Nonadherence to statins: individualized intervention strategies outside the pill box

References

• World Health OrganizationCardiovascular Diseases (CVDs). Fact Sheet2017 Available from: http://www.who.int/mediacentre/fact-sheets/fs317/enAccessed March 22, 2018
   Google Scholar
• StamlerJWentworthDNeatonJDIs relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT)JAMA198625620282328283773199
   PubMed Web of Science ®Google Scholar
• The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart diseaseJAMA198425133513646361299
   PubMed Web of Science ®Google Scholar
• The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol loweringJAMA198425133653746361300
   PubMed Web of Science ®Google Scholar
• PsatyBMAndersonMKronmalRAThe association between lipid levels and the risks of incident myocardial infarction, stroke, and total mortality: the cardiovascular health studyJ Am Geriatr Soc200452101639164715450039
   PubMed Web of Science ®Google Scholar
• World Health OrganizationGlobal Health Observatory (GHO) Data: Raised Cholesterol2017 Available from: http://www.who.int/gho/ncd/risk_factors/cholesterol_text/en/Accessed 22 March, 2018
   Google Scholar
• BeagleholeRBonitaRGlobal public health: a scorecardLancet200837296541988199618945485
   PubMed Web of Science ®Google Scholar
• VonbankAAgewallSKjeldsenKPComprehensive efforts to increase adherence to statin therapyEur Heart J201738322473247928077470
   PubMed Web of Science ®Google Scholar
• World Health OrganizationWorld Health Statistics 2009 Available from: http://www.who.int/whosis/whostat/2009/en/Accessed March 22, 2018
   Google Scholar
• FordESAjaniUACroftJBExplaining the decrease in U.S. deaths from coronary disease, 1980–2000N Engl J Med2007356232388239817554120
   PubMed Web of Science ®Google Scholar
• BerminghamMHaydenJDawkinsIProspective analysis of LDL-C goal achievement and self-reported medication adherence among statin users in primary careClin Ther20113391180118921840055
   PubMed Web of Science ®Google Scholar
• OsterbergLBlaschkeTAdherence to medicationN Engl J Med2005353548749716079372
   PubMed Web of Science ®Google Scholar
• LaufsURettig-EwenVBöhmMStrategies to improve drug adherenceEur Heart J201132326426820729544
   PubMed Web of Science ®Google Scholar
• ManingatPGordonBRBreslowJLHow do we improve patient compliance and adherence to long-term statin therapy?Curr Atheroscler Rep201315129129123225173
   PubMed Web of Science ®Google Scholar
• De VeraMABholeVBurnsLCLacailleDImpact of statin adherence on cardiovascular disease and mortality outcomes: a systematic reviewBr J Clin Pharmacol201478468469825364801
   PubMed Web of Science ®Google Scholar
• GatwoodJBaileyJEImproving medication adherence in hypercholesterolemia: challenges and solutionsVasc Health Risk Manag20141061562525395859
   PubMedGoogle Scholar
• YanATYanRTTanMVascular Protection (VP) and Guidelines Oriented Approach to Lipid Lowering (GOALL) Registries InvestigatorsContemporary management of dyslipidemia in high-risk patients: targets still not metAm J Med2006119867668316887414
   PubMed Web of Science ®Google Scholar
• VonbankASaelyCHReinPSturnDDrexelHCurrent cholesterol guidelines and clinical reality: a comparison of two cohorts of coronary artery disease patientsSwiss Med Wkly2013143w1382823832393
   PubMed Web of Science ®Google Scholar
• GislasonGHRasmussenJNAbildstrømSZLong-term compliance with beta-blockers, angiotensin-converting enzyme inhibitors, and statins after acute myocardial infarctionEur Heart J200627101153115816399775
   PubMed Web of Science ®Google Scholar
• EllisJJEricksonSRStevensonJGBemsteinSJStilesRAFendrickMASuboptimal statin adherence and discontinuation in primary and secondary prevention populations: should we target patients with the most to gain?J Gen Intern Med200419663864515209602
   PubMed Web of Science ®Google Scholar
• GuglielmiVBelliaAPecchioliSEffectiveness of adherence to lipid lowering therapy on LDL-cholesterol in patients with very high cardiovascular risk: a real-world evidence study in primary careAtherosclerosis2017263364128599257
   PubMed Web of Science ®Google Scholar
• JimmyBJoseJPatient medication adherence: measures in daily practiceOman Med J201126315515922043406
   PubMedGoogle Scholar
• KronishIMYeSAdherence to cardiovascular medications: lessons learned and future directionsProg Cardiovasc Dis201355659060023621969
   PubMed Web of Science ®Google Scholar
• JackeviciusCAMamdaniMTuJVAdherence with statin therapy in elderly patients with and without acute coronary syndromesJAMA2002288446246712132976
   PubMed Web of Science ®Google Scholar
• NissenSEStatin denial: an internet-driven cult with deadly consequencesAnn Intern Med2017167428128228738422
   PubMed Web of Science ®Google Scholar
• BaigentCKeechAKearneyPMCholesterol Treatment Trialists’ (CTT) CollaboratorsEfficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statinsLancet200536694931267127816214597
   PubMed Web of Science ®Google Scholar
• StoneNJRobinsonJLichtensteinAHAmerican College of Cardiology/American Heart Association Task Force on Practice Guidelines2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice GuidelinesJ Am Coll Cardiol20146325 Pt B2889293424239923
   PubMed Web of Science ®Google Scholar
• CollinsRReithCEmbersonJInterpretation of the evidence for the efficacy and safety of statin therapyLancet2016388100592532256127616593
   PubMed Web of Science ®Google Scholar
• SathasivamSLeckyBStatin induced myopathyBMJ2008337a228618988647
   PubMed Web of Science ®Google Scholar
• MammenALStatin-associated autoimmune myopathyThe N Engl J Med2016374766466926886523
   PubMed Web of Science ®Google Scholar
• SweidanAJLeungAKaiserCJA case of statin-associated autoimmune myopathyClin Med Insights Case Rep201710117954761668823128469499
   PubMed Web of Science ®Google Scholar
• van der PloegMAPoortvlietRKEvan BlijswijkSCEStatin use and self-reported hindering muscle complaints in older persons: a population based studyPloS One20161112e016685727911918
   PubMed Web of Science ®Google Scholar
• Pedro-BotetJRubies-PratJStatin-associated muscle symptoms: beware of the nocebo effectLancet2017389100882445244628476289
   PubMed Web of Science ®Google Scholar
• ZhangHPlutzkyJSkentzosSDiscontinuation of statins in routine care settings: a cohort studyAnn Intern Med2013158752653423546564
   PubMed Web of Science ®Google Scholar
• BetteridgeDJCarmenaRThe diabetogenic action of statins - mechanisms and clinical implicationsNat Rev Endocrinol20161229911026668119
   PubMed Web of Science ®Google Scholar
• WangKLLiuCJChaoTFRisk of new-onset diabetes mellitus versus reduction in cardiovascular events with statin therapyAm J Cardiol2014113463163624360773
   PubMed Web of Science ®Google Scholar
• VersmissenJScheeleMDippelDWvan den MeirackerAHSta-tine na een hersenbloeding: is dit veilig?Nederlands tijdschrift voor geneeskunde2015159A856326083841
   PubMedGoogle Scholar
• MaYLiZChenLLiXBlood lipid levels, statin therapy and the risk of intracerebral hemorrhageLipids Health Dis2016154326932585
   PubMed Web of Science ®Google Scholar
• StromBLSchinnarRKarlawishJHennessySTealVBilkerWBStatin therapy and risk of acute memory impairmentJAMA Intern Med201517581399140526054031
   PubMed Web of Science ®Google Scholar
• StulcTCeškaRGottoAMStatin intolerance: the clinician’s perspectiveCurr Atheroscler Rep201517126926490078
   PubMed Web of Science ®Google Scholar
• Lloyd-JonesDMMorrisPBBallantyneCM2017 Focused Update of the 2016ACCExpert Consensus Decision Pathway on the Role of Non-Statin Therapies for LDL-Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease Risk: a Report of the American College of Cardiology Task Force on Expert Consensus Decision PathwaysJ Am Coll Cardiol201770141785182228886926
   PubMed Web of Science ®Google Scholar
• StroesESThompsonPDCorsiniAEuropean Atherosclerosis Society Consensus PanelStatin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and ManagementEur Heart J201536171012102225694464
   PubMed Web of Science ®Google Scholar
• ManciniGBTashakkorAYBakerSDiagnosis, prevention, and management of statin adverse effects and intolerance: Canadian Working Group Consensus updateCan J Cardiol201329121553156824267801
   PubMed Web of Science ®Google Scholar
• RosensonRSBakerSKJacobsonTAKopeckySLParkerBAThe National Lipid Association’s Muscle Safety Expert PanelAn assessment by the statin muscle safety task force: 2014 updateJ Clin Lipidol201483 SupplS58S7124793443
   PubMed Web of Science ®Google Scholar
• NissenSEStroesEDent-AcostaREEfficacy and tolerability of evolocumab vs ezetimibe in patients with muscle-related statin intolerance: the GAUSS-3 randomized clinical trialJAMA2016315151580159027039291
   PubMed Web of Science ®Google Scholar
• OrringerCEJacobsonTASaseenJJUpdate on the use of PCSK9 inhibitors in adults: recommendations from an Expert Panel of the National Lipid AssociationJ Clin Lipidol201711488089028532784
   PubMed Web of Science ®Google Scholar
• QianLJGaoYZhangYMChuMYaoJXuDTherapeutic efficacy and safety of PCSK9-monoclonal antibodies on familial hypercholesterolemia and statin-intolerant patients: a meta-analysis of 15 randomized controlled trialsSci Rep20177123828331223
   PubMedGoogle Scholar
• WatersDDHsuePYBangaloreSPCSK9 inhibitors for statin intolerance?JAMA2016315151571157227039138
   PubMed Web of Science ®Google Scholar
• NaitoRMiyauchiKDaidaHRacial differences in the cholesterol-lowering effect of statinJ Atheroscler Thromb2017241192527733728
   PubMed Web of Science ®Google Scholar
• TzengTBSchneckDWBirminghamBKPopulation pharmacokinetics of rosuvastatin: implications of renal impairment, race, and dyslipidaemiaCurr Med Res Opin20082492575258518674408
   PubMed Web of Science ®Google Scholar
• NakamuraHArakawaKItakuraHMEGA Study GroupPrimary prevention of cardiovascular disease with pravastatin in Japan (MEGA Study): a prospective randomised controlled trialLancet200636895421155116317011942
   PubMed Web of Science ®Google Scholar
• LeeERyanSBirminghamBRosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environmentClin Pharmacol Ther200578433034116198652
   PubMed Web of Science ®Google Scholar
• BirminghamBKBujacSRElsbyRRosuvastatin pharmacokinetics and pharmacogenetics in Caucasian and Asian subjects residing in the United StatesEur J Clin Pharmacol201571332934025630984
   PubMed Web of Science ®Google Scholar
• LiuJELiuXYChenSSLCO1B1 521T > C polymorphism associated with rosuvastatin-induced myotoxicity in Chinese coronary artery disease patients: a nested case-control studyEur J Clin Phar-macol2017731114091416
   PubMed Web of Science ®Google Scholar
• GandelmanKFungGLMessigMLaskeyRSystemic exposure to atorvastatin between Asian and Caucasian subjects: a combined analysis of 22 studiesAm J Ther201219316417320975528
   PubMed Web of Science ®Google Scholar
• SetiaSFungSS-WWatersDDDoctors’ knowledge, attitudes, and compliance with 2013 ACC/AHA guidelines for prevention of atherosclerotic cardiovascular disease in SingaporeVasc Health Risk Manag20151130331026082642
   PubMed Web of Science ®Google Scholar
• YanPTanEKKChooJCJLiewCFSLauTWatersDDStatin-centric versus low-density lipoprotein-centric approach for atherosclerotic cardiovascular disease prevention: a Singapore perspectiveSingapore Med J201657736036727439304
   PubMed Web of Science ®Google Scholar
• TobertJANewmanCBThe nocebo effect in the context of statin intoleranceJ Clin Lipidol201610473974727578103
   PubMed Web of Science ®Google Scholar
• HäuserWHansenEEnckPNocebo Phenomena in medicine: their relevance in everyday clinical practiceDtsch Arztebl Int20121092645946522833756
   PubMed Web of Science ®Google Scholar
• PlanèsSVillierCMallaretMThe nocebo effect of drugsPharmacol Res Perspect201642e0020827069627
   PubMed Web of Science ®Google Scholar
• GuptaAThompsonDWhitehouseAAdverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA): a randomised double-blind placebo-controlled trial and its non-randomised non-blind extension phaseLancet2017389100882473248128476288
   PubMed Web of Science ®Google Scholar
• RizosCVElisafMSStatin myopathy: navigating the mazeCurr Med Res Opin201733232732927805428
   PubMed Web of Science ®Google Scholar
• FungVSinclairFWangHDaileyDHsuJShaberRPatients’ perspectives on nonadherence to statin therapy: a focus-group studyPerm J2010141410
   PubMedGoogle Scholar
• NielsenSFNordestgaardBGNegative statin-related news stories decrease statin persistence and increase myocardial infarction and cardiovascular mortality: a nationwide prospective cohort studyEur Heart J2016371190891626643266
   PubMed Web of Science ®Google Scholar
• Picker Institute EuropePerceptions of statins: research with patients, GPs and cardiologists 2016 Available from: http://www.picker.org/wp-content/uploads/2016/07/P2941-BHF-Statins_Final-Report_Publication.pdfAccessed March 22, 2018
   Google Scholar
• MatthewsAHerrettEGasparriniAImpact of statin related media coverage on use of statins: interrupted time series analysis with UK primary care dataBMJ2016353i3283
   PubMed Web of Science ®Google Scholar
• MannDMWoodardMMuntnerPFalzonLKronishIPredictors of non-adherence to statins: a systematic review and meta-analysisAnn Pharmacother20104491410142120702755
   PubMed Web of Science ®Google Scholar
• BennerJSGlynnRJMogunHNeumannPJWeinsteinMCAvornJLong-term persistence in use of statin therapy in elderly patientsJAMA2002288445546112132975
   PubMed Web of Science ®Google Scholar
• TajouriTHDriverSLHolmesDRJr“Take as directed” – strategies to improve adherence to cardiac medicationNat Rev Cardiol201411530430724343567
   PubMed Web of Science ®Google Scholar
• KarveSClevesMAHelmMHudsonTJWestDSMartinBCGood and poor adherence: optimal cut-point for adherence measures using administrative claims dataCurr Med Res Opin20092592303231019635045
   PubMed Web of Science ®Google Scholar
• Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final reportCirculation2002106253143342112485966
   PubMed Web of Science ®Google Scholar
• WoutersHVan DijkLGeersHCUnderstanding statin non-adherence: knowing which perceptions and experiences matter to different patientsPloS One2016111e014627226808151
   PubMed Web of Science ®Google Scholar
• BarrettBRiccoJWallaceMKieferDRakelDCommunicating statin evidence to support shared decision-makingBMC Fam Pract2016174127048421
   PubMed Web of Science ®Google Scholar
• WuJYLeungWYChangSEffectiveness of telephone counselling by a pharmacist in reducing mortality in patients receiving polypharmacy: randomised controlled trialBMJ2006333756752216916809
   PubMed Web of Science ®Google Scholar
• StoneNJRobinsonJGLichtensteinAH2013ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice GuidelinesCirculation201412925 Suppl 2S1S4524222016
   PubMed Web of Science ®Google Scholar
• PiepoliMFHoesAWAgewallS2016European Guidelines on cardiovascular disease prevention in clinical practice: the Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)Eur Heart J201637292315238127222591
   PubMed Web of Science ®Google Scholar
• DeshpandeSQuekRGWForbesCAA systematic review to assess adherence and persistence with statinsCurr Med Res Opin201733476977828076703
   PubMed Web of Science ®Google Scholar
• YilmazMBPinarMNaharciIBeing well-informed about statin is associated with continuous adherence and reaching targetsCardiovasc Drugs Ther200519643744016435071
   PubMed Web of Science ®Google Scholar
• GawATolmieELindsayGMThe statin breakthrough – remembering to involve the patientCardiovasc Drugs Ther200418534334415717135
   PubMed Web of Science ®Google Scholar
• GosseyJTWhitneySNCrouchMAJibaja-WeissMLZhangHVolkRJPromoting knowledge of statins in patients with low health literacy using an audio bookletPatient Prefer Adherence2011539740321949603
   PubMed Web of Science ®Google Scholar
• RuddPClinicians and patients with hypertension: unsettled issues about complianceAm Heart J19951303 Pt 15725797661077
   PubMed Web of Science ®Google Scholar
• SchedlbauerADaviesPFaheyTInterventions to improve adherence to lipid lowering medicationCochrane Database Syst Rev20103Cd00437120238331
   PubMed Web of Science ®Google Scholar
• DeroseSFGreenKMarrettEAutomated outreach to increase primary adherence to cholesterol-lowering medicationsJAMA InternMed201317313843
   PubMed Web of Science ®Google Scholar
• ChoudhryNKKrummeAAErcolePMEffect of reminder devices on medication adherence: the REMIND randomized clinical trialJAMA InterMed20171775624631
   PubMed Web of Science ®Google Scholar
• BoeniFSpinatschESuterKHersbergerKEArnetIEffect of drug reminder packaging on medication adherence: a systematic review revealing research gapsSyst Rev201432924661495
   PubMedGoogle Scholar
• HersbergerKEBoeniFArnetIDose-dispensing service as an intervention to improve adherence to polymedicationExpert Rev Clin Pharmacol20136441342123927669
   PubMed Web of Science ®Google Scholar
• FarrellBFrench MerkleyVIngarNReducing pill burden and helping with medication awareness to improve adherenceCan Pharm J (Ott)2013146526226924093037
   PubMedGoogle Scholar
• WebsterRPatelASelakVSPACE CollaborationEffectiveness of fixed dose combination medication (“polypills”) compared with usual care in patients with cardiovascular disease or at high risk: a prospective, individual patient data meta-analysis of 3140 patients in six countriesInt J Cardiol201620514715626736090
   PubMed Web of Science ®Google Scholar
• PetrillaAABennerJSBattlemanDSTierceJCHazardEHEvidence-based interventions to improve patient compliance with antihypertensive and lipid-lowering medicationsInt J Clin Pract200559121441145116351677
   PubMed Web of Science ®Google Scholar
• GrangerBBBosworthHBMedication adherence: emerging use of technologyCurr Opin Cardiol201126427928721597368
   PubMed Web of Science ®Google Scholar
• American College of CardiologyACC Statin Intolerance App2017 Available from: http://www.acc.org/StatinIntoleranceAppAccessed March 22, 2018
   Google Scholar
• GagnonMJacobJDGutaATreatment adherence redefined: a critical analysis of technotherapeuticsNurs Inq2013201607022381079
   PubMed Web of Science ®Google Scholar
• CalvertSBKramerJMAnstromKJKaltenbachLAStaffordJAAllen LaPointeNMPatient-focused intervention to improve long-term adherence to evidence-based medications: a randomized trialAm Heart J20121634657665.e65122520532
   PubMed Web of Science ®Google Scholar