised, placebo-controlled study in 10 European countriesJ Neurol Neurosurg Psychiatry200475929714707315
- BliwiseDLFreemanAIngramCDRyeDBChakravortySWattsRLRandomized, double-blind, placebo-controlled, short-term trial of ropinirole in restless legs syndromeSleep Med2005614114715716217
- BoganRKFryJMSchmidtMHRopinirole in the treatment of patients with restless legs syndrome: a US-based randomized, double-blind, placebo-controlled clinical trialMayo Clin Proc200681172716438474
- TompsonDJVearerDSteady-State Pharacokinetic Properties of a 23-hour Prolonged-Release Formulation fo Ropinirole: Results of Two Randomised Studies in Patients with Parkinson’s DiseaseClin Ther2007292654266618201581
- StocchiFGiorgiLEfficacy of ropinirole 24-hour prolonged release compared with immediate release formulation in early Parkinson’s disease (PD): the EASE-PD Monotherapy study. [abstract]Eur J Neurology200613Suppl 2205
- PahwaRStacyMAFactorSARopinirole 24-hour prolonged release. Randomized, controlled study in advanced Parkinson diseaseNeurology2007681108111517404192
- GlaxoSmithKlineClinical evaluation of ropinirole CR-RLS tablets in restless legs syndrome (RLS) open-label, uncontrolled studyStudy No. ROX1078462009http://www.gsk-clinicalstudyregister.com/files/pdf/20158.pdf
- GlaxoSmithKlineA 12-week, double-blind, placebo-controlled, parallel-group study to assess the efficacy and safety of ropinirole controlled release for RLS (CR-RLS) in patients with restless legs syndromeStudy No. SK&F-101468/2052008http://www.gsk-clinicalstudyregister.com/files/pdf/19930.pdf
- GlaxoSmithKlineA 52-Week, open-label study to assess the long-term safety of ropinirole extended release (XR) in patients with restless legs syndrome (RLS)Final report. Study No. SK&F-101468/2062008http://www.gsk-clinicalstudyregister.com/files/pdf/19931.pdf
- GlaxoSmithKlineA 52 week open-label extension study of the long-term safety of ropinirole in subjects suffering from restless legs syndrome (RLS)Study No. SKF-101468/2432005http://www.gsk-clinicalstudyregister.com/files/pdf/22613.pdf
- GlaxoSmithKlineA 12-week, multi-center, double-blind, placebo-controlled, parallel group, flexible dose polysomnography study of ropinirole controlled release for restless legs syndrome (CR-RLS) in RLS patients with sleep disturbance and periodic limb movements (PLM) during sleepStudy No. RRL103660. 2008http://www.gsk-clinicalstudyregister.com/files/pdf/21024