Assessment of a Single Intra-Articular Stifle Injection of Pure Platelet Rich Plasma on Symmetry Indices in Dogs with Unilateral or Bilateral Stifle Osteoarthritis from Long-Term Medically Managed Cranial Cruciate Ligament Disease

References

• Marshall W, Bockstahler B, Hulse D, Carmichael S. A review of osteoarthritis and obesity: current understanding of the relationship and benefit of obesity treatment and prevention in the dog. Vet Comp Ortho Traum. 2009;22:339–345. doi:10.3415/VCOT-08-08-0069
   PubMed Web of Science ®Google Scholar
• Hayashi K, Manley PA, Muir P. Cranial cruciate ligament pathophysiology in dogs with cruciate disease: a review. J Amer Anim Hosp Assoc. 2004;40(5):385–390. doi:10.5326/040038515347618
   PubMed Web of Science ®Google Scholar
• Wilke VL, Robinson DA, Evans RB, Rothschild MF, Conzemius MG. Estimate of the annual economic impact of treatment of cranial cruciate ligament injury in dogs in the United States. J Amer Vet Med Assoc. 2005;227:1604–1607. doi:10.2460/javma.2005.227.160416313037
   PubMed Web of Science ®Google Scholar
• Frye CW, Shmalberg JW, Wakshlag JJ. Obesity, exercise and orthopedic disease. Vet Clinics NA. 2016;46(5):831–841.
   Google Scholar
• Duerr FM, Martin KW, Rishniw M, Palmer RH, Selmic LE. Treatment of canine cranial cruciate ligament disease. Vet Comp Ortho Traum. 2014;27(6):478–483.
   PubMed Web of Science ®Google Scholar
• Vasseur PB. Clinical results following non-operative management for rupture of the cranial cruciate ligament in dogs. Vet Surg. 1984;13(4):243–246.
   Web of Science ®Google Scholar
• Hunt JR, Dean RS, Davis GN, Murrell JC. An analysis of the relative frequencies of reported adverse events associated with NSAID administration in dogs and cats in the United Kingdom. Vet J. 2015;206(2):183–190.26361747
   PubMed Web of Science ®Google Scholar
• Innes JF, Clayton J, Lascelles BD. Review of the safety and efficacy of long-term NSAID use in the treatment of canine osteoarthritis. Vet Rec. 2010;166(8):226–230.20173106
   PubMed Web of Science ®Google Scholar
• Lascelles BD, McFarland JM, Swann H. Guidelines for safe and effective use of NSAIDs in dogs. Vet Therap. 2005;6(3):237–251.16299670
   PubMedGoogle Scholar
• Whitney KE, Liebowitz A, Bolia IK, et al. Current perspectives on biological approaches for osteoarthritis. Ann N Y Acad Sci. 2017;1410:26–43. doi:10.1111/nyas.2017.1410.issue-129265418
   PubMed Web of Science ®Google Scholar
• Block TJ, Garza JR. Regenerative cells for the management of osteoarthritis and joint disorders: a concise literature review. Aesthet Surg J. 2017;37:S9–S15. doi:10.1093/asj/sjx01529025215
   PubMed Web of Science ®Google Scholar
• Laver L, Marom N, Dnyanesh L, Mei-dan O, Espregueira-mendes J, Gobbi A. PRP for degenerative cartilage disease: a systematic review of clinical studies. Cartilage. 2017;8:341–364. doi:10.1177/194760351667070928317389
   PubMed Web of Science ®Google Scholar
• Fahie MA, Ortolano GA, Guercio V, et al. A randomized controlled trial of the efficacy of autologous platelet therapy for the treatment of osteoarthritis in dogs. J Amer Vet Med Assoc. 2013;243:1291–1297. doi:10.2460/javma.243.9.129124134578
   PubMed Web of Science ®Google Scholar
• Vilar JM, Manera ME, Santana A, et al. Effect of leukocyte-reduced platelet-rich plasma on osteoarthritis caused by cranial cruciate ligament rupture: a canine gait analysis model. PLoS One. 2018;12:e0194752, 1–12.
   Google Scholar
• Cook JL, Smith PA, Bozynski CC, et al. Multiple injections of leuko reduced platelet rich plasma reduce pain and functional impairment in a canine model of ACL and meniscal deficiency. J Ortho Res. 2016;34:607–615. doi:10.1002/jor.23054
   PubMed Web of Science ®Google Scholar
• Silva RF, Camona JU, Rexende CMF. Intra-articular injections of autologous platelet concentrates in dogs with surgical reparation of cranial cruciate ligament rupture. Vet Comp Ortho Traum. 2013;26:285–290. doi:10.3415/VCOT-12-06-0075
   PubMed Web of Science ®Google Scholar
• Koch TG, Berg LC, Betts DH. Current and future regenerative medicine—principles, concepts, and therapeutic use of stem cell therapy and tissue engineering in equine medicine. Canad Vet J. 2009;50(2):155–165.19412395
   PubMed Web of Science ®Google Scholar
• Dhillon MS, Behera P, Patel S, Shetty V. Orthobiologics and platelet rich plasma. Ind J Orthopaed. 2014;48(1):1–8. doi:10.4103/0019-5413.125477
   PubMed Web of Science ®Google Scholar
• McCarrel TM, Mall NA, Lee AS, Cole BJ, Butty DC, Fortier LA. Considerations for the use of platelet-rich plasma in orthopedics. Sports Med. 2014;44:1025–1036. doi:10.1007/s40279-014-0195-524760591
   PubMed Web of Science ®Google Scholar
• Cole BJ, Karas V, Hussey K, Pilz K, Fortier LA. Hyaluronic acid versus platelet-rich plasma: a prospective, double-blind randomized controlled trial comparing clinical outcomes and effects on intra-articular biology for the treatment of knee osteoarthritis. Am J Sports Med. 2017;45:339–346. doi:10.1177/036354651666580928146403
   PubMed Web of Science ®Google Scholar
• Cook CS, Smith PA. Clinical update: why PRP should be your first choice for injection therapy in treating osteoarthritis of the knee. Curr Rev Musculoskelet Med. 2018;11:583–592. doi:10.1007/s12178-018-9524-x30350299
   PubMed Web of Science ®Google Scholar
• Frye CW, Enders A, Brooks MJ, Struble AM, Wakshlag JJ. Assessment of canine autologous platelet-rich plasma produced with a commercial centrifugation and platelet recovery kit. Vet Comp Ortho Traum. 2016;29:14–19. doi:10.3415/VCOT-15-03-0046
   PubMed Web of Science ®Google Scholar
• Franklin SP, Cook JL. Prospective trial of autologous conditioned plasma versus hyaluronan plus corticosteroid for elbow osteoarthritis in dogs. Canad Vet J. 2013;54(9):881.24155495
   PubMed Web of Science ®Google Scholar
• Lascelles BD, Roe SC, Smith E, et al. Evaluation of a pressure walkway system for measurement of vertical limb forces in clinically normal dogs. Am J Vet Res. 2006;67:277–282. doi:10.2460/ajvr.67.2.27716454633
   PubMed Web of Science ®Google Scholar
• Baltzer WI, Smith-ostrin S, Warnock JJ, Ruaux CG. Evaluation of the clinical effects of diet and physical rehabilitation in dogs following tibial plateau leveling osteotomy. J Am Vet Med Assoc. 2018;252:686–700. doi:10.2460/javma.252.6.68629504849
   PubMed Web of Science ®Google Scholar
• Budsberg SC, Jevens DJ, Brown J, Foutz TL, Decamp CE, Reece L. Evaluation of limb symmetry indices, using ground reaction forces in healthy dogs. Am J Vet Res. 1993;54:1569–1574.8250378
   PubMed Web of Science ®Google Scholar
• Bockstahler BA, Vorbornik A, Muller M, Peham C. Compensatory load redistribution in naturally occurring osteoarthritis of the elbow joint and induced weight-bearing lameness of the forelimbs compared to the clinically sound dog. Vet J. 2009;180:202–212. doi:10.1016/j.tvjl.2007.12.02518406183
   PubMed Web of Science ®Google Scholar
• Braun HJ, Kim HJ, Chu CR, Dragoo JL. The effect of platelet-rich plasma formulations and blood products on human synoviocytes: implications for intra-articular injury and therapy. Amer J Sports Med. 2014;42(5):1204–1210. doi:10.1177/036354651452559324634448
   PubMed Web of Science ®Google Scholar
• McCarrel T, Fortier L. Temporal growth factor release from platelet‐rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression. J Orthopaed Res. 2009;27(8):1033–1042. doi:10.1002/jor.v27:8
   PubMed Web of Science ®Google Scholar
• Riboh JC, Saltzman BM, Yanke AB, Fortier L, Cole BJ. Effect of leukocyte concentration on the efficacy of platelet-rich plasma in the treatment of knee osteoarthritis. Am J Sports Med. 2016;44(3):792–800. doi:10.1177/036354651558078725925602
   PubMed Web of Science ®Google Scholar
• Yun S, Ku SK, Kwon YS. Adipose-derived mesenchymal stem cells and platelet-rich plasma synergistically ameliorate the surgical-induced osteoarthritis in Beagle dogs. J Orthopaed Sur Res. 2016;11(1):9. doi:10.1186/s13018-016-0342-9
   PubMedGoogle Scholar
• Voss K, Wiestner T, Geleandro L, Hassig M, Montavon PM. Effect of dog breed and body conformation on vertical ground reaction forces, impulses and stance times. Vet Comp Ortho Traum. 2011;24:106–112. doi:10.3415/VCOT-10-06-0098
   PubMed Web of Science ®Google Scholar
• Krotscheck U, Todhunter RJ, Nelson SA, Sutter NB, Mohammed HO. Precision and accuracy of ground reaction force normalization in a heterogeneous population of dogs. Vet Surg. 2014;43(4):437–445. doi:10.1111/j.1532-950X.2014.12176.x24702543
   PubMed Web of Science ®Google Scholar
• Fanchon L, Grandjean D. Accuracy of asymmetry indices of ground reaction forces for diagnosis of hind limb lameness in dogs. Am J Vet Res. 2007;68(10):1089–1094. doi:10.2460/ajvr.68.10.108917916016
   PubMed Web of Science ®Google Scholar
• Oosterlinck M, Bosmans T, Gasthuys F, et al. Accuracy of pressure plate kinetic asymmetry indices and their correlation with visual gait assessment scores in lame and nonlame dogs. Am J Vet Res. 2011;72(6):820–825. doi:10.2460/ajvr.72.6.82021627529
   PubMed Web of Science ®Google Scholar
• Katic N, Bockstahler BA, Mueller M, Peham C. Fourier analysis of vertical ground reaction forces in dogs with unilateral hind limb lameness caused by degenerative disease of the hip joint and in dogs without lameness. Am J Vet Res. 2009;70(1):118–126. doi:10.2460/ajvr.70.1.11819119957
   PubMed Web of Science ®Google Scholar
• Fischer S, Anders A, Nolte I, Schilling N. Compensatory load redistribution in walking and trotting dogs with hind limb lameness. Vet J. 2013;197(3):746–752.23683534
   PubMed Web of Science ®Google Scholar
• Conzemius MG, Evans RB. Caregiver placebo effect for dogs with lameness from osteoarthritis. J Am Vet Med Assoc. 2012;241:1314–1319.23113523
   PubMed Web of Science ®Google Scholar