Challenges in the development of future treatments for breast cancer stem cells

References

• BonnetDDickJEHuman acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cellNat Med1997377307379212098
   PubMed Web of Science ®Google Scholar
• SchattonTFrankNYFrankMHIdentification and targeting of cancer stem cellsBioessays200931101038104919708024
   PubMed Web of Science ®Google Scholar
• SakariassenPOImmervollHChekenyaMCancer stem cells as mediators of treatment resistance in brain tumors: status and controversiesNeoplasia200791188289218030356
   PubMed Web of Science ®Google Scholar
• OdouxCFohrerHHoppoTA stochastic model for cancer stem cell origin in metastatic colon cancerCancer Res200868176932694118757407
   PubMed Web of Science ®Google Scholar
• KangSKParkJBChaSHMultipotent, dedifferentiated cancer stemlike cells from brain gliomasStem Cells Dev200615342343516846378
   PubMed Web of Science ®Google Scholar
• PolyakKHavivICampbellIGCo-evolution of tumor cells and their microenvironmentTrends Genet2009251303819054589
   PubMed Web of Science ®Google Scholar
• PolyakKBreast cancer: origins and evolutionJ Clin Invest2007117113155316317975657
   PubMed Web of Science ®Google Scholar
• CrokerAKAllanALCancer stem cells: implications for the progression and treatment of metastatic diseaseJ Cell Mol Med200812237439018182063
   PubMed Web of Science ®Google Scholar
• Al-HajjMWichaMSBenito-HernandezAMorrisonSJClarkeMFProspective identification of tumorigenic breast cancer cellsProc Natl Acad Sci U S A200310073983398812629218
   PubMed Web of Science ®Google Scholar
• KakaralaMWichaMSImplications of the cancer stem-cell hypothesis for breast cancer prevention and therapyJ Clin Oncol200826172813282018539959
   PubMed Web of Science ®Google Scholar
• LiuSGinestierCCharafe-JauffretEBRCA1 regulates human mammary stem/progenitor cell fateProc Natl Acad Sci U S A200810551680116518230721
   PubMed Web of Science ®Google Scholar
• GonzalezLOCorteMDJunqueraSExpression and prognostic significance of metalloproteases and their inhibitors in luminal A and basal-like phenotypes of breast carcinomaHum Pathol20094091224123319439346
   PubMed Web of Science ®Google Scholar
• LimEVaillantFWuDAberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriersNat Med200915890791319648928
   PubMed Web of Science ®Google Scholar
• LinnSCVan’t VeerLJClinical relevance of the triple-negative breast cancer concept: genetic basis and clinical utility of the conceptEur J Cancer200945Suppl 1112619775601
   PubMedGoogle Scholar
• LiuSDontuGMantleIDHedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cellsCancer Res200666126063607116778178
   PubMed Web of Science ®Google Scholar
• GeYSneigeNEltorkyMAImmunohistochemical characterization of subtypes of male breast carcinomaBreast Cancer Res2009113R2819442295
   PubMed Web of Science ®Google Scholar
• OhtaTWuWKoikeAAsakawaHKoizumiHFukudaMContemplating chemosensitivity of basal-like breast cancer based on BRCA1 dysfunctionBreast Cancer200916426827419459031
   PubMed Web of Science ®Google Scholar
• MacDougallJRMatrisianLMTargets of extinction: identification of genes whose expression is repressed as a consequence of somatic fusion between cells representing basal and luminal mammary epithelial phenotypesJ Cell Sci2000113Pt 340942310639329
   PubMed Web of Science ®Google Scholar
• TangPWangXSchiffhauerLRelationship between nuclear grade of ductal carcinoma in situ and cell origin markersAnn Clin Lab Sci2006361162216501232
   PubMed Web of Science ®Google Scholar
• CreightonCJLiXLandisMResidual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating featuresProc Natl Acad Sci U S A200910633138201382519666588
   PubMed Web of Science ®Google Scholar
• HennessyBTGonzalez-AnguloAMStemke-HaleKCharacterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristicsCancer Res200969104116412419435916
   PubMed Web of Science ®Google Scholar
• ShipitsinMCampbellLLArganiPMolecular definition of breast tumor heterogeneityCancer Cell200711325927317349583
   PubMed Web of Science ®Google Scholar
• MorelAPLièvreMThomasCHinkalGAnsieauSPuisieuxAGeneration of breast cancer stem cells through epithelial-mesenchymal transitionPLoS One200838e288818682804
   PubMed Web of Science ®Google Scholar
• GinestierCHurMHCharafe-JauffretEALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcomeCell Stem Cell2007155556718371393
   PubMed Web of Science ®Google Scholar
• NadinBMGoodellMAHirschiKKPhenotype and hematopoietic potential of side population cells throughout embryonic developmentBlood200310272436244312805065
   PubMed Web of Science ®Google Scholar
• MontanaroFLiadakiKSchiendaJFlintAGussoniEKunkelLMDemystifying SP cell purification: viability, yield, and phenotype are defined by isolation parametersExp Cell Res2004298114415415242769
   PubMed Web of Science ®Google Scholar
• OatesJEGreyBRAddlaSKHoechst 33342 side population identification is a conserved and unified mechanism in urological cancersStem Cells Dev2009
   Web of Science ®Google Scholar
• DittmarTNaglerCSchwitallaSReithGNiggemannBZänkerKSRecurrence cancer stem cells–made by cell fusion?Med Hypotheses2009734542719564079
   PubMed Web of Science ®Google Scholar
• KorkayaHPaulsonACharafe-JauffretERegulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signalingPLoS Biol200976e100012119492080
   PubMed Web of Science ®Google Scholar
• DontuGJacksonKWMcNicholasEKawamuraMJAbdallahWMWichaMSRole of Notch signaling in cell-fate determination of human mammary stem/progenitor cellsBreast Cancer Res200466R605R61515535842
   PubMed Web of Science ®Google Scholar
• IschenkoISeeligerHSchafferMJauchKWBrunsCJCancer stem cells: how can we target them?Curr Med Chem200815303171318419075661
   PubMed Web of Science ®Google Scholar
• SonnenbergMvan der KuipHHaubeisSHighly variable response to cytotoxic chemotherapy in carcinoma-associated fibroblasts (CAFs) from lung and breastBMC Cancer2008836419077243
   PubMed Web of Science ®Google Scholar
• TanARAlexeGReissMTransforming growth factor-beta signaling: emerging stem cell target in metastatic breast cancer?Breast Cancer Res Treat2009115345349518841463
   PubMed Web of Science ®Google Scholar
• DabiriGTumbarelloDATurnerCEVan de WaterLTGF-beta1 slows the growth of pathogenic myofibroblasts through a mechanism requiring the focal adhesion protein, Hic-5J Invest Dermatol2008128228029117671518
   PubMed Web of Science ®Google Scholar
• RhodesLVMuirSEElliottSAdult human mesenchymal stem cells enhance breast tumorigenesis and promote hormone independenceBreast Cancer Res Treat2009
   Web of Science ®Google Scholar
• CorcoranKETrzaskaKAFernandesHMesenchymal stem cells in early entry of breast cancer into bone marrowPLoS One200836e256318575622
   PubMed Web of Science ®Google Scholar
• MishraPJMerlinoGMicroRNA reexpression as differentiation therapy in cancerJ Clin Invest200911982119212319620782
   PubMed Web of Science ®Google Scholar
• MishraPJMishraPJHumeniukRCarcinoma-associated fibroblast-like differentiation of human mesenchymal stem cellsCancer Res200868114331433918519693
   PubMed Web of Science ®Google Scholar
• LinHJZuoTLinCHBreast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of Cystatin M in epithelial cellsCancer Res20086824102571026619074894
   PubMed Web of Science ®Google Scholar
• ModolellMChoiBSRyanROLocal suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasisPLoS Negl Trop Dis200937e48019597544
   PubMed Web of Science ®Google Scholar
• MatsuuraKYamaguchiYOsakiAFOXP3 expression of micrometastasis-positive sentinel nodes in breast cancer patientsOncol Rep20092251181118719787238
   PubMed Web of Science ®Google Scholar
• ScolaLGiacaloneAMarasàLGenetic determined downregulation of both type 1 and type 2 cytokine pathways might be protective against pancreatic cancerAnn N Y Acad Sci2009115528428819250218
   PubMed Web of Science ®Google Scholar
• WinquistRJBoucherDMWoodMFureyBFTargeting cancer stem cells for more effective therapies: Taking out cancer’s locomotive engineBiochem Pharmacol200978432633419539800
   PubMed Web of Science ®Google Scholar
• DalloulASainz-PerezAInterleukin-24: A Molecule with Potential Anti-Cancer Activity and a Cytokine in Search of a FunctionEndocr Metab Immune Disord Drug Targets2009
   Google Scholar
• YangYJChenDZLiLXShengQSJinZKZhaoDFTargeted IL-24 gene therapy inhibits cancer recurrence after liver tumor resection by inducing tumor cell apoptosis in nude miceHepatobiliary Pancreat Dis Int20098217417819357032
   PubMed Web of Science ®Google Scholar
• DumontNWilsonMBCrawfordYGReynoldsPASigaroudiniaMTlstyTDSustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancersProc Natl Acad Sci U S A200810539148671487218806226
   PubMed Web of Science ®Google Scholar
• Charafe-JauffretEMonvilleFGinestierCDontuGBirnbaumDWichaMSCancer stem cells in breast: current opinion and future challengesPathobiology2008752758418544962
   PubMed Web of Science ®Google Scholar
• Hao-XiangTQianWLian-ZhouCMicroRNA-9 reduces cell invasion and E-cadherin secretion in SK-Hep-1 cellMed Oncol2009
   Web of Science ®Google Scholar
• FidlerIJThe pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisitedNat Rev Cancer20033645345812778135
   PubMed Web of Science ®Google Scholar
• KuroishiSSudaTFujisawaTEpithelial-mesenchymal transition induced by transforming growth factor-beta1 in mouse tracheal epithelial cellsRespirology200914682883719659836
   PubMed Web of Science ®Google Scholar
• TuhkanenHSoiniYKosmaVMNuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progressionBMC Cancer20099128919695091
   PubMed Web of Science ®Google Scholar
• LiYVandenBoomTG2ndKongDUp-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cellsCancer Res200969166704671219654291
   PubMed Web of Science ®Google Scholar
• MoenIØyanAMKallandKHHyperoxic treatment induces mesenchymal-to-epithelial transition in a rat adenocarcinoma modelPLoS One200947e638119636430
   PubMed Web of Science ®Google Scholar
• HollierBGEvansKManiSAThe epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapiesJ Mammary Gland Biol Neoplasia2009141294319242781
   PubMed Web of Science ®Google Scholar
• ManiSAGuoWLiaoMJThe epithelial-mesenchymal transition generates cells with properties of stem cellsCell2008133470471518485877
   PubMed Web of Science ®Google Scholar
• SantistebanMReimanJMAsieduMKImmune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cellsCancer Res20096972887289519276366
   PubMed Web of Science ®Google Scholar
• GoodellMARosenzweigMKimHDye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple speciesNat Med1997312133713459396603
   PubMed Web of Science ®Google Scholar
• ChristgenMBallmaierMBruchhardtHvon WasielewskiRKreipeHLehmannUIdentification of a distinct side population of cancer cells in the Cal-51 human breast carcinoma cell lineMol Cell Biochem20073061–220121217660947
   PubMed Web of Science ®Google Scholar
• TrielCVestergaardMEBolundLJensenTGJensenUBSide population cells in human and mouse epidermis lack stem cell characteristicsExp Cell Res20042951799015051492
   PubMed Web of Science ®Google Scholar
• AlviAJClaytonHJoshiCFunctional and molecular characterisation of mammary side population cellsBreast Cancer Res200351R1R812559051
   PubMed Web of Science ®Google Scholar
• AsakuraASealePGirgis-GabardoARudnickiMAMyogenic specification of side population cells in skeletal muscleJ Cell Biol2002159112313412379804
   PubMed Web of Science ®Google Scholar
• ClaytonHTitleyIVivancoMGrowth and differentiation of progenitor/stem cells derived from the human mammary glandExp Cell Res2004297244446015212947
   PubMed Web of Science ®Google Scholar
• SummerRKottonDNSunXMaBFitzsimmonsKFineASide population cells and Bcrp1 expression in lungAm J Physiol Lung Cell Mol Physiol20032851L97L10412626330
   PubMed Web of Science ®Google Scholar
• GiangrecoAShenHReynoldsSDStrippBRMolecular phenotype of airway side population cellsAm J Physiol Lung Cell Mol Physiol20042864L624L63012909587
   PubMed Web of Science ®Google Scholar
• ShimanoKSatakeMOkayaAHepatic oval cells have the side population phenotype defined by expression of ATP-binding cassette transporter ABCG2/BCRP1Am J Pathol200316313912819005
   PubMed Web of Science ®Google Scholar
• LitmanTBrangiMHudsonEThe multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2)J Cell Sci2000113Pt 112011202110806112
   PubMed Web of Science ®Google Scholar
• DoyleLARossDDMultidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)Oncogene200322477340735814576842
   PubMed Web of Science ®Google Scholar
• ZhouSSchuetzJDBuntingKDThe ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotypeNat Med2001791028103411533706
   PubMed Web of Science ®Google Scholar
• ScharenbergCWHarkeyMATorok-StorbBThe ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitorsBlood200299250751211781231
   PubMed Web of Science ®Google Scholar
• KimMTurnquistHJacksonJThe multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cellsClin Cancer Res200281222811801536
   PubMed Web of Science ®Google Scholar
• ZhouSMorrisJJBarnesYLanLSchuetzJDSorrentinoBPBcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivoProc Natl Acad Sci U S A20029919123391234412218177
   PubMed Web of Science ®Google Scholar
• JonkerJWBuitelaarMWagenaarEThe breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyriaProc Natl Acad Sci U S A20029924156491565412429862
   PubMed Web of Science ®Google Scholar
• SchinkelAHSmitJJvan TellingenODisruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugsCell19947744915027910522
   PubMed Web of Science ®Google Scholar
• DoyleLAYangWAbruzzoLVA multidrug resistance transporter from human MCF-7 breast cancer cellsProc Natl Acad Sci U S A1998952615665156709861027
   PubMed Web of Science ®Google Scholar
• PatrawalaLCalhounTSchneider-BroussardRZhouJClaypoolKTangDGSide population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2− cancer cells are similarly tumorigenicCancer Res200565146207621916024622
   PubMed Web of Science ®Google Scholar
• LechnerALeechCAAbrahamEJNolanALHabenerJFNestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporterBiochem Biophys Res Commun2002293267067412054520
   PubMed Web of Science ®Google Scholar
• Hirschmann-JaxCFosterAEWulfGGA distinct “side population” of cells with high drug efflux capacity in human tumor cellsProc Natl Acad Sci U S A200410139142281423315381773
   PubMed Web of Science ®Google Scholar
• ChallenGABertoncelloIDeaneJARicardoSDLittleMHKidney side population reveals multilineage potential and renal functional capacity but also cellular heterogeneityJ Am Soc Nephrol20061771896191216707564
   PubMed Web of Science ®Google Scholar
• DontuGAbdallahWMFoleyJMIn vitro propagation and transcriptional profiling of human mammary stem/progenitor cellsGenes Dev200317101253127012756227
   PubMed Web of Science ®Google Scholar
• GaoQGengLKvalheimGGaudernackGSuoZIdentification of cancer stem-like side population cells in ovarian cancer cell line OVCAR-3Ultrastruct Pathol200933417518119728235
   PubMed Web of Science ®Google Scholar
• KabashimaAHiguchiHTakaishiHSide population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasionInt J Cancer2009124122771277919296540
   PubMed Web of Science ®Google Scholar
• LouHDeanMTargeted therapy for cancer stem cells: the patched pathway and ABC transportersOncogene20072691357136017322922
   PubMed Web of Science ®Google Scholar
• PeceSSerresiMSantoliniELoss of negative regulation by Numb over Notch is relevant to human breast carcinogenesisJ Cell Biol2004167221522115492044
   PubMed Web of Science ®Google Scholar
• RizzoPOsipoCForemanKGoldeTOsborneBMieleLRational targeting of Notch signaling in cancerOncogene200827385124513118758481
   PubMed Web of Science ®Google Scholar
• ZardawiSJO’TooleSASutherlandRLMusgroveEADysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancerHistol Histopathol200924338539819130408
   PubMed Web of Science ®Google Scholar
• GuptaPBOnderTTJiangGIdentification of selective inhibitors of cancer stem cells by high-throughput screeningCell2009138464565919682730
   PubMed Web of Science ®Google Scholar
• TanakaHNakamuraMKamedaCThe Hedgehog signaling pathway plays an essential role in maintaining the CD44+CD24−/low subpopulation and the side population of breast cancer cellsAnticancer Res20092962147215719528475
   PubMed Web of Science ®Google Scholar
• CromptonAMKirnDHFrom ONYX-015 to armed vaccinia viruses: the education and evolution of oncolytic virus developmentCurr Cancer Drug Targets20077213313917346104
   PubMed Web of Science ®Google Scholar
• IkedaKIchikawaTWakimotoHOncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responsesNat Med19995888188710426310
   PubMed Web of Science ®Google Scholar
• ShortJJCurielDTOncolytic adenoviruses targeted to cancer stem cellsMol Cancer Ther2009882096210219671759
   PubMed Web of Science ®Google Scholar
• CripeTPWangPYMarcatoPMahllerYYLeePWTargeting cancer-initiating cells with oncolytic virusesMol Ther20091017101677168219672244
   PubMed Web of Science ®Google Scholar
• ThirukkumaranCMorrisDGOncolytic viral therapy using reovirusMethods Mol Biol200954260763419565924
   PubMedGoogle Scholar
• MarcatoPDeanCAGiacomantonioCALeePWOncolytic reovirus effectively targets breast cancer stem cellsMol Ther200917697297919293772
   PubMed Web of Science ®Google Scholar
• LalRHarrisDPostel-VinaySde BonoJReovirus: Rationale and clinical trial updateCurr Opin Mol Ther200911553253919806501
   PubMedGoogle Scholar
• BauerschmitzGJRankiTKangasniemiLTissue-specific promoters active in CD44+CD24−/low breast cancer cellsCancer Res200868145533553918632604
   PubMed Web of Science ®Google Scholar
• SethPWangZGPisterADevelopment of oncolytic adenovirus armed with a fusion of soluble transforming growth factor-beta receptor II and human immunoglobulin Fc for breast cancer therapyHum Gene Ther200617111152116017032151
   PubMed Web of Science ®Google Scholar
• NguyenTLTumilasciVFSinghroyDArguelloMHiscottJThe emergence of combinatorial strategies in the development of RNA oncolytic virus therapiesCell Microbiol200911688989719388908
   PubMed Web of Science ®Google Scholar
• WaddingtonSNMcVeyJHBhellaDAdenovirus serotype 5 hexon mediates liver gene transferCell2008132339740918267072
   PubMed Web of Science ®Google Scholar
• SmithMCLukerKEGarbowJRCXCR4 regulates growth of both primary and metastatic breast cancerCancer Res200464238604861215574767
   PubMed Web of Science ®Google Scholar
• MelinkeriSRGuptaRKDabadghaoSA Sweet-like syndrome manifesting as gingival hyperplasia and myositis without cutaneous involvementAnn Hematol200281739739812185512
   PubMed Web of Science ®Google Scholar
• BajGArnulfoADeaglioSRetinoids in breast cancer prevention and treatment. A review of the literatureEur J Gynaecol Oncol200021441141511055498
   PubMed Web of Science ®Google Scholar
• HansenLASigmanCCAndreolaFRossSAKelloffGJDe LucaLMRetinoids in chemoprevention and differentiation therapyCarcinogenesis20002171271127910874003
   PubMed Web of Science ®Google Scholar
• MartirosyanARRahim-BataRFreemanABClarkeCDHowardRLStroblJSDifferentiation-inducing quinolines as experimental breast cancer agents in the MCF-7 human breast cancer cell modelBiochem Pharmacol20046891729173815450938
   PubMed Web of Science ®Google Scholar
• YuFYaoHZhuPlet-7 regulates self renewal and tumorigenicity of breast cancer cellsCell200713161109112318083101
   PubMed Web of Science ®Google Scholar
• ShimonoYZabalaMChoRWDownregulation of miRNA-200c links breast cancer stem cells with normal stem cellsCell2009138359260319665978
   PubMed Web of Science ®Google Scholar
• GocekEStudzinskiGPVitamin D and differentiation in cancerCrit Rev Clin Lab Sci200946419020919650715
   PubMed Web of Science ®Google Scholar
• LinCLWangMHQinYFFangMXieBBZhongXYDifferentiation of SWO-38 glioma cells induced by CDA-2 is mediated by peroxisome proliferator-activated receptor gammaJ Neurooncol2009951293619434372
   PubMed Web of Science ®Google Scholar
• LeporattiSVergaraDZacheoACytomechanical and topological investigation of MCF-7 cells by scanning force microscopyNanotechnology200920555103
   Web of Science ®Google Scholar
• WuXLiuHLiuJHaleyKNImmunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dotsNat Biotechnol2003211414612459735
   PubMed Web of Science ®Google Scholar
• WangHNVo-DinhTMultiplex detection of breast cancer biomarkers using plasmonic molecular sentinel nanoprobesNanotechnology200920665101
   PubMed Web of Science ®Google Scholar
• MangipudiSSCanineBFWangYHatefiADevelopment of a genetically engineered biomimetic vector for targeted gene transfer to breast cancer cellsMol Pharm2009641100110919419197
   PubMed Web of Science ®Google Scholar
• DisisMLSalazarLGKnutsonKLPeptide-Based Vaccines in Breast CancerBreast Dis20092031115687702
   PubMedGoogle Scholar