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Review

Cardiovascular toxicities of BCR-ABL tyrosine kinase inhibitors in chronic myeloid leukemia: preventive strategies and cardiovascular surveillance

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Pages 293-303 | Published online: 04 Aug 2017

References

  • EpsteinFHFaderlSTalpazMThe biology of chronic myeloid leukemiaN Engl J Med1999341316417210403855
  • DrukerBJTalpazMRestaDJEfficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemiaN Engl J Med2001344141031103711287972
  • Gambacorti-PasseriniCAntoliniLMahonF-XMulticenter independent assessment of outcomes in chronic myeloid leukemia patients treated with imatinibJ Natl Cancer Inst2011103755356121422402
  • BowerHBjorkholmMDickmanPWHoglundMLambertPCAnderssonTM-LLife expectancy of patients with chronic myeloid leukemia approaches the life expectancy of the general populationJ Clin Oncol201634242851285727325849
  • MoslehiJJDeiningerMTyrosine kinase inhibitor-associated cardiovascular toxicity in chronic myeloid leukemiaJ Clin Oncol201533354210421826371140
  • KrauseDSVan EttenRATyrosine kinases as targets for cancer therapyN Engl J Med2005 353235317218716014887
  • BellingerAMArteagaCLForceTCardio-oncologyCirculation2015132232248225826644247
  • D’AgostinoRBVasanRSPencinaMJGeneral cardiovascular risk profile for use in primary care: the Framingham heart studyCirculation2008117674375318212285
  • YusufSHawkenSOunpuuSEffect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control studyLancet20043649438937952
  • KaptogeSDi AngelantonioEPennellsLC-reactive protein, fibrinogen, and cardiovascular disease predictionN Engl J Med2012367141310132023034020
  • KimTDReaDSchwarzMPeripheral artery occlusive disease in chronic phase chronic myeloid leukemia patients treated with nilotinib or imatinibLeukemia20132761316132123459449
  • CortesJEKimD-WPinilla-IbarzJA phase 2 trial of ponatinib in Philadelphia chromosome–positive leukemiasN Engl J Med2013369191783179624180494
  • LiWCroceKSteensmaDPMcDermottDFBen-YehudaOMoslehiJVascular and metabolic implications of novel targeted cancer therapiesJ Am Coll Cardiol201566101160117826337996
  • HochhausASaglioGHughesTPLong-term benefits and risks of frontline nilotinib vs imatinib for chronic myeloid leukemia in chronic phase: 5-year update of the randomized ENESTnd trialLeukemia20163051044105426837842
  • StegPGBhattDLWilsonPWFOne-year cardiovascular event rates in outpatients with atherothrombosisJAMA200729711119717374814
  • HicksKATchengJEBozkurtB2014 ACC/AHA key data elements and definitions for cardiovascular endpoint events in clinical trialsJ Am Coll Cardiol201566440346925553722
  • WoodAJJSavageDGAntmanKHImatinib mesylate — a new oral targeted therapyN Engl J Med2002346968369311870247
  • SaglioGKimD-WIssaragrisilSNilotinib versus imatinib for newly diagnosed chronic myeloid leukemiaN Engl J Med2010362242251225920525993
  • KantarjianHShahNPHochhausADasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemiaN Engl J Med2010362242260227020525995
  • RixUHantschelODürnbergerGChemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targetsBlood2007110124055406317720881
  • BuchdungerEZimmermannJMettHInhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimi-dine derivativeCancer Res19965611001048548747
  • KerkeläRGrazetteLYacobiRCardiotoxicity of the cancer therapeutic agent imatinib mesylateNat Med200612890891616862153
  • HochhausALarsonRAGuilhotFLong-term outcomes of imatinib treatment for chronic myeloid leukemiaN Engl J Med20173761091792728273028
  • HatfieldAOwenSPilotPRIn reply to “Cardiotoxicity of the cancer therapeutic agent imatinib mesylate”Nat Med20071311313
  • RibeiroALMarcolinoMSBittencourtHNSAn evaluation of the cardiotoxicity of imatinib mesylateLeuk Res200832121809181418495246
  • EstabraghZRKnightKWatmoughSJA prospective evaluation of cardiac function in patients with chronic myeloid leukaemia treated with imatinibLeuk Res2011351495121030079
  • AgostinoNMChinchilliVMLynchCJEffect of the tyrosine kinase inhibitors (sunitinib, sorafenib, dasatinib, and imatinib) on blood glucose levels in diabetic and nondiabetic patients in general clinical practiceJ Oncol Pharm Pract201117319720220685771
  • LassilaMAllenTJCaoZImatinib attenuates diabetes- associated atherosclerosisArterioscler Thromb Vasc Biol200424593594214988091
  • ShahAMCampbellPRochaGQEffect of imatinib as add-on therapy on echocardiographic measures of right ventricular function in patients with significant pulmonary arterial hypertensionEur Heart J2015361062363224566799
  • MasudaSNakanoKFunakoshiKImatinib mesylate-incorporated nanoparticle-eluting stent attenuates in-stent neointimal formation in porcine coronary arteriesJ Atheroscler Thromb201118121043105321996703
  • GilesFJMauroMJHongFRates of peripheral arterial occlusive disease in patients with chronic myeloid leukemia in the chronic phase treated with imatinib, nilotinib, or non-tyrosine kinase therapy: a retrospective cohort analysisLeukemia20132761310131523459450
  • DeiningerMO’BrienSGGuilhotFInternational randomized study of interferon vs STI571 (IRIS) 8-year follow-up: sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinibBlood2009114221119574477
  • WeisbergEManleyPWBreitensteinWCharacterization of AMN107, a selective inhibitor of native and mutant Bcr-AblCancer Cell200574399
  • KantarjianHGilesFWunderleLNilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALLN Engl J Med2006354242542255116775235
  • AichbergerKJHerndlhoferSSchernthanerG-HProgressive peripheral arterial occlusive disease and other vascular events during nilotinib therapy in CMLAm J Hematol201186753353921538470
  • Le CoutrePReaDAbruzzeseESevere peripheral arterial disease during nilotinib therapyJ Natl Cancer Inst2011103171347134821813414
  • PoredosPJugBThe prevalence of peripheral arterial disease in high risk subjects and coronary or cerebrovascular patientsAngiology200758330931517626985
  • DouxfilsJHaguetHMullierFChatelainCGrauxCDognéJ-MAssociation between BCR-ABL tyrosine kinase inhibitors for chronic myeloid leukemia and cardiovascular events, major molecular response, and overall survivalJAMA Oncol201625625
  • Chai-AdisaksophaCLamWHillisCMajor arterial events in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a meta-analysisLeuk Lymphoma20165761300131026373533
  • RacilZRazgaFDrapalovaJMechanism of impaired glucose metabolism during nilotinib therapy in patients with chronic myelogenous leukemiaHaematologica20139810e124e12623716549
  • ReaDMiraultTCluzeauTEarly onset hypercholesterolemia induced by the 2nd-generation tyrosine kinase inhibitor nilotinib in patients with chronic phase-chronic myeloid leukemiaHaematologica20149971197120324658819
  • ShahNPTranCLeeFYChenPNorrisDSawyersCLOverriding imatinib resistance with a novel ABL kinase inhibitorScience2004305568239940115256671
  • LombardoLJLeeFYChenPDiscovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assaysJ Med Chem200447276658666115615512
  • CortesJESaglioGKantarjianHMFinal 5-year study results of DASISION: the dasatinib versus imatinib study in treatment-naïve chronic myeloid leukemia patients trialJ Clin Oncol201634202333234027217448
  • Quintas-CardamaAKantarjianHO’BrienSPleural effusion in patients with chronic myelogenous leukemia treated with dasatinib after imatinib failureJ Clin Oncol200725253908391417761974
  • MontaniDBergotEGüntherSPulmonary arterial hypertension in patients treated by dasatinibCirculation2012125172128213722451584
  • ShahNPRousselotPSchifferCDasatinib in imatinib-resistant or -intolerant chronic-phase, chronic myeloid leukemia patients: 7-year follow-up of study CA180-034Am J Hematol201691986987427192969
  • Remsing RixLLRixUColingeJGlobal target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cellsLeukemia200923347748519039322
  • KhouryHJCortesJEKantarjianHMBosutinib is active in chronic phase chronic myeloid leukemia after imatinib and dasatinib and/or nilotinib therapy failureBlood2012119153403341222371878
  • CortesJEJean KhouryHKantarjianHLong-term evaluation of cardiac and vascular toxicity in patients with Philadelphia chromosome-positive leukemias treated with bosutinibAm J Hematol201691660661626971533
  • CortesJEKantarjianHShahNPPonatinib in refractory Philadelphia chromosome-positive leukemiasN Engl J Med2012367222075208823190221
  • LiptonJHChuahCGuerci-BreslerAPonatinib versus imatinib for newly diagnosed chronic myeloid leukaemia: an international, randomised, open-label, phase 3 trialLancet Oncol201617561262127083332
  • CortesJEKantarjianHMReaDFinal analysis of the efficacy and safety of omacetaxine mepesuccinate in patients with chronic- or accelerated-phase chronic myeloid leukemia: results with 24 months of follow-upCancer2015121101637164425586015
  • DorerDJKnickerbockerRKBaccaraniMImpact of dose intensity of ponatinib on selected adverse events: multivariate analyses from a pooled population of clinical trial patientsLeuk Res201648849127505637
  • Poch MartellMSibaiHDeotareULiptonJHPonatinib in the therapy of chronic myeloid leukemiaExpert Rev Hematol201691092393227590270
  • BrecciaMPregnoPSpallarossaPIdentification, prevention and management of cardiovascular risk in chronic myeloid leukaemia patients candidate to ponatinib: an expert opinionAnn Hematol201796454955827686083
  • HoffmannVSBaccaraniMHasfordJThe EUTOS population-based registry: incidence and clinical characteristics of 2904 CML patients in 20 European CountriesLeukemia20152961336134325783795
  • ConroyRMPyöräläKFitzgeraldAPEstimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE projectEur Heart J20032411987100312788299
  • ReaDMiraultTRaffouxEUsefulness of the 2012 European CVD risk assessment model to identify patients at high risk of cardiovascular events during nilotinib therapy in chronic myeloid leukemiaLeukemia20152951206120925482133
  • BrecciaMMolicaMZacheoISerraoAAlimenaGApplication of systematic coronary risk evaluation chart to identify chronic myeloid leukemia patients at risk of cardiovascular diseases during nilotinib treatmentAnn Hematol201594339339725304102
  • Gerhard-HermanMDGornikHLBarrettC2016 AHA/ACC guideline on the management of patients with lower extremity peripheral artery disease: a report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelinesJ Am Coll Cardiol20176911e71e12627851992
  • RidkerPMBuringJERifaiNCookNRDevelopment and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk ScoreJAMA2007297661161917299196
  • RidkerPMPaynterNPRifaiNGazianoJMCookNRC-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for menCirculation200811822224351 4p following 225118997194
  • GoffDCLloyd-JonesDMBennettG2013 ACC/AHA guideline on the assessment of cardiovascular riskCirculation201412925 suppl 2S49S7324222018
  • Hippisley-CoxJCouplandCVinogradovaYRobsonJMayMBrindlePDerivation and validation of QRISK, a new cardiovascular disease risk score for the United Kingdom: prospective open cohort studyBMJ2007335761113617615182
  • ForceTKolajaKLCardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomesNat Rev Drug Discov201110211112621283106
  • BrownS-ANholaLHerrmannJCardiovascular toxicities of small molecule tyrosine kinase inhibitors: an opportunity for systems-based approachesClin Pharmacol Ther20171011658027806435
  • AndersonTJGrJPearsonGJ2016 Canadian Cardiovascular Society guidelines for the management of dyslipidemia for the prevention of cardiovascular disease in the adultCan J Cardiol201632111263128227712954
  • Ankle Brachial Index CollaborationFowkesFGRMurrayGDAnkle brachial index combined with Framingham risk score to predict cardiovascular events and mortalityJAMA2008300219718612117
  • PolonskyTSMcClellandRLJorgensenNWCoronary artery calcium score and risk classification for coronary heart disease predictionJAMA2010303161610161620424251
  • CapodannoDAngiolilloDJAspirin for primary cardiovascular risk prevention and beyond in diabetes mellitusCirculation2016134201579159427729421
  • Quintás-CardamaAKantarjianHRavandiFBleeding diathesis in patients with chronic myelogenous leukemia receiving dasatinib therapyCancer2009115112482249019280591
  • WittelesRMCaliforniaSBiomarkers as predictors of cardiac toxicity from targeted cancer therapiesJ Card Fail201622645946427038641
  • SteegmannJLBaccaraniMBrecciaMEuropean LeukemiaNet recommendations for the management and avoidance of adverse events of treatment in chronic myeloid leukaemiaLeukemia20163081648167127121688
  • ZamoranoJLLancellottiPRodriguez MuñozD2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice GuidelinesEur Heart J201637362768280127567406
  • van LeeuwenRWFvan GelderTMathijssenRHJJansmanFGADrug–drug interactions with tyrosine-kinase inhibitors: a clinical perspectiveLancet Oncol2014158e315e32624988935
  • HaoualaAWidmerNDuchosalMAMontemurroMBuclinTDecosterdLADrug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinibBlood20111178e75e8720810928
  • McLaughlinVVShahSJSouzaRHumbertMManagement of pulmonary arterial hypertensionJ Am Coll Cardiol201565181976199725953750
  • ShahNPWallisNFarberHWClinical features of pulmonary arterial hypertension in patients receiving dasatinibAm J Hematol201590111060106426284693
  • HoeperMMBogaardHJCondliffeRDefinitions and diagnosis of pulmonary hypertensionJ Am Coll Cardiol20136225D42D5024355641
  • CortesJEJimenezCAMauroMJGeyerAPinilla-IbarzJSmithBDPleural effusion in dasatinib-treated patients with chronic myeloid leukemia in chronic phase: identification and managementClin Lymphoma Myeloma Leuk2017172788228082112
  • BrecciaMArboscelloEBellodiAProposal for a tailored stratification at baseline and monitoring of cardiovascular effects during follow-up in chronic phase chronic myeloid leukemia patients treated with nilotinib frontlineCrit Rev Oncol Hematol201610719019827823647