References
- AlzheimerA1907Uber eine eigenartige Erkrankung der HirnrindeAllg Z Psychiat Psych-Gerichtl Med641468
- AmaducciLARoccaWASchoenbergBS1986Origin of the distinction between Alzheimer’s disease and senile dementia: How history can clarify nosologyNeurology36149793531918
- AnandtheerthavaradaHKBiswasGRobinMAAvadhaniMG2003Mitochondrial targeting and a novel transmembrane arrest of Alzheimer’s precursor protein impairs mitochondrial function in neuronal cellsJ Cell Biol164154
- ArendtT2000Alzheimer’s disease as a loss of differentiation control in a subset of neurons that retain immature features in the adult brainNeurobiol Aging217839611124422
- BlackerDTanziRE1998The genetics of Alzheimer disease: Current status and future prospectsArch Neurol5529469520001
- BlansjaarBAThomassenRVan SchaickHW2000Prevalence of dementia in centenariansInt J Geriatr Psychiatry152192510713579
- BlassJPBakerACKoLBlackRS1990Induction of Alzheimer antigens by an uncoupler of oxidative phosphorylationArch Neurol4786492375692
- BollerFForbesMM1998History of dementia and dementia in history: An overviewJ Neurol Sci158125339702682
- BowserRSmithMA2002Cell cycle proteins in Alzheimer’s disease: Plenty of wheels but no cycleJ Alzheimers Dis42495412226545
- CardosoSMSantosSSwerdlowRHOliveiraCR2001Functional mitochondria are required for amyloid beta-mediated neurotoxicityFASEB J1514394111387250
- CaselliRJGraff-RadfordNRReimanEM1999Preclinical memory decline in cognitively normal apolipoprotein E-ɛ4 homozygotesNeurology53201710408560
- CasleyCSCanevariLLandJMClarkJBSharpeMA2002Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activitiesJ Neurochem809110011796747
- CastellaniRJLeeHGZhuXNunomuraAPerryGSmithMA2006Neuropathology of Alzheimer disease: Pathognomonic but not pathogenicActa Neuropathol111503916718346
- ChagnonPGeeMFilionM1999Phylogenetic analysis of the mitochondrial genome indicates significant differences between patients with Alzheimer disease and controls in a French-Canadian founder populationAm J Med Genet85203010377009
- ChangSran MaTMirandaRD2005Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicityProc Natl Acad Sci USA10218694916344479
- Consensus recommendations for the postmortem diagnosis of Alzheimer’s disease1997The national institute on aging, and reagan institute working group on diagnostic criteria for the neuropathological assessment of Alzheimer’s diseaseNeurobiol Aging184 SupplS129330978
- CookDGLeverenzJBMcMillanPJ2003Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer’s disease is associated with the apolipoprotein E-epsilon4 alleleAm J Pathol162313912507914
- CorderEHSaundersAMStrittmatterWJ1993Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset familiesScience26192138346443
- CoskunPEBealMFWallaceDC2004Alzheimer’s brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replicationProc Natl Acad Sci USA101107263115247418
- CrouchPJBlakeRDuceJA2005Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1–42J Neurosci25672915659604
- DavisJN2ndChisholmJC1999Alois Alzheimer and the amyloid debateNature2681010476951
- DeMattosRBBalesKRParsadanianM2002Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer’s diseaseJ Neurochem812293612064470
- DeviLPrabhuBMGalatiDFAvadhaniNGAnandatheerthavaradaHK2006Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer’s disease brain is associated with mitochondrial dysfunctionJ Neurosci2690576816943564
- DingQDimayugaEKellerJN2006Proteasome regulation of oxidative stress in aging and age-related diseases of the CNSAntioxid Redox Signal81637216487050
- EdlandSDSilvermanJMPeskindER1996Increased risk of dementia in mothers of Alzheimer’s disease cases: Evidence for maternal inheritanceNeurology4725468710088
- EriksenJLSagiSASmithTE2003NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivoJ Clin Invest112440912897211
- EvansDAFunkensteinHHAlbertMS1989Prevalence of Alzheimer’s disease in a community population of older persons. Higher than previously reportedJAMA262255162810583
- FaganAMMintunMAMachRH2006Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta(42) in humansAnn Neurol59512916372280
- FerrerIBoada RoviraMSanchez GuerraMLReyMJCosta-JussaF2004Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer’s diseaseBrain Pathol14112014997933
- FischerO1907Miliare Nekrosen mit drusigen Wucherungen der Neurofibrillen, eine regelmabige Veranderung der Hirnrinde bei seniler DemenzMonatsschr Psychiatr Neurol2236172
- GabuzdaDBusciglioJChenLBMatsudairaPYanknerBA1994Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivativeJ Biol Chem2691362388175797
- GearingMMirraSSHedreenJC1995The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part X. Neuropathology confirmation of the clinical diagnosis of Alzheimer’s diseaseNeurology4546167898697
- GeldmacherDSFritschTMcClendonMJLernerAJLandrethGE2006A double-blind, placebo controlled, 18 momth pilot study of the PPAR-gamma agonist pioglitazone in Alzheimer’s diseaseProgram and abstracts of the 10th International Conference on Alzheimer’s Disease and Related Disorders, Abstract P2408
- GhoshSSSwerdlowRHMillerSW1999Use of cytoplasmic hybrid cell lines for elucidating the role of mitochondrial dysfunction in Alzheimer’s disease and Parkinson’s diseaseAnn N Y Acad Sci8931769110672237
- GibsonGESheuKFBlassJP1998Abnormalities of mitochondrial enzymes in Alzheimer’s diseaseJ Neural Transm105855709869323
- GilmanSKollerMBlackRS2005Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trialNeurology6415536215883316
- GlabeCGKayedR2006Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesisNeurology662 Suppl 1S74816432151
- GoateAChartier-HarlinMCMullanM1991Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s diseaseNature34970461671712
- HambletNSRaglandBAliMMutations in mitochondrial-encoded cytochrome c-oxidase subunits I, II, and III genes detected in Alzheimer’s disease using single-strand conformation polymorphismElectrophoresis2739840816358358
- HanssonCAFrykmanSFarmeryMR2004Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondriaJ Biol Chem279516546015456764
- HardyJAllsopD1991Amyloid deposition as the central event in the aetiology of Alzheimer’s diseaseTrends Pharmacol Sci1238381763432
- HardyJAHigginsGA1992Alzheimer’s disease: the amyloid cascade hypothesisScience25618451566067
- HarmanD1956Aging: a theory based on free radical and radiation chemistryJ Gerontol1129830013332224
- HarmanD1972A biological clock: The mitochondria?J Am Ger Soc201457
- JichaGAParisiJEDicksonDW2005Alzheimer and Lewy body pathology in centenarian case seriesNeurology6Suppl 1A275
- KatzmanR1976The prevalence and malignancy of Alzheimer’s disease: a major killerArch Neurol3321781259639
- KhachaturianZS1985Diagnosis of Alzheimer’s diseaseArch Neurol4210971062864910
- KhanSMCassarinoDSAbramovaNN2000Alzheimer’s disease cybrids replicate beta-amyloid abnormalities through cell death pathwaysAnn Neurol481485510939564
- KhanSMSmigrodzkiRMSwerdlowR2006Cell and animal models of mtDNA biology: Progress and prospectsAm J Physiol Cell Physiol89[Epub ahead of print]. PMID 16899549.
- KimberlyWTXiaWRahmaticJWolfeMSSelkoeDJ2000The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-wcretase activity and amyloid beta-protein generationJ Biol Chem2753173810652302
- KlunkWEEnglerHNordbergA2004Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-BAnn Neurol553061914991808
- KraepelinEPsychiatrie. 1910 Ein Lehrbuch fur Studierende und Artze. II. Band, Klinische Psychiatrie. Verlag Johann Ambrosius Barth, Leipzig.
- KujothGCHionaAPughTD 309. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian agingScience309481416020738
- LesneSKotilinekL2005Amyloid plaques and amyloid-beta oligomers: An ongoing debateJ Neurosci2593192016221839
- LevyR1994Aging-associated cognitive decline. Working Party of the International Psychogeriatric Association in collaboration with the World Health OrganizationInt Psychogeriatr66388054494
- Levy-LahadEWascoWPoorkajP1995Candidate gene for the chromosome 1 familial Alzheimer’s disease locusScience26997377638622
- LinMTSimonDKAhnCHKimLMBealMF2002High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer’s disease brainHum Mol Genet111334511809722
- LinnaneAWMarzukiSOzawaTTanakaM1989Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseasesLancet164252564461
- LockePAConneallyPMTanziREGusellaJFHainesJL1995Apolipoprotein E, survival in Alzheimer’s disease patients, and the competing risks of death and Alzheimer’s diseaseNeurology45132387617191
- LustbaderJWCirilliMLinC2004ABAD directly links Abeta to mitochondrial toxicity in Alzheimer’s diseaseScience3044485215087549
- ManczakMAnekondaTSHensonE2006Mitochondria are a direct site of A beta accumulation in Alzheimer‘s disease neurons: implications for free radical generation and oxidative damage in disease progressionHum Mol Genet1514374916551656
- MasliahEHansenLAdameA2005Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer diseaseNeurology641293115642916
- McSheaAWahlAFSmithMA1999Re-entry into the cell cycle: A mechanism for neurodegeneration in Alzheimer diseaseMed Hypotheses52525710459833
- MiquelJEconomosACFlemingJJohnsonJEJr1980Mitochondrial role in cell agingExp Gerontol15575917009178
- MirraSSHeymanAMcKeelD1991The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). II. Standardization of the neuropathological assessment of Alzheimer’s diseaseNeurology41479862011243
- MiyataMSmithJD1996Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptidesNat Genet1455618782820
- MizutaniTShimadaH1992Neuropathological background of twenty-seven centenarian brainsJ Neurol Sci108168771517748
- MorrisJC2006Mild cognitive impairment is early-stage Alzheimer disease: Time to revise diagnostic criteriaArch Neurol6315616401731
- NearyDSnowdenJMannD2005Frontotemporal dementiaLancet Neurol47718016239184
- NicollJAWilkinsonDHolmesC2003Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case reportNat Med94485212640446
- ParkerWDJrFilleyCMParksJK1990Cytochrome oxidase deficiency in Alzheimer’s diseaseNeurology40130232166249
- ParkerWDJrParksJK1995Cytochrome c oxidase in Alzheimer’s disease brain: purification and characterizationNeurology4548267898701
- PearlR1928The rate of living, being an account of some experimental studies on the biology of life durationNew YorkAlfred A. Knopf
- PereiraCSantosMSOliveiraC1998Mitochondrial function impairment induced by amyloid beta-peptide on PC12 cellsNeuroreport91749559665595
- PerlsT2004Dementia-free centenariansExp Gerontol3915879315582273
- PetersenRCSmithGEWaringSC1999Mild cognitive impairment: Clinical characterization and outcomeArch Neurol56303810190820
- PoirierJ2000Apoliproptein E and Alzheimer’s disease. A role in amyloid catabolismAnn NY Acad Sci924819011193807
- PolvikoskiTSulkavaRRastasS2005Incidence of dementia in very elderly individuals: A clinical, neuropathological and molecular genetic studyNeuroepidemiology26768216352910
- PriceJLKoAIWadeMJNeuron number in the entorhinal cortex and CA1 in preclinical Alzheimer diseaseArch Neurol58139540211559310
- ReddyPH2006Mitochondrial oxidative damage in aging and Alzheimer’s disease: Implications for mitochondrially targeted antoxidant therapeuticsJ Biomed Biotechnol20063137217047303
- ReimanEMCaselliRJYunLS1996Preclinical evidence of Alzheimer’s disease in persons homozygous for the epsilon 4 allele for apoliprotein ENEJM33475288592548
- RelkinNSzaboPAdamiakB2005Intravenous immunoglobulin (IVIg) treatment causes dose-dependent alterations in β-amyloid (Aβ) levels and anti-Aβ antibody titers in plasma and cerebrospinal fluid (CSF) of Alzheimer’s disease (AD) patientsNeurology64A144
- RentzDMBeckerJAMoranEK2006Amyloid imaging with Pittsburgh Compound-B (PIB) in AD, MCI, and highly intelligent older adultsNeurology66suppl 2A66
- RisnerMESaundersAMAltmanJF2006Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer’s diseasePharmacogenomics J62464516446752
- SaundersAM2000Apolipoprotein E and Alzheimer disease: An update on genetic and functional analysesJ Neuropath Exp Neurol59751811005255
- SchenkDBarbourRDunnW1999Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouseNature400173710408445
- ScheunerDEckmanCJensenM1996Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer’s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer’s diseaseNat Med2864708705854
- SherringtonRRogaevaEILiangY1995Cloning of a gene bearing missense mutations in early-onset familial Alzheimer’s diseaseNature375754607596406
- Shoghi-JadidKSmallGWAgdeppaED2002Localization of neurofibrillary tangles and beta amyloid plaques in the brains of living patients with Alzheimer diseaseAm J Geriatr Psychiatry10243511790632
- SmallGWMazziottaJCCollinsMT1995Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer diseaseJAMA27394277884953
- SmythKAFritschTCookTB2004Worker functions and traits associated with occupations and the development of ADNeurology6349850315304581
- SnowdonDAKemperSJMortimerJA1996Linguistic ability in early life and cognitive function and Alzheimer’s disease in late life. Findings from the Nun StudyJAMA275528328606473
- SternY2006Cognitive reserve and Alzheimer diseaseAlzheimer Dis Assoc Disord203 suppl 2S697416917199
- SwerdlowRHParksJKCassarinoDS1997Cybrids in Alzheimer’s disease: A cellular model of the disease?Neurology49918259339668
- SwerdlowRH2002Mitochondrial DNA – related mitochondrial dysfunction in neurodegenerative diseasesArch Pathol Lab Med1262718011860299
- SwerdlowRHKishSJ2002Mitochondria in Alzheimer’s diseaseInt Rev Neurobiol533418512512346
- SwerdlowRHKhanSM2004A “mitochondrial cascade hypothesis” for sporadic Alzheimer’s diseaseMed Hypotheses6382015193340
- SwerdlowRH2006Is aging part of Alzheimer’s disease, or is Alzheimer’s disease part of aging?Neurobiol Aging728[Epub ahead of print] PMID: 16876913.
- SwerdlowRH2007Mitochondria in cybrids containing mtDNA from persons with mitochondriopathiesJ Neurosci Res122[Epub ahead of print] PMID: 17243174.
- SzabadosTDulCMajtenyiK2004A chronic Alzheimer’s model evoked by mitochondrial poison sodium azide for pharmacological investigationsBehav Brain Res154314015302108
- TamagnoEBardiniPObbiliA2002Oxidative stress increases expression and activity of BACE in NT2 neuronsNeurobiol Dis102798812270690
- ThomassenRvan SchaickHWBlansjaarBA1998Prevalence of dementia over age 100Neurology5028369443495
- TrifunovicAWredenbergAFalkenbergM2004Premature ageing in mice expressing defective mitochondrial DNA polymeraseNature42941742315164064
- TuszynskiMHThalLPayM2005A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer diseaseNat Med11551515852017
- van der WaltJMDementievaYAMartinER2004Analysis of European mitochondrial haplogroups with Alzheimer disease riskNeurosci Lett365283215234467
- VincentIRosadoMDaviesP1996Mitotic mechanisms in Alzheimer’s disease?J Cell Biol132413258636218
- WallaceDC1992Mitochondrial genetics: a paradigm for aging and degenerative diseases?Science256628321533953
- WalshDMKlyubinIShankarGM2005The role of cell-derived oligomers of Abeta in Alzheimer’s disease and avenues for therapeutic interventionBiochem Soc Trans3310879016246051
- WolfeWTXiaWOstaszewskiBL1999Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activityNature398513710206644
- YangYGeldmacherDSHerrupK2001DNA replication precedes neuronal cell death in Alzheimer’s diseaseJ Neurosci2126628
- ZhengHJiangMTrumbauerME1995Beta-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomoter activityCell81525317758106
- ZhuXRainaAKPerryGSmithMA2004Alzheimer’s disease: The two-hit hypothesisLancet Neurol32192615039034
- ZlokovicBV2005Neurovascular mechanisms of Alzheimer’s neurodegenerationTrends Neurosci28202815808355