Management of obesity in cats

References

• Butterwick R. How fat is that cat? J Feline Med Surg. 2000;2:91–94.11716599
   PubMedGoogle Scholar
• Janssen I, Katzmarzyk PT, Ross R, et al Fitness alters the associations of BMI and waist circumference with total and abdominal fat. Obes Res. 2004;12:525–537.15044671
   PubMedGoogle Scholar
• Romero-Corral A, Somers VK, Sierra-Johnson J, et al Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality. Eur Heart J. 2010;31:737–746.19933515
   PubMed Web of Science ®Google Scholar
• Bjornvad CR, Nielsen DH, Armstrong J, et al Evaluation of a nine-point body condition scoring system in physically inactive pet cats. Am J Vet Res. 2011;72:433–437.21453142
   PubMed Web of Science ®Google Scholar
• Cline MG, Witzel AL, Moyers TD, Bartges JW, Kirk CA. Body composition of outdoor-intact cats compared to indoor-neutered cats using dual energy X-ray absorptiometry In: Proceedings of the 17th European Society of Veterinary and Comparative Nutrition Congress. Belgium: University Press; 2013: 51.
   Google Scholar
• Russell K, Sabin R, Holt S, Bradley R, Harper EJ. Influence of feeding regimen on body condition in the cat. J Small Anim Pract. 2000;41: 12–17.10713977
   PubMed Web of Science ®Google Scholar
• Sloth C. Practical management of obesity in dogs and cats. J Small Anim Pract. 1992;33:178–182.
   Web of Science ®Google Scholar
• Scarlett JM, Donoghue S, Saidla J, Wills J. Overweight cats: prevalence and risk factors. Int J Obes Relat Metab Disord. 1994;18 Suppl 1: S22–S28.8087161
   PubMedGoogle Scholar
• Lund EM, Armstrong J, Kirk CA, Klausner JS. Prevalence and risk factors for obesity in adult cats from private US veterinary practices. Int J Appl Res Vet Med. 2005;3:88–96.
   Google Scholar
• Courcier EA, Mellor DJ, Pendlebury E, Evans C, Yam PS. An investigation into the epidemiology of feline obesity in Great Britain: results of a cross-sectional study of 47 companion animal practises. Vet Rec. 2012;171:560–564.23081976
   PubMed Web of Science ®Google Scholar
• Häring T, Wichert B, Dolf G, Haase B. Segregation analysis of overweight body condition in an experimental cat population. J Hered. 2011;102 Suppl 1:S28–S31.21846744
   PubMedGoogle Scholar
• Colliard L, Paragon BM, Lemuet B, Bénet JJ, Blanchard G. Prevalence and risk factors of obesity in an urban population of healthy cats. J Feline Med Surg. 2009;11:135–140.18774325
   PubMed Web of Science ®Google Scholar
• Corbee RJ. Obesity in show cats In: Proceedings of the 17th European Society of Veterinary and Comparative Nutrition Congress. Belgium: University Press; 2013: 106.
   Google Scholar
• Courcier EA, O’Higgins RO, Mellor DJ, Yam PS. Prevalence and risk factors for feline obesity in a first opinion practice in Glasgow, Scotland. J Feline Med Surg. 2010;12:746–753.20685143
   PubMed Web of Science ®Google Scholar
• Flynn MF, Hardie EM, Armstrong PJ. Effect of ovariohysterectomy on maintenance energy requirement in cat. J Am Vet Med Assoc. 1996;209: 1572–1581.8899020
   PubMed Web of Science ®Google Scholar
• Fettman MJ, Stanton CA, Banks LL, Hamar DW. Effects of neutering on bodyweight, metabolic rate and glucose tolerance of domestic cats. Res Vet Sci. 1997;62:131–136.9243711
   PubMed Web of Science ®Google Scholar
• Kanchuk ML, Backus RC, Calvert CC, Morris JG, Rogers QR. Weight gain in gonadectomized normal and lipoprotein lipase-deficient male domestic cats results from increased food intake and not decreased energy expenditure. J Nutr. 2003;133:1866–1874.12771331
   PubMed Web of Science ®Google Scholar
• Martin G, Rand JS. Pharmacology of a 40 IU/mL porcine lente insulin preparation in diabetic cats: findings during the first week and after 5 or 9 weeks of therapy. J Feline Med Surg. 2001;3:23–30.11716627
   PubMedGoogle Scholar
• Belsito KR, Vester BM, Keel T, Graves TK, Swanson KS. Impact of ovariohysterectomy and food intake on body composition, physical activity, and adipose gene expression in cats. J Anim Sci. 2009;87:594–602.18997063
   PubMed Web of Science ®Google Scholar
• Harper EJ, Stack DM, Watson TD, Moxham G. Effects of feeding regimens on bodyweight, composition and condition score in cats following ovariohysterectomy. J Small Anim Pract. 2001;42:433–438.11570385
   PubMed Web of Science ®Google Scholar
• Hoenig M, Ferguson DC. Effects of neutering on hormonal concentrations and energy requirements in male and female cats. Am J Vet Res. 2002;63:634–639.12013460
   PubMed Web of Science ®Google Scholar
• Allaway D, Gilham M, Colyer A, Jonsson T, Swanson K, Morris PJ. Effects of puberty and timing of gonadectomy on the plasma metabolome of young cats In: The Waltham International Nutritional Sciences Symposium 2013: From Pet Food to Pet Care – Bridging the Gap. McLean (VA): Mars:59.
   Google Scholar
• Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab. 2004;89:2548–2556.15181022
   PubMed Web of Science ®Google Scholar
• Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol. 2011;11:85–97.21252989
   PubMed Web of Science ®Google Scholar
• Prahl A, Guptill L, Glickman NW, Tetrick M, GLickman LT. Time trends and risk factors for diabetes mellitus in cats presented to veterinary teaching hospitals. J Feline Med Surg. 2007;9:351–358.17449313
   PubMed Web of Science ®Google Scholar
• McCann TM, Simpson KE, Shaw DJ, Butt JA, Gunn-Moore DA. Feline diabetes mellitus in the UK: the prevalence within an insured cat population and a questionnaire-based putative risk factor analysis. J Feline Med Surg. 2007;9:289–299.17392005
   PubMed Web of Science ®Google Scholar
• Scarlett JM, Donoghue S. Associations between body condition and disease in cats. J Am Vet Med Assoc. 1998;212(11):1725–1731.9621878
   PubMed Web of Science ®Google Scholar
• Henson MS, O’Brien TD. Feline models of type 2 diabetes mellitus. ILAR J. 2006;47:234–242.16804198
   PubMed Web of Science ®Google Scholar
• Osto M, Zini E, Reusch CE, Lutz TA. Diabetes from humans to cats. Gen Comp Endocrinol. 2013;182:48–53.23247272
   PubMed Web of Science ®Google Scholar
• Brennan CL, Hoenig M, Ferguson DC. GLUT4 but not GLUT1 expression decreases early in the development of feline obesity. Domest Anim Endocrinol. 2004;26:291–301.15063922
   PubMed Web of Science ®Google Scholar
• Wilkins C, Long RC Jr, Waldron M, Ferguson DC, Hoenig M. Assessment of the influence of fatty acids on indices of insulin sensitivity and myocellular lipid content by use of magnetic resonance spectroscopy in cats. Am J Vet Res. 2004;65:1090–1099.15334843
   PubMed Web of Science ®Google Scholar
• Biourge V, Nelson RW, Feldman EC, Willits NH, Morris JG, Rogers QR. Effect of weight gain and subsequent weight loss on glucose tolerance and insulin response in healthy cats. J Vet Intern Med. 1997;11:86–91.9127295
   PubMed Web of Science ®Google Scholar
• Pottie P, Presle N, Terlain B, Netter P, Mainard D, Berenbaum F. Obesity and osteoarthritis: more complex than predicted! Ann Rheum Dis. 2006;65:1403–1405.17038451
   PubMed Web of Science ®Google Scholar
• Scherer PE. Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes. 2006;55:1537–1545.16731815
   PubMed Web of Science ®Google Scholar
• Hoenig M, Thomaseth K, Waldron M, Ferguson DC. Insulin sensitivity, fat distribution and adipocytokine response to different diets in lean and obese cats before and after weight loss. Am J Physiol Regul Integr Comp Physiol. 2007;292:R227–R234.16902186
   PubMed Web of Science ®Google Scholar
• Van de Velde H, Janssens GPJ, de Rooster H, et al The cat as a model for human obesity: insights into depot-specific inflammation associated with feline obesity. Br J Nutr. 2013;110:1326–1335.23702152
   PubMed Web of Science ®Google Scholar
• Bjornvad CR, Rand JS, Tan HY, et al Obesity and sex influence insulin resistance and total and multimer adiponectin levels in adult neutered domestic shorthair client-owned cats. Domest Anim Endocrinol. 2014;14:55–64.
   Google Scholar
• Appleton DJ, Rand JS, Sunvold GD. Plasma leptin concentrations in cats: reference range, effect of weight gain and relationship with adiposity as measured by dual energy X-ray absorptiometry. J Feline Med Surg. 2000;2:191–199.11716618
   PubMed Web of Science ®Google Scholar
• Hoenig M, Pach N, Thomaseth K, Le A, Schaeffer D, Ferguson DC. Cats differ from other species in their cytokine and antioxidant enzyme response when developing obesity. Obesity (Silver Spring). 2013;21: E407–E414.23408676
   PubMed Web of Science ®Google Scholar
• Appleton DJ, Rand JS, Sunvold GD. Plasma leptin concentrations are independently associated with insulin sensitivity in lean and overweight cats. J Feline Med Surg. 2002;4:83–93.12027507
   PubMed Web of Science ®Google Scholar
• Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 2006;116:1784–1792.16823476
   PubMed Web of Science ®Google Scholar
• Muranaka S, Mori N, Hatano Y, et al Obesity induced changes to plasma adiponectin concentration and cholesterol lipoprotein composition profile in cats. Res Vet Sci. 2011;91:358–361.20980035
   PubMed Web of Science ®Google Scholar
• Ishioka K, Omachi A, Sasaki N, Kimura K, Saito M. Feline adiponectin: molecular structures and plasma concentrations in obese cats. J Vet Med Sci. 2009;71:189–194.19262030
   PubMed Web of Science ®Google Scholar
• Tan HY, Rand JS, Morton JM, et al Adiponectin profiles are affected by chronic and acute changes in carbohydrate intake in healthy cats. Gen Comp Endocrinol. 2011;172:468–474.21530529
   PubMed Web of Science ®Google Scholar
• Tvarijonaviciute A, Ceron JJ, Holden SL, Morris PJ, Biourge V, German AJ. Effects of weight loss in obese cats on biochemical analytes related to inflammation and glucose homeostasis. Domest Anim Endocrinol. 2012;42:129–141.22177629
   PubMed Web of Science ®Google Scholar
• Hoenig M, McGoldrick JB, DeBeer M, Demacker PN, Ferguson DC. Activity and tissue-specific expression of lipases and tumor-necrosis factor alpha in lean and obese cats. Domest Anim Endocrinol. 2006;30: 333–344.16219442
   PubMed Web of Science ®Google Scholar
• Miller C, Bartges J, Cornelius L, Norton N, Barton M. Tumor necrosis factor-α levels in adipose tissue of lean and obese cats. J Nutr. 1998;128: 2751S–2752S.9868256
   PubMedGoogle Scholar
• Ul-Haq Z, Mackay DF, Fenwick E, Pell JP. Meta-analysis of the association between body mass index and health-related quality of life among adults, assessed by the SF-36. Obesity (Silver Spring). 2013; 21(3):E322–E327.23592685
   PubMed Web of Science ®Google Scholar
• German AJ, Holden SL, Wiseman-Orr ML, et al Quality of life is reduced in obese dogs but improves after successful weight loss. Vet J. 2012;192:428–434.22075257
   PubMed Web of Science ®Google Scholar
• Munday HS, Booles D, Anderson P, Poore DW, Earle KE. The repeatability of body composition measurements in dogs and cats using dual energy X-ray absorptiometry. J Nutr. 1994;124:2619S–2621S.7996252
   PubMedGoogle Scholar
• Lauten SD, Cox NR, Baker GH, Painter DJ, Morrison NE, Baker HJ. Body composition of growing and adult cats as measured by use of dual energy X-ray absorptiometry. Comp Med. 2000;50(2):175–183.10857009
   PubMed Web of Science ®Google Scholar
• Kienzle E, Moik K. A pilot study on the body weight of pure-bred client-owned adult cats. Br J Nutr. 2011;106:S113–S115.22005404
   PubMed Web of Science ®Google Scholar
• Laflamme D. Development and validation of a body condition score system for cats: a clinical tool. Feline Pract. 1997;25:13–18.
   Google Scholar
• German AJ, Holden SL, Moxham GL, Holmes KL, Hackett RM, Rawlings JM. A simple, reliable tool for owners to assess the body condition of their dog or cat. J Nutr. 2006;136:2031S–2033S.16772488
   PubMed Web of Science ®Google Scholar
• Hawthorne A, Butterwick RF. Predicting the body composition of cats: development of a zoometric measurement for estimation of percentage body fat in cats [abstract]. J Vet Intern Med. 2000;14:365.
   Google Scholar
• Hoenig M, Traas AM, Schaeffer DJ. Evaluation of routine hematology profile results and fructosamine, thyroxine, insulin, and proinsulin concentrations in lean, overweight, obese, and diabetic cats. J Am Vet Med Assoc. 2013;243:1302–1309.24134581
   PubMed Web of Science ®Google Scholar
• Witzel A. What can we learn from DEXA, BCS, BFI and HWP? Poster presented at: Hill’s Global Symposium on Obesity; May 24, 2013; Barcelona.
   Google Scholar
• Brooks D, Churchill J, Fein K, et al 2014 AAHA weight management guidelines for dogs and cats. J Am Anim Hosp Assoc. 2014;50:1–11.24216501
   PubMed Web of Science ®Google Scholar
• Laflamme DP. Nutrition for aging cats and dogs and the importance of body condition. Vet Clin North Am Small Anim Pract. 2005;35: 713–742.15833567
   PubMed Web of Science ®Google Scholar
• Blanchard G, Paragon BM, Sérougne C, Férézou J, Milliat F, Lutton C. Plasma lipids, lipoprotein composition and profile during induction and treatment of hepatic lipidosis in cats and the metabolic effect of one daily meal in healthy cats. J Anim Physiol Anim Nutr (Berl). 2004;88:73–87.
   PubMed Web of Science ®Google Scholar
• Bissot T, Servet E, Vidal S, et al Novel dietary strategies can improve the outcome of weight loss programmes in obese client-owned cats. J Feline Med Surg. 2010;12:104–112.19682935
   PubMed Web of Science ®Google Scholar
• Dimski DS, Buffington CA, Johnson SE, Sherding RG, Rosol TJ. Serum lipoprotein concentrations and hepatic lesions in obese cats undergoing weight loss. Am J Vet Res. 1992;53:1259–1262.1497199
   PubMed Web of Science ®Google Scholar
• German AJ, Holden S, Bissot T, Morris PJ, Biourge V. Changes in body composition during weight loss in obese client-owned cats: loss of lean tissue mass correlates with overall percentage of weight lost. J Feline Med Surg. 2008;10:452–459.18417397
   PubMed Web of Science ®Google Scholar
• Kienzle E, Bergler R. Human-animal relationship of owners of normal and overweight cats. J Nutr. 2006;136:1947S–1950S.16772465
   PubMed Web of Science ®Google Scholar
• Verbrugghe A, Hesta M, Daminet S, Janssens GP. Nutritional modulation of insulin resistance in the true carnivorous cat: a review. Crit Rev Food Sci Nutr. 2012;52:172–182.22059962
   PubMed Web of Science ®Google Scholar
• Verbrugghe A, Hesta M, Van Weyenberg S, et al The glucose and insulin response to isoenergetic reduction of dietary energy sources in a true carnivore: the domestic cat (Felis catus). Br J Nutr. 2010;104: 214–221.20193098
   PubMed Web of Science ®Google Scholar
• Coradini M, Rand JS, Morton JM, Rawlings JM. Effects of two commercially available feline diets on glucose and insulin concentrations, insulin sensitivity and energetic efficiency of weight gain. Br J Nutr. 2011;106:S64–S77.22005439
   PubMed Web of Science ®Google Scholar
• Mori A, Sako T, Lee P, et al Comparison of three commercially available prescription diet regimens on short-term post-prandial serum glucose and insulin concentrations in healthy cats. Vet Res Commun. 2009;33:669–680.19322671
   PubMed Web of Science ®Google Scholar
• Farrow HA, Rand JS, Morton JM, O’Leary CA, Sunvold GD. Effect of dietary carbohydrate, fat, and protein on postprandial glycemia and energy intake in cats. J Vet Intern Med. 2013;27:1121–1135.23869495
   PubMed Web of Science ®Google Scholar
• Leray V, Freuchet B, Le Bloc’h J, Jeusette I, Torre C, Nguyen P. Effect of citrus polyphenol- and curcumin-supplemented diet on inflammatory state in obese cats. Br J Nutr. 2011;106:S198–S201.22005428
   PubMed Web of Science ®Google Scholar
• Linder DE, Freeman LM. Evaluation of caloric density and feeding directions for commercially available diets designed for weight loss in dogs and cats. J Am Vet Med Assoc. 2010;236:74–77.20043803
   PubMed Web of Science ®Google Scholar
• National Research Council. Nutrient Requirements of Dogs and Cats. Washington: National Academies; 2006.
   Google Scholar
• German AJ, Holden SL, Mason SL, et al Imprecision when using measuring cups to weigh out extruded dry kibbled food. J Anim Physiol Anim Nutr. 2011;95:368–373.
   PubMed Web of Science ®Google Scholar
• Michel K, Scherk M. From problem to success: feline weight loss programs that work. J Feline Med Surg. 2012;14:327–336.22511475
   PubMed Web of Science ®Google Scholar
• Deagle G, Holden SL, Biourge V, Morris PJ, German AJ. Long-term outcomes of weight management in obese cats In: The Waltham International Nutritional Sciences Symposium 2013: From Pet Food to Pet Care – Bridging the Gap. McLean (VA): Mars:49.
   Google Scholar
• German AJ, Holden SL, Morris PJ, Biourge V. Long-term follow-up after weight management in obese dogs: the role of diet in preventing regain. Vet J. 2012;192:65–70.21570327
   PubMed Web of Science ®Google Scholar
• German AJ, Holden SL, Mather NJ, et al Low-maintenance energy requirements of obese dogs after weight loss. Br J Nutr. 2011;106: S93–S96.22005443
   PubMed Web of Science ®Google Scholar
• Nagaoka D, Mitsuhashi Y, Angell R, Bigley KE, Bauer JE. Re-induction of obese body weight occurs more rapidly and at a lower caloric intake in beagles. J Anim Physiol Anim Nutr. 2010;94:287–292.
   PubMed Web of Science ®Google Scholar
• Kreymann B, Williams G, Ghatei MA, Bloom SR. Glucagon-like peptide-1 7–36: a physiological incretin in man. Lancet. 1987;2: 1300–1304.2890903
   PubMed Web of Science ®Google Scholar
• Kelly AS, Metzig AM, Rudser KD, et al Exenatide as a weight-loss therapy in extreme pediatric obesity: a randomized, controlled pilot study. Obesity (Silver Spring). 2012;20:364–370.22076596
   PubMed Web of Science ®Google Scholar
• Kim W, Egan JM. The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev. 2008;60:470–512.19074620
   PubMed Web of Science ®Google Scholar
• Astrup A, Carraro R, Finer N, et al Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide. Int J Obes (Lond). 2012;36:843–854.21844879
   PubMed Web of Science ®Google Scholar
• Rosenstock J, Klaff LJ, Schwartz S, et al Effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without pre-diabetes. Diabetes Care. 2010;33(6): 1173–1175.20332357
   PubMed Web of Science ®Google Scholar
• Dushay J, Gao C, Gopalakrishnan GS, et al Short-term exenatide treatment leads to significant weight loss in a subset of obese women without diabetes. Diabetes Care. 2012;35:4–11.22040840
   PubMed Web of Science ®Google Scholar
• Gilor C, Graves TK, Gilor S, Ridge TK, Rick M. The GLP-1 mimetic exenatide potentiates insulin secretion in healthy cats. Domest Anim Endocrinol. 2011;41:42–49.21645806
   PubMed Web of Science ®Google Scholar
• Padrutt I, Zini E, Kaufmann K, Menard J, Lutz TA, Reusch CE. Comparison of the glp-1 analogues exenatide (short-acting), exenatide (long-acting) and the DPP-4 inhibitor sitagliptin to increase insulin secretion in healthy cats [abstract]. J Vet Intern Med. 2012;26: 1520–1521.
   Google Scholar
• German AJ, Morgan LE. How often do veterinarians assess the bodyweight and body condition of dogs? Vet Rec. 2008;163:503–505.18953073
   PubMed Web of Science ®Google Scholar
• Freeman L, Becvarova I, Cave N, et al WSAVA nutritional assessment guidelines. Comp Contin Educ Vet. 2011;33:E1–E9.
   Google Scholar
• Allan FJ, Pfeiffer DU, Jones BR, Esslemont DH, Wiseman MS. A cross-sectional study of risk factors for obesity in cats in New Zealand. Prev Vet Med. 2000;46:183–196.10913803
   PubMed Web of Science ®Google Scholar
• Cave NJ, Allan FJ, Schokkenbroek SL, Metekohy CA, Pfeiffer DU. A cross-sectional study to compare changes in the prevalence and risk factors for feline obesity between 1993 and 2007 in New Zealand. Prev Vet Med. 2012;107:121–133.22703979
   PubMed Web of Science ®Google Scholar