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Original Research

Serum untargeted lipidomic profiling reveals dysfunction of phospholipid metabolism in subclinical coronary artery disease

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Pages 123-135 | Published online: 13 May 2019

References

  • Szummer K, Wallentin L, Lindhagen L, et al. Improved outcomes in patients with ST-elevation myocardial infarction during the last 20 years are related to implementation of evidence-based treatments: experiences from the SWEDEHEART registry 1995–2014. Eur Heart J. 2017;38(41):3056–3065. doi:10.1093/eurheartj/ehx51529020314
  • Yusuf S, Islam S, Chow CK, et al. Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological survey. Lancet. 2011;378(9798):1231–1243. doi:10.1016/S0140-6736(11)61215-421872920
  • Tunstall-Pedoe H, Vanuzzo D, Hobbs M, et al. Estimation of contribution of changes in coronary care to improving survival, event rates, and coronary heart disease mortality across the WHO MONICA Project populations. Lancet. 2000;355(9205):688–700.10703800
  • Finegold JA, Asaria P, Francis DP. Mortality from ischaemic heart disease by country, region, and age: statistics from World Health Organisation and United Nations. Int J Cardiol. 2013;168(2):934–945. doi:10.1016/j.ijcard.2012.10.04623218570
  • D’Agostino RB, Vasan RS, Pencina MJ, et al. General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation. 2008;117(6):743–753. doi:10.1161/CIRCULATIONAHA.107.69957918212285
  • Goff DC Jr., Lloyd-Jones DM, Bennett G, et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(25 Suppl 2):S49–S73. doi:10.1161/01.cir.0000437741.48606.9824222018
  • Peters SA, Den Ruijter HM, Bots ML, Moons KG. Improvements in risk stratification for the occurrence of cardiovascular disease by imaging subclinical atherosclerosis: a systematic review. Heart. 2012;98(3):177–184. doi:10.1136/heartjnl-2011-30074722095617
  • Qamar A, Khetarpal SA, Khera AV, Qasim A, Rader DJ, Reilly MP. Plasma apolipoprotein C-III levels, triglycerides, and coronary artery calcification in type 2 diabetics. Arterioscler Thromb Vasc Biol. 2015;35(8):1880–1888. doi:10.1161/ATVBAHA.115.30541526069232
  • Rajamannan NM, Moura L. The lipid hypothesis in calcific aortic valve disease: the role of the multi-ethnic study of atherosclerosis. Arterioscler Thromb Vasc Biol. 2016;36(5):774–776. doi:10.1161/ATVBAHA.116.30743527122627
  • Wong ND, Kouwabunpat D, Vo AN, et al. Coronary calcium and atherosclerosis by ultrafast computed tomography in asymptomatic men and women: relation to age and risk factors. Am Heart J. 1994;127(2):422–430.8296711
  • Mahoney LT, Burns TL, Stanford W, et al. Coronary risk factors measured in childhood and young adult life are associated with coronary artery calcification in young adults: the Muscatine Study. J Am Coll Cardiol. 1996;27(2):277–284.8557894
  • Paramsothy P, Katz R, Owens DS, Burke GL, Probstfield JL, O’Brien KD. Age-modification of lipoprotein, lipid, and lipoprotein ratio-associated risk for coronary artery calcium (from the Multi-Ethnic Study of Atherosclerosis [MESA]). Am J Cardiol. 2010;105(3):352–358. doi:10.1016/j.amjcard.2009.09.04020102947
  • Sarwar N, Danesh J, Eiriksdottir G, et al. Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation. 2007;115(4):450–458. doi:10.1161/CIRCULATIONAHA.106.63779317190864
  • Do R, Willer CJ, Schmidt EM, et al. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet. 2013;45(11):1345–1352. doi:10.1038/ng.279524097064
  • Jørgensen AB, Frikke-Schmidt R, West AS, Grande P, Nordestgaard BG, Tybjærg-Hansen A. Genetically elevated non-fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction. Eur Heart J. 2013;34(24):1826–1833. doi:10.1093/eurheartj/ehs43123248205
  • Djekic D, Nicoll R, Novo M, Henein M. Metabolomics in atherosclerosis. IJC Metab Endocr. 2015;8:26–30. doi:10.1016/j.ijcme.2014.11.004
  • Janowitz WR, Agatston AS, Viamonte M. Comparison of serial quantitative evaluation of calcified coronary artery plaque by ultrafast computed tomography in persons with and without obstructive coronary artery disease. Am J Cardiol. 1991;68(1):1–6.2058541
  • Pluskal T, Castillo S, Villar-Briones A, Oresic M. MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data. BMC Bioinformatics. 2010;11:395. doi:10.1186/1471-2105-11-39520650010
  • Bowden JA, Heckert A, Ulmer CZ, et al. Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma. J Lipid Res. 2017;58(12):2275–2288. doi:10.1194/jlr.M07901228986437
  • Jolliffe IT. Principal Component Analysis. 2nd ed. New York: Springer; 2002.
  • Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B Stat Methodol. 1995;57(1):289–300. doi:10.1111/rssb.1995.57.issue-1
  • Hartigan JA, Wong MA. A K-means clustering algorithm. J R Stat Soc Ser C Appl Stat. 1979;28:100–108.
  • Rousseeuw PJ. Silhouettes: a graphical aid to the interpretation and validation of cluster analysis. J Comput Appl Math. 1987;20:53–65. doi:10.1016/0377-0427(87)90125-7
  • Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med. 2013;368(19):1845–1846. doi:10.1056/NEJMc1303158
  • Verheye S, Martinet W, Kockx MM, et al. Selective clearance of macrophages in atherosclerotic plaques by autophagy. J Am Coll Cardiol. 2007;49(6):706–715. doi:10.1016/j.jacc.2006.09.04717291937
  • Liao X, Sluimer JC, Wang Y, et al. Macrophage autophagy plays a protective role in advanced atherosclerosis. Cell Metab. 2012;15(4):545–553. doi:10.1016/j.cmet.2012.01.02222445600
  • Rockenfeller P, Koska M, Pietrocola F, et al. Phosphatidylethanolamine positively regulates autophagy and longevity. Cell Death Differ. 2015;22:499. doi:10.1038/cdd.2014.21925571976
  • Akiba S, Yoneda Y, Ohno S, Nemoto M, Sato T. Oxidized LDL activates phospholipase A2 to supply fatty acids required for cholesterol esterification. J Lipid Res. 2003;44(9):1676–1685. doi:10.1194/jlr.M300012-JLR20012777475
  • Brilakis ES, Khera A, Saeed B, et al. Association of lipoprotein-associated phospholipase A2 mass and activity with coronary and aortic atherosclerosis: findings from the Dallas Heart Study. Clin Chem. 2008;54(12):1975–1981. doi:10.1373/clinchem.2008.10735918832472
  • Oei HH, van der Meer IM, Hofman A, et al. Lipoprotein-associated phospholipase A2 activity is associated with risk of coronary heart disease and ischemic stroke: the Rotterdam Study. Circulation. 2005;111(5):570–575. doi:10.1161/01.CIR.0000154553.12214.CD15699277
  • Pokharel Y, Sun W, Polfus LM, et al. Lipoprotein associated phospholipase A2 activity, apolipoprotein C3 loss-of-function variants and cardiovascular disease: the Atherosclerosis Risk in Communities Study. Atherosclerosis. 2015;241(2):641–648. doi:10.1016/j.atherosclerosis.2015.06.03326117401
  • Garg PK, McClelland RL, Jenny NS, et al. Lipoprotein-associated phospholipase A2 and risk of incident cardiovascular disease in a multi-ethnic cohort: the multi ethnic study of atherosclerosis. Atherosclerosis. 2015;241(1):176–182. doi:10.1016/j.atherosclerosis.2015.05.00626004387
  • White HD, Held C, Stewart R, et al. Darapladib for preventing ischemic events in stable coronary heart disease. N Engl J Med. 2014;370(18):1702–1711. doi:10.1056/NEJMoa131587824678955
  • Vorkas PA, Isaac G, Holmgren A, et al. Perturbations in fatty acid metabolism and apoptosis are manifested in calcific coronary artery disease: an exploratory lipidomic study. Int J Cardiol. 2015;197:192–199. doi:10.1016/j.ijcard.2015.06.04826142205
  • Djekic D, Pinto R, Vorkas PA, Henein MY. Replication of LC-MS untargeted lipidomics results in patients with calcific coronary disease: an interlaboratory reproducibility study. Int J Cardiol. 2016;222:1042–1048. doi:10.1016/j.ijcard.2016.07.21427543723
  • Meikle PJ, Wong G, Tsorotes D, et al. Plasma lipidomic analysis of stable and unstable coronary artery disease. Arterioscler Thromb Vasc Biol. 2011;31(11):2723–2732. doi:10.1161/ATVBAHA.111.23409621903946
  • Sutter I, Klingenberg R, Othman A, et al. Decreased phosphatidylcholine plasmalogens–a putative novel lipid signature in patients with stable coronary artery disease and acute myocardial infarction. Atherosclerosis. 2016;246:130–140. doi:10.1016/j.atherosclerosis.2016.01.00326773473
  • Sousa B, Melo T, Campos A, et al. Alteration in phospholipidome profile of myoblast H9c2 cell line in a model of myocardium starvation and ischemia. J Cell Physiol. 2016;231(10):2266–2274. doi:10.1002/jcp.2534426887290
  • Paapstel K, Kals J, Eha J, et al. Inverse relations of serum phosphatidylcholines and lysophosphatidylcholines with vascular damage and heart rate in patients with atherosclerosis. Nutr Metab Cardiovasc Dis. 2018;28(1):44–52. doi:10.1016/j.numecd.2017.07.01128986077
  • Fernandez C, Sandin M, Sampaio JL, et al. Plasma lipid composition and risk of developing cardiovascular disease. PLoS One. 2013;8(8):e71846. doi:10.1371/journal.pone.007184623967253
  • Mahendran Y, Vangipurapu J, Cederberg H, et al. Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men. Diabetes. 2013;62(10):3618–3626. doi:10.2337/db12-136323557707
  • Braun JE, Severson DL. Regulation of the synthesis, processing and translocation of lipoprotein lipase. Biochem J. 1992;287(Pt 2):337–347.1445192
  • Mathew M, Tay E, Cusi K. Elevated plasma free fatty acids increase cardiovascular risk by inducing plasma biomarkers of endothelial activation, myeloperoxidase and PAI-1 in healthy subjects. Cardiovasc Diabetol. 2010;9:9. doi:10.1186/1475-2840-9-920158910
  • Barazzoni R, Zanetti M, Gortan Cappellari G, et al. Fatty acids acutely enhance insulin-induced oxidative stress and cause insulin resistance by increasing mitochondrial reactive oxygen species (ROS) generation and nuclear factor-κB inhibitor (IκB)-nuclear factor-κB (NFκB) activation in rat muscle, in the absence of mitochondrial dysfunction. Diabetologia. 2012;55(3):773–782. doi:10.1007/s00125-011-2396-x22159911
  • Boden G, She P, Mozzoli M, et al. Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver. Diabetes. 2005;54(12):3458–3465.16306362
  • Brodeur MR, Bouvet C, Barrette M, Moreau P. Palmitic acid increases medial calcification by inducing oxidative stress. J Vasc Res. 2013;50(5):430–441. doi:10.1159/00035423524080574
  • Alshehry ZH, Mundra PA, Barlow CK, et al. Plasma lipidomic profiles improve on traditional risk factors for the prediction of cardiovascular events in type 2 diabetes mellitus. Circulation. 2016;134(21):1637–1650. doi:10.1161/CIRCULATIONAHA.116.02323327756783
  • Stegemann C, Pechlaner R, Willeit P, et al. Lipidomics profiling and risk of cardiovascular disease in the prospective population-based Bruneck study. Circulation. 2014;129(18):1821–1831. doi:10.1161/CIRCULATIONAHA.113.00250024622385
  • Rhee EP, Cheng S, Larson MG, et al. Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. J Clin Invest. 2011;121(4):1402–1411. doi:10.1172/JCI4444221403394
  • Borland SJ, Morris TG, Borland SC, et al. Regulation of vascular smooth muscle cell calcification by syndecan-4/FGF-2/PKCα signalling and cross-talk with TGFβ. Cardiovasc Res. 2017;113(13):1639–1652. doi:10.1093/cvr/cvx17829016732
  • Nicoll R, Wiklund U, Zhao Y, et al. Gender and age effects on risk factor-based prediction of coronary artery calcium in symptomatic patients: a Euro-CCAD study. Atherosclerosis. 2016;252:32–39. doi:10.1016/j.atherosclerosis.2016.07.90627494449
  • Djekic D, Angerås O, Lappas G, et al. Impact of socioeconomic status on coronary artery calcification. Eur J Prev Cardiol. 2018;25(16):1756–1764. doi:10.1177/204748731879210330095278
  • Meikle PJ, Wong G, Barlow CK, Kingwell BA. Lipidomics: potential role in risk prediction and therapeutic monitoring for diabetes and cardiovascular disease. Pharmacol Ther. 2014;143(1):12–23. doi:10.1016/j.pharmthera.2014.02.00124509229