Metabolite Profiling of Osteoporosis and Atherosclerosis in Postmenopausal Women: A Cross-Sectional Study

References

• Tamaki J, Iki M, Hirano Y, et al. Low bone mass is associated with carotid atherosclerosis in postmenopausal women: the Japanese Population-based Osteoporosis (JPOS) Cohort Study. Osteoporos Int. 2009;20(1):53–60. doi:10.1007/s00198-008-0633-z
   PubMed Web of Science ®Google Scholar
• Varri M, Tuomainen T-P, Honkanen R, et al. Carotid intima-media thickness and calcification in relation to bone mineral density in postmenopausal women—The OSTPRE-BBA study. Maturitas. 2014;78(4):304–309. doi:10.1016/j.maturitas.2014.05.017
   PubMed Web of Science ®Google Scholar
• Ye C, Xu M, Wang S, et al. Decreased bone mineral density is an independent predictor for the development of atherosclerosis: a systematic review and meta-analysis. PLoS One. 2016;11(5):e0154740. doi:10.1371/journal.pone.0154740
   PubMed Web of Science ®Google Scholar
• Bagger YZ, Rasmussen HB, Alexandersen P, et al. Links between cardiovascular disease and osteoporosis in postmenopausal women: serum lipids or atherosclerosis per se? Osteoporos Int. 2007;18(4):505–512. doi:10.1007/s00198-006-0255-2
   PubMed Web of Science ®Google Scholar
• Ala-Korpela M, Kangas AJ, Soininen P. Quantitative high-throughput metabolomics: a new era in epidemiology and genetics. Genome Med. 2012;4(4):36. doi:10.1186/gm335
   PubMedGoogle Scholar
• Soininen P, Kangas AJ, Wurtz P, et al. High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism. Analyst. 2009;134(9):1781–1785. doi:10.1039/b910205a
   PubMed Web of Science ®Google Scholar
• Makovey J, Chen JS, Hayward C, Williams FMK, Sambrook PN. Association between serum cholesterol and bone mineral density. Bone. 2009;44(2):208–213. doi:10.1016/j.bone.2008.09.020
   PubMed Web of Science ®Google Scholar
• Parhami F, Garfinkel A, Demer LL. Role of lipids in osteoporosis. Arterioscler Thromb Vasc Biol. 2000;20(11):2346–2348. doi:10.1161/01.ATV.20.11.2346
   PubMed Web of Science ®Google Scholar
• Steinberg D. The LDL modification hypothesis of atherogenesis: an update. J Lipid Res. 2009;50(Supplement):S376–S381. doi:10.1194/jlr.R800087-JLR200
   PubMedGoogle Scholar
• Buizert PJ, van Schoor NM, Lips P, Deeg DJ, Eekhoff EM. Lipid levels: a link between cardiovascular disease and osteoporosis? J Bone Miner Res. 2009;24(6):1103–1109. doi:10.1359/jbmr.081262
   PubMed Web of Science ®Google Scholar
• Kris-Etherton PM, Lichtenstein AH, Howard BV, Steinberg D, Witztum JL. Nutrition Committee of the American Heart Association Council on Nutrition, Physical Activity, and Metabolism. Antioxidant vitamin supplements and cardiovascular disease. Circulation. 2004;110(5):637–641. doi:10.1161/01.CIR.0000137822.39831.F1
   PubMed Web of Science ®Google Scholar
• Jeong I-K, Cho SW, Kim SW, et al. Lipid profiles and bone mineral density in pre- and postmenopausal women in Korea. Calcif Tissue Int. 2010;87(6):507–512. doi:10.1007/s00223-010-9427-3
   PubMed Web of Science ®Google Scholar
• Li S, Guo H, Liu Y, et al. Relationships of serum lipid profiles and bone mineral density in postmenopausal Chinese women. Clin Endocrinol (Oxf). 2015;82(1):53–58. doi:10.1111/cen.12616
   PubMed Web of Science ®Google Scholar
• D’Amelio P, Di Bella S, Tamone C, et al. HDL cholesterol and bone mineral density in normal-weight postmenopausal women: is there any possible association? Panminerva Med. 2008;50(2):89–96.
   PubMed Web of Science ®Google Scholar
• Go J-H, Song Y-M, Park J-H, Park J-Y, Choi Y-H. Association between serum cholesterol level and bone mineral density at lumbar spine and femur neck in postmenopausal korean women. Korean J Fam Med. 2012;33(3):166–173. doi:10.4082/kjfm.2012.33.3.166
   PubMedGoogle Scholar
• Parhami F, Jackson SM, Tintut Y, et al. Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells. J Bone Miner Res. 1999;14(12):2067–2078. doi:10.1359/jbmr.1999.14.12.2067
   PubMed Web of Science ®Google Scholar
• Wurtz P, Havulinna AS, Soininen P, et al. Metabolite profiling and cardiovascular event risk: A prospective study of 3 population-based cohorts. Circulation. 2015;131(9):774–785. doi:10.1161/CIRCULATIONAHA.114.013116
   PubMed Web of Science ®Google Scholar
• Moayyeri A, Cheung C-L, Tan KC, et al. Metabolomic pathways to osteoporosis in middle-aged women: a genome-metabolome-wide mendelian randomization study. J Bone Miner Res. 2018;33(4):643–650. doi:10.1002/jbmr.3358
   PubMed Web of Science ®Google Scholar
• Miyamoto T, Hirayama A, Sato Y, et al. A serum metabolomics-based profile in low bone mineral density postmenopausal women. Bone. 2017;95:1–4. doi:10.1016/j.bone.2016.10.027
   PubMed Web of Science ®Google Scholar
• Qi H, Bao J, An G, et al. Association between the metabolome and bone mineral density in pre- and post-menopausal chinese women using GC-MS. Mol Biosyst. 2016;12(7):2265–2275. doi:10.1039/C6MB00181E
   PubMedGoogle Scholar
• Soininen P, Kangas AJ, Wurtz P, Suna T, Ala-Korpela M. Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics. Circ Cardiovasc Genet. 2015;8(1):192–206. doi:10.1161/CIRCGENETICS.114.000216
   PubMedGoogle Scholar
• Bonjour P, Clark P, Cooper C, et al. WHO scientific group on the assessment of osteoporosis at primary health care level. J Med. 2004;7:2020.
   Google Scholar
• Aguilar-Shea AL, Gallardo-Mayo C, Garrido-Elustondo S, Calvo-Manuel E, Zamorano-Gomez JL. Carotid intima-media thickness as a screening tool in cardiovascular primary prevention. Eur J Clin Invest. 2011;41(5):521–526. doi:10.1111/j.1365-2362.2010.02440.x
   PubMed Web of Science ®Google Scholar
• Raynor LA, Schreiner PJ, Loria CM, Carr JJ, Pletcher MJ, Shikany JM. Associations of retrospective and concurrent lipid levels with subclinical atherosclerosis prediction after 20 years of follow-up: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Annals of Epidemiology. 2013;23(8):492–497. doi:10.1016/j.annepidem.2013.06.003
   PubMed Web of Science ®Google Scholar
• Prenner SB, Mulvey CK, Ferguson JF, Rickels MR, Bhatt AB, Reilly MP. Very low density lipoprotein cholesterol associates with coronary artery calcification in type 2 diabetes beyond circulating levels of triglycerides. Atherosclerosis. 2014;236(2):244–250. doi:10.1016/j.atherosclerosis.2014.07.008
   PubMed Web of Science ®Google Scholar
• Sivas F, Alemdaroglu E, Elverici E, Kulug T, Ozoran K. Serum lipid profile: its relationship with osteoporotic vertebrae fractures and bone mineral density in turkish postmenopausal women. Rheumatol Int. 2009;29(8):885–890. doi:10.1007/s00296-008-0784-4
   PubMed Web of Science ®Google Scholar
• Shen H, Damcott CM, Rampersaud E, et al. Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish. Arch Intern Med. 2010;170(20):1850–1855. doi:10.1001/archinternmed.2010.384
   PubMedGoogle Scholar
• Yerges-Armstrong LM, Shen H, Ryan KA, Streeten EA, Shuldiner AR, Mitchell BD. Decreased bone mineral density in subjects carrying familial defective apolipoprotein B-100. J Clin Endocrinol Metab. 2013;98(12):1999–2005. doi:10.1210/jc.2013-2471
   Web of Science ®Google Scholar
• Sabour H, Nazari M, Latifi S, et al. The relationship between dietary intakes of amino acids and bone mineral density among individuals with spinal cord injury. Oman Med J. 2016;31(1):22–28. doi:10.5001/omj.2016.05
   PubMedGoogle Scholar
• Bray GA, Redman LM, de Jonge L, Rood J, Sutton EF, Smith SR. Plasma amino acids during 8 weeks of overfeeding: relation to diet body composition and fat cell size in the PROOF study. Obesity. 2018;26(2):324–331. doi:10.1002/oby.22087
   PubMed Web of Science ®Google Scholar
• Murr C, Grammer TB, Meinitzer A, Kleber ME, Marz W, Fuchs D. Immune activation and inflammation in patients with cardiovascular disease are associated with higher phenylalanine to tyrosine ratios: the ludwigshafen risk and cardiovascular health study. J Amino Acids. 2014;2014:783730. doi:10.1155/2014/783730
   PubMedGoogle Scholar
• Deidda M, Piras C, Cadeddu Dessalvi C, et al. Blood metabolomic fingerprint is distinct in healthy coronary and in stenosing or microvascular ischemic heart disease. J Transl Med. 2017;15(1):112. doi:10.1186/s12967-017-1215-7
   PubMedGoogle Scholar
• Boogaard A, Griffioen M, Cohen LH. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in human hepatoma cell line hep G2. Effects of inhibitors of cholesterol synthesis on enzyme activity. Biochem J. 1987;241(2):345–351. doi:10.1042/bj2410345
   PubMed Web of Science ®Google Scholar
• Rosvall M, Persson M, Ostling G, et al. Risk factors for the progression of carotid intima-media thickness over a 16-year follow-up period: the Malmö Diet and Cancer Study. Atherosclerosis. 2015;239(2):615–621. doi:10.1016/j.atherosclerosis.2015.01.030
   PubMed Web of Science ®Google Scholar
• Li GH, Cheung CL, Au PC, Tan KC, Wong IC, Sham PC. Positive effects of low LDL-C and statins on bone mineral density: an integrated epidemiological observation analysis and mendelian randomization study. Int J Epidemiol. 2019;dyz145.
   Web of Science ®Google Scholar
• Warburton DE. Health benefits of physical activity: the evidence. CMAJ. 2006;174(6):801–809. doi:10.1503/cmaj.051351
   PubMed Web of Science ®Google Scholar
• Feuchtner G, Langer C, Barbieri F, et al. Relationship of exercise to coronary artery disease extent, severity and plaque type: a coronary computed tomography angiography study. Journal of Cardiovascular Computed Tomography. 2019;13(3):34–40. doi:10.1016/j.jcct.2019.02.001
   PubMed Web of Science ®Google Scholar