403
Views
5
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Platelet, Neutrophil and Lymphocyte Quantitative Abnormalities in Patients with Heart Failure: A Retrospective Study

ORCID Icon & ORCID Icon
Pages 69-78 | Received 25 Oct 2022, Accepted 01 Feb 2023, Published online: 05 Feb 2023

References

  • Naik N, Narula J. Heart failure in low-income and middle-income countries: failing REPORT card grades. Lancet Global Health. 2020;8(3):e318. doi:10.1016/S2214-109X(20)30028-0
  • Bragazzi NL, Zhong W, Shu J, et al. Burden of heart failure and underlying causes in 195 countries and territories from 1990 to 2017. Eur J Prev Cardiol. 2021;28(15):1682–1690. doi:10.1093/eurjpc/zwaa147
  • Groenewegen A, Rutten FH, Mosterd A, Hoes AW. Epidemiology of heart failure. Eur J Heart Fail. 2020;22(8):1342–1356. doi:10.1002/ejhf.1858
  • Angaw DA, Ali R, Tadele A, Shumet S. The prevalence of cardiovascular disease in Ethiopia: a systematic review and meta-analysis of institutional and community-based studies. BMC Cardiovasc Disord. 2021;21(1):1–9. doi:10.1186/s12872-020-01828-z
  • Zhu Z, Zhou S. Leukocyte count and the risk of adverse outcomes in patients with HFpEF. BMC Cardiovasc Disord. 2021;21(1):1–9. doi:10.1186/s12872-021-02142-y
  • Kalogeropoulos A, Georgiopoulou V, Psaty BM, et al. Inflammatory markers and incident heart failure risk in older adults: the Health ABC (Health, Aging, and Body Composition) study. J Am Coll Cardiol. 2010;55(19):2129–2137. doi:10.1016/j.jacc.2009.12.045
  • Engström G, Melander O, Hedblad B. Leukocyte count and incidence of hospitalizations due to heart failure. Circ Heart Fail. 2009;2(3):217–222. doi:10.1161/CIRCHEARTFAILURE.108.827071
  • Ahmad A, Alharbi MN, Aldhabaan OA, et al. Prevalence and risk factors of leukocytosis among heart failure patients. Int J Med Dev Countries. 2019;3(5):468–473. doi:10.24911/IJMDC.51-1547423021
  • Jan AF, Habib S, Naseeb K, Khatri MA, Zaman KS. High total leukocyte count and heart failure after myocardial infarction. Pakistan Heart J. 2011;44:1–2.
  • Madjid M, Fatemi O. Components of the complete blood count as risk predictors for coronary heart disease: in-depth review and update. Texas Heart Institute J. 2013;40(1):17.
  • Núñez J, Miñana G, Bodí V, et al. Low lymphocyte count and cardiovascular diseases. Curr Med Chem. 2011;18(21):3226–3233. doi:10.2174/092986711796391633
  • Bian C, Wu Y, Shi Y, et al. Predictive value of the relative lymphocyte count in coronary heart disease. Heart Vessels. 2010;25(6):469–473. doi:10.1007/s00380-010-0010-7
  • Delcea C, Buzea C, Daha I, et al. P751 Low platelets in heart failure: small cells, important impact on all-cause long-term mortality. Eur Heart J. 2019;40(Supplement_1):ehz747. doi:10.1093/eurheartj/ehz747.0353
  • Lassale C, Curtis A, Abete I, van der Schouw Y, Verschuren W, Lu Y. Elements of the complete blood count associated with cardiovascular disease incidence: findings from the EPIC-NL cohort study. Sci Rep. 2018;8(1):1–11. doi:10.1038/s41598-018-21661-x
  • Polat N, Yildiz A, Bilik MZ, et al. The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure. Turk Kardiyol Dern Ars. 2015;43(2):157–165. doi:10.5543/tkda.2015.76281
  • Bao K, Huang H, Huang G, et al. Platelet-to-hemoglobin ratio as a valuable predictor of long-term all-cause mortality in coronary artery disease patients with congestive heart failure. BMC Cardiovasc Disord. 2021;21(1):1–9. doi:10.1186/s12872-021-02423-6
  • Kassa E, Enawgaw B, Gelaw A, Gelaw B. Effect of anti-tuberculosis drugs on hematological profiles of tuberculosis patients attending at University of Gondar Hospital, Northwest Ethiopia. BMC Hematol. 2016;16(1):1–11. doi:10.1186/s12878-015-0037-1
  • Erkurt MA, Kaya E, Berber I, Koroglu M, Kuku I. Thrombocytopenia in adults. J Hematol. 2012;1(2–3):44–53.
  • Tefferi A, Hanson CA, Inwards DJ. How to Interpret and Pursue an Abnormal Complete Blood Cell Count in Adults. Elsevier; 2005.
  • Seaquist ER, Anderson J, Childs B, et al. Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society. Diabetes Care. 2013;36(5):1384–1395. doi:10.2337/dc12-2480
  • Bisetegn H, Feleke DG, Debash H, Erkihun Y, Ebrahim H. Hematological and Biochemical changes in Schistosoma mansoni infected patients at Haik Primary Hospital, North-East Ethiopia: a comparative cross-sectional study. PLoS Negl Trop Dis. 2022;16(8):e0010728. doi:10.1371/journal.pntd.0010728
  • Glezeva N, Voon V, Watson C, et al. Exaggerated inflammation and monocytosis associate with diastolic dysfunction in heart failure with preserved ejection fraction: evidence of M2 macrophage activation in disease pathogenesis. J Card Fail. 2015;21(2):167–177. doi:10.1016/j.cardfail.2014.11.004
  • Glezeva N, Gilmer JF, Watson CJ, Ledwidge M. A central role for monocyte–platelet interactions in heart failure. J Cardiovasc Pharmacol Ther. 2016;21(3):245–261. doi:10.1177/1074248415609436
  • Davì G, Patrono C. Platelet activation and atherothrombosis. N Eng J Med. 2007;357(24):2482–2494. doi:10.1056/NEJMra071014
  • Balta S, Ozturk C. The platelet-lymphocyte ratio: a simple, inexpensive and rapid prognostic marker for cardiovascular events. Platelets. 2015;26(7):680–681. doi:10.3109/09537104.2014.979340
  • Uçar FM, Açar B, Gul M, Özeke Ö, Aydogdu S. The association between platelet/lymphocyte ratio and coronary artery disease severity in asymptomatic low ejection fraction patients. Korean Circ J. 2016;46(6):821–826. doi:10.4070/kcj.2016.46.6.821
  • Bajaj NS, Kalra R, Gupta K, et al. Leucocyte count predicts cardiovascular risk in heart failure with preserved ejection fraction: insights from TOPCAT Americas. ESC Heart Failure. 2020;7(4):1676–1687. doi:10.1002/ehf2.12724
  • Wheeler JG, Mussolino ME, Gillum RF, Danesh J. Associations between differential leucocyte count and incident coronary heart disease: 1764 incident cases from seven prospective studies of 30 374 individuals. Eur Heart J. 2004;25(15):1287–1292. doi:10.1016/j.ehj.2004.05.002
  • Kain V, Halade GV. Role of neutrophils in ischemic heart failure. Pharmacol Ther. 2020;205:107424. doi:10.1016/j.pharmthera.2019.107424
  • Arruda-Olson AM, Reeder GS, Bell MR, Weston SA, Roger VL. Neutrophilia predicts death and heart failure after myocardial infarction: a community-based study. Circ Cardiovasc Qual Outcomes. 2009;2(6):656–662. doi:10.1161/CIRCOUTCOMES.108.831024
  • Russell CJ, Exley AR, Ritchie AJ. Widespread coronary inflammation in unstable angina. N Eng J Med. 2003;348(19):1931. doi:10.1056/NEJM200305083481919
  • Dinerman JL, Mehta JL, Saldeen TG, et al. Increased neutrophil elastase release in unstable angina pectoris and acute myocardial infarction. J Am Coll Cardiol. 1990;15(7):1559–1563. doi:10.1016/0735-1097(90)92826-N
  • Biasucci LM, D’Onofrio G, Liuzzo G, et al. Intracellular neutrophil myeloperoxidase is reduced in unstable angina and acute myocardial infarction, but its reduction is not related to ischemia. J Am Coll Cardiol. 1996;27(3):611–616. doi:10.1016/0735-1097(95)00524-2
  • Naruko T, Ueda M, Haze K, et al. Neutrophil infiltration of culprit lesions in acute coronary syndromes. Circulation. 2002;106(23):2894–2900. doi:10.1161/01.CIR.0000042674.89762.20
  • Tracchi I, Ghigliotti G, Mura M, et al. Increased neutrophil lifespan in patients with congestive heart failure. Eur J Heart Fail. 2009;11(4):378–385. doi:10.1093/eurjhf/hfp031
  • Narducci ML, Grasselli A, Biasucci LM, et al. High telomerase activity in neutrophils from unstable coronary plaques. J Am Coll Cardiol. 2007;50(25):2369–2374. doi:10.1016/j.jacc.2007.08.048
  • Yan X, Anzai A, Katsumata Y, et al. Temporal dynamics of cardiac immune cell accumulation following acute myocardial infarction. J Mol Cell Cardiol. 2013;62:24–35. doi:10.1016/j.yjmcc.2013.04.023
  • Frangogiannis NG. Regulation of the inflammatory response in cardiac repair. Circ Res. 2012;110(1):159–173. doi:10.1161/CIRCRESAHA.111.243162
  • Rudiger A, Burckhardt OA, Harpes P, Müller SA, Follath F. The relative lymphocyte count on hospital admission is a risk factor for long-term mortality in patients with acute heart failure. Am J Emerg Med. 2006;24(4):451–454. doi:10.1016/j.ajem.2005.10.010
  • Vaduganathan M, Ambrosy AP, Greene SJ, et al. Predictive value of low relative lymphocyte count in patients hospitalized for heart failure with reduced ejection fraction: insights from the EVEREST trial. Circ Heart Fail. 2012;5(6):750–758. doi:10.1161/CIRCHEARTFAILURE.112.970525
  • Ommen SR, Hodge DO, Rodeheffer RJ, McGregor CG, Thomson SP, Gibbons RJ. Predictive power of the relative lymphocyte concentration in patients with advanced heart failure. Circulation. 1998;97(1):19–22. doi:10.1161/01.CIR.97.1.19
  • Chao DT, Korsmeyer SJ. BCL-2 family: regulators of cell death. Annu Rev Immunol. 1998;1:16.
  • Strasser A, Harris AW, Huang D, Krammer PH, Cory S. Bcl‐2 and Fas/APO‐1 regulate distinct pathways to lymphocyte apoptosis. EMBO J. 1995;14(24):6136–6147. doi:10.1002/j.1460-2075.1995.tb00304.x
  • Mojadidi MK, Galeas JN, Goodman-Meza D, et al. Thrombocytopaenia as a prognostic indicator in heart failure with reduced ejection fraction. Heart Lung Circ. 2016;25(6):568–575. doi:10.1016/j.hlc.2015.11.010
  • Aynalem M, Adane T, Getawa S. Magnitude of Coagulation Abnormalities and Associated Factors Among Patients with Heart Diseases at the University of Gondar Comprehensive Specialized Hospital. Vasc Health Risk Manag. 2022;18:617. doi:10.2147/VHRM.S371912
  • Gregg D, Goldschmidt-Clermont PJ. Platelets and cardiovascular disease. Circulation. 2003;108(13):e88–e90. doi:10.1161/01.CIR.0000086897.15588.4B
  • Klinger MH, Jelkmann W. Role of blood platelets in infection and inflammation. J Interferon Cytokine Res. 2002;22(9):913–922. doi:10.1089/10799900260286623
  • Chung I, Lip GY. Platelets and heart failure. Eur Heart J. 2006;27(22):2623–2631. doi:10.1093/eurheartj/ehl305