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Review

The clinical efficacy of dabigatran etexilate for preventing stroke in atrial fibrillation patients

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Pages 341-352 | Published online: 09 Jul 2013

References

  • CoppensMEikelboomJWGustafssonDWeitzJIHirshJTranslational success stories: development of direct thrombin inhibitorsCirc Res2012111792092922982873
  • OlssonSBExecutive Steering Committee of the SPORTIF III InvestigatorsStroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): randomised controlled trialLancet200336293971691169814643116
  • MohapatraRTranMGoreJMSpencerFAA review of the oral direct thrombin inhibitor ximelagatran: not yet the end of the warfarin eraAm Heart J20051501192616084146
  • BatesSMWeitzJIThe mechanism of action of thrombin inhibitorsJ Invasive Cardiol200012Suppl F27F32F
  • ErikssonBIQuinlanDJEikelboomJWNovel oral factor Xa and thrombin inhibitors in the management of thromboembolismAnnu Rev Med201162415721226611
  • BeckerRCCell-based models of coagulation: a paradigm in evolutionJ Thromb Thrombolysis2005201656816133899
  • WeitzJIHudobaMMasselDMaraganoreJHirshJClot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitorsJ Clin Invest19908623853912384594
  • WeitzJILeslieBHudobaMThrombin binds to soluble fibrin degradation products where it is protected from inhibition by heparin-antithrombin but susceptible to inactivation by antithrombin-independent inhibitorsCirculation19989765445529494024
  • VanasscheTVerhaegenJPeetermansWEInhibition of staphylothrombin by dabigatran reduces Staphylococcus aureus virulenceJ Thromb Haemost20119122436244622040101
  • XiaoZThérouxPPlatelet activation with unfractionated heparin at therapeutic concentrations and comparisons with a low-molecular-weight heparin and with a direct thrombin inhibitorCirculation19989732512569462526
  • AnsellJWarfarin versus new agents: interpreting the dataHematology Am Soc Hematol Educ Program2010201022122821239798
  • WrigleyBJLipGYShantsilaENovel oral anticoagulants: the potential relegation of vitamin K antagonists in clinical practiceInt J Clin Pract201064783583820584215
  • StangierJClinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilateClin Pharmacokinet200847528529518399711
  • StangierJErikssonBIDahlOEPharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacementJ Clin Pharmacol200545555556315831779
  • StangierJRathgenKStähleHGansserDRothWThe pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjectsBr J Clin Pharmacol200764329230317506785
  • EisertWGHauelNStangierJWienenWClemensAvan RynJDabigatran: an oral novel potent reversible nonpeptide inhibitor of thrombinArterioscler Thromb Vasc Biol201030101885188920671233
  • StangierJRathgenKStähleHMazurDInfluence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre studyClin Pharmacokinet201049425926820214409
  • WannLSCurtisABEllenbogenKA2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (update on dabigatran): a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelinesJ Am Coll Cardiol201157111330133721324629
  • BlechSEbnerTLudwig-SchwellingerEStangierJRothWThe metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humansDrug Metab Dispos200836238639918006647
  • StangierJStähleHRathgenKRothWShakeri-NejadKPharmacokinetics and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor, are not affected by moderate hepatic impairmentJ Clin Pharmacol200848121411141918827075
  • NutescuEChuatrisornIHellenbartEDrug and dietary interactions of warfarin and novel oral anticoagulants: an updateJ Thromb Thrombolysis201131332634321359645
  • StangierJStähleHRathgenKFuhrRPharmacokinetics and pharma-codynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjectsClin Pharmacokinet2008471475918076218
  • van RynJStangierJHaertterSDabigatran etexilate – a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activityThromb Haemost201010361116112720352166
  • StangierJFeuringMUsing the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatranBlood Coagul Fibrinolysis201223213814322227958
  • ConnollySJEzekowitzMDYusufSDabigatran versus warfarin in patients with atrial fibrillationN Engl J Med2009361121139115119717844
  • SkanesACHealeyJSCairnsJAFocused 2012 update of the Canadian Cardiovascular Society atrial fibrillation guidelines: recommendations for stroke prevention and rate/rhythm controlCan J Cardiol201228212513622433576
  • CammAJLipGYDe CaterinaRESC Committee for Practice Guidelines-(PG)Document Reviewers 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm AssociationEur Heart J201233212719274722922413
  • HartRGDienerHCYangSIntracranial hemorrhage in atrial fibrillation patients during anticoagulation with warfarin or dabigatran: the RE-LY trialStroke20124361511151722492518
  • GrangerCBAlexanderJHMcMurrayJJApixaban versus warfarin in patients with atrial fibrillationN Engl J Med20113651198199221870978
  • PatelMRMahaffeyKWGargJROCKET AF InvestigatorsRivaroxaban versus warfarin in nonvalvular atrial fibrillationN Engl J Med20113651088389121830957
  • EikelboomJWWallentinLConnollySJRisk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trialCirculation2011123212363237221576658
  • UchinoKHernandezAVDabigatran association with higher risk of acute coronary events: meta-analysis of noninferiority randomized controlled trialsArch Intern Med2012172539740222231617
  • HohnloserSHOldgrenJYangSMyocardial ischemic events in patients with atrial fibrillation treated with dabigatran or warfarin in the RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trialCirculation2012125566967622215856
  • DansALConnollySJWallentinLConcomitant use of antiplatelet therapy with dabigatran or warfarin in the randomized evaluation of long-term anticoagulation therapy (RE-LY) trialCirculation2013127563464023271794
  • EikelboomJWWeitzJIAnticoagulation therapy. Dabigatran and risk of myocardial infarctionNat Rev Cardiol20129526026222411291
  • WallentinLYusufSEzekowitzMDRE-LY investigatorsEfficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trialLancet2010376974597598320801496
  • BeasleyBNUngerEFTempleRAnticoagulant options – why the FDA approved a higher but not a lower dose of dabigatranN Engl J Med2011364191788179021488759
  • DienerHCConnollySJEzekowitzMDRE-LY study groupDabigatran compared with warfarin in patients with atrial fibrillation and previous transient ischaemic attack or stroke: a subgroup analysis of the RE-LY trialLancet Neurol20109121157116321059484
  • Birman-DeychERadfordMJNilasenaDSGageBFUse and effectiveness of warfarin in Medicare beneficiaries with atrial fibrillationStroke20063741070107416528001
  • RajiMALoweryMLinYLKuoYFBaillargeonJGoodwinJSNational utilization patterns of warfarin use in older patients with atrial fibrillation: a population-based study of Medicare Part D benefciariesAnn Pharmacother2013471354223324508
  • MercaldiCJCiarametaroMHahnBCost efficiency of anticoagulation with warfarin to prevent stroke in medicare beneficiaries with nonvalvular atrial fibrillationStroke201142111211821148442
  • HealeyJSEikelboomJDouketisJRE-LY InvestigatorsPeriprocedural bleeding and thromboembolic events with dabigatran compared with warfarin: results from the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) randomized trialCirculation2012126334334822700854
  • WazniOMBeheirySFahmyTAtrial fibrillation ablation in patients with therapeutic international normalized ratio: comparison of strategies of anticoagulation management in the periprocedural periodCirculation2007116222531253417998456
  • WinkleRAMeadRHEngelGKongMHPatrawalaRAThe use of dabigatran immediately after atrial fibrillation ablationJ Cardiovasc Electrophysiol201223326426821955008
  • LakkireddyDReddyYMDi BiaseLFeasibility and safety of dabigatran versus warfarin for periprocedural anticoagulation in patients undergoing radiofrequency ablation for atrial fibrillation: results from a multicenter prospective registryJ Am Coll Cardiol201259131168117422305113
  • KaiserDWStreurMMNagarakantiRWhalenSPEllisCRContinuous warfarin versus peri-procedural dabigatran to reduce stroke and systemic embolism in patients undergoing catheter ablation for atrial fibrillation or left atrial futterJ Interv Card Electrophysiol [Epub April 28, 2013]
  • KimJSSheFJongnarangsinKDabigatran vs warfarin for radiofrequency catheter ablation of atrial fibrillationHeart Rhythm201310448348923237911
  • VranckxPVerheugtFWde MaatMPA randomised study of dabigatran in elective percutaneous coronary intervention in stable coronary artery disease patientsEuro Intervention2013891052106023182947
  • EzekowitzMDReillyPANehmizGDabigatran with or without concomitant aspirin compared with warfarin alone in patients with non-valvular atrial fibrillation (PETRO Study)Am J Cardiol200710091419142617950801
  • LownBPerlrothMGKaidbeySAbeTHarkenDE“Cardioversion” of atrial fibrillation. A report on the treatment of 65 episodes in 50 patientsN Engl J Med196326932533113931297
  • JensenJBHumphriesJOKouwenhovenWBJudeJRElectroshock for atrial futter and atrial fibrillation. Follow-up studies on 50 patientsJAMA196519411118111845897736
  • BjerkelundCJOrningOMThe efficacy of anticoagulant therapy in preventing embolism related to DC electrical conversion of atrial fibrillationAm J Cardiol19692322082164180019
  • FusterVRydénLECannomDSAmerican College of Cardiology/American Heart Association Task Force on Practice GuidelinesEuropean Society of Cardiology Committee for Practice GuidelinesEuropean Heart Rhythm AssociationHeart Rhythm SocietyACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm SocietyCirculation20061147e257e35416908781
  • NagarakantiREzekowitzMDOldgrenJDabigatran versus warfarin in patients with atrial fibrillation: an analysis of patients undergoing cardioversionCirculation2011123213113621200007
  • Van de WerfFBrueckmannMConnollySJA comparison of dabigatran etexilate with warfarin in patients with mechanical heart valves: THE Randomized, phase II study to evaluate the safety and pharmacokinetics of oral dabigatran etexilate in patients after heart valve replacement (RE-ALIGN)Am Heart J2012163693193722709744
  • SouthworthMRReichmanMEUngerEFDabigatran and postmarketing reports of bleedingN Engl J Med2013368141272127423484796
  • NagarakantiREllisCRDabigatran in clinical practiceClin Ther201234102051206023031622
  • HylekEMGoASChangYEffect of intensity of oral anticoagulation on stroke severity and mortality in atrial fibrillationN Engl J Med2003349111019102612968085