Facial transplantation: a review of ethics, progress, and future targets

References

• Murray JE, Tilney NL, Wilson RE. Renal transplantation: a twenty-five year experience. Ann Surg. 1976;184(5):565–573.
   Web of Science ®Google Scholar
• Devauchelle B, Badet L, Lengelé B, et al. First human face allograft: early report. Lancet. 2006;368(9531):203–209.
   PubMed Web of Science ®Google Scholar
• Barker JH, Stamos N, Furr A, et al. Research and events leading to facial transplantation. Clin Plast Surg. 2007;34(2):233–250, ix.
   Web of Science ®Google Scholar
• Gordon CR, Siemionow M, Papay F, et al. The world’s experience with facial transplantation: what have we learned thus far? Ann Plast Surg. 2009;63(5):572–578.
   Web of Science ®Google Scholar
• Brown CS, Gander B, Cunningham M, et al. Ethical considerations in face transplantation. Int J Surg. 2007;5(5):353–364.
   Google Scholar
• Annas GJ. Self experimentation and the Nuremberg Code. BMJ. 2010;341:c7103.
   Google Scholar
• Salako SE. The declaration of Helsinki 2000: ethical principles and the dignity of difference. Med Law. 2006;25(2):341–354.
   Google Scholar
• Vollmer SH, Howard G. Statistical power, the Belmont report, and the ethics of clinical trials. Sci Eng Ethics. 2010;16(4):675–691.
   Web of Science ®Google Scholar
• Kelly M, Butler PE. Patient selection for facial transplantation I: anatomical and surgical considerations. Int J Surg. 2004;2(2):114–115; discussion 115–116.
   Google Scholar
• Furr LA, Wiggins O, Cunningham M, et al. Psychosocial implications of disfigurement and the future of human face transplantation. Plast Reconstr Surg. 2007;120(2):559–565.
   Web of Science ®Google Scholar
• Gardiner MD, Topps A, Richardson G, Sacker A, Clarke A, Butler PE. Differential judgements about disfigurement: the role of location, age and gender in decisions made by observers. J Plast Reconstr Aesthet Surg. 2010;63(1):73–77.
   PubMed Web of Science ®Google Scholar
• Clarke A, Butler PE. Patient selection for facial transplantation II: psychological considerations. Int J Surg. 2004;2(2):116–117 ; discussion 117–118.
   PubMedGoogle Scholar
• Morris P, Bradley A, Doyal L, et al. Face transplantation: a review of the technical, immunological, psychological and clinical issues with recommendations for good practice. Transplantation. 2007;83(2):109–128.
   Web of Science ®Google Scholar
• Brill SE, Clarke A, Veale DM, Butler PE. Psychological management and body image issues in facial transplantation. Body Image. 2006;3(1): 1–15.
   Google Scholar
• Renshaw A, Clarke A, Diver AJ, Ashcroft RE, Butler PE. Informed consent for facial transplantation. Transpl Int. 2006;19(11):861–867.
   Web of Science ®Google Scholar
• Butler PE, Clarke A, Ashcroft RE. Face transplantation: when and for whom? Am J Bioeth. 2004;4(3):16–17; discussion W23-W31.
   PubMed Web of Science ®Google Scholar
• Hurlburt M. Facial transplantation: understanding the interests of patients and hurdles to informed consent. Med Sci Monit. 2007;13(8): RA147-RA153.
   Web of Science ®Google Scholar
• Clarke A, Butler PE. The psychological management of facial transplantation. Expert Rev Neurother. 2009;9(7):1087–1100.
   PubMed Web of Science ®Google Scholar
• Morris PJ, Bradley JA, Doyal L, et al. Facial transplantation: a working party report from the Royal College of Surgeons of England. Transplantation. 2004;77(3):330–338.
   PubMed Web of Science ®Google Scholar
• Morris P, Bradley A, Doyal L, et al. Face transplantation: a review of the technical, immunological, psychological and clinical issues with recommendations for good practice. Transplantation. 2007;83(2): 109–128.
   Web of Science ®Google Scholar
• Johnson SE, Corsten MJ. Facial transplantation in a new era: what are the ethical implications? Curr Opin Otolaryngol Head Neck Surg. 2009;17(4):274–278.
   Web of Science ®Google Scholar
• Lengelé BG. Current concepts and future challenges in facial transplantation. Clin Plast Surg. 2009;36(3):507–521.
   Web of Science ®Google Scholar
• Thorburn G, Hettiaratchy S, Ashcroft R, Butler PE. Patient selection for facial transplantation III: ethical considerations. Int J Surg. 2004;2(2):118–119; discussion 119.
   PubMedGoogle Scholar
• Clarke A, Butler PE. Facial transplantation: adding to the reconstructive options after severe facial injury and disease. Expert Opin Biol Ther. 2005;5(12):1539–1546.
   PubMed Web of Science ®Google Scholar
• Trachtman H. Facing the truth: a response to “On the ethics of facial transplantation research” by Wiggins, et al. Am J Bioeth. 2004;4(3): W33–W34.
   Web of Science ®Google Scholar
• Wiggins OP, Barker JH, Martinez S, et al. On the ethics of facial transplantation research. Am J Bioeth. 2004;4(3):1–12.
   PubMed Web of Science ®Google Scholar
• Sacks JM, Keith JD, Fisher C, Lee WP The surgeon’s role and responsibility in facial tissue allograft transplantation. Ann Plast Surg. 2007; 58(6):595–601.
   Web of Science ®Google Scholar
• Petit F, Paraskevas A, Minns AB, Lee WP, Lantieri LA. Face transplantation: where do we stand? Plast Reconstr Surg. 2004; 113(5): 1429–1433.
   Web of Science ®Google Scholar
• Pomahac B, Aflaki P, Nelson C, Balas B. Evaluation of appearance transfer and persistence in central face transplantation: a computer simulation analysis. J Plast Reconstr Aesthet Surg. 2010;63(5):733–738.
   Web of Science ®Google Scholar
• Butler PE, Clarke A, Hettiaratchy S. Facial transplantation. BMJ. 2005;331(7529):1349–1350.
   Google Scholar
• Renshaw A, Chooneea T, Clarke A, Butler PE. An artificial prosthesis to reconstruct donor defects following facial transplantation. Clin Transplant. 2007;21(4):574–576.
   Web of Science ®Google Scholar
• Vasilic D, Barker JH, Blagg R, Whitaker I, Kon M, Gossman MD. Facial transplantation: an anatomic and surgical analysis of the periorbital functional unit. Plast Reconstr Surg. 2010;125(1):125–134.
   Web of Science ®Google Scholar
• Dubernard JM, Lengelé B, Morelon E, et al. Outcomes 18 months after the first human partial face transplantation. N Engl J Med. 2007;357(24):2451–2460.
   PubMed Web of Science ®Google Scholar
• Butler PE, Hettiaratchy S, Clarke A. Managing the risks of facial transplantation. Lancet. 2006;368(9535):561–563.
   Web of Science ®Google Scholar
• Paradis C, Siemionow M, Papay F, et al. Ethical considerations in the first American face transplant. Plast Reconstr Surg. 2010;126(3):896–901.
   Web of Science ®Google Scholar
• Siemionow MZ, Papay F, Djohan R, et al. First US near-total human face transplantation: a paradigm shift for massive complex injuries. Plast Reconstr Surg. 2010;125(1):111–122.
   Web of Science ®Google Scholar
• Siemionow MZ, Zor F, Gordon CR. Face, upper extremity, and concomitant transplantation: potential concerns and challenges ahead. Plast Reconstr Surg. 2010;126(1):308–315.
   Web of Science ®Google Scholar
• Morris PJ, Bradley JA, Doyal L, et al. Facial transplantation: a working party report from the Royal College of Surgeons of England. Transplantation. 2004;77(3):330–338.
   PubMed Web of Science ®Google Scholar
• Majzoub RK, Cunningham M, Grossi F, Maldonado C, Banis JC, Barker JH. Investigation of risk acceptance in hand transplantation. J Hand Surg Am. 2006;31(2):295–302.
   Google Scholar
• Dubernard JM, Owen E, Herzberg G, et al. Human hand allograft: report on first 6 months. Lancet. 1999;353(9161):1315–1320.
   PubMed Web of Science ®Google Scholar
• Selvaggi G, Levi DM, Cipriani R, Sgarzani R, Pinna AD, Tzakis AG. Abdominal wall transplantation: surgical and immunologic aspects. Transplant Proc. 2009;41(2):521–522.
   Web of Science ®Google Scholar
• Madani H, Hettiaratchy S, Clarke A, Butler PE. Immunosuppression in an emerging field of plastic reconstructive surgery: composite tissue allotransplantation. J Plast Reconstr Aesthet Surg. 2008;61(3): 245–249.
   Web of Science ®Google Scholar
• Vasilic D, Alloway RR, Barker JH, et al. Risk assessment of immunosuppressive therapy in facial transplantation. Plast Reconstr Surg. 2007;120(3):657–668.
   Web of Science ®Google Scholar
• Chenggang Y, Yan H, Xudong Z, et al. Some issues in facial transplantation. Am J Transplant. 2008;8(10):2169–2172.
   Web of Science ®Google Scholar
• Baumeister S, Kleist C, Döhler B, Bickert B, Germann G, Opelz G. Risks of allogeneic hand transplantation. Microsurgery. 2004;24(2): 98–103.
   Web of Science ®Google Scholar
• Barker JH, Furr A, Cunningham M, et al. Investigation of risk acceptance in facial transplantation. Plast Reconstr Surg. 2006;118(3):663–670.
   PubMed Web of Science ®Google Scholar
• Pomahac B, Lengele B, Ridgway EB, et al. Vascular considerations in composite midfacial allotransplantation. Plast Reconstr Surg. 2010; 125(2):517–522.
   PubMed Web of Science ®Google Scholar
• Siemionow M, Gordon CR. Overview of guidelines for establishing a face transplant program: a work in progress. Am J Transplant. 2010; 10(5):1290–1296.
   Web of Science ®Google Scholar
• Chung KC, Oda T, Saddawi-Konefka D, Shauver MJ. An economic analysis of hand transplantation in the United States. Plast Reconstr Surg. 2010;125(2):589–598.
   Google Scholar
• Toure G, Meningaud JP, Bertrand JC, Hervé C. Facial transplantation: a comprehensive review of the literature. J Oral Maxillofac Surg. 2006; 64(5):789–793.
   Web of Science ®Google Scholar
• McFarlane PA. Should patients remain on intensive hemodialysis rather than choosing to receive a kidney transplant? Semin Dial. 2010;23(5): 516–519.
   Web of Science ®Google Scholar
• Siemionow MZ, Gordon CR. Institutional review board-based recommendations for medical institutions pursuing protocol approval for facial transplantation. Plast Reconstr Surg. 2010;126(4):1232–1239.
   Web of Science ®Google Scholar
• Hobson JE. How the system functions. The roles of the United Network of Organ Sharing, the organ procurement and transplantation network, and the organ procurement organization in heart transplantation. Crit Care Nurs Clin North Am. 2000;12(1):11–21.
   Google Scholar
• Thomas JM, Neville DM, Contreras JL, et al. Preclinical studies of allograft tolerance in rhesus monkeys: a novel anti-CD3-immunotoxin given peritransplant with donor bone marrow induces operational tolerance to kidney allografts. Transplantation. 1997;64(1):124–135.
   PubMed Web of Science ®Google Scholar
• Knechtle SJ, Vargo D, Fechner J, et al. FN18-CRM9 immunotoxin promotes tolerance in primate renal allografts. Transplantation. 1997; 63(1):1–6.
   PubMed Web of Science ®Google Scholar
• Calne R, Moffatt SD, Friend PJ, et al. Campath IH allows low-dose cyclosporine monotherapy in 31 cadaveric renal allograft recipients. Transplantation. 1999;68(10):1613–1616.
   PubMed Web of Science ®Google Scholar
• Kirk AD, Hale DA, Mannon RB, et al. Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (CAMPATH-1H). Transplantation. 2003; 76(1):120–129.
   PubMed Web of Science ®Google Scholar
• Kirk AD, Mannon RB, Kleiner DE, et al. Results from a human renal allograft tolerance trial evaluating T-cell depletion with alemtuzumab combined with deoxyspergualin. Transplantation. 2005;80(8): 1051–1059.
   PubMed Web of Science ®Google Scholar
• Farney AC, Doares W, Rogers J, et al. A randomized trial of alemtuzumab versus antithymocyte globulin induction in renal and pancreas transplantation. Transplantation. 2009;88(6):810–819.
   PubMed Web of Science ®Google Scholar
• Kawai T, Poncelet A, Sachs DH, et al. Long-term outcome and alloantibody production in a non-myeloablative regimen for induction of renal allograft tolerance. Transplantation. 1999;68(11):1767–1775.
   Web of Science ®Google Scholar
• Sharabi Y, Sachs DH. Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen. J Exp Med. 1989;169(2):493–502.
   Web of Science ®Google Scholar
• Kawai T, Cosimi AB, Colvin RB, et al. Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation. 1995;59(2):256–262.
   Web of Science ®Google Scholar
• Kimikawa M, Sachs DH, Colvin RB, Bartholomew A, Kawai T, Cosimi AB. Modifications of the conditioning regimen for achieving mixed chimerism and donor-specific tolerance in cynomolgus monkeys. Transplantation. 1997;64(5):709–716.
   Web of Science ®Google Scholar
• Helg C, Chapuis B, Bolle JF, et al. Renal transplantation without immunosuppression in a host with tolerance induced by allogeneic bone marrow transplantation. Transplantation. 1994;58(12):1420–1422.
   Web of Science ®Google Scholar
• Jacobsen N, Taaning E, Ladefoged J, Kristensen JK, Pedersen FK. Tolerance to an HLA-B, DR disparate kidney allograft after bone-marrow transplantation from same donor. Lancet. 1994;343(8900):800.
   Web of Science ®Google Scholar
• Sayegh MH, Fine NA, Smith JL, Rennke HG, Milford EL, Tilney NL. Immunologic tolerance to renal allografts after bone marrow transplants from the same donors. Ann Intern Med. 1991;114(11):954–955.
   Web of Science ®Google Scholar
• Fudaba Y, Spitzer TR, Shaffer J, et al. Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplantation: in vivo and in vitro analyses. Am J Transplant. 2006;6(9): 2121–2133.
   Web of Science ®Google Scholar
• Mapara MY, Kim YM, Marx J, Sykes M. Donor lymphocyte infusionmediated graft-versus-leukemia effects in mixed chimeras established with a nonmyeloablative conditioning regimen: extinction of graft-versus-leukemia effects after conversion to full donor chimerism. Transplantation. 2003;76(2):297–305.
   Web of Science ®Google Scholar
• Mapara MY, Kim YM, Wang SP, Bronson R, Sachs DH, Sykes M. Donor lymphocyte infusions mediate superior graft-versus-leukemia effects in mixed compared to fully allogeneic chimeras: a critical role for host antigen-presenting cells. Blood. 2002;100(5):1903–1909.
   Web of Science ®Google Scholar
• Kawai T, Cosimi AB, Spitzer TR, et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med. 2008;358(4):353–361.
   PubMed Web of Science ®Google Scholar
• Spitzer TR. Engraftment syndrome following hematopoietic stem cell transplantation. Bone Marrow Transplant. 2001;27(9):893–898.
   PubMed Web of Science ®Google Scholar