Treatment of Chinese Patients with Hypertriglyceridemia with a Pharmaceutical-Grade Preparation of Highly Purified Omega-3 Polyunsaturated Fatty Acid Ethyl Esters: Main Results of a Randomized, Double-Blind, Controlled Trial

References

• Backes J, Anzalone D, Hilleman D, Catini J. The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia. Lipids Health Dis. 2016;15(1):118. doi:10.1186/s12944-016-0286-4
   PubMed Web of Science ®Google Scholar
• Hu Y, Hu FB, Manson JE. Marine omega-3 supplementation and cardiovascular disease: an updated meta-analysis of 13 randomized controlled trials involving 127 477 participants. J Am Heart Assoc. 2019;8(19):e013543. doi:10.1161/JAHA.119.013543
   PubMed Web of Science ®Google Scholar
• Shen C, Ge J. Epidemic of cardiovascular disease in China: current perspective and prospects for the future. Circulation. 2018;138(4):342–344. doi:10.1161/CIRCULATIONAHA.118.033484
   PubMed Web of Science ®Google Scholar
• Kris-Etherton PM, Richter CK, Bowen KJ, et al. Recent clinical trials shed new light on the cardiovascular benefits of omega-3 fatty acids. Methodist Debakey Cardiovasc J. 2019;15(3):171–178.
   PubMedGoogle Scholar
• Joint Committee for Developing Chinese guidelines on Prevention and Treatment of Dyslipidemia in Adults. [Chinese guidelines on prevention and treatment of dyslipidemia in adults]. Zhonghua Xin Xue Guan Bing Za Zhi. 2007;35(4):390–419. Chinese.
   PubMedGoogle Scholar
• Zhang XL, Li F, Zhen YM, Li A, Fang Y. Clinical study of 224 patients with hypertriglyceridemia pancreatitis. Chin Med J (Engl). 2015;128(15):2045–2049. doi:10.4103/0366-6999.161361
   PubMed Web of Science ®Google Scholar
• Deng LH, Xue P, Xia Q, Yang XN, Wan MH. Effect of admission hypertriglyceridemia on the episodes of severe acute pancreatitis. World J Gastroenterol. 2008;14(28):4558–4561. doi:10.3748/wjg.14.4558
   PubMed Web of Science ®Google Scholar
• Schwartz GG, Abt M, Bao W, et al. Fasting triglycerides predict recurrent ischemic events in patients with acute coronary syndrome treated with statins. J Am Coll Cardiol. 2015;65(21):2267–2275.
   PubMed Web of Science ®Google Scholar
• China Cholesterol Education Program. [Chinese expert consensus on hypertriglyceridemia and hypertriglyceridemia-related cardiovascular risk management]. Zhonghua Xin Xue Guan Bing Za Zhi. 2017;45(2):108–115. Chinese. doi:10.3760/cma.j.issn.0253-3758.2017.02.008
   PubMedGoogle Scholar
• Authors/Task Force Members; ESC Committee for Practice Guidelines (CPG); ESC National Cardiac Societies. 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Atherosclerosis. 2019;290:140–205. doi:10.1016/j.atherosclerosis.2019.08.014
   PubMed Web of Science ®Google Scholar
• Wang J, Shen X, He S, et al. Hypertriglyceridaemia predicts subsequent long-term risk of cardiovascular events in Chinese adults: 23-year follow-up of the Daqing Diabetes Study. Diabetes Metab Res Rev. 2019;35(6):e3163. doi:10.1002/dmrr.3163
   PubMed Web of Science ®Google Scholar
• Li X, Wang J, Shen X, et al. Higher blood pressure predicts diabetes and enhances long-term risk of cardiovascular disease events in individuals with impaired glucose tolerance: twenty-three-year follow-up of the Daqing diabetes prevention study. J Diabetes. 2019;11(7):593–598. doi:10.1111/1753-0407.12887
   PubMed Web of Science ®Google Scholar
• Lu J, Wang L, Li M, et al. 2010 China Noncommunicable Disease Surveillance Group. Metabolic syndrome among adults in China: the 2010 China noncommunicable disease surveillance. J Clin Endocrinol Metab. 2017;102(2):507–515. doi:10.1210/jc.2016-2477
   PubMed Web of Science ®Google Scholar
• Jiang B, Zheng Y, Chen Y, et al. Age and gender-specific distribution of metabolic syndrome components in East China: role of hypertriglyceridemia in the SPECT-China study. Lipids Health Dis. 2018;17(1):92. doi:10.1186/s12944-018-0747-z
   PubMed Web of Science ®Google Scholar
• Pan L, Yang Z, Wu Y, et al. China National Survey of Chronic Kidney Disease Working Group. The prevalence, awareness, treatment and control of dyslipidemia among adults in China. Atherosclerosis. 2016;248:2–9. doi:10.1016/j.atherosclerosis.2016.02.006
   PubMed Web of Science ®Google Scholar
• Xia S, Du X, Guo L, et al. Sex differences in primary and secondary prevention of cardiovascular disease in China. Circulation. 2020;141(7):530–539. doi:10.1161/CIRCULATIONAHA.119.043731
   PubMed Web of Science ®Google Scholar
• Kim CH, Han KA, Yu J, et al. Efficacy and safety of adding omega-3 fatty acids in statin-treated patients with residual hypertriglyceridemia: ROMANTIC (Rosuvastatin-OMAcor iN residual hyperTrIglyCeridemia), a randomized, double-blind, and placebo-controlled trial. Clin Ther. 2018;40(1):83–94. doi:10.1016/j.clinthera.2017.11.007
   PubMed Web of Science ®Google Scholar
• Bays HE, McKenney J, Maki KC, Doyle RT, Carter RN, Stein E. Effects of prescription omega-3-acid ethyl esters on non–high-density lipoprotein cholesterol when coadministered with escalating doses of atorvastatin. Mayo Clin Proc. 2010;85(2):122–128. doi:10.4065/mcp.2009.0397
   PubMed Web of Science ®Google Scholar
• Wei MY, Jacobson TA. Effects of eicosapentaenoic acid versus docosahexaenoic acid on serum lipids: a systematic review and meta-analysis. Curr Atheroscler Rep. 2011;13(6):474–483. doi:10.1007/s11883-011-0210-3
   PubMed Web of Science ®Google Scholar
• Asztalos IB, Gleason JA, Sever S, et al. Effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular disease risk factors: a randomized clinical trial. Metabolism. 2016;65(11):1636–1645. doi:10.1016/j.metabol.2016.07.010
   PubMed Web of Science ®Google Scholar
• Skulas-Ray AC, Wilson PWF; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology et al. Omega-3 fatty acids for the management of hypertriglyceridemia: a science advisory from the American Heart Association. Circulation. 2019;140(12):e673–e691. doi:10.1161/CIR.0000000000000709
   PubMed Web of Science ®Google Scholar