Is Nigella sativa an Effective Bodyweight Lowering Agent and a Mitigator of Obesity Risk? A Literature Review

References

• World Health Organization. Health topics; Obesity. Available from: https://www.who.int/health-topics/obesity. Accessed July 8, 2021.
   Google Scholar
• Abdelaal M, le Roux CW, Docherty NG. Morbidity and mortality associated with obesity. Ann Transl Med. 2017;5(7):161. doi:10.21037/atm.2017.03.107
   PubMed Web of Science ®Google Scholar
• Safaei M, Sundararajan EA, Driss M, Boulila W, Shapi’i A. A systematic literature review on obesity: understanding the causes & consequences of obesity and reviewing various machine learning approaches used to predict obesity. Comput Biol Med. 2021;136:104754. doi:10.1016/j.compbiomed.2021.104754
   PubMed Web of Science ®Google Scholar
• Zheng J, Zhou Y, Li Y, Xu DP, Li S, Li HB. Spices for prevention and treatment of cancers. Nutrients. 2016;8:8. doi:10.3390/nu8080495
   PubMed Web of Science ®Google Scholar
• Dalli M, Daoudi NE, Azizi SE, Benouda H, Bnouham M, Gseyra N. Chemical composition analysis using HPLC-UV/GC-MS and inhibitory activity of different. Biomed Res Int. 2021;2021:9979419. doi:10.1155/2021/9979419
   PubMed Web of Science ®Google Scholar
• Dalli M, Bekkouch O, Azizi SE, Azghar A, Gseyra N, Kim BL. Phytochemistry and pharmacological activities: a review (2019–2021). Biomolecules. 2021;12(1):20. doi:10.3390/biom12010020
   PubMed Web of Science ®Google Scholar
• Bamosa A. Nigella sativa is a safe herbal product. J Integr Med. 2014;12(1):66. doi:10.1016/S2095-4964(14)60007-8
   PubMedGoogle Scholar
• Hawsawi ZA, Ali BA, Bamosa AO. Effect of Nigella sativa (Black Seed) and thymoquinone on blood glucose in albino rats. Ann Saudi Med. 2001;21(3–4):242–244. doi:10.5144/0256-4947.2001.242
   PubMed Web of Science ®Google Scholar
• Al-Asoom LI, Al-Shaikh BA, Bamosa AO, El-Bahai MN. Comparison of Nigella sativa- and exercise-induced models of cardiac hypertrophy: structural and electrophysiological features. Cardiovasc Toxicol. 2014;14(3):208–213. doi:10.1007/s12012-014-9244-4
   PubMed Web of Science ®Google Scholar
• Al-Asoom LI, Al-Shaikh BA, Bamosa AO, El-Bahai MN. Effect of Nigella sativa supplementation to exercise training in a novel model of physiological cardiac hypertrophy. Cardiovasc Toxicol. 2014;14(3):243–250. doi:10.1007/s12012-014-9248-0
   PubMed Web of Science ®Google Scholar
• Al Asoom L. Inventor; Imam Abdulrahman Bin Faisal University, assignee. Method for effecting angiogenesis by administering Nigella sativa. Saudi Arabia; 2020.
   Google Scholar
• Al Asoom LI. Molecular mechanisms of Nigella sativa- and Nigella sativa exercise-induced cardiac hypertrophy in rats. Evid Based Complement Altern Med. 2021;2021:5553022. doi:10.1155/2021/5553022
   PubMed Web of Science ®Google Scholar
• Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L seed. Int Immunopharmacol. 2005;5(13–14):1749–1770. doi:10.1016/j.intimp.2005.06.008
   PubMed Web of Science ®Google Scholar
• Kaatabi H, Bamosa AO, Badar A, et al. Nigella sativa improves glycemic control and ameliorates oxidative stress in patients with type 2 diabetes mellitus: placebo controlled participant blinded clinical trial. PLoS One. 2015;10(2):e0113486. doi:10.1371/journal.pone.0113486
   PubMed Web of Science ®Google Scholar
• Mohtashami A, Entezari MH. Effects of Nigella sativa supplementation on blood parameters and anthropometric indices in adults: a systematic review on clinical trials. J Res Med Sci. 2016;21:21. doi:10.4103/1735-1995.179889
   PubMed Web of Science ®Google Scholar
• Mousavi SM, Sheikhi A, Varkaneh HK, Zarezadeh M, Rahmani J, Milajerdi A. Effect of Nigella sativa supplementation on obesity indices: a systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 2018;38:48–57. doi:10.1016/j.ctim.2018.04.003
   PubMed Web of Science ®Google Scholar
• Payab M, Hasani-Ranjbar S, Shahbal N, et al. Effect of the herbal medicines in obesity and metabolic syndrome: a systematic review and meta-analysis of clinical trials. Phytother Res. 2020;34(3):526–545. doi:10.1002/ptr.6547
   PubMed Web of Science ®Google Scholar
• Safi S, Razmpoosh E, Fallahzadeh H, et al. The effect of Nigella sativa on appetite, anthropometric and body composition indices among overweight and obese women: a crossover, double-blind, placebo-controlled, randomized clinical trial. Complement Ther Med. 2021;57:102653. doi:10.1016/j.ctim.2020.102653
   PubMed Web of Science ®Google Scholar
• Mostafa TM, Hegazy SK, Elnaidany SS, Shehabeldin WA, Sawan ES. Nigella sativa as a promising intervention for metabolic and inflammatory disorders in obese prediabetic subjects: a comparative study of Nigella sativa versus both lifestyle modification and metformin. J Diabetes Complications. 2021;35(7):107947. doi:10.1016/j.jdiacomp.2021.107947
   PubMed Web of Science ®Google Scholar
• Hadi S, Daryabeygi-Khotbehsara R, Mirmiran P, et al. Effect of Nigella sativa oil extract on cardiometabolic risk factors in type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2021;35(7):3747–3755. doi:10.1002/ptr.6990
   PubMed Web of Science ®Google Scholar
• Tavakoli-Rouzbehani OM, Abbasnezhad M, Kheirouri S, Alizadeh M. Effects of Nigella sativa oil supplementation on selected metabolic parameters and anthropometric indices in patients with coronary artery disease: a randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2021;35(7):3988–3999. doi:10.1002/ptr.7115
   PubMed Web of Science ®Google Scholar
• Shirazi M, Khodakarami F, Feizabad E, Ghaemi M. The effects of nigella sativa on anthropometric and biochemical indices in postmenopausal women with metabolic syndrome. Endocrine. 2020;69(1):49–52. doi:10.1007/s12020-020-02265-w
   PubMed Web of Science ®Google Scholar
• Moustafa HAM, El Wakeel LM, Halawa MR, Sabri NA, El-Bahy AZ, Singab AN. Effect of Nigella sativa oil versus metformin on glycemic control and biochemical parameters of newly diagnosed type 2 diabetes mellitus patients. Endocrine. 2019;65(2):286–294. doi:10.1007/s12020-019-01963-4
   PubMed Web of Science ®Google Scholar
• Hussain M, Tunio AG, Akhtar L, Shaikh GS. Effects of nigella sativa on various parameters in Patients of non-alcoholic fatty liver disease. J Ayub Med Coll Abbottabad. 2017;29(3):403–407.
   PubMedGoogle Scholar
• Farhangi MA, Dehghan P, Tajmiri S, Abbasi MM. The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto’s thyroiditis: a randomized controlled trial. BMC Complement Altern Med. 2016;16(1):471. doi:10.1186/s12906-016-1432-2
   PubMed Web of Science ®Google Scholar
• Mahdavi R, Namazi N, Alizadeh M, Farajnia S. Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk factors in obese women: a randomized controlled clinical trial. Food Funct. 2015;6(6):2041–2048. doi:10.1039/C5FO00316D
   PubMed Web of Science ®Google Scholar
• Namazi N, Mahdavi R, Alizadeh M, Farajnia S. Oxidative stress responses to nigella sativa oil concurrent with a low-calorie diet in obese women: a randomized, double-blind controlled clinical trial. Phytother Res. 2015;29(11):1722–1728. doi:10.1002/ptr.5417
   PubMed Web of Science ®Google Scholar
• Latiff LA, Parhizkar S, Dollah MA, Hassan ST. Alternative supplement for enhancement of reproductive health and metabolic profile among perimenopausal women: a novel role of Nigella sativa. Iran J Basic Med Sci. 2014;17(12):980–985.
   PubMed Web of Science ®Google Scholar
• Bamosa AO, Kaatabi H, Lebdaa FM, Elq AM, Al-Sultanb A. Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian J Physiol Pharmacol. 2010;54(4):344–354.
   PubMedGoogle Scholar
• Datau EA, Surachmanto EE, Pandelaki K, Langi JA. Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male. Acta Med Indones. 2010;42(3):130–134.
   PubMedGoogle Scholar
• Qidwai W, Hamza HB, Qureshi R, Gilani A. Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial. J Altern Complement Med. 2009;15(6):639–644. doi:10.1089/acm.2008.0367
   PubMed Web of Science ®Google Scholar
• Anwar N, Nadeem A, Naheed K, et al. Impact of Nigella sativa on body weight, volume and weight of ovary in letrozole induced polycystic ovarian syndrome in mice. Pak J Med Health Sci. 2021;15(9):2355–2357. doi:10.53350/pjmhs211592355
   Web of Science ®Google Scholar
• Al Asoom LI. Coronary angiogenic effect of long-term administration of Nigella sativa. BMC Complement Altern Med. 2017;17(1):308. doi:10.1186/s12906-017-1795-z
   PubMed Web of Science ®Google Scholar
• Parhizkar S, Latiff LA, Rahman SA, Dollah MA. Preventive effect of Nigella sativa on metabolic syndrome in menopause induced rats. J Med Plant Res. 2011;5(8):1478–1484.
   Google Scholar
• Meddah B, Ducroc R, El Abbes Faouzi M, et al. Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. J Ethnopharmacol. 2009;121(3):419–424. doi:10.1016/j.jep.2008.10.040
   PubMed Web of Science ®Google Scholar
• Le PM, Benhaddou-Andaloussi A, Elimadi A, Settaf A, Cherrah Y, Haddad PS. The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat. J Ethnopharmacol. 2004;94(2–3):251–259. doi:10.1016/j.jep.2004.04.030
   PubMed Web of Science ®Google Scholar
• Mahdavi R, Alizadeh M, Namazi N, Farajnia S. Changes of body composition and circulating adipokines in response to Nigella sativa oil with a calorie restricted diet in obese women. J Herb Med. 2016;6(2):67–72. doi:10.1016/j.hermed.2016.03.003
   Web of Science ®Google Scholar
• Razmpoosh E, Safi S, Mazaheri M, et al. Effects of oral Nigella sativa oil on the expression levels and serum concentrations of adiponectin, PPAR-gamma, and TNF-alpha in overweight and obese women: a study protocol for a crossover-designed, double-blind, placebo-controlled randomized clinical trial. Trials. 2019;20(1). doi:10.1186/s13063-019-3568-0
   PubMed Web of Science ®Google Scholar
• Tiruppur VSK, Pattekhan H, Divakar S, US K. Chemical composition of Nigella sativa L. seed extracts obtained by supercritical carbon dioxide. J Food Sci Technol. 2010;47(6):598–605. doi:10.1007/s13197-010-0109-y
   PubMed Web of Science ®Google Scholar
• Hossain MS, Sharfaraz A, Dutta A, et al. A review of ethnobotany, phytochemistry, antimicrobial pharmacology and toxicology of Nigella sativa L. Biomed Pharmacother. 2021;143:112182. doi:10.1016/j.biopha.2021.112182
   PubMed Web of Science ®Google Scholar
• Jehan S, Huang J, Farooq U, Basheer I, Zhou W. Combinatorial effect of thymoquinone with chemo agents for tumor therapy. Phytomedicine. 2022;98:153936. doi:10.1016/j.phymed.2022.153936
   PubMed Web of Science ®Google Scholar
• Mahdavi R, Namazi N, Alizadeh M, Farajnia S. Nigella sativa oil with a calorie-restricted diet can improve biomarkers of systemic inflammation in obese women: a randomized double-blind, placebo-controlled clinical trial. J Clin Lipidol. 2016;10(5):1203–1211. doi:10.1016/j.jacl.2015.11.019
   PubMed Web of Science ®Google Scholar
• Timper K, Brüning JC. Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity. Dis Model Mech. 2017;10(6):679–689. doi:10.1242/dmm.026609
   PubMed Web of Science ®Google Scholar