Understanding Erectile Dysfunction in Hypertensive Patients: The Need for Good Patient Management

References

• Shamloul R, Ghanem H. Erectile dysfunction. Lancet. 2013;381(9861):153–165. doi:10.1016/S0140-6736(12)60520-0
   PubMed Web of Science ®Google Scholar
• Aytaç IA, McKinlay JB, Krane RJ. The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU Int. 1999;84(1):50–56. doi:10.1046/j.1464-410x.1999.00142.x
   PubMed Web of Science ®Google Scholar
• Yafi FA, Jenkins L, Albersen M, et al. Erectile dysfunction. Nat Rev Dis Primers. 2016;2(1):16003. doi:10.1038/nrdp.2016.3
   PubMedGoogle Scholar
• Cordero A, Bertomeu-Martínez V, Mazón P, et al. Erectile dysfunction in high-risk hypertensive patients treated with beta-blockade agents. Cardiovasc Ther. 2010;28(1):15–22. doi:10.1111/j.1755-5922.2009.00123.x
   PubMed Web of Science ®Google Scholar
• Viigimaa M, Vlachopoulos C, Doumas M. Erectile Dysfunction in Hypertension and Cardiovascular Disease. Switzerland: Springer International Publishing; 2015.
   Google Scholar
• De F, Erección LA, Martínez-Salamanca JI, et al. Monográfico: disfunción eréctil hemodinámica: erección y detumescencia. Arch Esp Urol. 2010;63.
   Google Scholar
• Clavijo RI, Miner MM, Rajfer J. Erectile dysfunction and essential hypertension: the same aging-related disorder? Rev Urol. 2014;16(4):167–171.
   PubMedGoogle Scholar
• Nehra A, Goldstein I, Pabby A, et al. Mechanisms of venous leakage: a prospective clinicopathological correlation of corporeal function and structure. J Urol. 1996;156(4):1320–1329. doi:10.1016/S0022-5347(01)65578-2
   PubMed Web of Science ®Google Scholar
• Jiang R, Chen JH, Jin J, Shen W, Li QM. Ultrastructural comparison of penile cavernous tissue between hypertensive and normotensive rats. Int J Impot Res. 2005;17(5):417–423. doi:10.1038/sj.ijir.3901329
   PubMed Web of Science ®Google Scholar
• Konukoglu D, Uzun H. Endothelial dysfunction and hypertension. In: Advances in Experimental Medicine and Biology. New York LLC: Springer; 2016:511–540.
   Google Scholar
• Hurt KJ, Sezen SF, Lagoda GF, et al. Cyclic AMP-dependent phosphorylation of neuronal nitric oxide synthase mediates penile erection. Proc Natl Acad Sci U S A. 2012;109(41):16624–16629. doi:10.1073/pnas.1213790109
   PubMed Web of Science ®Google Scholar
• Mirone V, Imbimbo C, Fusco F, Verze P, Creta M, Tajana G. Androgens and morphologic remodeling at penile and cardiovascular levels: a common piece in complicated puzzles? Eur Urol. 2009;56(2):309–316. doi:10.1016/j.eururo.2008.12.037
   PubMed Web of Science ®Google Scholar
• Corona G, Maggi M. The role of testosterone in erectile dysfunction. Nat Rev Urol. 2010;7(1):46–56. doi:10.1038/nrurol.2009.235
   PubMed Web of Science ®Google Scholar
• Mulligan T, Frick MF, Zuraw QC, Stemhagen A, McWhirter C. Prevalence of hypogonadism in males aged at least 45 years: the HIM study. Int J Clin Pract. 2006;60(7):762–769. doi:10.1111/j.1742-1241.2006.00992.x
   PubMed Web of Science ®Google Scholar
• Baumhäkel M, Schlimmer N, Kratz M, Hacket G, Jackson G, Böhm M. Cardiovascular risk, drugs and erectile function - A systematic analysis. Int J Clin Pract. 2011;65(3):289–298. doi:10.1111/j.1742-1241.2010.02563.x
   PubMed Web of Science ®Google Scholar
• Vecchio M, Palmer SC, Tonelli M, Johnson DW, Strippoli GFM. Depression and sexual dysfunction in chronic kidney disease: a narrative review of the evidence in areas of significant unmet need. Nephrol Dial Transplant. 2012;27(9):3420–3428. doi:10.1093/ndt/gfs135
   PubMed Web of Science ®Google Scholar
• Costa MR, Ponciano VC, Costa TR, De Oliveira AM, Gomes CP, De Oliveira EC. Prevalence and factors associated with erectile dysfunction in patients with chronic kidney disease on conservative treatment. Int J Impot Res. 2017;29(6):219–224. doi:10.1038/ijir.2017.20
   PubMed Web of Science ®Google Scholar
• Rosas SE, Joffe M, Franklin E, et al. Prevalence and determinants of erectile dysfunction in hemodialysis patients. Kidney Int. 2001;59(6):2259–2266. doi:10.1046/j.1523-1755.2001.00742.x
   PubMed Web of Science ®Google Scholar
• Mendes Ribeiro AC, Brunini TM, Ellory JC, Mann GE. Abnormalities in ?-arginine transport and nitric oxide biosynthesis in chronic renal and heart failure. Cardiovasc Res. 2001;49(4):697–712. doi:10.1016/S0008-6363(00)00267-4
   PubMed Web of Science ®Google Scholar
• Alberti L, Torlasco C, Lauretta L, et al. Erectile dysfunction in heart failure patients: a critical reappraisal. Andrology. 2013;1(2):177–191. doi:10.1111/j.2047-2927.2012.00048.x
   PubMed Web of Science ®Google Scholar
• Jankowska EA, Filippatos G, Ponikowska B, et al. Reduction in circulating testosterone relates to exercise capacity in men with chronic heart failure. J Card Fail. 2009;15(5):442–450. doi:10.1016/j.cardfail.2008.12.011
   PubMed Web of Science ®Google Scholar
• Rhoden EL, Telöken C, Sogari PR, Vargas Souto CA. The use of the simplified International Index of Erectile Function (IIEF-5) as a diagnostic tool to study the prevalence of erectile dysfunction. Int J Impot Res. 2002;14(4):245–250. doi:10.1038/sj.ijir.3900859
   PubMed Web of Science ®Google Scholar
• Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH guidelines for the management of arterial hypertension. Eur Heart J. 2018;39:3021–3104.
   PubMed Web of Science ®Google Scholar
• Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ. 2009;338(may19 1):1245. doi:10.1136/bmj.b1665
   Google Scholar
• Turnbull F, Neal B, Algert C, et al. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Lancet. 2003;362(9395):1527–1535.
   PubMed Web of Science ®Google Scholar
• Doumas M. Factors affecting the increased prevalence of erectile dysfunction in Greek hypertensive compared with normotensive subjects. J Androl. 2006;27(3):469–477. doi:10.2164/jandrol.04191
   PubMed Web of Science ®Google Scholar
• Cordero A, Bertomeu-Martínez V, Mazón P, Fácila L, González-Juanatey JR. Erectile dysfunction may improve by blood pressure control in patients with high-risk hypertension. Postgrad Med. 2010;122(6):51–56. doi:10.3810/pgm.2010.11.2223
   PubMed Web of Science ®Google Scholar
• Brixius K, Middeke M, Lichtenthal A, Jahn E, Schwinger RHG. Nitric oxide, erectile dysfunction and beta-blocker treatment (Mr Noed Study): benefit of nebivolol versus metoprolol in hypertensive men. Clin Exp Pharmacol Physiol. 2007;34(4):327–331. doi:10.1111/j.1440-1681.2007.04551.x
   PubMed Web of Science ®Google Scholar
• Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 2003;348(14):1309–1321.
   PubMed Web of Science ®Google Scholar
• Wassertheil-Smoller S, Blaufox MD, Oberman A, et al. Effect of antihypertensives on sexual function and quality of life: the TAIM study. Ann Intern Med. 1991;114(8):613–620. doi:10.7326/0003-4819-114-8-613
   PubMed Web of Science ®Google Scholar
• Doumas M, Tsakiris A, Douma S, et al. Beneficial effects of switching from beta-blockers to nebivolol on the erectile function of hypertensive patients. Asian J Androl. 2006;8(2):177–182. doi:10.1111/j.1745-7262.2006.00076.x
   PubMed Web of Science ®Google Scholar
• Düsing R. Effect of the angiotensin II antagonist valsartan on sexual function in hypertensive men. Blood Press Suppl. 2003;12(sup2):29–34. doi:10.1080/08038020310021967
   Google Scholar
• Mobley DF, Khera M, Baum N. Recent advances in the treatment of erectile dysfunction. Postgrad Med J. 2017;93(1105):679–685. doi:10.1136/postgradmedj-2016-134073
   PubMed Web of Science ®Google Scholar
• Bohm M, Burkart M, Baumann G. Sildenafil is well tolerated by erectile dysfunction patients taking antihypertensive medications, including those on multidrug regimens. Curr Drug Saf. 2007;2(1):5–8. doi:10.2174/157488607779315462
   PubMedGoogle Scholar
• Hall SA, Shackelton R, Rosen RC, Araujo AB. Sexual activity, erectile dysfunction, and incident cardiovascular events. Am J Cardiol. 2010;105(2):192–197. doi:10.1016/j.amjcard.2009.08.671
   PubMed Web of Science ®Google Scholar
• Zullig LL, Ramos K, Bosworth HB. Improving medication adherence in coronary heart disease. Curr Cardiol Rep. 2017;19(11):113. doi:10.1007/s11886-017-0918-y
   PubMed Web of Science ®Google Scholar
• McLaughlin T, Harnett J, Burhani S, Scott B. Evaluation of erectile dysfunction therapy in patients previously nonadherent to long-term medications: a retrospective analysis of prescription claims. Am J Ther. 2005;12(6):605–611. doi:10.1097/01.mjt.0000181305.44330.4a
   PubMedGoogle Scholar
• Kloner RA, Goggin P, Goldstein I, et al. A new perspective on the nitrate–phosphodiesterase type 5 inhibitor interaction. J Cardiovasc Pharmacol Ther. 2018;23(5):375–386. doi:10.1177/1074248418771896
   PubMed Web of Science ®Google Scholar
• Oliver JJ, Hughes VEC, Dear JW, Webb DJ. Clinical potential of combined organic nitrate and phosphodiesterase type 5 inhibitor in treatment-resistant hypertension. Hypertension. 2010;56(1):62–67. doi:10.1161/HYPERTENSIONAHA.109.147686
   PubMed Web of Science ®Google Scholar
• Isidori AM, Giannetta E, Gianfrilli D, et al. Effects of testosterone on sexual function in men: results of a meta-analysis. Clin Endocrinol (Oxf). 2005;63(4):381–394. doi:10.1111/j.1365-2265.2005.02350.x
   PubMed Web of Science ®Google Scholar
• Basaria S, Coviello AD, Travison TG, et al. Adverse events associated with testosterone administration. N Engl J Med. 2010;363(2):109–122. doi:10.1056/NEJMoa1000485
   PubMed Web of Science ®Google Scholar
• Xu L, Freeman G, Cowling BJ, Schooling CM. Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials. BMC Med. 2013;11(1). doi:10.1186/1741-7015-11-108
   Google Scholar
• Sharma R, Oni OA, Gupta K, et al. Normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men. Eur Heart J. 2015;36(40):2706–2715. doi:10.1093/eurheartj/ehv346
   PubMed Web of Science ®Google Scholar
• Cheetham TC, An JJ, Jacobsen SJ, et al. Association of testosterone replacement with cardiovascular outcomes among men with androgen deficiency. JAMA Intern Med. 2017;177(4):491–499. doi:10.1001/jamainternmed.2016.9546
   PubMed Web of Science ®Google Scholar
• Traish AM, Haider A, Haider KS, Doros G, Saad F. Long-term testosterone therapy improves cardiometabolic function and reduces risk of cardiovascular disease in men with hypogonadism: a real-life observational registry study setting comparing treated and untreated (control) groups. J Cardiovasc Pharmacol Ther. 2017;22(5):414–433. doi:10.1177/1074248417691136
   PubMed Web of Science ®Google Scholar
• Corona G, Rastrelli G, Di Pasquale G, Sforza A, Mannucci E, Maggi M. Testosterone and cardiovascular risk: meta-analysis of interventional studies. J Sex Med. 2018;15(6):820–838. doi:10.1016/j.jsxm.2018.04.641
   PubMed Web of Science ®Google Scholar
• Gupta BP, Murad MH, Clifton MM, Prokop L, Nehra A, Kopecky SL. The effect of lifestyle modification and cardiovascular risk factor reduction on erectile dysfunction: a systematic review and meta-analysis. Arch Intern Med. 2011;171(20):1797–1803. doi:10.1001/archinternmed.2011.440
   PubMedGoogle Scholar
• He J, Reynolds K, Chen J, et al. Cigarette smoking and erectile dysfunction among Chinese men without clinical vascular disease. Am J Epidemiol. 2007;166(7):803–809. doi:10.1093/aje/kwm154
   PubMed Web of Science ®Google Scholar
• Derby CA, Mohr BA, Goldstein I, Feldman HA, Johannes CB, McKinlay JB. Modifiable risk factors and erectile dysfunction: can lifestyle changes modify risk? Urology. 2000;56(2):302–306. doi:10.1016/S0090-4295(00)00614-2
   PubMed Web of Science ®Google Scholar
• Chitaley K, Kupelian V, Subak L, Wessells H. Diabetes, obesity and erectile dysfunction: field overview and research priorities. J Urol. 2009;182(6S). doi:10.1016/j.juro.2009.07.089
   PubMedGoogle Scholar
• Selvin E, Burnett AL, Platz EA. Prevalence and risk factors for erectile dysfunction in the US. Am J Med. 2007;120(2):151–157. doi:10.1016/j.amjmed.2006.06.010
   PubMed Web of Science ®Google Scholar
• Cheng JYW, Ng EML, Ko JSN, Chen RYL. Physical activity and erectile dysfunction: meta-analysis of population-based studies. Int J Impot Res. 2007;19(3):245–252. doi:10.1038/sj.ijir.3901521
   PubMed Web of Science ®Google Scholar
• Estruch R, Ros E, Salas-Salvadó J, et al. Primary prevention of cardiovascular disease with a mediterranean diet. N Engl J Med. 2013;368(14):1279–1290. doi:10.1056/NEJMoa1200303
   PubMed Web of Science ®Google Scholar
• Montorsi P, Ravagnani PM, Galli S, et al. Association between erectile dysfunction and coronary artery disease: matching the right target with the right test in the right patient. Eur Urol. 2006;50(4):721–731. doi:10.1016/j.eururo.2006.07.015
   PubMed Web of Science ®Google Scholar
• Vlachopoulos CV, Terentes-Printzios DG, Ioakeimidis NK, Aznaouridis KA, Stefanadis CI. Prediction of cardiovascular events and all-cause mortality with erectile dysfunction a systematic review and meta-analysis of cohort studies. Circ: Cardiovasc Qual Outcomes. 2013;6(1):99–109. doi:10.1161/CIRCOUTCOMES.112.966903
   PubMed Web of Science ®Google Scholar
• Dong JY, Zhang YH, Qin LQ. Erectile dysfunction and risk of cardiovascular disease: meta-analysis of prospective cohort studies. J Am Coll Cardiol. 2011;58(13):1378–1385. doi:10.1016/j.jacc.2011.06.024
   PubMed Web of Science ®Google Scholar
• Montorsi P, Ravagnani PM, Galli S, et al. Association between erectile dysfunction and coronary artery disease. Role of coronary clinical presentation and extent of coronary vessels involvement: the COBRA trial. Eur Heart J. 2006;27(22):2632–2639. doi:10.1093/eurheartj/ehl142
   PubMed Web of Science ®Google Scholar
• Nehra A, Jackson G, Miner M, et al. The Princeton III consensus recommendations for the management of erectile dysfunction and cardiovascular disease. Mayo Clin Proc. 2012;87(8):766–778. doi:10.1016/j.mayocp.2012.06.015
   PubMed Web of Science ®Google Scholar
• Frey A, Sønksen J, Fode M. Low-intensity extracorporeal shockwave therapy in the treatment of postprostatectomy erectile dysfunction: a pilot study. Scand J Urol. 2016;50(2):123–127. doi:10.3109/21681805.2015.1100675
   PubMed Web of Science ®Google Scholar
• Chen X, Yang Q, Zheng T, et al. Neurotrophic effect of adipose tissue-derived stem cells on erectile function recovery by pigment epithelium-derived factor secretion in a rat model of cavernous nerve injury. Stem Cells Int. 2016;2016:5161248.
   PubMed Web of Science ®Google Scholar