137
Views
6
CrossRef citations to date
0
Altmetric
Review

Erlotinib in the treatment of advanced pancreatic cancer

&
Pages 83-95 | Published online: 07 Mar 2008

References

  • Abou-AlfaGKLetourneauRHarkerG2006Randomized phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic cancerJ Clin Oncol244441716983112
  • ArteagaC2001The epidermal growth factor receptor: from mutant oncogene in nonhuman cancers to therapeutic target in human neoplasiaJ Clin Oncol1918s32s40s11560969
  • BellDWLynchTJHaserlatSM2005Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trialsJ Clin Oncol2380819216204011
  • BerlinJDCatalanoPThomasJP2002Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297J Clin Oncol203270512149301
  • BlaszkowskyLSKulkeKHRyanKP2005A phase II study of erlotinib in combination with capecitabine in previously treated patients with metastatic pancreatic cancerJ Clin Oncol2316S abstract 4099
  • BloomstonMBhardwajAEllisonE2006Epidermal growth factor receptor expression in pancreatic carcinoma using tissue microarray techniqueDig Surg2374916717472
  • BrunsCJSolorzanoCCHarbisonMT2000Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinomaCancer Res6029263410850439
  • BurrisHAMooreMJAndersenJ1997Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trialJ Clin Oncol152403139196156
  • CappuzzoFHirschFRRossiE2005Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancerJ Nat Cancer Inst976435515870435
  • CappuzzoFLigorioCJannePA2007Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridization-positive/phospho-Akt-positive or never smoker patients with advanced non-small-cell lung cancer: the ONCOBELL trialJ Clin Oncol2522485517538169
  • ChungKYShiaJKemenyN2005Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor by immunohistochemistryJ Clin Oncol2318031015677699
  • CohenuramMSaifM2007Epidermal growth factor receptor inhibition strategies in pancreatic cancer: past, present, and the futureJ Pancreas8415
  • CunninghamDChauIStockenD2005Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancerECCO 13 European Cancer Conference abstract PS11
  • DentPReardonDBParkJS1999Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell deathMol Biol Cell10249350610436007
  • DragovichTHubermanMvon HoffDD2007Erlotinib plus gemcitabine in patients with unresectable pancreatic cancer and other solid tumors: phase IB trialCancer Chemother Pharmacol6029530317149608
  • DuffyAKortmanskyJSchwartzGK2008A phase I study of erlotinib in combination with gemcitabine and radiation in locally advanced, non-operable pancreatic adenocarcinomaAnn Oncol19869117878176
  • DurkinAJOsborneDAYeatmanTJ2006EGF receptor antagonism improves survival in a murine model of pancreatic carcinomaJ Surg Res13519520116678855
  • EberhardDAJohnsonBEAmlerLC2005Predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinibJ Clin Oncol235900916043828
  • EpelbaumRSchnaiderJGluzmanA2007Erlotinib as a single-agent therapy in patients with advanced pancreatic cancerASCO Gastrointestinal Cancers Symposium abstract 202
  • GatzemeierUPluzanskaASzczesnaA2007Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: the Tarceva lung cancer investigation trialJ Clin Oncol2515455217442998
  • Gomez-MartinCCamaraJCCortesH2007A phase I study of erlotinib, bevacizumab, and gemcitabine in patients with advanced pancreatic cancerJ Clin Oncol2518s abstract 4611
  • GrandisJRSokJC2004Signaling through the epidermal growth factor receptor during the development of malignancyPharmacol Ther102374615056497
  • GridelliCMaionePAmorosoD2007Clinical significance and treatment of skin rash from erlotinib in non-small cell lung cancer patients: Results of an Experts Panel MeetingCrit Rev OncIn press
  • GrunwaldVHidalgoM2003Developing inhibitors of the epidermal growth factor receptor for cancer treatmentJ Nat Cancer Inst958516712813169
  • HeinemannVHinkeABöckSGemcitabine-based combinations (gem+x) vs gemcitabine (gem) alone in the treatment of advanced pancreatic cancer: a meta-analysis of sixteen randomized trialsJ Clin Oncol2518s abstract 4515
  • HeinemannVLabiancaRHinkeALouvetC2007Increased survival using platinum analog combined with gemcitabine as compared to single-agent gemcitabine in advanced pancreatic cancer: pooled analysis of two randomized trials, the GERCOR/GISCAD intergroup study and a German multicenter studyAnn Oncol18101652917660491
  • HerrmannRBodokyGRuhstallerT2007Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: a randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology GroupJ Clin Oncol252212717538165
  • HidalgoMSiuLNemunaitisJ2001Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignanciesJ Clin Oncol1932677911432895
  • HirschFRVarella-GarciaMCappuzzoF2007Combination of EGFR gene copy number and protein expression predicts outcome for advanced non-small-cell lung cancer patients treated with gefitinibAnnals of Oncology187526017317677
  • HirschFRVarella-GarciaMMcCoyJ2005Increased epidermal growth factor recptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group StudyJ Clin Oncol2368384515998906
  • HuangSMBockJMHarariPM1999Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of head and neckCancer Res5919354010213503
  • JemalASiegelRWardE2007Cancer statistics 2007CA Cancer J Clin57436617237035
  • KindlerHLBylowKAHochsterHS2006A randomized phase II study of bevacizumab (B) and gemcitabine (G) plus cetuximab (C) or erlotinib (E) in patients (pts) with advanced pancreatic cancer (PC): a preliminary analysisJ Clin Oncol2418s abstract 4040
  • KoAHDitoESchillingerB2007A phase II trial of bevacizumab plus erlotinib for patients with metastatic gemcitabine-refractory pancreatic cancerASCO Gastrointestinal Cancers Symposium abstract 187
  • KolbAKeelfJArnoldN2006Expression and differential signaling of heregulins in pancreatic cancer cellsInt J Cancer1205142317096356
  • KrishnanSBrownPDBallmanKV2006Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: results of North Central Cancer Treatment Group protocol N0177Int J Radiat Oncol Biol Phys651192916626884
  • KwakELJankowskiJThayerSP2006Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adeno-carcinomasClin Cancer Res124283716857803
  • LammeringGValerieKLinPS2001Radiosensitization of malignant glioma cells through overexpression of dominant-negative epidermal growth factor receptorClin Cancer Res76829011297265
  • LeeJJangKTKiCS2007Impact of epidermal growth factor receptor (EFGR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinomaCancer1091561917354229
  • LenzH-JVan CutsemEKhambata-FordS2006Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidinesJ Clin Oncol2449142117050875
  • LiJKleefJGieseN2004Gefitinib (Iressa, ZD1839), a selective epidermal growth factor receptor tyrosine kinase inhibitor, inhibits pancreatic cancer cell growth, invasion, and colony formationInt J Oncol252031015202007
  • LouvetCLabiancaRHammelP2005Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trialJ Clin Oncol2335091615908661
  • LynchTJBellDWSordellaR2004Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinibN Engl J Med35021293915118073
  • MarshallJ2006Clinical implications of the mechanism of epidermal growth factor receptor inhibitorsCancer10712071816909423
  • MendelsohnJBaselgaJ2003Status of epidermal growth factor receptor antagonists in the biology and treatment of cancerJ Clin Oncol212787279912860957
  • MooreMJGoldsteinDHammJ2005Erlotinib plus gemcitabine compared to gemcitabine alone in patients with advanced pancreatic cancer. A phase III trial of the National Cancer Institute of Canada Clinical Trials Group (NCIC-CTG)J Clin Oncol2316s abstract 1
  • MooreMJda Cunha SantosGKamel-ReidS2007aThe relationship of K-ras mutations and EGFR gene copy number to outcome in patients treated with erlotinib on National Cancer Institute of Canada Clinical Trials Group trial study PA.3J Clin Oncol2518S abstract 4521
  • MooreMJGoldsteinDHammJ2007bErlotinib plus gemictabine compared to gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials GroupJ Clin Oncol251960617452677
  • MoyerJDBarbacciEGIwataKK1997Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinaseCancer Res574838489354447
  • MurphyLOCluckMWLovasS2001Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditionsBrit J Cancer8492693511286473
  • NgSSTsaoMSNickleeT2002Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinomaMol Cancer Ther17778312492110
  • OettleHPostSNeuhausPGellertK2007Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancerJAMA2972677717227978
  • PaezJGJannePALeeJC2004EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapyScience304149750015118125
  • PaoWMillerVA2005Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: current knowledge and future directionsJ Clin Oncol2325566815767641
  • Perez-SolerRSaltzL2005Cutaneous adverse effects with HER1/EGFR-targeted agents: is there a silver lining?J Clin Oncol2352354616051966
  • PhilipPABenedettiJFenoglio-PreiserC2007Phase III study of gemcitabine [G] plus cetuximab [C] versus gemcitabine in patients [pts] with locally advanced or metastatic pancreatic adenocarcinoma [PC]: SWOG S0205 studyJ Clin Oncol2518s abstract LBA4509
  • PollackVASavageDMBakerDA1999Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and antitumor effects in athymic miceJ Pharmacol Exp Ther2917394810525095
  • PorterfieldBWDragovichTPatnaikAErlotinib + gemcitabine in patients with unresectable pancreatic carcinoma: results from a phase IB trialJ Clin Oncol2214S abstract 4110
  • Rocha LimaCMGreenMRRotcheR2004Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rateJ Clin Oncol2237768315365074
  • Schmidt-UllrichRKMikkelsenRBDentP1997Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylationOncogene15119179294612
  • SegaertSVan CutsemE2005Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitorsAnn Oncol1614253316012181
  • ShepherdFATsaoMS2006Unraveling the mystery of prognostic and predictive factors in epidermal growth factor receptor therapyJ Clin Oncol2412192016505443
  • SoulieresDSenzerNNVokesEE2004Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrpsine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neckJ Clin Oncol22778514701768
  • TakanoTOheYSakamotoH2005Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancerJ Clin Oncol2368293715998907
  • TejparSPeetersMHumbletY2007Phase I/II study of cetuximab dose-escalation in patients with metastatic colorectal cancer (mCRC) with no or slight skin reactions on cetuximab standard dose treatment (EVEREST): Pharmacokinetic (PK), pharmacodynamic (PD), and efficacy dataJ Clin Oncol2518s abstract 4037
  • TobitaKKijimaHDowakiS2003Epidermal growth factor receptor expression in human pancreatic cancer: significance for liver metastasesInt J Mol Med11305912579331
  • TzengCWFrolovAFrolovaN2007Epidermal growth factor receptor (EGFR) is highly conserved in pancreatic cancerSurgery141464917383523
  • TzengCWFrolovAFrolovaN2007Pancreatic cancer epidermal growth factor receptor (EGFR) intron 1 polymorphism influences postoperative patient survival and in vitro erlotinib responseAnn Surg Onc1421508
  • UedaSOgataSTsudaH2004The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness; poor prognosis in patients with pancreatic ductal adenocarcinomaPancreas29e1815211117
  • WackerBNagraniTWeinbergJ2007Correlation between development of rash and efficacy in patients treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in two large phase III studiesClin Cancer Res1339132117606725
  • YardenYSliwkowskiM2001Untangling the ErbB signaling networkNat Rev Mol Cell Biol21273711252954
  • YipDKarapetisCStricklandA2006Chemotherapy and radio-therapy for inoperable advanced pancreatic cancerCochrane Database Syst Rev3CD00209316855985
  • YamanakaYFriessHKobrinMS1993Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressivenessAnticancer Res1356598317885

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.