Atrial fibrillation and silent stroke: links, risks, and challenges

References

• GoASHylekEMPhillipsKAPrevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) StudyJAMA2001285182370237511343485
   PubMed Web of Science ®Google Scholar
• Lloyd-JonesDMWangTJLeipEPLifetime risk for development of atrial fibrillation: the Framingham Heart StudyCirculation200411091042104615313941
   PubMed Web of Science ®Google Scholar
• MiyasakaYBarnesMEGershBJSecular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalenceCirculation2006114211912516818816
   PubMed Web of Science ®Google Scholar
• BenjaminEJWolfPAD’AgostinoRBSilbershatzHKannelWBLevyDImpact of atrial fibrillation on the risk of death: the Framingham Heart StudyCirculation199898109469529737513
   PubMed Web of Science ®Google Scholar
• HealeyJSConnollySJGoldMRSubclinical atrial fibrillation and the risk of strokeN Engl J Med2012366212012922236222
   PubMed Web of Science ®Google Scholar
• BornsteinNMAronovichBDKarepovVGThe Tel Aviv Stroke Registry: 3600 consecutive patientsStroke19962710177017738841327
   PubMed Web of Science ®Google Scholar
• KaarisaloMMImmonen-RaihaPMarttilaRJAtrial fibrillation and stroke. Mortality and causes of death after the first acute ischemic strokeStroke19972823113159040681
   PubMed Web of Science ®Google Scholar
• LinHJWolfPAKelly-HayesMStroke severity in atrial fibrillation. The Framingham StudyStroke19962710176017648841325
   PubMed Web of Science ®Google Scholar
• MariniCDeSFSaccoSContribution of atrial fibrillation to incidence and outcome of ischemic stroke: results from a population-based studyStroke20053661115111915879330
   PubMed Web of Science ®Google Scholar
• BenjaminEJLevyDVaziriSMD’AgostinoRBBelangerAJWolfPAIndependent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart StudyJAMA1994271118408448114238
   PubMed Web of Science ®Google Scholar
• WolfPAAbbottRDKannelWBAtrial fibrillation as an independent risk factor for stroke: the Framingham StudyStroke19912289839881866765
   PubMed Web of Science ®Google Scholar
• SamolAMasinMGellnerRPrevalence of unknown atrial fibrillation in patients with risk factorsEuropace201315565766223258819
   PubMed Web of Science ®Google Scholar
• GaitaFCorsinoviLAnselminoMPrevalence of silent cerebral ischemia in paroxysmal and persistent atrial fibrillation and correlation with cognitive functionJ Am Coll Cardiol201362211990199723850917
   PubMed Web of Science ®Google Scholar
• RaihaITarvonenSKurkiTRajalaTSouranderLRelationship between vascular factors and white matter low attenuation of the brainActa Neurol Scand19938742862898503257
   PubMed Web of Science ®Google Scholar
• KempsterPAGerratyRPGatesPCAsymptomatic cerebral infarction in patients with chronic atrial fibrillationStroke19881989559573400107
   PubMed Web of Science ®Google Scholar
• StefansdottirHArnarDOAspelundTAtrial fibrillation is associated with reduced brain volume and cognitive function independent of cerebral infarctsStroke20134441020102523444303
   PubMed Web of Science ®Google Scholar
• WilkeTGrothAMuellerSOral anticoagulation use by patients with atrial fibrillation in Germany. Adherence to guidelines, causes of anticoagulation under-use and its clinical outcomes, based on claims-data of 183,448 patientsThromb Haemost201210761053106522398417
   PubMed Web of Science ®Google Scholar
• KimBJLeeSHPrognostic impact of cerebral small vessel disease on stroke outcomeJ Stroke201517210111026060797
   PubMed Web of Science ®Google Scholar
• CaoLPokorneySDHaydenKWelsh-BohmerKNewbyLKCognitive function: is there more to anticoagulation in atrial fibrillation than stroke?J Am Heart Assoc201548e00157326240065
   PubMed Web of Science ®Google Scholar
• FisherCMLacunes: small, deep cerebral infarctsNeurology19651577478414315302
   PubMed Web of Science ®Google Scholar
• FanningJPWongAAFraserJFThe epidemiology of silent brain infarction: a systematic review of population-based cohortsBMC Med20141211925012298
   PubMed Web of Science ®Google Scholar
• LongstrethWTJrDulbergCManolioTAIncidence, manifestations, and predictors of brain infarcts defined by serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health StudyStroke200233102376238212364724
   PubMed Web of Science ®Google Scholar
• DasRRSeshadriSBeiserASPrevalence and correlates of silent cerebral infarcts in the Framingham offspring studyStroke200839112929293518583555
   PubMed Web of Science ®Google Scholar
• UeharaTTabuchiMMoriERisk factors for silent cerebral infarcts in subcortical white matter and basal gangliaStroke19993023783829933274
   PubMed Web of Science ®Google Scholar
• VermeerSEDen HeijerTKoudstaalPJIncidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan StudyStroke200334239239612574548
   PubMed Web of Science ®Google Scholar
• RitterMABrachSRogalewskiADiscrepancy between theoretical knowledge and real action in acute stroke: self-assessment as an important predictor of time to admissionNeurol Res200729547647917535554
   PubMed Web of Science ®Google Scholar
• MorrisZWhiteleyWNLongstrethWTJrIncidental findings on brain magnetic resonance imaging: systematic review and meta-analysisBMJ2009339b301619687093
   PubMed Web of Science ®Google Scholar
• LovbladKOLaubachHJBairdAEClinical experience with diffusion-weighted MR in patients with acute strokeAJNR Am J Neuroradiol1998196106110669672012
   PubMed Web of Science ®Google Scholar
• KalantarianSAyHGollubRLAssociation between atrial fibrillation and silent cerebral infarctions: a systematic review and meta-analysisAnn Intern Med2014161965065825364886
   PubMed Web of Science ®Google Scholar
• DenekeTJaisPScaglioneMSilent cerebral events/lesions related to atrial fibrillation ablation: a clinical reviewJ Cardiovasc Electrophysiol201526445546325556518
   PubMed Web of Science ®Google Scholar
• BokuraHKobayashiSYamaguchiSDistinguishing silent lacunar infarction from enlarged Virchow-Robin spaces: a magnetic resonance imaging and pathological studyJ Neurol199824521161229507419
   PubMed Web of Science ®Google Scholar
• WieczorekMHoeltgenRBrueckMDoes the number of simultaneously activated electrodes during phased RF multielectrode ablation of atrial fibrillation influence the incidence of silent cerebral microembolism?Heart Rhythm201310795395923567660
   PubMed Web of Science ®Google Scholar
• ShinkawaAUedaKKiyoharaYSilent cerebral infarction in a community-based autopsy series in Japan. The Hisayama StudyStroke19952633803857886710
   PubMed Web of Science ®Google Scholar
• Valdés-HernándezMDMaconickLCMunoz ManiegaSA comparison of location of acute symptomatic vs. “silent” small vessel lesionsInt J Stroke20151071044105526120782
   PubMed Web of Science ®Google Scholar
• ToyodaGBokuraHMitakiSAssociation of mild kidney dysfunction with silent brain lesions in neurologically normal subjectsCerebrovasc Dis Extra201551222725873927
   PubMedGoogle Scholar
• VermeerSEPrinsNDdenHTHofmanAKoudstaalPJBretelerMMSilent brain infarcts and the risk of dementia and cognitive declineN Engl J Med2003348131215122212660385
   PubMed Web of Science ®Google Scholar
• SatoRBryanRNFriedLPNeuroanatomic and functional correlates of depressed mood: the Cardiovascular Health StudyAm J Epidemiol1999150991992910547137
   PubMed Web of Science ®Google Scholar
• FukudaKTakashimaYHashimotoMUchinoAYuzurihaTYaoHEarly menopause and the risk of silent brain infarction in community-dwelling elderly subjects: the Sefuri brain MRI studyJ Stroke Cerebrovasc Dis201423581782224045081
   PubMed Web of Science ®Google Scholar
• ZhangCQinYYChenQAlcohol intake and risk of stroke: a dose-response meta-analysis of prospective studiesInt J Cardiol2014174366967724820756
   PubMed Web of Science ®Google Scholar
• LeeSJChoYJKimJGModerate alcohol intake reduces risk of ischemic stroke in KoreaNeurology201585221950195626519539
   PubMed Web of Science ®Google Scholar
• MukamalKJLongstrethWTJrMittlemanMACrumRMSiscovickDSAlcohol consumption and subclinical findings on magnetic resonance imaging of the brain in older adults: the cardiovascular health studyStroke20013291939194611546878
   PubMed Web of Science ®Google Scholar
• FukudaKYuzurihaTKinukawaNAlcohol intake and quantitative MRI findings among community dwelling Japanese subjectsJ Neurol Sci20092781–2303419059611
   PubMed Web of Science ®Google Scholar
• HowardGWagenknechtLECaiJCooperLKrautMATooleJFCigarette smoking and other risk factors for silent cerebral infarction in the general populationStroke19982959139179596234
   PubMed Web of Science ®Google Scholar
• VermeerSEKoudstaalPJOudkerkMHofmanABretelerMMPrevalence and risk factors of silent brain infarcts in the population-based Rotterdam Scan StudyStroke2002331212511779883
   PubMed Web of Science ®Google Scholar
• ParkKYasudaNToyonagaSTsubosakiENakabayashiHShimizuKSignificant associations of metabolic syndrome and its components with silent lacunar infarction in middle aged subjectsJ Neurol Neurosurg Psychiatry200879671972118270234
   PubMed Web of Science ®Google Scholar
• BokuraHYamaguchiSIijimaKNagaiAOguroHMetabolic syndrome is associated with silent ischemic brain lesionsStroke20083951607160918323475
   PubMed Web of Science ®Google Scholar
• AonoYOhkuboTKikuyaMPlasma fibrinogen, ambulatory blood pressure, and silent cerebrovascular lesions: the Ohasama studyArterioscler Thromb Vasc Biol200727496396817272746
   PubMed Web of Science ®Google Scholar
• LiebetrauMSteenBHamannGFSkoogISilent and symptomatic infarcts on cranial computerized tomography in relation to dementia and mortality: a population-based study in 85-year-old subjectsStroke20043581816182015205488
   PubMed Web of Science ®Google Scholar
• PrinsNDvan DijkEJden HeijerTCerebral white matter lesions and the risk of dementiaArch Neurol200461101531153415477506
   PubMed Web of Science ®Google Scholar
• Saavedra PerezHCDirekNHofmanAVernooijMWTiemeierHIkramMASilent brain infarcts: a cause of depression in the elderly?Psychiatry Res2013211218018223154097
   PubMed Web of Science ®Google Scholar
• HowardVJMcClureLAMeschiaJFPulleyLOrrSCFridayGHHigh prevalence of stroke symptoms among persons without a diagnosis of stroke or transient ischemic attack in a general population: the REasons for Geographic And Racial Differences in Stroke (REGARDS) studyArch Intern Med2006166181952195817030827
   PubMedGoogle Scholar
• SongIUKimJSKimYIEahKYLeeKSClinical significance of silent cerebral infarctions in patients with Alzheimer diseaseCogn Behav Neurol2007202939817558252
   PubMed Web of Science ®Google Scholar
• YamashitaHFujikawaTTakamiHLong-term prognosis of patients with major depression and silent cerebral infarctionNeuropsychobiology201062317718120664230
   PubMed Web of Science ®Google Scholar
• FujikawaTYamawakiSTouhoudaYSilent cerebral infarctions in patients with late-onset maniaStroke19952669469497762043
   PubMed Web of Science ®Google Scholar
• BokuraHKobayashiSYamaguchiSSilent brain infarction and subcortical white matter lesions increase the risk of stroke and mortality: a prospective cohort studyJ Stroke Cerebrovasc Dis2006152576317904049
   PubMedGoogle Scholar
• KobayashiSOkadaKKoideHBokuraHYamaguchiSSubcortical silent brain infarction as a risk factor for clinical strokeStroke19972810193219399341698
   PubMed Web of Science ®Google Scholar
• VermeerSEHollanderMvan DijkEJSilent brain infarcts and white matter lesions increase stroke risk in the general population: the Rotterdam Scan StudyStroke20033451126112912690219
   PubMed Web of Science ®Google Scholar
• CouttsSBEliasziwMHillMDAn improved scoring system for identifying patients at high early risk of stroke and functional impairment after an acute transient ischemic attack or minor strokeInt J Stroke20083131018705908
   PubMed Web of Science ®Google Scholar
• EzekowitzMDJamesKENazarianSMSilent cerebral infarction in patients with nonrheumatic atrial fibrillation. The veterans affairs stroke prevention in nonrheumatic atrial fibrillation investigatorsCirculation1995928217821827554199
   PubMed Web of Science ®Google Scholar
• Silent brain infarction in nonrheumatic atrial fibrillationEAFT Study Group. European Atrial Fibrillation TrialNeurology19964611591658559367
   PubMedGoogle Scholar
• PetersenPMadsenEBBrunBPedersenFGyldenstedCBoysenGSilent cerebral infarction in chronic atrial fibrillationStroke1987186109811003686584
   PubMed Web of Science ®Google Scholar
• NeumannTWojcikMBerkowitschACryoballoon ablation of paroxysmal atrial fibrillation: 5-year outcome after single procedure and predictors of successEuropace20131581143114923419659
   PubMed Web of Science ®Google Scholar
• KobayashiAIguchiMShimizuSUchiyamaSSilent cerebral infarcts and cerebral white matter lesions in patients with nonvalvular atrial fibrillationJ Stroke Cerebrovasc Dis201221431031721111632
   PubMed Web of Science ®Google Scholar
• ChenLYLopezFLGottesmanRFAtrial fibrillation and cognitive decline-the role of subclinical cerebral infarcts: the atherosclerosis risk in communities studyStroke20144592568257425052319
   PubMed Web of Science ®Google Scholar
• MarfellaRSassoFCSiniscalchiMBrief episodes of silent atrial fibrillation predict clinical vascular brain disease in type 2 diabetic patientsJ Am Coll Cardiol201362652553023684685
   PubMed Web of Science ®Google Scholar
• ZabalgoitiaMHalperinJLPearceLABlackshearJLAsingerRWHartRGTransesophageal echocardiographic correlates of clinical risk of thromboembolism in nonvalvular atrial fibrillation. Stroke prevention in atrial fibrillation III investigatorsJ Am Coll Cardiol1998317162216269626843
   PubMed Web of Science ®Google Scholar
• SugiokaKTakagiMSakamotoSPredictors of silent brain infarction on magnetic resonance imaging in patients with nonvalvular atrial fibrillation: a transesophageal echocardiographic studyAm Heart J2015169678379026027615
   PubMed Web of Science ®Google Scholar
• PepiMEvangelistaANihoyannopoulosPRecommendations for echocardiography use in the diagnosis and management of cardiac sources of embolism: European Association of Echocardiography (EAE) (a registered branch of the ESC)Eur J Echocardiogr201011646147620702884
   PubMed Web of Science ®Google Scholar
• ChimowitzMIDeGeorgiaMAPooleRMHepnerAArmstrongWMLeft atrial spontaneous echo contrast is highly associated with previous stroke in patients with atrial fibrillation or mitral stenosisStroke1993247101510198322375
   PubMed Web of Science ®Google Scholar
• RastegarRHarnickDJWeidemannPSpontaneous echo contrast videodensity is flow-related and is dependent on the relative concentrations of fibrinogen and red blood cellsJ Am Coll Cardiol200341460361012598072
   PubMed Web of Science ®Google Scholar
• FeinbergWMSeegerJFCarmodyRFAndersonDCHartRGPearceLAEpidemiologic features of asymptomatic cerebral infarction in patients with nonvalvular atrial fibrillationArch Intern Med199015011234023442241443
   PubMedGoogle Scholar
• CammAJKirchhofPLipGYGuidelines for the management of atrial fibrillation: the task force for the management of atrial fibrillation of the European Society of Cardiology (ESC)Eur Heart J201031192369242920802247
   PubMed Web of Science ®Google Scholar
• CammAJLipGYDe CaterinaR2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm AssociationEur Heart J201233212719274722922413
   PubMed Web of Science ®Google Scholar
• ArbeloEBrugadaJHindricksGESC-EURObservational Research Programme: the Atrial Fibrillation Ablation Pilot Study, conducted by the European Heart Rhythm AssociationEuropace20121481094110322628450
   PubMed Web of Science ®Google Scholar
• Herrera SiklodyCDenekeTHociniMIncidence of asymptomatic intracranial embolic events after pulmonary vein isolation: comparison of different atrial fibrillation ablation technologies in a multicenter studyJ Am Coll Cardiol201158768168821664090
   PubMed Web of Science ®Google Scholar
• Di BiaseLGaitaFTosoEDoes periprocedural anticoagulation management of atrial fibrillation affect the prevalence of silent thromboembolic lesion detected by diffusion cerebral magnetic resonance imaging in patients undergoing radiofrequency atrial fibrillation ablation with open irrigated catheters? Results from a prospective multicenter studyHeart Rhythm201411579179824607716
   PubMed Web of Science ®Google Scholar
• GaitaFLeclercqJFSchumacherBIncidence of silent cerebral thromboembolic lesions after atrial fibrillation ablation may change according to technology used: comparison of irrigated radiofrequency, multipolar nonirrigated catheter and cryoballoonJ Cardiovasc Electrophysiol201122996196821453372
   PubMed Web of Science ®Google Scholar
• WissnerEMetznerANeuzilPAsymptomatic brain lesions following laserballoon-based pulmonary vein isolationEuropace201416221421923933850
   PubMed Web of Science ®Google Scholar
• DenekeTShinDIBaltaOPostablation asymptomatic cerebral lesions: long-term follow-up using magnetic resonance imagingHeart Rhythm20118111705171121726519
   PubMed Web of Science ®Google Scholar
• RilligAMeyerfeldtUTilzRRIncidence and long-term follow-up of silent cerebral lesions after pulmonary vein isolation using a remote robotic navigation system as compared with manual ablationCirc Arrhythm Electrophysiol201251152122247481
   PubMed Web of Science ®Google Scholar
• MartinekMSigmundELemesCAsymptomatic cerebral lesions during pulmonary vein isolation under uninterrupted oral anticoagulationEuropace201315332533123097222
   PubMed Web of Science ®Google Scholar
• NeumannTKunissMConradiGMEDAFI-Trial (Micro-embolization during ablation of atrial fibrillation): comparison of pulmonary vein isolation using cryoballoon technique vs. radiofrequency energyEuropace2011131374420829189
   PubMed Web of Science ®Google Scholar
• SchmidtBGunawardeneMKriegDA prospective randomized single-center study on the risk of asymptomatic cerebral lesions comparing irrigated radiofrequency current ablation with the cryoballoon and the laser balloonJ Cardiovasc Electrophysiol201324886987423601001
   PubMed Web of Science ®Google Scholar
• LickfettLHackenbrochMLewalterTCerebral diffusion-weighted magnetic resonance imaging: a tool to monitor the thrombogenicity of left atrial catheter ablationJ Cardiovasc Electrophysiol20061711716426390
   PubMed Web of Science ®Google Scholar
• WieczorekMLukatMHoeltgenRInvestigation into causes of abnormal cerebral MRI findings following PVAC duty-cycled, phased RF ablation of atrial fibrillationJ Cardiovasc Electrophysiol201324212112823134483
   PubMed Web of Science ®Google Scholar
• VermaADebruynePNardiSEvaluation and reduction of asymptomatic cerebral embolism in ablation of atrial fibrillation, but high prevalence of chronic silent infarction: results of the evaluation of reduction of asymptomatic cerebral embolism trialCirc Arrhythm Electrophysiol20136583584223983245
   PubMed Web of Science ®Google Scholar
• ScaglioneMBlandinoARaimondoCImpact of ablation catheter irrigation design on silent cerebral embolism after radiofrequency catheter ablation of atrial fibrillation: results from a pilot studyJ Cardiovasc Electrophysiol201223880180522494043
   PubMed Web of Science ®Google Scholar
• AnselminoMScaglioneMDi BiaseLLeft atrial appendage morphology and silent cerebral ischemia in patients with atrial fibrillationHeart Rhythm20141112724120872
   PubMed Web of Science ®Google Scholar
• PageSPSiddiquiMSFinlayMCatheter ablation for atrial fibrillation on uninterrupted warfarin: can it be done without echo guidance?J Cardiovasc Electrophysiol201122326527021040095
   PubMed Web of Science ®Google Scholar
• GautamSJohnRMStevensonWGEffect of therapeutic INR on activated clotting times, heparin dosage, and bleeding risk during ablation of atrial fibrillationJ Cardiovasc Electrophysiol201122324825420812929
   PubMed Web of Science ®Google Scholar
• GopinathDLewisWRDi BiaseLNataleAPulmonary vein antrum isolation for atrial fibrillation on therapeutic coumadin: special considerationsJ Cardiovasc Electrophysiol201122223623921044211
   PubMed Web of Science ®Google Scholar
• GaitaFCaponiDPianelliMRadiofrequency catheter ablation of atrial fibrillation: a cause of silent thromboembolism? Magnetic resonance imaging assessment of cerebral thromboembolism in patients undergoing ablation of atrial fibrillationCirculation2010122171667167320937975
   PubMed Web of Science ®Google Scholar
• LakkireddyDReddyYMDi BiaseLFeasibility and safety of uninterrupted rivaroxaban for periprocedural anticoagulation in patients undergoing radiofrequency ablation for atrial fibrillation: results from a multicenter prospective registryJ Am Coll Cardiol2014631098298824412445
   PubMed Web of Science ®Google Scholar
• KissANagy-BaloESandorfiGEdesICsanadiZCerebral microembolization during atrial fibrillation ablation: comparison of different single-shot ablation techniquesInt J Cardiol2014174227628124767748
   PubMed Web of Science ®Google Scholar
• KochhäuserSLohmannHHRitterMANeuropsychological impact of cerebral microemboli in ablation of atrial fibrillationClin Res Cardiol2015104323424025336357
   PubMed Web of Science ®Google Scholar
• HaeuslerKGKochLHermJ3 Tesla MRI-detected brain lesions after pulmonary vein isolation for atrial fibrillation: results of the MACPAF studyJ Cardiovasc Electrophysiol2013241142122913568
   PubMed Web of Science ®Google Scholar
• ParkHHildrethAThomsonRO’ConnellJNon-valvular atrial fibrillation and cognitive decline: a longitudinal cohort studyAge Ageing200736215716317259637
   PubMed Web of Science ®Google Scholar
• MavaddatNRoalfeAFletcherKWarfarin versus aspirin for prevention of cognitive decline in atrial fibrillation: randomized controlled trial (Birmingham Atrial Fibrillation Treatment of the Aged Study)Stroke20144551381138624692475
   PubMed Web of Science ®Google Scholar
• BarberMTaitRCScottJRumleyALoweGDStottDJDementia in subjects with atrial fibrillation: hemostatic function and the role of anticoagulationJ Thromb Haemost20042111873187815550013
   PubMed Web of Science ®Google Scholar
• FlakerGCPogueJYusufSCognitive function and anticoagulation control in patients with atrial fibrillationCirc Cardiovasc Qual Outcomes20103327728320233976
   PubMed Web of Science ®Google Scholar
• PriceTRManolioTAKronmalRASilent brain infarction on magnetic resonance imaging and neurological abnormalities in community-dwelling older adults. The Cardiovascular Health Study. CHS Collaborative Research GroupStroke1997286115811649183343
   PubMed Web of Science ®Google Scholar
• HaraMOoieTYufuKSilent cortical strokes associated with atrial fibrillationClin Cardiol199518105735748785902
   PubMed Web of Science ®Google Scholar
• RitterMADittrichRRingelsteinEBKlinisch stumme Hirninfarkte [Silent brain infarctions]Nervenarzt201182810431052 German21761183
   PubMedGoogle Scholar