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Review

Update on ranolazine in the management of angina

, &
Pages 353-362 | Published online: 24 Jun 2014

References

  • GoASMozaffarianDRogerVLHeart disease and stroke statistics – 2013 update: a report from the American Heart AssociationCirculation20131271e6e24523239837
  • Centers for Disease Control and Prevention, National Center for Health StatisticsCompressed Mortality File 1999–2009. Underlying cause-of-death 1999–2009 Available from: http://wonder.cdc.gov/mortSQl.htmlAccessed February 25, 2014
  • YehRWSidneySChandraMSorelMSelbyJVGoASPopulation trends in the incidence and outcomes of acute myocardial infarctionN Engl J Med2010362232155216520558366
  • FordESAjaniUACroftJBExplaining the decrease in US deaths from coronary disease, 1980–2000N Engl J Med2007356232388239817554120
  • SilvermanMEWilliam Heberden and some account of a disorder of the breastClin Cardiol19871032112133549087
  • National Institutes of Health, National Heart, Lung, and Blood InstituteIncidence and Prevalence: 2006 Chart Book on Cardiovascular and Lung Diseases2006 Available from: https://www.nhlbi.nih.gov/resources/docs/06a_ip_chtbk.pdfAccessed May 13, 2014
  • MontalescotGSechtemUAchenbachS2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of CardiologyEur Heart J201334382949300323996286
  • US Food and Drug AdministrationFDA approves new treatment for chest pain Available from: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2006/ucm108587.htmAccessed February 25, 2014
  • JerlingMClinical pharmacokinetics of ranolazineClin Pharmacokinet200645546949116640453
  • RanexaFull prescribing information Available from: http://www.gilead.com/~/media/Files/pdfs/medicines/cardiovascular/ranexa/ranexa_pi.ashAccessed February 25, 2014
  • JerlingMHuanBLLeungKStudies to investigate the pharmacokinetic interactions between ranolazine and ketoconazole, diltiazem, or simvastatin during combined administration in healthy subjectsJ Clin Pharmacol200545442243315778423
  • AntzelevitchCBelardinelliLWuLElectrophysiologic properties and antiarrhythmic actions of a novel anti-anginal agentJ Cardiovasc Pharmacol Ther20049Suppl 1S65S8315378132
  • AntzelevitchCBurashnikovASicouriSBelardinelliLElectrophysiologic basis for the antiarrhythmic actions of ranolazineHeart Rhythm2011881281129021421082
  • TavazziLRanolazine, a new antianginal drugFuture Cardiol200511919804055
  • StanleyWCLopaschukGDHallJLMcCormackJGRegulation of myocardial carbohydrate metabolism under normal and ischaemic conditions: potential for pharmacological interventionsCardiovasc Res19973322432579074687
  • LopaschukGDOptimising cardiac energy metabolism: a new approach to treating ischaemic heart diseaseEur Heart J Suppl19991SupplO32O39
  • McCormackJGBarrRLWolffAARanolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat heartsCirculation19969311351428616920
  • MacInnesAFairmanDABindingPThe antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolaseCirc Res200393e26e3212869391
  • NobleDNoblePJLate sodium current in the pathophysiology of cardiovascular disease: consequences of sodium-calcium overloadHeart200692Suppl 4iviv5
  • BelardinelliLShryockJCFraserHInhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazineHeart200692Suppl 4iv6iv1416775092
  • ReddyBMWeintraubHSSchwartzbardAZRanolazine: a new approach to treating an old problemTex Heart Inst J201037664164721224931
  • ValdiviaCRChuWWPuJIncreased late sodium current in myocytes from a canine heart failure model and from failing human heartJ Mol Cell Cardiol200538347548315733907
  • BelardinelliLAntzelevitchCFraserHInhibition of late (sustained/persistent) sodium current: a potential drug target to reduce intracellular sodium dependent calcium overload and its detrimental effects on cardiomyocyte functionEur Heart J20046Suppl II3I7
  • HouserSRCan novel therapies for arrhythmias caused by spontaneous sarcoplasmic reticulum Ca2+ release be developed using mouse models?Circ Res200596101031103215920024
  • BersDMBarryWHDespaSIntracellular Na regulation in cardiac myocytesCardiovasc Res200357489791212650868
  • MurphyECrossHSteenbergenCSodium regulation during ischemia versus reperfusion and its role in injuryCirc Res199984121469147010381900
  • ChaitmanBRRanolazine for the treatment of chronic angina and potential use in other cardiovascular conditionsCirculation2006113202462247216717165
  • SongYShryockJCWuLBelardenelliLAntagonism by ranolazine of the proarrhythmic effects of increasing late INa in guinea pig ventricular myocytesJ Cardiovasc Pharmacol200444219219915243300
  • PepineCJWolffAAA controlled trial with a novel anti-ischemic agent, ranolazine, in chronic stable angina pectoris that is responsive to conventional antianginal agents. Ranolazine Study GroupAm J Cardiol1999841465010404850
  • RousseauMFPouleurHCoccoGWolffAAComparative efficacy of ranolazine versus atenolol for chronic angina pectorisAm J Cardiol200595331131615670536
  • ChaitmanBRSkettinoSLParkerJOAnti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe anginaJ Am Coll Cardiol20044381375138215093870
  • ChaitmanBRPepineCJParkerJOEffects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trialJAMA2004291330931614734593
  • SendonJLLeeSChengMLBen-YehudaOCARISA Study InvestigatorsEffects of ranolazine on exercise tolerance and angina frequency in patients with severe chronic angina receiving maximally-tolerated background therapy: analysis from the Combination Assessment of Ranolazine In Stable Angina (CARISA) randomized trialEur J Prev Cardiol201219595295922689417
  • TimmisADChaitmanBRCragerMEffects of ranolazine on exercise tolerance and HbA1c in patients with chronic angina and diabetesEur Heart J2006271424816176940
  • WhiteHDSkettinoSLChaitmanBRAnti-anginal efficacy of ranolazine addition to beta blocker or calcium antagonist therapy in patients with a history of heart failureCirculation200210619 Suppl 234935012119252
  • KorenMJCragerMRSweeneyMLong-term safety of a novel antianginal agent in patients with severe chronic stable angina: the Ranolazine Open Label Experience (ROLE)J Am Coll Cardiol200749101027103417349881
  • StonePHGratsianskyNABlokhinAHuangIZMengLERICA InvestigatorsAntianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (Efficacy of Ranolazine in Chronic Angina) trialJ Am Coll Cardiol200648356657516875985
  • RichMWCragerMMcKayCRSafety and efficacy of extended-release ranolazine in patients aged 70 years or older with chronic stable angina pectorisAm J Geriatr Cardiol200716421622117617747
  • WengerNKChaitmanBVetrovecGWGender comparison of efficacy and safety of ranolazine for chronic angina pectoris in four randomized clinical trialsAm J Cardiol2007991111817196454
  • KosiborodMArnoldSVSpertusJAEvaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina)J Am Coll Cardiol201361202038204523500237
  • MorrowDASciricaBMKarwatowska-ProkopczukEEffects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trialJAMA2007297161775178317456819
  • ArnoldSVMorrowDAWangKEffects of ranolazine on disease-specific health status and quality of life among patients with acute coronary syndromes: results from the MERLIN-TIMI 36 randomized trialCirc Cardiovasc Qual Outcomes20081210711520031797
  • WilsonSRSciricaBMBraunwaldEEfficacy of ranolazine in patients with chronic angina observations from the randomized, double-blind, placebo-controlled MERLIN-TIMI (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST-Segment Elevation Acute Coronary Syndromes) 36 TrialJ Am Coll Cardiol200953171510151619389561
  • WeiszGFarzaneh-FarRBen-YehudaOUse of ranolazine in patients with incomplete revascularization after percutaneous coronary intervention: design and rationale of the Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (RIVER-PCI) trialAm Heart J20131666953959.e95324268208
  • FigueredoVMPressmanGSRomero-CorralAImprovement in left ventricular systolic and diastolic performance during ranolazine treatment in patients with stable anginaJ Cardiovasc Pharmacol Ther201116216817220924097
  • MaierLSLayugBKarwatowska-ProkopczukERAnoLazIne for the treatment of diastolic heart failure in patients with preserved ejection fraction: the RALI-DHF proof-of-concept studyJ Am Coll Cardiol201312115122
  • AntzelevitchCBelardinelliLZygmuntACElectrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic propertiesCirculation2004110890491015302796
  • SciricaBMMorrowDAHodHEffect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: results from the Metabolic Efficiency With Ranolazine for Less Ischemia in Non ST-Elevation Acute Coronary Syndrome Thrombolysis in Myocardial Infarction 36 (MERLINTIMI 36) randomized controlled trialCirculation2007116151647165217804441
  • MurdockDKOvertonNKerstenMKaliebeJDevecchiFThe effect of ranolazine on maintaining sinus rhythm in patients with resistant atrial fibrillationIndian Pacing Electrophysiol J20088317518118679523
  • MurdockDKKerstenMKaliebeJLarrainGThe use of oral ranolazine to convert new or paroxysmal atrial fibrillation: a review of experience with implications for possible “pill in the pocket” approach to atrial fibrillationIndian Pacing Electrophysiol J20099526026719763194
  • VaishnavAVaishnavALokhandwalaYRefractory atrial fibrillation effectively treated with ranolazineIndian Heart J201466111511824581108
  • BurashnikovASicouriSDi DiegoJMBelardinelliLAntzelevitchCSynergistic effect of the combination of dronedarone and ranolazine to suppress atrial fibrillationJ Am Coll Cardiol201056151216122420883928
  • MilesRHPassmanRMurdockDKComparison of effectiveness and safety of ranolazine versus amiodarone for preventing atrial fibrillation after coronary artery bypass graftingAm J Cardiol2011108567367621726841
  • US National Institutes of Health, ClinicalTrials.gov, Menarini GroupRanolazine in atrial fibrillation following an electricaL cardioversion, RAFFAELLO, ClinicalTrials.gov identifier NCT01534962 Available from: http://clinicaltrials.gov/ct2/show/NCT01534962Accessed May 13, 2014
  • US National Institutes of Health, ClinicalTrials.gov, Gilead SciencesA study to evaluate the effect of ranolazine and dronedarone when given alone and in combination in patients with paroxysmal atrial fibrillation HARMONY, ClinicalTrials.gov identifier NCT01522651 Available from: http://clinicaltrials.gov/show/NCT01522651Accessed May 13, 2014
  • BunchTJMahapatraSMurdockDRanolazine reduces ventricular tachycardia burden and ICD shocks in patients with drug-refractory ICD shocksPacing Clin Electrophysiol201134121600160621895727
  • MossAJZarebaWSchwarzKQRoseroSMcNittSRobinsonJLRanolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndromeJ Cardiovasc Electrophysiol200819121289129318662191
  • YeungEKrantzMJSchullerJLDaleRARanolazine for the suppression of ventricular arrhythmia: a case seriesAnn Noninvasive Electrocardiol272014 [Epub ahead of print.]
  • PhelpsCEBuysmanEKGomez ReyGCosts and clinical outcomes associated with use of ranolazine for treatment of anginaClin Ther201234613951407.e139422608105
  • KohnCGParkerMWLimoneBLColemanCICost-effectiveness of ranolazine added to standard-of-care treatment in patients with chronic stable angina pectorisAm J Cardiol201411381306131124560062
  • Hidalgo-VegaARamos-GoniJMVilloroRCost-utility of ranolazine for the symptomatic treatment of patients with chronic angina pectoris in SpainEur J Health Econ10122013 [Epub ahead of print.]