591
Views
13
CrossRef citations to date
0
Altmetric
Review

Safety and efficacy of doxycycline in the treatment of rosacea

, , &
Pages 129-140 | Published online: 12 Aug 2009

References

  • BergMLidenSAn epidemiological study of rosaceaActa Derm Venerol1989694194232572109
  • PowellFCRosaceaN Engl J Med200535279380315728812
  • WilkinJDahlMDetmarMStandard classification of rosacea: report of the National Rosacea Society Expert Committee on the Classification and Staging of RosaceaJ Am Acad Dermatol20024658458711907512
  • PelleMTCrawfordGHJamesWDRosacea: II. TherapyJ Am Acad Dermatol20045149951215389184
  • SneddonIBA clinical trial of tetracycline in rosaceaBr J Dermatol1966786496524224811
  • SmilackJDThe tetracyclinesMayo Clin Proc19997472772910405705
  • SapadinANFleischmajerRTetracyclines: Nonantibiotic properties and their clinical implicationsJ Am Acad Dermatol200654225826516443056
  • MaibachHSecond-generation tetracyclines, a dermatologic overview: Clinical uses and pharmacologyCutis1991484114171764965
  • CunhaBASibleyCMRistucciaAMReview doxycyclineTher Drug Monit198241151357048645
  • JonasMCunhaBAReview minocyclineTher Drug Monit198241371457048646
  • MacdonaldHKellyRGAllenESPharmacokinetic studies of minocycline in manClin Pharmacol Ther1973148524199710
  • SaivinSHouinGClinical pharmacokinetics of doxycycline and minocyclineClinical Pharmacokinet198815355366
  • FabreJMilekEKalfopoulosPThe kinetics of tetracyclines in man. Digestive absorption and serum concentrationsSchweiz Med Wochenschr19711015935984995974
  • WeinbergJMThe anti-inflammatory effects of tetracyclinesCutis200575 Suppl 4S6S11
  • CullenSCrounseRCutaneous pharmacology of the tetracyclinesJ Invest Dermatol1965452632684953785
  • PallettAPSmythEGClinician’s guide to antibiotics. TetracyclineBr J Hosp Med1988403853903069173
  • WebsterGDel RossoJQAntiinflammatory effects of TetracyclinesDermatology Clin200725133135
  • EsterlyNBFureyNLFlannaganLEThe effect of antimicrobial agents on chemotaxisJ Invest Dermatol1978705155618981
  • EsterlyNBKovanskyJSFureyNSNeutrophil chemotaxis in patients with acne receiving tetracyclinesArch Dermatol1984120130813136237616
  • GablerWLCreamerHRSupression of human neutrophil functions by tetracyclineJ Periodontal Res19912652581847418
  • ThongYHFerranteAInhibition of mitogen-induced human lymphocyte proliferative responses by tetracycline analogsClin Exp Immunol197935443446455782
  • PruzanskiWGreenwaldRAStreetIPLaliberteFStefanskiEVadasPInhibition of enzymatic activity of phospholipase A2 by minocycline and doxycyclineBiochem Pharmacol1992P44116511701417938
  • WiseRDSubmicrobial doxycycline and rosaceaComp Ther2007337881
  • BikowskiJBSubantimicrobial dose doxycycline for acne and rosaceaSkinmed2003223424514673277
  • GolubLMLeeHMRyanMEGiannobileWVPayneJSorsaTTetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanismsAdv Dent Res19981212269972117
  • GolubLMLeeHMLehrerGMinocycline reduces gingival collagenolytic activity during diabetes: preliminary observations and a proposed new mechanism of actionJ Periodont Res1983185165266315909
  • GolubLMRamamurthyNSMcNamaraTFGreenwaldRARifkinBRTetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugsCrit Rev Oral Biol Med199122973211654139
  • BermanBZellDSubantimicrobial dose doxycycline: a unique treatment for rosaceaCutis200575 Suppl 4S19S24
  • BikowskiJNew approaches to rosacea therapySkin Aging200513 Suppl 2S13S15
  • HanemaaijerRVisserHKoolwijkPInhibition of MMP synthesis by doxycycline and chemically modified tetracyclines (CMTs) in human endothelial cellsAdv Dent Res1998121141189972133
  • Del RossoJQWebsterGFJacksonMTwo randomized phase III clinical trials evaluating anti-inflammatory dose doxycycline (40-mg doxycycline, USP capsules) administered once daily for treatment of rosaceaJ Am Acad Dermatol20075679180217367893
  • WebsterGFTosoSMHegemannLInhibition of a model of in vitro granuloma formation by tetracyclines and ciprofloxacin. Involvement of protein kinase CArch Dermatol19941307487528002645
  • AminARAtturMGThakkerGDA novel mechanism of action of tetracyclines: effects on nitric oxide synthasesProc Natl Acad of Sci U S A19969314014140198943052
  • AminARPatelRNThakkerGDLowensteinCJAtturMGAbramsonSBPost-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclinesFEBS Lett19974102592649237641
  • SkidmoreRKovachRWalkerCEffects of subantimicrobial-dose doxycycline in the treatment of moderate acneArch Dermatol2003139 445946412707093
  • ThiboutotDEfficacy and safety of subantmicrobial-dose doxycycline for the treatment of rosacea [poster]63rd Annual Meeting of the American Academy of DermatologyFebruary 18–22, 2005New Orleans, LAP128
  • SanchezJSomolinosALAlmodovarPIWebsterGBradshawMPowalaCA randomized, double-blinded, placebo-controlled trial of the combined effect of doxycycline hyclate 20-mg tablets and metronidazole 0.75% topical lotion in the treatment of rosaceaJ Am Acad Dermatol20055379179716243127
  • FowlerJFCombined effect of anti-inflammatory dose doxycycline (40-mg doxycycline, USP monohydrate controlled-release capsules) and metronidazole topical gel 1% in the treatment of rosaceaJ Drugs Dermatol2007664164517668530
  • Del RossoJSchlessingerJWerschlerPComparison of anti-inflammatory dose doxycycline versus doxycycline 100 mg in the treatment of rosaceaJ Drugs Dermatol2008757357618561589
  • AkpekEKMerchantAPinarVFosterCSOcular rosacea: Patient characteristics and follow-upOphthalmology1997104186318679373118
  • Frucht-PeryJChayetASFelmanSTLinSBrownSIThe effect of doxycycline in ocular rosaceaAm J Ophthalmol19891074344352522739
  • Frucht-PeryJSagiEHemoIEver-HadaniPEfficacy of doxycycline and tetracycline in ocular rosaceaAm J Ophthalmol199311688928328549
  • QuatermanMJJohnsonDWAbeleDCLesherJLHullDSDavisLSOcular rosacea: Signs, symptoms, and tear studies before and after treatment with doxycyclineArch Dermatol199713349549006372
  • TorresaniCPavesiAManaraGCClarithromycin versus doxycycline in the treatment of rosáceaInt J Dermatol1997369389469466205
  • AkhyaniMEhsaniAHGhiasiMJafariAKComparison of efficacy of azithromycin vs. doxycycline in the treatment of rosacea: a randomized open clinical trialInt J Dermatol20084728428818289334
  • HersleKGisslenHMinocycline in acne vulgaris: a double-blind studyCurr Ther Res197619339342131678
  • HarrisonPVA comparison of doxycycline and minocycline in the treatment of acne vulgarisClin Exp Dermatol1988132422442977578
  • LauxBTreatment of acne vulgaris. A comparison of doxycycline versus minocyclineDermatologist198940577581
  • OlafssonJHGudgiersonJEggertsdottirGEKristjanssonFDoxycycline versus minocycline in the treatment of acne vulgaris: a doubleblind studyJ Dermatol Treat198911517
  • Del RossoJQRecently approved systemic therapies for acne vulgaris and rosaceaCutis20078011312017944168
  • EadyAHCoveJHLaytonAMIs antibiotic resitance in cutaneous propionibacteria clinically relevant? Implications of resistance for acne patients and prescribersAm J Clin Dermatol2003481383114640775
  • ThomasJWalkerCBradshawMLong-term use of subantimicrobial dose doxycycline does not lead to changes in antimicrobial susceptibilityJ Perio20007114721483
  • GolubLMSorsaTLeeHMDoxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingivaJ Clin Periodontol1995221001097775665
  • Del RossoJQA status report on the use of subantimicrobial-dose doxycycline: A review of the biologic and antimicrobial effects of the tetracyclinesCutis20047411812215379364
  • WalkerCWebsterGFDel RossoJQA muticenter, double-blind, randomized trial to evaluate the long-term anti-inflammatory doxycycline (40 mg) therapy: results of the lack of effect on bacterial flora [poster]Foundation for Reaserch and Education in Dermatology, Fall Clinical Dermatology ConferenceOctober 6–9, 2006Las Vegas, Nevada
  • SloanBScheinfeldNThe use and safety of doxycycline hyclate and other second-generation tetracyclinesExpert Opin Drug Saf2008757157718759709
  • Del RossoJQSystemic therapy for rosacea: focus on oral antibiotic therapy and safetyCutis20006671311455753
  • ShapiroLEKnowlesSRShearNHComparative safety of tetracycline, minocycline, and doxycyclineArch Dermatol1997133122412309382560
  • SmithKLeydenJJSafety of doxycycline and mnocycline: a systematic reviewClin Ther2005271329134216291409
  • SegelnickSLWeinbergMARecognizing doxycycline-induced esophageal ulcers in dental practice: a case report and reviewJ Am Dent Assoc200813958158518451374
  • BillerJAFloresABuieTMazorSKatzAJTetracycline-induced esophagitis in adolescent patientsJ Pediatr19921201441451731012
  • SmilackJDThe tetracyclinesMayo Clin Proc19997472772910405705
  • LanzaFLEsophageal ulceration produced by doxycycline Review of the literature and comparison of the injury from doxycycline hyclate and hydrochloride with that from doxycycline monohydrateCurr Ther Res Clin Exp198844475484
  • BergerRSA double-blind, multiple-dose, placebo-controlled, cross-over study to compare the incidence of gastrointestinal complaints in healthy subjects given Doryx R and Vibramycin RJ Clin Pharmacol1988283673703392234
  • SmithKLeydenJJSafety of doxycycline and minocycline: a systematic reviewClin Ther2005271329134216291409
  • CarrollLALaumannAEDoxycycline-induced photo-onycholysisJ Drugs Dermatol2003266266314711147
  • LaytonAMCunliffeWJPhototoxic eruptions due to doxycycline-a dose-related phenomenonClin Exp Dermatol1993184254278252763
  • SimpsonMBPryzbylikJInnisBDenhamMAHemolytic anemia after tetracycline therapyN Engl J Med19853128408423974663
  • PierogSHAl-SalihiFLCinottiDPseudotumor cerebri – a complication of tetracycline treatment of acneJ Adolesc Health Care198671391402937759
  • NelsonRParkerSRDoxycycline-induced staining of adult teeth: the first reported caseArch Dermatol20061421081108216924074
  • CacNNMessinghamMJSniezekPJWallingHWStevens-Johnson syndrome induced by doxycyclineCutis20077911912217388211
  • CurleyRKVerbowJLStevens-Johnson syndrome due to tetracycline-a case report (doxycycline) and a review of the literatureClin Exp Dermatol1987121241253677470
  • GallaisVRandrianjohannyARobineauMLarocheLStevens-Johnson syndrome caused by doxycyclinePresse Med1997268559207884
  • RoblesDTLeonardJLComptonNSevere drug hypersensitivity reaction in a young woman treated with doxycyclineDermatology2008217232618332631
  • GulUGonulMSoyluSKayaIDoxycycline-induced fixed drug eruptionJ Dermatolog Treat20081912612718484432
  • TrüebRMBurgGAcute generalized exanthematous pustulosis due to doxycyclineDermatology199318675788435524
  • Khan DuraniBJappeUDrug-induced Sweet’s syndrome in acne caused by different tetracyclines: case report and review of the literatureBr J Dermatol200214755856212207601
  • BermanBPerezOAZellDUpdate on rosacea and anti-inflammatory-dose doxycyclineDrugs Today200743273417315050
  • HarrisonPVA comparison of doxycycline and minocycline in the treatment of acne vulgarisClin Exp Dermatol1988132422442977578
  • AllenJCMinocyclineAnn Intern Med197685482487788583
  • BaciewiczAMBalBSBleeding associated with doxycycline and warfarin treatmentArch Intern Med2001161123111343446
  • CaracoYRubinowAEnhanced anticoagulant effect of coumarin derivatives induced by doxycycline coadministrationAnn Pharmacother199226108410861421670
  • HasanSAInteraction of doxycycline and warfarin: an enhanced anti-coagulant effectCornea20072674274317592328
  • Penning-van BeestFJKoerselmanJHeringsRMRisk of major bleeding during concomitant use of antibiotic drugs and coumarin anticoagulantsJ Thromb Haemost2008628429018031295
  • BarrancoVPUpdate on clinically significant drug interactions in dermatologyJ Am Acad Dermatol20065467668416546592
  • DickinsonBDAltmanRDNielsenNHSterlingMLCouncil on Scientific Affairs, American Medical AssociationDrug interactions between oral contraceptives and antibioticsObstet Gynecol20019885386011704183
  • BackDJGrimmerSFOrmeMLProudloveCMannRDBreckenridgeAMEvaluation of Committee on Safety of Medicines yellow card reports on oral contraceptive-drug interactions with anti-convulsants and antibioticsBr J Clin Pharmacol1988255275323408633
  • SzokaPREdgrenRADrug interactions with oral contraceptives: compilation and analysis of an adverse experience report databaseFertil Steril19884931S38S3282933
  • NeelyJLAbateMSwinkerMD’AngioRThe effect of doxycycline on serum levels of ethinyl estradiol, norethindrone, and endogenous progesteroneObstet Gynecol1991774164201992409
  • MurphyAAZacurHACharachePBurkmanRTThe effect of tetracycline on levels of oral contraceptivesAm J Obstet Gynecol199116428331986620
  • ArcherJSArcherDFOral contraceptive efficacy and antibiotic interaction: a myth debunkedJ Am Acad Dermatol20024691792312063491
  • FDA.gov (homepage on the Internet)Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) (updated 2009 Jan 23; cited 2009 Feb 26) Available from: http://www.fda.gov/cder/orange/default.htm